Experiment set9S487 for Escherichia coli BL21

Compare to:

EV116

200 most detrimental genes:

  gene name fitness t score description  
ECD_02907 +11.4 56.1 transport channel compare
ECD_03489 +9.2 56.5 lipopolysaccharide core biosynthesis protein compare
ECD_03488 +8.8 26.1 UDP-glucose:(heptosyl)lipopolysaccharide alpha-1,3-glucosyltransferase; lipopolysaccharide core biosynthesis protein; lipopolysaccharide glucosyltransferase I compare
ECD_03733 +7.9 17.9 transcription antitermination protein compare
ECD_01801 +5.4 44.5 carboxy-terminal protease for penicillin-binding protein 3 compare
ECD_03657 +5.1 28.2 guanosine pentaphosphatase/exopolyphosphatase compare
ECD_02118 +4.9 24.0 essential inner membrane DUF3413 domain-containing protein; lipid A production and membrane permeability factor compare
ECD_03486 +4.9 21.1 UDP-glucose:(Glucosyl) LPS alpha1,3-glucosyltransferase WaaO compare
ECD_03506 +4.9 20.7 RNA polymerase, omega subunit compare
ECD_03089 +4.6 19.7 stringent starvation protein A, phage P1 late gene activator, RNAP-associated acid-resistance protein, inactive glutathione S-transferase-like protein compare
ECD_02525 +4.2 10.7 DNA binding protein, nucleoid-associated compare
ECD_02104 +4.1 15.2 lipid A 1-diphosphate synthase; undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase compare
ECD_00634 +4.0 11.0 N-acetylglucosamine-6-phosphate deacetylase compare
ECD_00417 +4.0 5.7 DUF2496 family protein compare
ECD_03746 +3.8 20.7 periplasmic protein disulfide isomerase I compare
ECD_03662 +3.6 21.1 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase compare
ECD_00387 +3.5 18.4 peptidyl-prolyl cis/trans isomerase (trigger factor) compare
ECD_03848 +3.4 20.7 transcriptional repressor of fabA and fabB compare
ECD_04093 +3.4 9.7 GGCT-like protein compare
ECD_t00077 +3.3 5.3 tRNA-Thr compare
ECD_01681 +3.0 5.9 integration host factor (IHF), DNA-binding protein, alpha subunit compare
ECD_03067 +3.0 5.5 RNA polymerase, sigma 54 (sigma N) factor compare
ECD_01629 +2.9 7.6 transcriptional repressor, hypoxanthine-binding compare
ECD_02085 +2.8 22.4 lysine transporter compare
ECD_01970 +2.8 13.2 suppressor of OmpF assembly mutants; putative outer membrane protein assembly factor; inner membrane-anchored periplasmic protein compare
ECD_03030 +2.8 17.9 lipoprotein involved in osmotic sensitivity and filamentation compare
ECD_00165 +2.7 9.3 uridylyltransferase compare
ECD_02214 +2.6 17.8 transcriptional repressor of flagellar, motility and chemotaxis genes compare
ECD_02906 +2.6 13.0 ADP-ribose pyrophosphatase compare
ECD_00962 +2.6 18.1 SOS cell division inhibitor compare
ECD_03064 +2.6 1.8 periplasmic membrane-anchored LPS-binding protein; LPS export protein compare
ECD_03681 +2.5 10.3 adenylate cyclase compare
ECD_00361 +2.4 8.3 Nrd regulon repressor compare
ECD_00893 +2.4 11.6 leucine-responsive global transcriptional regulator compare
ECD_00415 +2.4 12.6 transcriptional repressor compare
ECD_02728 +2.4 13.2 toxin of CptAB toxin-antitoxin pair compare
ECD_02729 +2.4 6.7 flavinator of succinate dehydrogenase; antitoxin of CptAB toxin-antitoxin pair compare
ECD_02898 +2.3 14.0 quorum sensing sensory histidine kinase in two-component regulatory system with QseB compare
ECD_03660 +2.3 2.5 rho operon leader peptide compare
ECD_02203 +2.3 10.1 NADH:ubiquinone oxidoreductase, membrane subunit L compare
ECD_03755 +2.3 11.3 glutamine synthetase compare
ECD_01556 +2.2 2.2 putative selenate reductase, periplasmic compare
ECD_00418 +2.2 6.2 primosomal replication protein N'' compare
ECD_02365 +2.2 2.5 palmitoyl-CoA esterase activity, uncertain physiological substrate compare
ECD_03088 +2.2 11.0 ClpXP protease specificity enhancing factor compare
