Experiment set9IT088 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Cephalothin sodium salt 0.0000078125 mM

200 most detrimental genes:

  gene name fitness t score description  
b0929 ompF +4.7 16.4 outer membrane porin 1a (Ia;b;F) (NCBI) compare
b1185 dsbB +4.4 9.6 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b4509 ylcG +4.1 7.0 DLP12 prophage; predicted protein (NCBI) compare
b1831 proQ +4.0 8.9 putative solute/DNA competence effector (NCBI) compare
b3860 dsbA +4.0 28.8 periplasmic protein disulfide isomerase I (NCBI) compare
b1855 lpxM +3.9 20.7 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b1111 ycfQ +3.8 11.6 orf, hypothetical protein (VIMSS) compare
b2188 yejM +3.7 24.3 predicted hydrolase, inner membrane (NCBI) compare
b1604 ydgH +3.7 9.9 hypothetical protein (NCBI) compare
b3181 greA +3.6 10.9 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b3261 fis +3.6 6.2 DNA-binding protein Fis (NCBI) compare
b0147 yadP +3.5 13.9 orf, hypothetical protein (VIMSS) compare
b2064 asmA +3.5 12.0 predicted assembly protein (NCBI) compare
b0191 yaeJ +3.5 12.3 hypothetical protein (NCBI) compare
b0122 yacC +3.4 13.1 orf, hypothetical protein (VIMSS) compare
b2617 smpA +3.1 10.3 small membrane protein A (VIMSS) compare
b3405 ompR +3.0 15.9 osmolarity response regulator (NCBI) compare
b3035 tolC +2.9 17.1 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b4603 rseX +2.7 1.3 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b3404 envZ +2.7 9.4 osmolarity sensor protein (NCBI) compare
b0178 hlpA +2.7 8.7 periplasmic chaperone (NCBI) compare
b3780 rhlB +2.6 18.4 ATP-dependent RNA helicase (NCBI) conserved
b0393 rdgC +2.6 16.9 recombination associated protein (NCBI) compare
b2236 yfaE +2.6 5.6 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b0148 hrpB +2.6 8.8 helicase, ATP-dependent (VIMSS) compare
b2512 yfgL +2.6 10.6 protein assembly complex, lipoprotein component (NCBI) compare
b3281 aroE +2.5 19.1 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b0547 ybcN +2.5 3.2 DLP12 prophage; predicted protein (NCBI) compare
b2571 rseB +2.5 11.5 periplasmic negative regulator of sigmaE (NCBI) compare
b1530 marR +2.5 3.0 multiple antibiotic resistance protein; repressor of mar operon (VIMSS) compare
b3260 dusB +2.4 4.2 tRNA-dihydrouridine synthase B (NCBI) compare
b3620 rfaF +2.4 13.1 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b1049 mdoH +2.4 17.6 glucosyltransferase MdoH (NCBI) compare
b3842 rfaH +2.4 13.4 transcriptional activator RfaH (NCBI) compare
b0819 ybiS +2.3 9.3 hypothetical protein (NCBI) compare
b0438 clpX +2.3 13.3 ATP-dependent protease ATP-binding subunit (NCBI) compare
b1693 aroD +2.3 11.9 3-dehydroquinate dehydratase (NCBI) compare
b0418 pgpA +2.3 10.1 phosphatidylglycerophosphatase A (NCBI) compare
b3778 rep +2.3 13.8 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b0226 dinJ +2.3 6.6 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b1293 sapB +2.3 4.0 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1048 mdoG +2.2 12.4 glucan biosynthesis protein, periplasmic (NCBI) compare
b2314 dedD +2.2 6.3 putative lipoprotein (VIMSS) compare
b1627 rsxA +2.2 4.4 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b3632 rfaQ +2.2 19.6 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2572 rseA +2.2 7.4 anti-sigma factor (NCBI) compare
b2904 gcvH +2.2 4.1 glycine cleavage system protein H (NCBI) compare
b3911 cpxA +2.1 11.5 two-component sensor protein (NCBI) compare
