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Cofit
Protein
Homologs
Fitness for 5 genes in
Escherichia coli BW25113
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500 nt
uhpC and uhpB are separated by 9 nucleotides
uhpB and uhpA overlap by 1 nucleotides
uhpA and ilvN are separated by 75 nucleotides
ilvN and ilvB are separated by 3 nucleotides
b3667: uhpC - regulator of uhpT (VIMSS), at 3,845,328 to 3,846,647
uhpC
b3668: uhpB - sensor histidine protein kinase phosphorylates UhpA (VIMSS), at 3,846,657 to 3,848,159
uhpB
b3669: uhpA - DNA-binding response regulator in two-component regulatory system wtih UhpB (NCBI), at 3,848,159 to 3,848,749
uhpA
b3670: ilvN - acetolactate synthase small subunit (NCBI), at 3,848,825 to 3,849,115
ilvN
b3671: ilvB - acetolactate synthase large subunit (NCBI), at 3,849,119 to 3,850,807
ilvB
Group
Condition
b3667
b3668
b3669
b3670
b3671
uhpC
uhpB
uhpA
ilvN
ilvB
carbon source
D-Glucose-6-Phosphate (C)
-0.9
-0.8
-1.2
-1.5
-4.0
carbon source
D-Glucose-6-Phosphate (C)
-1.2
-0.9
-0.8
-1.4
-3.5
carbon source
D-Xylose (C)
-0.2
-0.1
+0.1
-2.8
-4.2
carbon source
D-Maltose (C)
-0.1
-0.0
-0.1
-2.5
-4.0
carbon source
D-Maltose (C)
+0.0
-0.0
-0.0
-2.0
-4.6
carbon source
D-Xylose (C)
+0.0
+0.0
+0.2
-2.2
-3.8
nutrient
M9 Glucose 0.2%, Thauer's vit mix
-0.0
-0.1
-0.1
-1.8
-3.7
nutrient
M9 Glucose 0.2%, Thauer's vit mix
-0.1
-0.1
-0.0
-1.8
-3.7
carbon source
Glycolic Acid (C)
-0.0
-0.1
+0.3
-2.5
-3.5
nutrient
M9 Glucose 0.2%, Thauer's vit mix without biotin
-0.0
-0.1
-0.0
-1.8
-3.8
sulfur source
M63 no sulfur + 5 mM sulfate
-0.0
-0.0
-0.0
-2.3
-3.3
nutrient
M9 Glucose 0.2%, Thauer's vit mix
-0.1
-0.0
-0.1
-1.8
-3.7
nitrogen source
Putrescine (N)
-0.0
-0.0
+0.1
-2.4
-3.2
carbon source
D-Glucosamine Hydrochloride (C)
-0.1
-0.1
+0.0
-1.0
-4.4
carbon source
Glycolic Acid (C)
+0.0
+0.1
+0.0
-3.0
-2.7
nutrient
M9 Glucose 0.2%, Thauer's vit mix without biotin
-0.1
-0.1
-0.1
-1.6
-3.7
sulfur source
M63 no sulfur + 5 mM sulfate
+0.1
-0.1
-0.1
-2.1
-3.3
nutrient
M9 Glucose 0.2%, Thauer's vit mix without biotin with Avidin
-0.0
-0.0
-0.0
-1.8
-3.6
carbon source
D-Ribose (C)
-0.1
-0.0
+0.1
-1.7
-3.5
nutrient
M9 Glucose 0.2%, Thauer's vit mix without biotin with Avidin
-0.0
-0.0
-0.1
-1.5
-3.7
nitrogen source
L-Glutamine (N)
-0.0
-0.0
-0.2
-1.8
-3.1
carbon source
D-Trehalose (C)
-0.1
+0.1
+0.1
-1.4
-3.9
nitrogen source
Ammonium chloride (N)
-0.2
-0.0
-0.1
-1.5
-3.4
nitrogen source
Putrescine (N)
-0.1
+0.0
-0.0
-1.7
-3.3
nutrient
M9 Glucose 0.2%, Thauer's vit mix without biotin
-0.0
-0.0
-0.1
-1.4
-3.6
nitrogen source
L-Glutamine (N)
-0.1
-0.0
-0.2
-1.6
-3.2
carbon source
D-Sorbitol (C)
+0.0
+0.1
-0.0
-1.4
-3.6
sulfur source
M63 no sulfur + 5 mM L-cys
+0.1
-0.1
+0.1
-1.9
-3.2
nitrogen source
Cytidine (N)
+0.1
+0.1
+0.0
-2.4
-2.6
carbon source
D-Ribose (C)
-0.1
+0.2
+0.3
-1.1
-3.8
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