ECD_02173 +2.1 3.0 L-rhamnonate dehydratase compare
ECD_02404 +2.1 3.4 BamABCDE complex OM biogenesis lipoprotein compare
ECD_03740 +2.1 11.3 potassium transporter compare
ECD_02202 +2.0 8.1 NADH:ubiquinone oxidoreductase, membrane subunit M compare
ECD_00388 +2.0 8.8 proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases compare
ECD_01080 +2.0 3.5 endoribonuclease; RNA-binding protein compare
ECD_03063 +2.0 6.4 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase compare
ECD_03696 +1.9 2.5 DUF2628 family putative inner membrane protein compare
ECD_03685 +1.9 1.1 diaminopimelate epimerase compare
ECD_00196 +1.9 11.2 DL-methionine transporter subunit compare
ECD_02840 +1.8 2.8 secretin (GspDbeta) OM localization lipoprotein pilotin compare
ECD_00202 +1.8 8.1 endo/exonuclease/phosphatase family protein compare
ECD_03029 +1.8 6.7 ATP-dependent RNA helicase compare
ECD_02747 +1.8 6.9 transcriptional regulator for arginine transport and DNA replication genes; replication initiation inhibitor compare
ECD_01529 +1.8 2.0 Qin prophage; uncharacterized protein compare
ECD_03396 +1.8 14.8 KDO phosphoethanolamine transferase, Ca(2+)-inducible conserved
ECD_00658 +1.7 2.1 Rhs protein with putative toxin domain; putative neighboring cell growth inhibitor compare
ECD_03060 +1.7 10.1 ABC transporter maintaining OM lipid asymmetry, ATP-binding protein compare
ECD_04259 +1.7 5.0 phosphopentomutase compare
ECD_03261 +1.7 14.0 ferrous iron transporter protein B and GTP-binding protein; membrane protein conserved
ECD_02098 +1.7 1.6 fused fructose-specific PTS enzymes: IIA component/HPr component compare
ECD_01226 +1.6 3.6 membrane spanning protein in TonB-ExbB-ExbD transport complex compare
ECD_02765 +1.6 5.3 transketolase 1, thiamine triphosphate-binding compare
ECD_03812 +1.6 7.8 glycerol facilitator compare
ECD_02272 +1.5 6.7 ABC transporter maintaining OM lipid asymmetry, OM lipoprotein component compare
ECD_03058 +1.5 10.4 OM lipid asymmetry maintenance protein; membrane-anchored ABC family periplasmic binding protein compare
ECD_t00059 +1.5 2.1 tRNA-Thr compare
ECD_02201 +1.5 6.1 NADH:ubiquinone oxidoreductase, membrane subunit N compare
ECD_03057 +1.5 9.3 ABC transporter maintaining OM lipid asymmetry, periplasmic binding protein compare
ECD_01694 +1.5 2.0 fructosamine kinase family protein compare
ECD_03664 +1.5 9.4 UDP-N-acetyl glucosamine-2-epimerase compare
ECD_03059 +1.5 7.2 ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein compare
ECD_03260 +1.4 5.1 ferrous iron transporter, protein A conserved
ECD_02446 +1.4 8.3 response regulator regulating glmY sRNA in two-component system with sensor protein GlrK compare
ECD_03342 +1.4 6.5 phosphate transporter, low-affinity; tellurite importer compare
ECD_01972 +1.4 3.5 uridine/cytidine kinase compare
ECD_00702 +1.4 2.8 periplasmic TolA-binding protein compare
ECD_04250 +1.4 10.1 peptide chain release factor RF-3 compare
ECD_03021 +1.4 1.8 UPF0306 family protein compare
ECD_02477 +1.4 2.3 DTW domain protein compare
ECD_03686 +1.4 6.8 DUF484 family protein compare
ECD_02100 +1.4 2.7 UPF0153 cysteine cluster protein compare
ECD_03031 +1.4 5.3 polynucleotide phosphorylase/polyadenylase compare
ECD_02205 +1.4 3.8 NADH:ubiquinone oxidoreductase, membrane subunit J compare
ECD_00335 +1.4 2.5 shikimate kinase II compare
ECD_02447 +1.3 7.2 putative outer membrane protein modulating the QseEF response compare
ECD_01058 +1.3 2.1 dihydro-orotase compare
ECD_01773 +1.3 2.3 putative YeaWX dioxygenase beta subunit, reductase component compare
ECD_02208 +1.3 5.3 NADH:ubiquinone oxidoreductase, chain G compare
ECD_03678 +1.3 7.0 putative uroporphyrinogen III methyltransferase compare
ECD_04391 +1.3 1.3 hypothetical protein compare
