Gene info for b2504 in Escherichia coli BW25113

Name: yfgG
Updated annotation (from data): Negative regulator of nickel and cobalt uptake (YfgG)
Rationale: YfgG is important for resisting cobalt and nickel stress, as is its ortholog in Klebsiella (BWI76_RS21010). Furthermore, overexpression of yfgG confers increased resistance to cobalt (PMID:30659179). YfgG has strong negative cofitness with the Mg/Ni/Co transporter corA, as does its ortholog in Klebsiella. YfgG is a small putative membrane protein and might bind corA to inhibit it or reduce its abundance (by analogy to the magnesium transporter MtgE and the small membrane protein MtgS that binds and stabilizes MtgS.)
Original annotation: hypothetical protein (NCBI)
Type 1: Protein-coding gene
Located on scaffold 7023, + strand, nucleotides 2,627,312 to 2,627,503
See nucleotide sequence around b2504 or for all of scaffold 7023

Other databases: MicrobesOnline, EcoCyc, NCBI, IMG: 646314469, uniprot: P64545

Nearby Genes

500 ntpurM and purN overlap by 1 nucleotidespurN and ppk are separated by 171 nucleotidesppk and ppx are separated by 4 nucleotidesppx and yfgF are separated by 38 nucleotidesyfgF and yfgG are separated by 351 nucleotidesyfgG and yfgH are separated by 310 nucleotidesyfgH and yfgI are separated by 15 nucleotidesyfgI and guaA are separated by 92 nucleotidesguaA and guaB are separated by 68 nucleotidesguaB and xseA are separated by 161 nucleotides b2499: purM - phosphoribosylaminoimidazole synthetase (NCBI), at 2,619,219 to 2,620,256 purM b2500: purN - phosphoribosylglycinamide formyltransferase (NCBI), at 2,620,256 to 2,620,894 purN b2501: ppk - polyphosphate kinase (NCBI), at 2,621,066 to 2,623,132 ppk b2502: ppx - exopolyphosphatase (NCBI), at 2,623,137 to 2,624,678 ppx b2503: yfgF - predicted inner membrane protein (NCBI), at 2,624,717 to 2,626,960 yfgF b2504: yfgG - Negative regulator of nickel and cobalt uptake (YfgG) (from data), at 2,627,312 to 2,627,503 yfgG b2505: yfgH - predicted outer membrane lipoprotein (NCBI), at 2,627,814 to 2,628,332 yfgH b2506: yfgI - hypothetical protein (NCBI), at 2,628,348 to 2,628,887 yfgI b2507: guaA - bifunctional GMP synthase/glutamine amidotransferase protein (NCBI), at 2,628,980 to 2,630,557 guaA b2508: guaB - inositol-5-monophosphate dehydrogenase (NCBI), at 2,630,626 to 2,632,092 guaB b2509: xseA - exodeoxyribonuclease VII large subunit (NCBI), at 2,632,254 to 2,633,624 xseA
Locus Name Description Strand Phenotype
b2499 purM phosphoribosylaminoimidazole synthetase (NCBI) + strong
b2500 purN phosphoribosylglycinamide formyltransferase (NCBI) + strong
b2501 ppk polyphosphate kinase (NCBI) + strong
b2502 ppx exopolyphosphatase (NCBI) + strong
b2503 yfgF predicted inner membrane protein (NCBI) - insig.
b2504 yfgG Negative regulator of nickel and cobalt uptake (YfgG) (from data) + strong
b2505 yfgH predicted outer membrane lipoprotein (NCBI) + insig.
b2506 yfgI hypothetical protein (NCBI) + insig.
b2507 guaA bifunctional GMP synthase/glutamine amidotransferase protein (NCBI) - no data
b2508 guaB inositol-5-monophosphate dehydrogenase (NCBI) - no data
b2509 xseA exodeoxyribonuclease VII large subunit (NCBI) + strong

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