Experiment set9IT080 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Ciprofloxacin Hydrochloride 0.00000001953125 mM

200 most important genes:

  gene name fitness t score description  
b4201 priB -3.9 -2.7 primosomal replication protein N (NCBI) compare
b0463 acrA -3.9 -11.8 multidrug efflux system (NCBI) compare
b3035 tolC -3.8 -7.2 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0462 acrB -3.7 -17.2 multidrug efflux system protein (NCBI) compare
b2509 xseA -3.5 -9.0 exodeoxyribonuclease VII large subunit (NCBI) compare
b1334 fnr -2.9 -3.3 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b0912 ihfB -2.7 -3.1 integration host factor subunit beta (NCBI) compare
b2528 iscA -2.5 -2.4 iron-sulfur cluster assembly protein (NCBI) compare
b4237 nrdG -2.3 -11.0 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b1346 ydaQ -2.2 -2.0 orf, hypothetical protein (VIMSS) compare
b0729 sucD -2.2 -4.3 succinyl-CoA synthetase subunit alpha (NCBI) compare
b0049 apaH -2.1 -3.1 diadenosinetetraphosphatase (NCBI) compare
b2830 nudH -2.1 -1.4 dinucleoside polyphosphate hydrolase (NCBI) compare
b0765 modC -2.0 -5.8 molybdate transporter subunit (NCBI) compare
b4238 nrdD -2.0 -14.0 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b0902 pflA -1.9 -6.2 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b3163 nlpI -1.8 -5.0 hypothetical protein (NCBI) compare
b3935 priA -1.8 -3.1 primosome assembly protein PriA (NCBI) compare
b3792 wzxE -1.8 -5.9 O-antigen translocase (NCBI) compare
b2215 ompC -1.8 -8.3 outer membrane porin protein C (NCBI) compare
b0053 surA -1.8 -4.8 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0145 dksA -1.7 -2.5 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0799 dinG -1.7 -6.9 ATP-dependent DNA helicase (NCBI) compare
b1454 yncG -1.7 -3.0 predicted enzyme (NCBI) compare
b4503 yafF -1.7 -1.1 no description compare
b1125 potB -1.6 -4.0 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b1882 cheY -1.6 -0.8 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b0728 sucC -1.6 -5.9 succinyl-CoA synthetase subunit beta (NCBI) compare
b2258 b2258 -1.6 -1.9 putative transport/receptor protein (VIMSS) compare
b0683 fur -1.6 -1.5 ferric uptake regulator (NCBI) compare
b2330 yfcB -1.5 -1.0 putative adenine-specific methylase (VIMSS) compare
b3813 uvrD -1.5 -10.5 DNA-dependent ATPase I and helicase II (NCBI) compare
b0783 moaC -1.5 -5.1 molybdenum cofactor biosynthesis protein C (NCBI) compare
b3443 yrhA -1.5 -1.3 orf, hypothetical protein (VIMSS) compare
b3930 menA -1.4 -10.7 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b0949 uup -1.4 -6.1 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1506 yneL -1.4 -1.3 predicted transcriptional regulator (NCBI) compare
b2807 ygdD -1.4 -3.9 conserved inner membrane protein (NCBI) compare
b2288 nuoA -1.3 -3.1 NADH dehydrogenase I chain A (VIMSS) compare
b1248 b1248 -1.3 -2.6 orf, hypothetical protein (VIMSS) compare
b3199 yrbK -1.3 -2.7 hypothetical protein (NCBI) compare
b1575 dicB -1.3 -1.1 Qin prophage; cell division inhibition protein (NCBI) compare
b0764 modB -1.3 -4.0 molybdate ABC transporter permease protein (NCBI) compare
b2616 recN -1.3 -7.2 recombination and repair protein (NCBI) compare
b0014 dnaK -1.3 -1.8 molecular chaperone DnaK (NCBI) compare
b1176 minC -1.3 -2.3 septum formation inhibitor (NCBI) compare
b4402 yjjY -1.3 -1.1 hypothetical protein (NCBI) compare
b0239 frsA -1.3 -7.0 fermentation/respiration switch protein (NCBI) compare
