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Cofit
Protein
Homologs
Fitness for 5 genes in
Escherichia coli ECOR27
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Top 22 experiments (either direction), sorted by average fitness
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500 nt
hisA and hisH overlap by 1 nucleotides
hisH and hisB overlap by 1 nucleotides
hisB and hisC overlap by 1 nucleotides
hisC and hisD overlap by 4 nucleotides
NOLOHH_15810: hisA - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)me thylideneamino]imidazole-4-carboxamide isomerase, at 3,117,328 to 3,118,065
hisA
NOLOHH_15815: hisH - imidazole glycerol phosphate synthase subunit HisH, at 3,118,065 to 3,118,655
hisH
NOLOHH_15820: hisB - bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB, at 3,118,655 to 3,119,722
hisB
NOLOHH_15825: hisC - histidinol-phosphate transaminase, at 3,119,722 to 3,120,792
hisC
NOLOHH_15830: hisD - Histidinol dehydrogenase, at 3,120,789 to 3,122,093
hisD
Group
Condition
NOLOHH
_15810
NOLOHH
_15815
NOLOHH
_15820
NOLOHH
_15825
NOLOHH
_15830
hisA
hisH
hisB
hisC
hisD
carbon source
D-Glucose
-8.6
-4.5
-3.4
-4.6
-7.0
carbon source
L-Rhamnose
-5.1
-6.9
-5.7
-3.9
-6.4
carbon source
Sodium-DL-Lactate
-4.9
-4.2
-4.6
-6.7
-7.0
carbon source
L-Arabinose
-7.5
-1.9
-4.3
-6.4
-5.6
carbon source
L-Rhamnose
-3.7
-3.1
-6.9
-5.3
-5.1
carbon source
L-Arabinose
-5.3
-4.3
-4.9
-3.8
-5.9
carbon source
D-Glucose
-7.9
-7.1
-2.8
-3.0
-3.0
carbon source
Sodium-DL-Lactate
-4.3
-3.4
-6.8
-4.6
-4.3
phage
TP12
-0.0
-0.8
-0.1
-0.0
-0.1
phage
TP7
-0.3
-0.2
-0.4
+0.4
-0.4
phage
Bas67
-0.1
-0.0
+0.0
-0.4
-0.3
phage
K5
+0.3
-0.6
-0.4
+0.3
-0.6
phage
Bas69
+0.7
-0.0
-0.2
-1.0
-0.4
phage
Bas67
+0.2
-0.4
-0.1
+0.2
-0.4
phage
TP12
-0.2
+0.2
-0.1
+0.1
-0.6
no phage control
Control_ECOR27
+0.0
-0.0
-0.3
-0.1
-0.1
phage
RB49
-0.4
+0.2
-0.0
-0.3
-0.1
carbon source
Casamino-acids
-0.3
+0.2
-0.4
+0.2
-0.2
phage
Bas09
+0.5
-0.0
-0.4
-0.1
-0.5
carbon source
Casamino-acids
+0.0
-0.3
-0.5
+0.3
-0.0
phage
K5
+0.2
-0.2
+0.1
-0.2
-0.1
phage
TP2
+0.2
+0.5
-0.1
+0.3
-0.4
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