MetaCyc Pathway: pentachlorophenol degradation in Agrobacterium fabrum C58

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Reactions and Genes 2-6-dihydroxybenzoic (C)
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Pentachlorophenol monooxygenase:
pentachlorophenol + NADPH + dioxygen + H+→2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + NADP+ + H2O
(EC 1.14.13.50)
No genes
2,3,5,6-tetrachloro-1,4-benzoquinone + NADH→2,3,5,6-tetrachlorohydroquinone + NAD+ + H+ (EC 1.1.1.404)
No genes
2,3,5,6-tetrachlorohydroquinone + glutathione + H+→2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone + chloride (EC 1.21.4.5; 2.5.1.18)
Atu0293 N.D.
Atu0835 +0.0
Atu0836 +0.2
Atu1394 +0.0
Atu1871 +0.2
Atu2261 -0.2
Atu3010 -0.5
Atu3585 -0.2
Atu3701 -0.1
Atu5150 +0.1
Atu5272 N.D.
Atu8169 +0.2
2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone + glutathione→2,3,6-trichlorohydroquinone + glutathione disulfide + H+ (EC 1.21.4.5; 1.8.5.7)
No genes
2,3,6-trichlorohydroquinone + glutathione→2,6-dichloro-3-(glutathion-S-yl)-hydroquinone + chloride (EC 1.21.4.5; 2.5.1.18)
Atu0293 N.D.
Atu0835 +0.0
Atu0836 +0.2
Atu1394 +0.0
Atu1871 +0.2
Atu2261 -0.2
Atu3010 -0.5
Atu3585 -0.2
Atu3701 -0.1
Atu5150 +0.1
Atu5272 N.D.
Atu8169 +0.2
2,6-dichloro-3-(glutathion-S-yl)-hydroquinone + glutathione→2,6-dichlorohydroquinone + glutathione disulfide + H+ (EC 1.21.4.5; 1.8.5.7)
No genes
2,6-dichlorohydroquinone + dioxygen + H2O→2-chloromaleylacetate + chloride + 2 H+
No genes
Maleylacetate reductase (in reverse):
2-chloromaleylacetate + NAD(P)H + H+→5-chloro-3-oxoadipate + NAD(P)+
(EC 1.3.1.32)
No genes
5-chloro-3-oxoadipate→2-maleylacetate + chloride + H+ (spontaneous)
No genes
Maleylacetate reductase (in reverse):
2-maleylacetate + NAD(P)H + H+→3-oxoadipate + NAD(P)+
(EC 1.3.1.32)
Atu2528 -1.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information