MetaCyc Pathway: noradrenaline and adrenaline degradation in Agrobacterium fabrum C58

Add experiment(s):


Reactions and Genes 4-Aminobutyric (C)
remove
Catechol O-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→L-normetanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
(R)-noradrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.28)
No genes
Monoamine oxidase:
(R)-adrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
No genes
Catechol O-methyltransferase:
(R)-adrenaline + S-adenosyl-L-methionine→metanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
L-normetanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
Alcohol dehydrogenase (in reverse):
3,4-dihydroxyphenylglycolaldehyde + NADH + H+→(R)-3,4-dihydroxyphenylglycol + NAD+ (EC 1.1.1.1)
Atu0626 -1.1
Atu1557 -0.1
Atu1595 N.D.
Atu1670 -0.0
Atu2022 +0.2
Atu2138 -0.2
Atu2151 +0.2
Atu2528 +0.1
Atu4236 +0.1
Atu4289 -0.1
Atu5074 -0.1
Atu5138 +0.0
Atu5202 +0.0
Atu5240 N.D.
Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O→3,4-dihydroxymandelate + NADH + 2 H+ (EC 1.2.1.3)
Atu2139 +0.1
Atu2224 -1.6
Atu3401 +0.1
Atu3403 -0.0
Atu3950 -0.1
Atu3959 +0.0
Atu4153 +0.0
Atu4241 +0.1
Atu4849 +0.1
Atu5228 N.D.
Monoamine oxidase:
metanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
No genes
Catechol O-methyltransferase:
(R)-3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine→3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Catechol O-methyltransferase:
3,4-dihydroxymandelate + S-adenosyl-L-methionine→vanillylmandelate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Alcohol dehydrogenase:
3-methoxy-4-hydroxyphenylglycol + NAD+→3-methoxy-4-hydroxyphenylglycolaldehyde + NADH + H+ (EC 1.1.1.1)
Atu0626 -1.1
Atu1557 -0.1
Atu1595 N.D.
Atu1670 -0.0
Atu2022 +0.2
Atu2138 -0.2
Atu2151 +0.2
Atu2528 +0.1
Atu4236 +0.1
Atu4289 -0.1
Atu5074 -0.1
Atu5138 +0.0
Atu5202 +0.0
Atu5240 N.D.
Aldehyde dehydrogenase (NAD(+)):
3-methoxy-4-hydroxyphenylglycolaldehyde + NAD+ + H2O→vanillylmandelate + NADH + 2 H+ (EC 1.2.1.3)
Atu2139 +0.1
Atu2224 -1.6
Atu3401 +0.1
Atu3403 -0.0
Atu3950 -0.1
Atu3959 +0.0
Atu4153 +0.0
Atu4241 +0.1
Atu4849 +0.1
Atu5228 N.D.

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information