MetaCyc Pathway: serotonin degradation in Pseudomonas putida KT2440

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Reactions and Genes Vanillic Acid (C)
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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
PP_4983 +0.0
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
PP_0545 +0.0
PP_0665 -0.2
PP_0708 +0.0
PP_1948 -0.0
PP_2487 -0.0
PP_2589 -0.0
PP_2680 +0.0
PP_2694 +0.2
PP_3270 +0.0
PP_3463 +0.1
PP_3646 +0.1
PP_5258 +0.2
PP_5278 +0.1
PP_5372 +0.1
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
PP_1616 -4.2
PP_2049 -0.2
PP_2426 +0.2
PP_2650 +0.5
PP_2803 -0.3
PP_3839 +0.2
PP_4760 +0.5
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information