MetaCyc Pathway: dTDP-D-desosamine biosynthesis in Escherichia coli BW25113

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Reactions and Genes Trimethoprim 0.00125 mM
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Glucose-1-phosphate thymidylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + dTTP→dTDP-α-D-glucose + diphosphate (EC 2.7.7.24)
b0363 (yaiP) +0.0
b2039 (rfbA) -2.6
b3789 (rffH) +0.6
dTDP-glucose 4,6-dehydratase:
dTDP-α-D-glucose→dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H2O (EC 4.2.1.46)
b2041 (rfbB) +1.7
b3788 (rffG) +0.4
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase (in reverse):
dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + L-glutamate→dTDP-viosamine + 2-oxoglutarate (EC 2.6.1.33)
No genes
dTDP-viosamine + a reduced two electron carrier + S-adenosyl-L-methionine→dTDP-3-dehydro-4,6-deoxy-α-D-glucose + ammonium + an oxidized electron carrier + 5'-deoxyadenosine + L-methionine + H+ (EC 4.3.1.30)
No genes
dTDP-3-dehydro-4,6-deoxy-α-D-glucose + L-glutamate→dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose + 2-oxoglutarate (EC 2.6.1.106)
No genes
dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose + 2 S-adenosyl-L-methionine→dTDP-D-desosamine + 2 S-adenosyl-L-homocysteine + 2 H+ (EC 2.1.1.234)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information