b3630 rfaP +2.1 16.7 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2912 ygfA +2.1 5.2 putative ligase (VIMSS) compare
b1438 ydcQ +2.1 3.5 predicted DNA-binding transcriptional regulator (RefSeq) compare
b1865 nudB +2.1 3.2 dATP pyrophosphohydrolase (NCBI) compare
b1676 pykF +2.0 6.3 pyruvate kinase (NCBI) compare
b3631 rfaG +2.0 17.8 glucosyltransferase I (NCBI) compare
b0683 fur +2.0 3.0 ferric uptake regulator (NCBI) compare
b3963 fabR +2.0 10.4 DNA-binding transcriptional repressor (RefSeq) compare
b0439 lon +2.0 9.2 DNA-binding ATP-dependent protease La (NCBI) compare
b0462 acrB +2.0 16.1 multidrug efflux system protein (NCBI) compare
b2749 ygbE +2.0 9.1 conserved inner membrane protein (NCBI) conserved
b1278 pgpB +1.9 4.0 phosphatidylglycerophosphatase B (NCBI) compare
b0463 acrA +1.9 11.2 multidrug efflux system (NCBI) compare
b4152 frdC +1.9 1.4 fumarate reductase subunit C (NCBI) compare
b0840 deoR +1.9 5.5 DNA-binding transcriptional repressor (NCBI) compare
b3751 rbsB +1.9 6.7 D-ribose transporter subunit (NCBI) compare
b1291 sapD +1.9 2.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1290 sapF +1.8 4.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3389 aroB +1.8 10.1 3-dehydroquinate synthase (NCBI) compare
b2688 gshA +1.8 8.5 glutamate--cysteine ligase (NCBI) compare
b2947 gshB +1.8 5.8 glutathione synthetase (NCBI) compare
b0548 ninE +1.8 2.4 DLP12 prophage; conserved protein (NCBI) compare
b0146 sfsA +1.8 4.6 sugar fermentation stimulation protein A (NCBI) compare
b0965 b0965 +1.7 1.5 orf, hypothetical protein (VIMSS) compare
b0437 clpP +1.7 8.9 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1235 rssB +1.7 9.3 response regulator of RpoS (NCBI) compare
b0015 dnaJ +1.7 8.0 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b3347 fkpA +1.7 11.4 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) (NCBI) compare
b3133 agaV +1.7 2.0 PTS system, cytoplasmic, N-acetylgalactosamine-specific IIB component 2 (EIIB-AGA) (VIMSS) compare
b1236 galU +1.7 7.1 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3673 emrD +1.7 11.4 2-module integral membrane pump; multidrug resistance (VIMSS) compare
b3204 ptsN +1.7 6.7 sugar-specific enzyme IIA component of PTS (NCBI) compare
b2300 yfcE +1.7 2.3 orf, hypothetical protein (VIMSS) compare
b0928 aspC +1.7 3.7 aspartate aminotransferase, PLP-dependent (NCBI) compare
b3806 cyaA +1.7 7.5 adenylate cyclase (NCBI) compare
b2186 yejK +1.7 9.9 nucleoid-associated protein NdpA (NCBI) compare
b1594 dgsA +1.7 4.8 DNA-binding transcriptional repressor (NCBI) compare
b0688 pgm +1.7 6.2 phosphoglucomutase (NCBI) compare
b0200 gmhB +1.6 2.7 hypothetical protein (NCBI) compare
b3009 yghB +1.6 7.7 conserved inner membrane protein (NCBI) conserved
b2038 rfbC +1.6 8.4 dTDP-4-deoxyrhamnose-3,5-epimerase (NCBI) compare
b1143 ymfI +1.6 3.0 orf, hypothetical protein (VIMSS) compare
b1221 narL +1.6 5.8 DNA-binding response regulator in two-component regulatory system with NarX (or NarQ) (NCBI) compare
b3238 yhcN +1.6 3.4 orf, hypothetical protein (VIMSS) compare
b1480 sra +1.6 1.6 30S ribosomal subunit protein S22 (NCBI) compare
b1292 sapC +1.5 3.7 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3250 mreC +1.5 1.6 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b3426 glpD +1.5 5.4 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b2214 yojL +1.5 5.1 predicted thiamine biosynthesis lipoprotein (NCBI) compare
b4373 rimI +1.5 2.6 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b1095 fabF +1.5 7.8 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3248 yhdE +1.5 6.4 Maf-like protein (NCBI) compare
