MetaCyc Pathway: preQ0 biosynthesis in Escherichia coli BW25113

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Reactions and Genes Trimethoprim 0.00125 mM
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GTP cyclohydrolase I:
GTP + H2O→7,8-dihydroneopterin 3'-triphosphate + formate + H+ (EC 3.5.4.16)
b2153 (folE) N.D.
7,8-dihydroneopterin 3'-triphosphate + H2O→6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate + H+ (EC 4.1.2.50)
b2765 (ygcM) +1.4
6-carboxy-5,6,7,8-tetrahydropterin + H+→7-carboxy-7-deazaguanine + ammonium (EC 4.3.99.3)
No genes
7-carboxy-7-deazaguanine + ammonium + ATP→preQ0 + ADP + H+ + phosphate + H2O (EC 6.3.4.20)
b0444 (ybaX) +0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information