MetaCyc Pathway: 4-methylcatechol degradation (ortho cleavage) in Agrobacterium fabrum C58

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Reactions and Genes 4-Hydroxybenzoic Acid (C)
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4-methylcatechol + dioxygen→3-methyl-cis,cis-muconate + 2 H+
No genes
Chloromuconate cycloisomerase (in reverse):
3-methyl-cis,cis-muconate + H+→4-methylmuconolactone (EC 5.5.1.7)
No genes
4-carboxymethyl-4-methylbutenolide mutase:
4-methylmuconolactone→3-methylmuconolactone (EC 5.4.99.14)
No genes
Muconolactone Delta-isomerase:
3-methylmuconolactone→4-methyl-3-oxoadipate-enol-lactone (EC 5.3.3.4)
No genes
3-oxoadipate enol-lactonase:
4-methyl-3-oxoadipate-enol-lactone + H2O→4-methyl-3-oxoadipate + H+ (EC 3.1.1.24)
Atu4238 +0.2
Atu4542 -2.4
Atu5226 N.D.
3-oxoadipate CoA-transferase:
4-methyl-3-oxoadipate + succinyl-CoA→4-methyl-3-oxoadipyl-CoA + succinate (EC 2.8.3.6)
Atu4547 -3.0
Atu4548 -2.9
3-oxoadipyl-CoA thiolase (in reverse):
4-methyl-3-oxoadipyl-CoA + coenzyme A→acetyl-CoA + (2S)-methylsuccinyl-CoA (EC 2.3.1.174)
Atu4549 -2.9

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information