MetaCyc Pathway: 2,4,5-trichlorophenoxyacetate degradation in Agrobacterium fabrum C58

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Reactions and Genes 2-6-dihydroxybenzoic (C)
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2,4,5-trichloro-phenoxyacetate + NADH + dioxygen→2,4,5-trichlorophenol + glyoxylate + NAD+ + H2O
No genes
2,4,5-trichlorophenol + FADH2 + dioxygen→2,5-dichloro-p-quinone + chloride + FAD + H+ + H2O
No genes
2,5-dichloro-p-quinone + FADH2→2,5-dichloro-p-quinol + FAD + H+ (spontaneous)
No genes
2,5-dichloro-p-quinol + FADH2 + dioxygen→5-chlorohydroxyquinone + chloride + FAD + 3 H+ + H2O
No genes
5-chlorohydroxyquinone + FADH2→5-chlorohydroxyquinol + FAD (spontaneous)
No genes
5-chlorohydroxyquinol→2-hydroxy-1,4-benzoquinone + chloride + 2 H+
Atu2649 -0.2
2-hydroxy-1,4-benzoquinone reductase:
2-hydroxy-1,4-benzoquinone + NADH + 2 H+→hydroxyquinol + NAD+
(EC 1.6.5.7)
No genes
Hydroxyquinol 1,2-dioxygenase:
hydroxyquinol + dioxygen→2-maleylacetate + 2 H+
(EC 1.13.11.37)
Atu2527 -1.0
Maleylacetate reductase (in reverse):
2-maleylacetate + NAD(P)H + H+→3-oxoadipate + NAD(P)+
(EC 1.3.1.32)
Atu2528 -1.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information