ECD_00848 +1.3 2.2 bacteriophage tail fiber protein compare
ECD_02505 +1.3 9.6 lipoprotein component of BamABCDE OM biogenesis complex compare
ECD_04278 +1.3 3.0 uncharacterized protein compare
ECD_00011 +1.3 2.4 UPF0174 family protein compare
ECD_03811 +1.3 9.5 glycerol kinase compare
ECD_02321 +1.3 2.1 cysteine synthase B (O-acetylserine sulfhydrolase B) compare
ECD_00480 +1.3 2.4 FimA-like protein compare
ECD_01122 +1.2 2.1 spermidine/putrescine ABC transporter permease compare
ECD_03314 +1.2 1.5 16S rRNA m(2)G966 methyltransferase, SAM-dependent compare
ECD_02924 +1.2 6.8 inorganic triphosphatase compare
ECD_03982 +1.2 8.8 proline/glycine betaine transporter compare
ECD_01198 +1.2 1.9 putative invasin compare
ECD_02593 +1.2 10.1 L-isoaspartate protein carboxylmethyltransferase type II compare
ECD_02693 +1.2 8.6 putative transporter compare
ECD_02623 +1.2 1.4 TPM domain protein, putative phosphatase compare
ECD_00082 +1.2 1.5 RsmH methytransferase inhibitor compare
ECD_01003 +1.2 3.6 DnaK co-chaperone; curved DNA-binding protein compare
ECD_01727 +1.2 1.2 CDP-alcohol phosphatidyltransferase family inner membrane protein compare
ECD_00233 +1.2 2.5 xanthine phosphoribosyltransferase; xanthine-guanine phosphoribosyltransferase compare
ECD_02103 +1.2 2.0 Zn-stimulated GTPase involved in zinc homeostasis; mutants are cadmium and EDTA sensitive; Zn(2+) binding protein compare
ECD_01124 +1.2 1.3 spermidine/putrescine ABC transporter ATPase compare
ECD_03412 +1.2 3.6 uncharacterized protein compare
ECD_01042 +1.2 2.3 O-acetyl-ADP-ribose deacetylase; RNase III inhibitor during cold shock; putative cardiolipin synthase C regulatory subunit compare
ECD_00955 +1.2 2.0 paraquat-inducible, SoxRS-regulated MCE domain protein compare
ECD_03665 +1.2 6.7 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase compare
ECD_01043 +1.1 1.6 stationary phase cardiolipin synthase 3 compare
ECD_01248 +1.1 1.6 inner membrane protein, S49 peptidase family protein compare
ECD_02377 +1.1 1.9 hydrogenase 4, membrane subunit compare
ECD_02641 +1.1 5.4 putative serine transporter conserved
ECD_00428 +1.1 7.4 inosine/guanosine kinase compare
ECD_02101 +1.1 3.4 elongation factor P-like protein compare
ECD_02951 +1.1 1.4 antitoxinof the HigB-HigA toxin-antitoxin system compare
ECD_03045 +1.1 5.3 RNA binding protein conserved
ECD_03141 +1.1 3.0 mechanosensitive channel protein, high conductance compare
ECD_02861 +1.1 2.6 putative ATP-binding protein compare
ECD_00439 +1.1 2.1 inner membrane protein; stimulator of the QmcA suppressor of ftsH-htpX compare
ECD_01896 +1.1 2.2 putative multdrug exporter, MATE family compare
ECD_01062 +1.1 4.5 ribosomal-protein-S5-alanine N-acetyltransferase compare
ECD_04153 +1.1 3.8 ferric citrate ABC transporter ATPase compare
ECD_01427 +1.1 1.5 nitrate/nitrite transporter compare
ECD_01980 +1.1 3.6 multidrug efflux system, subunit B compare
ECD_00911 +1.1 5.3 3-phosphoserine/phosphohydroxythreonine aminotransferase compare
ECD_01620 +1.1 1.5 chromate reductase, quinone reductase, FMN-linked; N-Ethylmaleimide reductase; old yellow enzyme compare
ECD_00857 +1.1 3.4 ribosomal protein S6 modification protein compare
ECD_00240 +1.1 5.0 gamma-glutamylphosphate reductase compare
ECD_01059 +1.1 2.0 lipoprotein, DUF1439 family compare
ECD_00100 +1.0 4.0 dGTP-preferring nucleoside triphosphate pyrophosphohydrolase compare
ECD_04194 +1.0 1.7 uncharacterized protein compare
ECD_02226 +1.0 2.6 glutathione S-transferase compare
ECD_01800 +1.0 2.9 putative endopeptidase compare
ECD_02385 +1.0 4.7 putative UPF0118 family inner membrane permease compare
ECD_03455 +1.0 7.0 mannitol-1-phosphate dehydrogenase, NAD-dependent compare
ECD_03111 +1.0 8.7 targeting factor for csrBC sRNA degradation compare