b0763 modA -1.3 -4.4 molybdate transporter subunit (NCBI) compare
b0785 moaE -1.2 -3.9 molybdopterin synthase, large subunit (NCBI) compare
b1361 ydaW -1.2 -0.6 orf, hypothetical protein (VIMSS) compare
b2553 glnB -1.2 -3.4 regulatory protein P-II for glutamine synthetase (NCBI) compare
b3857 mobA -1.2 -5.5 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b0866 ybjQ -1.1 -1.3 hypothetical protein (NCBI) compare
b3839 tatC -1.1 -5.3 TatABCE protein translocation system subunit (NCBI) compare
b1292 sapC -1.1 -1.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4603 rseX -1.1 -0.5 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b4025 pgi -1.1 -5.7 glucose-6-phosphate isomerase (NCBI) compare
b1252 tonB -1.1 -2.2 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b1266 yciV -1.1 -2.3 hypothetical protein (NCBI) compare
b0903 pflB -1.1 -6.8 pyruvate formate lyase I (NCBI) compare
b4000 hupA -1.1 -3.9 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b1830 prc -1.1 -3.4 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0641 rlpB -1.0 -2.3 minor lipoprotein (NCBI) compare
b4246 pyrL -1.0 -2.2 pyrBI operon leader peptide (NCBI) compare
b1600 mdtJ -1.0 -0.7 multidrug efflux system transporter (NCBI) compare
b3863 polA -1.0 -0.7 DNA polymerase I (NCBI) compare
b4535 yniD -1.0 -1.3 predicted protein (RefSeq) compare
b0781 moaA -1.0 -5.3 molybdenum cofactor biosynthesis protein A (NCBI) compare
b1109 ndh -1.0 -2.6 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b3096 yqjB -1.0 -4.0 hypothetical protein (NCBI) compare
b0535 fimZ -1.0 -2.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1527 yneK -1.0 -1.3 hypothetical protein (NCBI) compare
b1482 osmC -1.0 -1.4 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b2276 nuoN -1.0 -3.8 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b1686 ydiI -1.0 -1.1 hypothetical protein (NCBI) compare
b2896 ygfX -0.9 -4.4 hypothetical protein (NCBI) compare
b0740 tolB -0.9 -2.6 translocation protein TolB precursor (NCBI) compare
b1192 ldcA -0.9 -2.3 L,D-carboxypeptidase A (NCBI) compare
b1936 intG -0.9 -0.8 predicted defective phage integrase (pseudogene) (RefSeq) compare
b1693 aroD -0.9 -3.8 3-dehydroquinate dehydratase (NCBI) compare
b0386 proC -0.9 -3.2 pyrroline-5-carboxylate reductase (NCBI) compare
b0617 citD -0.9 -1.8 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b3652 recG -0.9 -5.0 ATP-dependent DNA helicase (NCBI) compare
b1848 yebG -0.9 -1.3 conserved protein regulated by LexA (NCBI) compare
b3787 rffD -0.9 -6.1 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b1434 ydcN -0.9 -1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b3183 obgE -0.9 -0.8 GTPase involved in cell partioning and DNA repair (NCBI) compare
b1765 ydjA -0.9 -1.0 predicted oxidoreductase (NCBI) compare
b2284 nuoF -0.9 -3.0 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b2859 ygeO -0.9 -1.3 hypothetical protein (RefSeq) compare
b4592 yccB -0.9 -1.2 hypothetical protein (RefSeq) compare
b2937 speB -0.9 -4.0 agmatinase (NCBI) compare
b0737 tolQ -0.9 -1.7 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0957 ompA -0.9 -2.3 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b2897 ygfY -0.9 -1.9 hypothetical protein (NCBI) compare
b1712 ihfA -0.8 -0.5 integration host factor subunit alpha (NCBI) compare
b0688 pgm -0.8 -2.1 phosphoglucomutase (NCBI) compare
b3778 rep -0.8 -3.8 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3164 pnp -0.8 -1.6 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b3398 yrfF -0.8 -2.3 predicted inner membrane protein (NCBI) compare
