MetaCyc Pathway: superpathway of hexitol degradation (bacteria) in Escherichia coli BL21

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Reactions and Genes Tailocin 256
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Mannitol-1-phosphate 5-dehydrogenase:
D-mannitol 1-phosphate + NAD+→β-D-fructofuranose 6-phosphate + NADH + H+ (EC 1.1.1.17)
ECD_03455 +2.5
Sorbitol-6-phosphate 2-dehydrogenase:
D-sorbitol 6-phosphate + NAD+→keto-D-fructose 6-phosphate + NADH + H+ (EC 1.1.1.140)
ECD_02555 -0.3
galactitol[out] + an [HPr protein]-Nπ-phospho-L-histidine[in]→galactitol 1-phosphate[in] + an [HPr]-L-histidine[in] (EC 2.7.1.200)
ECD_02018 -0.5
ECD_02019 N.D.
ECD_02020 N.D.
Galactitol-1-phosphate 5-dehydrogenase:
galactitol 1-phosphate + NAD+→keto-D-tagatose 6-phosphate + NADH + H+ (EC 1.1.1.251)
ECD_02017 -0.1
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
ECD_01692 +0.3
ECD_03801 -0.1
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
ECD_02025 -0.5
ECD_02756 N.D.
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
ECD_00330 +0.3
ECD_02761 -0.3
ECD_03810 -0.1
ECD_04100 +0.4
keto-D-tagatose 6-phosphate→D-tagatofuranose 6-phosphate (spontaneous)
No genes
Tagatose-6-phosphate kinase:
D-tagatofuranose 6-phosphate + ATP→D-tagatofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.144)
ECD_01692 +0.3
ECD_02021 -0.3
ECD_02097 +0.9
ECD_02997 -0.5
ECD_03801 -0.1
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
ECD_03804 N.D.
Tagatose-bisphosphate aldolase:
D-tagatofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.40)
ECD_02021 -0.3
ECD_02024 +0.5
ECD_02997 -0.5
ECD_03004 -0.4
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
ECD_01371 N.D.
ECD_01748 N.D.
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
ECD_02757 N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
ECD_00708 -0.1
ECD_03470 -0.2
ECD_04271 +0.1
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
ECD_00708 -0.1
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
ECD_02624 N.D.
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
ECD_01645 +2.1
ECD_01825 +2.2
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
ECD_01671 -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information