b0065 yabI +1.5 6.7 conserved inner membrane protein (NCBI) compare
b2784 relA +1.5 9.6 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b1739 osmE +1.5 2.6 DNA-binding transcriptional activator (NCBI) compare
b2340 sixA +1.5 6.2 phosphohistidine phosphatase (NCBI) compare
b3052 rfaE +1.4 6.8 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b4438 cyaR +1.4 3.2 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b3750 rbsC +1.4 5.9 ribose ABC transporter permease protein (NCBI) compare
b3198 kdsC +1.4 4.5 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b3283 yrdD +1.4 8.2 predicted DNA topoisomerase (NCBI) compare
b2096 gatY +1.4 3.1 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b2570 rseC +1.4 6.2 RseC protein involved in reduction of the SoxR iron-sulfur cluster (NCBI) compare
b1753 ynjA +1.4 2.4 hypothetical protein (NCBI) compare
b2903 gcvP +1.4 9.6 glycine dehydrogenase (NCBI) compare
b4000 hupA +1.4 5.0 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b0849 grxA +1.4 1.8 glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a) (NCBI) compare
b3621 rfaC +1.4 7.1 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b3190 yrbA +1.4 3.8 orf, hypothetical protein (VIMSS) compare
b1936 intG +1.4 1.7 predicted defective phage integrase (pseudogene) (RefSeq) compare
b0125 hpt +1.4 5.6 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b1424 mdoD +1.4 6.5 glucan biosynthesis protein, periplasmic (RefSeq) compare
b3644 yicC +1.3 6.2 hypothetical protein (NCBI) compare
b2189 proL +1.3 1.6 tRNA-Pro (NCBI) compare
b1238 tdk +1.3 5.7 thymidine kinase (NCBI) compare
b3129 sohA +1.3 3.3 predicted regulator (NCBI) compare
b3197 kdsD +1.3 3.4 D-arabinose 5-phosphate isomerase (NCBI) compare
b2501 ppk +1.3 7.7 polyphosphate kinase (NCBI) compare
b0190 yaeQ +1.3 4.4 hypothetical protein (NCBI) compare
b0007 yaaJ +1.3 7.5 predicted transporter (NCBI) compare
b3398 yrfF +1.2 4.9 predicted inner membrane protein (NCBI) compare
b1294 sapA +1.2 5.6 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3119 tdcR +1.2 2.7 threonine dehydratase operon activator protein (VIMSS) compare
b2301 yfcF +1.2 2.5 predicted enzyme (NCBI) compare
b1350 recE +1.2 3.6 Rac prophage; exonuclease VIII, 5' -> 3' specific dsDNA exonuclease (NCBI) compare
b1841 yobA +1.2 1.9 hypothetical protein (NCBI) compare
b3749 rbsA +1.2 6.1 fused D-ribose transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b0726 sucA +1.2 4.2 alpha-ketoglutarate decarboxylase (NCBI) compare
b3252 yhdA +1.2 7.7 conserved inner membrane protein (NCBI) compare
b0613 citG +1.2 1.7 triphosphoribosyl-dephospho-CoA transferase (NCBI) compare
b1823 cspC +1.2 2.1 stress protein, member of the CspA-family (NCBI) compare
b1766 sppA +1.2 5.5 protease IV (signal peptide peptidase) (NCBI) compare
b1055 yceA +1.2 2.7 hypothetical protein (NCBI) compare
b0617 citD +1.2 1.8 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b2204 napH +1.2 2.0 quinol dehydrogenase membrane component (NCBI) compare
b1632 rsxE +1.2 6.3 NADH-ubiquinone oxidoreductase (NCBI) compare
b0222 lpcA +1.1 3.3 phosphoheptose isomerase (NCBI) compare
b3196 yrbG +1.1 4.0 predicted calcium/sodium:proton antiporter (NCBI) compare
b4699 fnrS +1.1 0.7 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b4410 ecnA +1.1 1.2 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b4215 ytfI +1.1 1.9 hypothetical protein (NCBI) compare
b0767 ybhE +1.1 2.9 6-phosphogluconolactonase (NCBI) compare
