MetaCyc Pathway: colanic acid building blocks biosynthesis in Pseudomonas syringae pv. syringae B728a ΔmexB

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Reactions and Genes KB with Novobiocin 7.75 ug/ml
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Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
Psyr_0826 +2.9
Phosphoglucomutase (in reverse):
D-glucopyranose 6-phosphate→α-D-glucopyranose 1-phosphate (EC 5.4.2.2)
Psyr_0219 +1.3
Psyr_2908 -0.1
Psyr_4185 N.D.
UTP-monosaccharide-1-phosphate uridylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + UTP→UDP-α-D-glucose + diphosphate (EC 2.7.7.64; 2.7.7.9)
Psyr_2980 +3.4
Mannose-6-phosphate isomerase (in reverse):
β-D-fructofuranose 6-phosphate→D-mannopyranose 6-phosphate (EC 5.3.1.8)
Psyr_0603 +0.2
Psyr_0937 +1.2
Psyr_1052 -0.0
Phosphomannomutase (in reverse):
D-mannopyranose 6-phosphate→α-D-mannose 1-phosphate (EC 5.4.2.8)
Psyr_0219 +1.3
UDP-glucose 4-epimerase:
UDP-α-D-glucose→UDP-α-D-galactose (EC 5.1.3.2)
Psyr_2704 -0.4
Psyr_3638 +1.5
Psyr_4475 N.D.
UDP-glucose 6-dehydrogenase:
UDP-α-D-glucose + 2 NAD+ + H2O→UDP-α-D-glucuronate + 2 NADH + 3 H+ (EC 1.1.1.22)
Psyr_2696 -0.1
Psyr_5105 -0.1
Mannose-1-phosphate guanylyltransferase:
α-D-mannose 1-phosphate + GTP + H+→GDP-α-D-mannose + diphosphate (EC 2.7.7.13)
Psyr_0937 +1.2
Psyr_1052 -0.0
GDP-mannose 4,6-dehydratase:
GDP-α-D-mannose→GDP-4-dehydro-α-D-rhamnose + H2O (EC 4.2.1.47)
Psyr_0916 +2.0
GDP-L-fucose synthase:
GDP-4-dehydro-α-D-rhamnose→GDP-4-dehydro-6-deoxy-β-L-galactose (EC 1.1.1.271)
No genes
GDP-L-fucose synthase (in reverse):
GDP-4-dehydro-6-deoxy-β-L-galactose + NADPH + H+→GDP-β-L-fucose + NADP+ (EC 1.1.1.271)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information