MetaCyc Pathway: superpathway of cardiolipin biosynthesis (bacteria) in Escherichia coli BW25113

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Reactions and Genes LB Anaerobic with Vancomycin Hydrochloride from Streptomyces orientalis 0.00003125 mM
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Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) (in reverse):
glycerone phosphate + NAD(P)H + H+→sn-glycerol 3-phosphate + NAD(P)+ (EC 1.1.1.94)
b3608 (gpsA) N.D.
a fatty acyl-[acyl-carrier protein] + phosphate→an acyl phosphate + a soluble [acyl-carrier protein] (EC 2.3.1.274)
No genes
Glycerol-3-phosphate O-acyltransferase:
sn-glycerol 3-phosphate + an acyl-[acyl-carrier protein]→a 2-lysophosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.15)
b1090 (plsX) +1.4
b3059 (ygiH) +0.3
b4041 (plsB) +1.4
an acyl phosphate + sn-glycerol 3-phosphate→a 2-lysophosphatidate + phosphate (EC 2.3.1.275)
No genes
1-acylglycerol-3-phosphate O-acyltransferase:
a 2-lysophosphatidate + an acyl-[acyl-carrier protein]→a phosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.51)
b3018 (plsC) N.D.
b3862 (yihG) +0.2
Phosphatidate cytidylyltransferase:
a phosphatidate + CTP + H+→a CDP-diacylglycerol + diphosphate (EC 2.7.7.41)
b0175 (cdsA) N.D.
b1409 (ynbB) -0.3
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase:
a CDP-diacylglycerol + sn-glycerol 3-phosphate→a phosphatidylglycerophosphate + CMP + H+ (EC 2.7.8.5)
b1408 (b1408) +0.1
b1912 (pgsA) N.D.
CDP-diacylglycerol--serine O-phosphatidyltransferase:
a CDP-diacylglycerol + L-serine→a phosphatidylserine + CMP + H+ (EC 2.7.8.8)
b2585 (pssA) N.D.
a CDP-diacylglycerol + a phosphatidylglycerol→a cardiolipin + CMP + H+ (EC 2.7.8.41)
b0789 (ybhO) +0.3
b1046 (ymdC) -0.1
b1249 (cls) -2.5
Phosphatidylglycerophosphatase:
a phosphatidylglycerophosphate + H2O→a phosphatidylglycerol + phosphate (EC 3.1.3.27)
b0418 (pgpA) +1.5
b1278 (pgpB) -1.4
b2560 (yfhB) -0.4
Phosphatidylserine decarboxylase:
a phosphatidylserine + H+→a phosphatidylethanolamine + CO2 (EC 4.1.1.65)
b4160 (psd) N.D.
2 a phosphatidylglycerol→a cardiolipin + glycerol (EC 2.7.8.41)
b0789 (ybhO) +0.3
b1249 (cls) -2.5
a phosphatidylethanolamine + a phosphatidylglycerol→a cardiolipin + ethanolamine (EC 2.7.8.41)
b1046 (ymdC) -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information