b3094 exuR -0.8 -2.6 negative regulator of exu regulon, exuT, uxaAC, and uxuB (VIMSS) compare
b0249 ykfF -0.8 -1.8 CP4-6 prophage; predicted protein (NCBI) compare
b2281 nuoI -0.8 -1.9 NADH dehydrogenase subunit I (NCBI) compare
b0896 dmsC -0.8 -4.2 dimethyl sulfoxide reductase, anaerobic, subunit C (NCBI) compare
b3784 rfe -0.8 -6.1 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b4389 radA -0.8 -4.5 predicted repair protein (NCBI) conserved
b0232 yafN -0.8 -0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b2531 iscR -0.8 -0.8 DNA-binding transcriptional repressor (NCBI) compare
b2783 chpR -0.8 -1.5 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b1524 yneH -0.8 -0.9 predicted glutaminase (NCBI) compare
b0009 mog -0.8 -4.3 molybdenum cofactor biosynthesis protein (NCBI) compare
b3071 yqjI -0.8 -2.2 predicted transcriptional regulator (NCBI) compare
b2479 gcvR -0.8 -2.8 transcriptional regulation of gcv operon (VIMSS) compare
b3619 rfaD -0.8 -2.2 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3082 ygjM -0.8 -0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b2419 yfeK -0.7 -1.3 hypothetical protein (NCBI) compare
b3613 yibP -0.7 -1.3 putative membrane protein (VIMSS) compare
b1730 ydjO -0.7 -0.4 predicted protein (RefSeq) compare
b1485 ddpC -0.7 -2.2 D-ala-D-ala transporter subunit (NCBI) compare
b2698 recX -0.7 -1.7 RecA regulator RecX (NCBI) compare
b2184 yejH -0.7 -4.2 DNA damage response helicase (yejH or radD) (from data) compare
b1579 intQ -0.7 -0.9 Qin prophage; predicted defective integrase (RefSeq) compare
b2456 cchB -0.7 -2.9 predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) compare
b4509 ylcG -0.7 -1.4 DLP12 prophage; predicted protein (NCBI) compare
b1101 ptsG -0.7 -4.5 fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) compare
b1088 yceD -0.7 -1.8 hypothetical protein (NCBI) compare
b3838 tatB -0.7 -4.1 sec-independent translocase (NCBI) compare
b1667 ydhR -0.7 -1.6 hypothetical protein (NCBI) compare
b1295 ymjA -0.7 -1.7 hypothetical protein (NCBI) compare
b4435 isrC -0.7 -1.5 unknown RNA (NCBI) compare
b2809 b2809 -0.7 -1.9 orf, hypothetical protein (VIMSS) compare
b2366 dsdA -0.7 -2.4 D-serine dehydratase (NCBI) compare
b3786 rffE -0.7 -4.9 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b0317 yahC -0.7 -3.3 predicted inner membrane protein (NCBI) compare
b0430 cyoC -0.7 -2.2 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b2085 b2085 -0.7 -1.6 orf, hypothetical protein (VIMSS) compare
b3129 sohA -0.7 -2.2 predicted regulator (NCBI) compare
b3149 yraO -0.7 -3.3 DnaA initiator-associating factor for replication initiation (NCBI) compare
b0440 hupB -0.7 -2.3 HU, DNA-binding transcriptional regulator, beta subunit (NCBI) compare
b3389 aroB -0.7 -4.2 3-dehydroquinate synthase (NCBI) compare
b1330 ynaI -0.7 -1.8 conserved inner membrane protein (NCBI) compare
b1563 relE -0.7 -1.0 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b3341 rpsG -0.7 -0.9 30S ribosomal protein S7 (NCBI) compare
b3794 rffM -0.7 -3.7 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b2283 nuoG -0.7 -3.3 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b1518 lsrG -0.7 -1.2 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b1643 ydhI -0.7 -2.8 predicted inner membrane protein (NCBI) compare
b1824 yobF -0.7 -1.7 hypothetical protein (NCBI) compare
b3871 bipA -0.7 -4.4 GTP-binding protein (NCBI) compare
b0296 ykgM -0.7 -2.1 50S ribosomal protein L31 (NCBI) compare
