MetaCyc Pathway: superpathway of glyoxylate cycle and fatty acid degradation in Agrobacterium fabrum C58

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Reactions and Genes 2-6-dihydroxybenzoic (C)
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a 2,3,4-saturated fatty acid + ATP + coenzyme A→a 2,3,4-saturated fatty acyl CoA + AMP + diphosphate
No genes
Acyl-CoA oxidase:
a 2,3,4-saturated fatty acyl CoA + dioxygen→a (2E)-2-enoyl-CoA + hydrogen peroxide
(EC 1.3.3.6)
No genes
Enoyl-CoA hydratase (in reverse):
a (2E)-2-enoyl-CoA + H2O→a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA
(EC 4.2.1.17)
Atu0322 +0.1
Atu0503 -1.0
Atu0733 +0.2
Atu1417 -0.2
Atu3481 -0.1
Atu3505 -0.1
3-hydroxyacyl-CoA dehydrogenase:
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA + NAD+→a 2,3,4-saturated 3-oxoacyl-CoA + NADH + H+
(EC 1.1.1.35)
Atu0503 -1.0
Atu1415 -0.3
Acetyl-CoA C-acyltransferase (in reverse):
a 2,3,4-saturated 3-oxoacyl-CoA + coenzyme A→a 2,3,4-saturated fatty acyl CoA + acetyl-CoA
(EC 2.3.1.16)
Atu0502 -1.2
Atu2769 -0.1
Atu3475 -0.1
Atu4549 -2.5
Atu4823 +0.2
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+
(EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
Atu1392 N.D.
Atu4851 N.D.
Atu5306 N.D.
Atu5307 N.D.
Aconitate hydratase:
citrate→cis-aconitate + H2O
(EC 4.2.1.3)
Atu2685 +0.1
Atu4734 +0.0
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate
(EC 4.2.1.3)
Atu2685 +0.1
Atu4734 +0.0
Isocitrate lyase:
D-threo-isocitrate→glyoxylate + succinate
(EC 4.1.3.1)
Atu0607 -0.8
Malate synthase:
acetyl-CoA + glyoxylate + H2O→(S)-malate + coenzyme A + H+
(EC 2.3.3.9)
Atu0047 -1.8
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol
(EC 1.3.5.1)
Atu2643 N.D.
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate
(EC 4.2.1.2)
Atu1616 N.D.
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+
(EC 1.1.1.37; 1.1.1.38)
Atu1652 N.D.
Atu2639 N.D.
Phosphoenolpyruvate carboxykinase (ATP):
oxaloacetate + ATP→phosphoenolpyruvate + ADP + CO2
(EC 4.1.1.49)
Atu0035 -2.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information