| Reactions and Genes | Trimethoprim 0.0025 mM |
|---|
| remove |
Glucose-1-phosphate thymidylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + dTTP→dTDP-α-D-glucose + diphosphate (EC 2.7.7.24) |
| b0363 (yaiP) | -0.2 |
| b2039 (rfbA) | -2.4 |
| b3789 (rffH) | +0.9 |
dTDP-glucose 4,6-dehydratase:
dTDP-α-D-glucose→dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H2O (EC 4.2.1.46) |
| b2041 (rfbB) | +1.9 |
| b3788 (rffG) | +0.6 |
| dTDP-4-dehydro-6-deoxy-α-D-glucopyranose→dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H+ + H2O (EC 4.2.1.159) |
| No genes |
| dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H+→dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose (spontaneous) (EC 4.2.1.159) |
| No genes |
| dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose + NADPH + H+→dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + NADP+ (EC 1.1.1.384) |
| No genes |
| dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + NADPH + H+→dTDP-α-D-olivose + NADP+ |
| No genes |
| dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + NADPH + H+→dTDP-α-D-oliose + NADP+ |
| No genes |
| dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose + S-adenosyl-L-methionine→dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-α-D-glucose + S-adenosyl-L-homocysteine + H+ |
| No genes |
| dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-α-D-glucose + NADPH + H+→dTDP-α-D-mycarose + NADP+ |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information