MetaCyc Pathway: serotonin degradation in Agrobacterium fabrum C58

Reactions and Genes	anthranilamide (C)
Aryl sulfotransferase: serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase: serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)): 5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
Atu2139	+0.2
Atu2224	-2.9
Atu3401	+0.3
Atu3403	-0.1
Atu3950	+0.1
Atu3959	-0.1
Atu4153	-0.2
Atu4241	-0.0
Atu4849	-0.0
Atu5228	N.D.
Alcohol dehydrogenase (in reverse): 5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
Atu0626	-1.7
Atu1557	+0.0
Atu1595	N.D.
Atu1670	+0.1
Atu2022	-0.1
Atu2138	+0.3
Atu2151	+0.0
Atu2528	-0.1
Atu4236	-0.1
Atu4289	-0.2
Atu5074	-0.1
Atu5138	-0.1
Atu5202	+0.0
Atu5240	N.D.
Aryl sulfotransferase: 5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase: 5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information