ECD_03056 +1.0 2.4 ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component compare
ECD_00420 +1.0 1.6 adenine phosphoribosyltransferase compare
ECD_01805 +1.0 3.0 MCE domain protein compare
ECD_04260 +1.0 3.6 purine nucleoside phosphorylase 1; nicotinamide 1-beta-D-riboside phosphorylase compare
ECD_03215 +1.0 7.4 putative transporter compare
ECD_00389 +1.0 4.6 ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease compare
ECD_03623 +1.0 1.7 ATP synthase, membrane-bound accessory factor compare
ECD_00399 +1.0 1.8 putative DNA-binding transcriptional regulator compare
ECD_02209 +1.0 3.1 NADH:ubiquinone oxidoreductase, chain F compare
ECD_03511 +1.0 6.0 glutamate transporter compare
ECD_00197 +1.0 3.5 DL-methionine transporter subunit compare
ECD_02042 +1.0 1.4 DUF2574 family protein compare
ECD_02400 +1.0 3.9 IMP dehydrogenase compare
ECD_02207 +1.0 2.1 NADH:ubiquinone oxidoreductase, membrane subunit H compare
ECD_02622 +1.0 2.8 7-carboxy-7-deazaguanine synthase; queosine biosynthesis compare
ECD_02491 +1.0 3.9 lipoprotein compare
ECD_01044 +1.0 1.0 OPG biosynthetic transmembrane succinyltransferase compare
ECD_01403 +1.0 1.8 DUF2526 family protein compare
ECD_03324 +0.9 2.7 4'-phosphopantetheinyl transferase compare
ECD_00594 +0.9 1.9 fluoride efflux channel, dual topology membrane protein compare
ECD_02250 +0.9 1.0 uncharacterized protein compare
ECD_00988 +0.9 2.5 putative O-antigen capsule production periplasmic protein compare
ECD_02287 +0.9 1.4 DUF2545 family putative inner membrane protein compare
ECD_03142 +0.9 2.1 alternate ribosome-rescue factor A compare
ECD_01842 +0.9 1.6 tRNA (cmo5U34)-carboxymethyltransferase, carboxy-SAM-dependent compare
ECD_00156 +0.9 2.7 UPF0126 family inner membrane protein compare
ECD_00994 +0.9 1.4 putative phosphatidylethanolamine synthesis regulator compare
ECD_00683 +0.9 2.8 succinate dehydrogenase, flavoprotein subunit compare
ECD_01067 +0.9 1.3 anti-sigma factor for FliA (sigma 28) compare
ECD_01056 +0.9 1.4 biofilm regulator compare
ECD_01604 +0.9 2.5 dipeptide and tripeptide permease A compare
ECD_02829 +0.9 3.0 putative membrane-anchored secretion pathway M-type protein compare
ECD_00383 +0.9 4.4 cytochrome o ubiquinol oxidase subunit II compare
ECD_02448 +0.9 2.9 sensor protein kinase regulating glmY sRNA in two-component system with response regulator GlrR compare
ECD_00198 +0.9 5.5 DL-methionine transporter subunit compare
ECD_00616 +0.9 1.5 Hsp70 family chaperone Hsc62; RpoD-binding transcription inhibitor compare
ECD_02224 +0.9 1.9 putative NUDIX hydrolase compare
ECD_00967 +0.9 1.7 methylglyoxal synthase compare
ECD_01667 +0.9 1.8 putative electron transfer flavoprotein, FAD-binding subunit compare
ECD_03798 +0.9 1.2 response regulator in two-component regulatory system with CpxA compare
ECD_02062 +0.9 1.5 beta-D-glucoside glucohydrolase, periplasmic compare
ECD_01020 +0.9 2.9 inactive ferrous ion transporter EfeUOB compare
ECD_00327 +0.9 1.4 DUF2754 family putative inner membrane protein compare
ECD_01861 +0.9 2.5 proton conductor component of flagella motor compare
ECD_01876 +0.9 1.2 UPF0149 family protein compare
ECD_01572 +0.9 1.6 pyridine nucleotide transhydrogenase, alpha subunit compare
ECD_01290 +0.9 1.9 putative Zn-dependent NAD(P)-binding oxidoreductase compare
ECD_00007 +0.9 6.3 putative transporter compare
ECD_01698 +0.8 3.5 putative transporter compare
ECD_00651 +0.8 1.4 response regulator in two-component regulatory system with KdpD compare
ECD_01498 +0.8 1.2 NADP-dependent 3-hydroxy acid dehydrogenase; malonic semialdehyde reductase compare


Specific Phenotypes

For 38 genes in this experiment

For phage MOI 10 in Escherichia coli BL21

For phage MOI 10 across organisms