MetaCyc Pathway: L-threonine degradation I in Escherichia coli BW25113
| Reactions and Genes | LB Aerobic with Ramoplanin 0.000125 mM |
|---|---|
| remove | |
| Threonine ammonia-lyase: L-threonine→(Z)-2-aminobutenoate + H2O (EC 4.3.1.19) | |
| b3117 (tdcB) | -0.1 |
| b3772 (ilvA) | -0.0 |
| 1-aminocyclopropane-1-carboxylate deaminase: (Z)-2-aminobutenoate→2-iminobutanoate (spontaneous) (EC 3.5.99.7; 4.3.1.19; 4.4.1.1; 4.4.1.11; 4.4.1.2) | |
| b3117 (tdcB) | -0.1 |
| b3772 (ilvA) | -0.0 |
| 2-iminobutanoate + H2O→2-oxobutanoate + ammonium (spontaneous) (EC 3.5.99.10; 3.5.99.7; 4.3.1.19; 4.4.1.1; 4.4.1.11; 4.4.1.2) | |
| b3113 (yhaR) | -0.2 |
| b3117 (tdcB) | -0.1 |
| b3772 (ilvA) | -0.0 |
| b4243 (yjgF) | -1.9 |
| Formate C-acetyltransferase (in reverse): 2-oxobutanoate + coenzyme A→propanoyl-CoA + formate (EC 2.3.1.54) | |
| b0823 (ybiW) | -0.1 |
| b0903 (pflB) | +0.1 |
| b2579 (yfiD) | +0.7 |
| b3951 (pflD) | -0.1 |
| b3114 (tdcE) | -0.0 |
| propanoyl-CoA + phosphate→propanoyl phosphate + coenzyme A (EC 2.3.1.222) | |
| b2297 (pta) | -0.1 |
| Acetate kinase (in reverse): propanoyl phosphate + ADP→propanoate + ATP (EC 2.7.2.1; 2.7.2.14; 2.7.2.15; 2.7.2.7) | |
| b2296 (ackA) | N.D. |
| b3115 (tdcD) | -0.1 |
Links:
- Pathway details at MetaCyc
- Fitness data for 12 genes
- All MetaCyc pathways for Escherichia coli BW25113
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information