MetaCyc Pathway: adipate degradation in Pseudomonas putida KT2440

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Reactions and Genes Protocatechuic Acid (C)
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Succinate--CoA ligase (ADP-forming):
adipate + ATP + coenzyme A→adipoyl-CoA + ADP + phosphate (EC 6.2.1.5)
PP_4185 N.D.
PP_4186 N.D.
adipoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-5-carboxy-2-pentenoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
PP_0368 -1.7
PP_0370 +0.0
PP_2048 -0.1
PP_3354 +0.1
PP_3554 -0.0
PP_4780 +0.0
PP_4948 -0.1
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
PP_1412 +0.2
PP_1845 +0.0
PP_2047 -0.2
PP_2136 -0.5
PP_2217 +0.2
PP_3283 +0.2
PP_3284 -0.0
PP_3358 -0.0
PP_3491 -0.1
PP_3726 -0.5
PP_3732 -0.3
PP_4030 +0.1
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
PP_2047 -0.2
PP_2136 -0.5
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
PP_1377 -6.4
PP_3280 -0.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information