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Cofit
Protein
Homologs
Fitness for 5 genes in
Escherichia coli BW25113
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Top 30 experiments (either direction), sorted by average fitness
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500 nt
aroB and aroK are separated by 56 nucleotides
aroK and hofQ are separated by 400 nucleotides
hofQ and yrfA overlap by 89 nucleotides
yrfA and yrfB overlap by 11 nucleotides
b3389: aroB - 3-dehydroquinate synthase (NCBI), at 3,515,420 to 3,516,508
aroB
b3390: aroK - shikimate kinase I (NCBI), at 3,516,565 to 3,517,086
aroK
b3391: hofQ - predicted fimbrial transporter (NCBI), at 3,517,487 to 3,518,725
hofQ
b3392: yrfA - orf, hypothetical protein (VIMSS), at 3,518,637 to 3,519,041
yrfA
b3393: yrfB - hypothetical protein (NCBI), at 3,519,031 to 3,519,471
yrfB
Group
Condition
b3389
b3390
b3391
b3392
b3393
aroB
aroK
hofQ
yrfA
yrfB
carbon source
Ying_OrganicAcid7 rep B; time point 2
-8.4
-6.5
+0.1
+0.1
-0.0
carbon source
Ying_sugar7 rep C; time point 2
-8.3
-6.5
+0.2
+0.2
-0.0
carbon source
Ying_Nucleobase14 rep C; time point 3
-8.1
-6.3
+0.1
+0.1
+0.1
carbon source
Ying_OrganicAcid7 rep A; time point 3
-8.1
-6.4
+0.1
+0.2
+0.2
carbon source
Ying_sugar7 rep B; time point 3
-8.3
-6.4
+0.4
+0.3
+0.3
carbon source
Ying_OrganicAcid7 rep C; time point 3
-7.8
-6.3
+0.1
+0.1
+0.2
carbon source
Ying_sugar7 rep A; time point 3
-8.3
-6.3
+0.3
+0.4
+0.2
carbon source
Ying_sugar7 rep C; time point 3
-8.2
-6.3
+0.3
+0.2
+0.4
carbon source
Ying_OrganicAcid7 rep C; time point 2
-7.0
-6.5
+0.1
+0.1
+0.1
carbon source
carbon source D-Mannose 0.5mM
-7.6
-5.6
+0.1
+0.0
-0.1
carbon source
Ying_sugar7 rep B; time point 2
-8.5
-4.7
+0.2
+0.3
-0.0
carbon source
Ying_OrganicAcid7 rep B; time point 3
-8.1
-4.9
+0.2
+0.2
+0.1
carbon source
carbon source D-Mannose 1mM
-6.6
-5.4
+0.1
-0.1
-0.7
carbon source
Ying_Nucleobase14 rep B; time point 3
-8.1
-4.2
-0.1
+0.1
-0.2
carbon source
carbon source D-Mannose 1mM
-7.8
-5.2
+0.0
+0.2
+0.5
carbon source
carbon source D-Glucose 1mM
-6.9
-5.6
+0.3
+0.2
+0.2
carbon source
Ying_sugar7 rep A; time point 2
-8.0
-4.3
+0.3
+0.3
-0.1
carbon source
Ying_Nucleobase14 rep B; time point 2
-7.4
-4.1
-0.0
+0.1
-0.2
carbon source
Ying_Nucleobase14 rep A; time point 3
-8.1
-3.6
-0.1
+0.2
+0.0
carbon source
carbon source D-Mannose 0.5mM
-7.1
-5.1
+0.2
-0.1
+0.6
carbon source
carbon source D-Glucose 1mM
-5.7
-5.7
+0.1
+0.3
-0.1
carbon source
carbon source D-Glucose 0.25mM
-6.6
-5.3
+0.2
+0.3
+0.4
carbon source
carbon source D-Glucose 0.5mM
-5.9
-5.7
+0.3
+0.3
+0.2
carbon source
D-Galacturonic Acid (C)
-6.1
-4.8
+0.1
+0.0
-0.0
carbon source
D-Glucose-6-Phosphate (C)
-5.7
-4.7
-0.0
+0.1
-0.4
carbon source
D-Galacturonic Acid (C)
-5.9
-4.7
+0.1
+0.2
-0.3
carbon source
D-Glucose-6-Phosphate (C)
-5.9
-4.8
+0.1
+0.0
+0.1
carbon source
Glucose (C)
-6.5
-3.9
+0.1
+0.2
-0.1
carbon source
carbon source D-Mannose 20mM
-5.1
-5.7
+0.2
+0.4
+0.2
phage
T7_phage 0.0015625 MOI TC2
+1.6
+9.8
-0.0
-1.0
+0.2
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