Gene info for PP_3357 in Pseudomonas putida KT2440

Updated annotation (from data): p-hydroxybenzaldehyde dehydrogenase vdh (EC 1.2.1.64)
Rationale: Specifically important in carbon source p-Coumaric acid. This gene is known as vdh and has vanillin dehydrogenase activity, but it is not required for growth on vanillin (PMID:25026441). Instead, its primary substrate in vivo seems to be p-hydroxybenzaldehyde (which is the product of hydroxycinnamoyl-CoA hydratase-lyase)
Original annotation: vanillin dehydrogenase
Type 1: Protein-coding gene
Located on scaffold AE015451, - strand, nucleotides 3,796,545 to 3,797,993
See nucleotide sequence around PP_3357 or for all of scaffold AE015451

Other databases: NCBI, uniprot: Q88HJ9

Nearby Genes

500 ntPP_3352 and PP_3353 overlap by 4 nucleotidesPP_3353 and PP_3354 overlap by 20 nucleotidesPP_3354 and PP_3355 are separated by 14 nucleotidesPP_3355 and PP_3356 are separated by 47 nucleotidesPP_3356 and PP_3357 are separated by 91 nucleotidesPP_3357 and PP_3358 are separated by 75 nucleotidesPP_3358 and PP_3359 are separated by 197 nucleotidesPP_3359 and PP_3360 are separated by 98 nucleotidesPP_3360 and PP_3361 are separated by 78 nucleotidesPP_3361 and PP_3362 are separated by 143 nucleotides PP_3352: PP_3352 - Arylsulfatase, at 3,788,896 to 3,790,560 _3352 PP_3353: PP_3353 - putative sulfatase-modifying factor (C-alpha-formyglycine- generating enzyme), at 3,790,557 to 3,791,582 _3353 PP_3354: PP_3354 - putative Acyl-CoA dehydrogenase, ferrulic acid biotransformation protein, at 3,791,563 to 3,793,317 _3354 PP_3355: PP_3355 - Beta-ketothiolase, at 3,793,332 to 3,794,522 _3355 PP_3356: PP_3356 - p-coumarate CoA-ligase (EC 6.2.1.12) (from data), at 3,794,570 to 3,796,453 _3356 PP_3357: PP_3357 - p-hydroxybenzaldehyde dehydrogenase vdh (EC 1.2.1.64) (from data), at 3,796,545 to 3,797,993 _3357 PP_3358: PP_3358 - hydroxycinnamoyl-CoA hydratase-lyase (EC 4.1.2.61) (from data), at 3,798,069 to 3,798,899 _3358 PP_3359: PP_3359 - putative Hydroxycinnamic acid degradation regulator, at 3,799,097 to 3,799,567 _3359 PP_3360: PP_3360 - conserved membrane protein of unknown function, at 3,799,666 to 3,800,790 _3360 PP_3361: PP_3361 - putative aminotransferase, at 3,800,869 to 3,803,916 _3361 PP_3362: PP_3362 - Transcriptional regulator, AsnC family, at 3,804,060 to 3,804,500 _3362
Locus Name Description Strand Phenotype
PP_3352 PP_3352 Arylsulfatase + insig.
PP_3353 PP_3353 putative sulfatase-modifying factor (C-alpha-formyglycine- generating enzyme) + sig.
PP_3354 PP_3354 putative Acyl-CoA dehydrogenase, ferrulic acid biotransformation protein - insig.
PP_3355 PP_3355 Beta-ketothiolase - sig.
PP_3356 PP_3356 p-coumarate CoA-ligase (EC 6.2.1.12) (from data) - strong
PP_3357 PP_3357 p-hydroxybenzaldehyde dehydrogenase vdh (EC 1.2.1.64) (from data) - strong
PP_3358 PP_3358 hydroxycinnamoyl-CoA hydratase-lyase (EC 4.1.2.61) (from data) - strong
PP_3359 PP_3359 putative Hydroxycinnamic acid degradation regulator + strong
PP_3360 PP_3360 conserved membrane protein of unknown function + insig.
PP_3361 PP_3361 putative aminotransferase - insig.
PP_3362 PP_3362 Transcriptional regulator, AsnC family + sig.

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