b3264 envR +1.1 4.0 DNA-binding transcriptional regulator (NCBI) compare
b4359 mdoB +1.1 8.2 phosphoglycerol transferase I (VIMSS) compare
b1709 btuD +1.1 0.7 vitamin B12-transporter ATPase (NCBI) compare
b1418 cybB +1.1 2.0 cytochrome b(561) (VIMSS) compare
b1630 rsxD +1.1 3.3 electron transport complex protein RnfD (NCBI) compare
b2432 yfeY +1.0 1.3 hypothetical protein (NCBI) compare
b2905 gcvT +1.0 5.0 glycine cleavage system aminomethyltransferase T (NCBI) compare
b1179 ycgL +1.0 1.7 conserved protein (NCBI) compare
b3465 yhhF +1.0 4.9 predicted methyltransferase (NCBI) compare
b0982 yccY +1.0 2.2 putative phosphatase (VIMSS) compare
b2480 bcp +1.0 2.3 thioredoxin-dependent thiol peroxidase (NCBI) compare
b2946 yggJ +1.0 3.5 orf, hypothetical protein (VIMSS) compare
b2095 gatZ +1.0 3.6 D-tagatose 1,6-bisphosphate aldolase 2, subunit (NCBI) compare
b2057 wcaC +1.0 1.8 predicted glycosyl transferase (NCBI) compare
b1677 lpp +1.0 2.4 murein lipoprotein (NCBI) compare
b3849 trkH +1.0 6.6 potassium transporter (NCBI) compare
b2066 udk +1.0 3.4 uridine/cytidine kinase (VIMSS) compare
b0440 hupB +1.0 3.3 HU, DNA-binding transcriptional regulator, beta subunit (NCBI) compare
b1829 htpX +1.0 3.5 heat shock protein HtpX (NCBI) compare
b0537 intD +1.0 4.9 DLP12 prophage; predicted integrase (NCBI) compare
b4538 yoeF +1.0 0.5 hypothetical protein (RefSeq) compare
b2094 gatA +1.0 3.4 galactitol-specific enzyme IIA component of PTS (NCBI) compare
b2911 ssrS +1.0 1.2 6S regulatory RNA (NCBI) compare
b4484 cpxP +1.0 3.5 periplasmic protein combats stress (NCBI) compare
b1311 ycjO +0.9 3.7 predicted sugar transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2426 ucpA +0.9 2.0 putative oxidoreductase (VIMSS) compare
b4646 yrdE +0.9 1.3 no description compare
b0435 bolA +0.9 3.0 possible regulator of murein genes (VIMSS) compare
b3057 bacA +0.9 3.7 undecaprenyl pyrophosphate phosphatase (NCBI) compare
b1427 rimL +0.9 2.2 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b4513 kdpF +0.9 2.5 potassium ion accessory transporter subunit (NCBI) compare
b3563 yiaB +0.9 3.1 orf, hypothetical protein (VIMSS) compare
b0183 rnhB +0.9 1.5 ribonuclease HII (NCBI) compare
b0999 cbpM +0.9 2.0 modulator of CbpA co-chaperone (NCBI) compare
b0539 ybcC +0.9 3.0 DLP12 prophage; predicted exonuclease (RefSeq) compare
b1362 rzpR +0.9 1.6 putative Rac prophage endopeptidase (VIMSS) compare
b2886 ygfS +0.9 2.3 putative oxidoreductase, Fe-S subunit (VIMSS) compare
b1446 ydcY +0.9 1.7 hypothetical protein (NCBI) compare
b1920 fliY +0.9 1.7 cystine transporter subunit (NCBI) compare
b1333 uspE +0.9 2.0 stress-induced protein (NCBI) compare
b3619 rfaD +0.9 3.4 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b2168 fruK +0.9 1.0 1-phosphofructokinase (NCBI) compare
b3515 gadW +0.9 4.4 DNA-binding transcriptional activator (NCBI) compare
b4648 ysaC +0.9 1.8 no description compare
b2754 ygbF +0.9 2.0 orf, hypothetical protein (VIMSS) compare
b1830 prc +0.9 3.8 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0698 kdpA +0.9 3.4 potassium-transporting ATPase subunit A (NCBI) compare
b4207 fklB +0.9 2.8 FKBP-type 22KD peptidyl-prolyl cis-trans isomerase (rotamase) (VIMSS) compare
b4177 purA +0.9 1.4 adenylosuccinate synthetase (NCBI) compare
b0880 cspD +0.9 1.1 cold shock protein homolog (NCBI) compare


Specific Phenotypes

For 78 genes in this experiment

For stress Cephalothin sodium salt in Escherichia coli BW25113

For stress Cephalothin sodium salt across organisms