MetaCyc Pathway: superpathway of salicylate degradation in Agrobacterium fabrum C58

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Reactions and Genes 4-Hydroxybenzoic Acid (C)
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Salicylate 1-monooxygenase:
salicylate + NADH + dioxygen + 2 H+→catechol + CO2 + NAD+ + H2O (EC 1.14.13.1)
Atu1574 N.D.
Catechol 1,2-dioxygenase:
catechol + dioxygen→cis,cis-muconate + 2 H+ (EC 1.13.11.1)
Atu2527 +0.2
Muconate cycloisomerase (in reverse):
cis,cis-muconate + H+→(+)-muconolactone (EC 5.5.1.1)
Atu1648 -0.0
Atu5478 -0.1
Muconolactone Delta-isomerase:
(+)-muconolactone→(4,5-dihydro-5-oxofuran-2-yl)-acetate (EC 5.3.3.4)
No genes
3-oxoadipate enol-lactonase:
(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O→3-oxoadipate + H+ (EC 3.1.1.24)
Atu4238 +0.2
Atu4542 -2.8
Atu5226 N.D.
3-oxoadipate CoA-transferase:
3-oxoadipate + succinyl-CoA→3-oxoadipoyl-CoA + succinate (EC 2.8.3.6)
Atu4547 -4.0
Atu4548 -4.1
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→acetyl-CoA + succinyl-CoA (EC 2.3.1.174)
Atu4549 -4.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information