MetaCyc Pathway: L-tyrosine degradation III in Escherichia coli BW25113
| Reactions and Genes | LB Anaerobic with Spiramycin 0.000125 mM |
|---|---|
| remove | |
| Phenylalanine(histidine) transaminase: L-tyrosine + pyruvate→3-(4-hydroxyphenyl)pyruvate + L-alanine (EC 2.6.1.58) | |
| No genes | |
| Aspartate transaminase: L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57) | |
| b0928 (aspC) | +0.1 |
| b2021 (hisC) | +0.0 |
| b4054 (tyrB) | -0.1 |
| b4340 (yjiR) | +0.1 |
| 4-hydroxyphenylpyruvate decarboxylase: 3-(4-hydroxyphenyl)pyruvate + H+→(4-hydroxyphenyl)acetaldehyde + CO2 (EC 4.1.1.80) | |
| No genes | |
| Alcohol dehydrogenase (in reverse): (4-hydroxyphenyl)acetaldehyde + NADH + H+→4-tyrosol + NAD+ (EC 1.1.1.1) | |
| b0325 (yahK) | +0.1 |
| b0356 (frmA) | +0.0 |
| b1241 (adhE) | -1.3 |
| b1478 (adhP) | +0.6 |
| b3253 (yhdH) | -1.3 |
| b4269 (yjgB) | +0.3 |
| b3589 (yiaY) | +0.2 |
Links:
- Pathway details at MetaCyc
- Fitness data for 11 genes
- All MetaCyc pathways for Escherichia coli BW25113
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information