b3836 b3836 -0.7 -2.7 orf, hypothetical protein (VIMSS) compare
b0450 glnK -0.7 -1.5 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b1861 ruvA -0.7 -0.4 Holliday junction DNA helicase motor protein (NCBI) compare
b2277 nuoM -0.7 -2.7 NADH dehydrogenase subunit M (NCBI) compare
b2819 recD -0.6 -3.5 exonuclease V (RecBCD complex), alpha chain (NCBI) compare
b0092 ddlB -0.6 -2.5 D-alanylalanine synthetase (NCBI) compare
b2954 yggV -0.6 -2.5 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b4551 yheV -0.6 -1.2 hypothetical protein (NCBI) compare
b2506 yfgI -0.6 -1.4 hypothetical protein (NCBI) compare
b1758 b1758 -0.6 -0.9 putative cytochrome oxidase (VIMSS) compare
b2017 yefM -0.6 -0.9 orf, hypothetical protein (VIMSS) compare
b4179 vacB -0.6 -2.5 putative enzyme (VIMSS) compare
b1901 araF -0.6 -2.2 L-arabinose transporter subunit (NCBI) compare
b4571 wbbL -0.6 -1.5 no description compare
b2892 recJ -0.6 -3.9 ssDNA exonuclease, 5' --> 3'-specific (NCBI) compare
b1201 b1201 -0.6 -2.6 putative sensor-type regulator (VIMSS) compare
b1836 yebV -0.6 -1.9 orf, hypothetical protein (VIMSS) compare
b1837 yebW -0.6 -1.2 orf, hypothetical protein (VIMSS) compare
b3476 nikA -0.6 -4.0 nickel transporter subunit (NCBI) compare
b2990 hybG -0.6 -1.3 hydrogenase 2 accessory protein (NCBI) compare
b1977 asnT -0.6 -1.6 tRNA-Asn (NCBI) compare
b4407 thiS -0.6 -0.9 sulfur carrier protein ThiS (NCBI) compare
b1195 ymgE -0.6 -1.6 predicted inner membrane protein (NCBI) compare
b1505 ydeT -0.6 -0.4 hypothetical protein (RefSeq) compare
b0826 moeB -0.6 -2.5 molybdopterin biosynthesis protein MoeB (NCBI) compare
b1951 rcsA -0.6 -0.5 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b0894 dmsA -0.6 -4.0 anaerobic dimethyl sulfoxide reductase subunit A (VIMSS) compare
b4642 yoeD -0.6 -1.1 no description compare
b0438 clpX -0.6 -2.7 ATP-dependent protease ATP-binding subunit (NCBI) compare
b4595 yciY -0.6 -1.0 hypothetical protein (RefSeq) compare
b1881 cheZ -0.6 -2.5 chemotaxis regulator, protein phosphatase for CheY (NCBI) compare
b2736 ygbJ -0.6 -1.8 predicted dehydrogenase, with NAD(P)-binding Rossmann-fold domain (NCBI) compare
b1161 ycgX -0.6 -0.5 hypothetical protein (NCBI) compare
b3616 tdh -0.6 -2.6 L-threonine 3-dehydrogenase (NCBI) compare
b0827 moeA -0.6 -2.3 molybdopterin biosynthesis protein (NCBI) compare
b1863 ruvC -0.6 -0.6 Holliday junction resolvase (NCBI) compare
b1279 yciS -0.6 -0.7 conserved inner membrane protein (NCBI) compare
b3755 yieP -0.6 -2.9 predicted transcriptional regulator (NCBI) compare
b2375 yfdX -0.6 -1.3 hypothetical protein (NCBI) compare
b3237 argR -0.6 -1.9 arginine repressor (NCBI) compare
b2646 ypjF -0.6 -1.5 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b3928 yiiU -0.6 -3.0 hypothetical protein (NCBI) compare
b1175 minD -0.6 -1.6 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b2022 hisB -0.6 -2.5 imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) compare
b4313 fimE -0.6 -2.9 tyrosine recombinase/inversion of on/off regulator of fimA (NCBI) compare
b3147 yraM -0.6 -4.3 hypothetical protein (NCBI) compare
b4240 treB -0.6 -3.8 fused trehalose(maltose)-specific PTS enzyme: IIB component/IIC component (NCBI) compare
b1531 marA -0.6 -1.3 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b4653 yicT -0.6 -1.2 no description compare


Specific Phenotypes

For 8 genes in this experiment

For stress Ciprofloxacin Hydrochloride in Escherichia coli BW25113

For stress Ciprofloxacin Hydrochloride across organisms