Experiment set9IT077 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Novobiocin sodium salt 0.000125 mM

200 most important genes:

  gene name fitness t score description  
b0463 acrA -5.1 -8.5 multidrug efflux system (NCBI) compare
b0462 acrB -4.7 -15.9 multidrug efflux system protein (NCBI) compare
b2512 yfgL -3.8 -5.1 protein assembly complex, lipoprotein component (NCBI) compare
b3341 rpsG -3.7 -2.5 30S ribosomal protein S7 (NCBI) compare
b3035 tolC -3.7 -7.0 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b3163 nlpI -3.6 -4.3 hypothetical protein (NCBI) compare
b2378 ddg -3.6 -7.5 putative heat shock protein (VIMSS) compare
b3199 yrbK -3.4 -3.2 hypothetical protein (NCBI) compare
b0677 nagA -3.4 -4.6 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b0222 lpcA -3.3 -3.2 phosphoheptose isomerase (NCBI) compare
b4201 priB -3.3 -3.2 primosomal replication protein N (NCBI) compare
b0178 hlpA -3.2 -5.7 periplasmic chaperone (NCBI) compare
b3052 rfaE -3.2 -3.1 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b4238 nrdD -3.0 -17.9 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b1677 lpp -3.0 -3.4 murein lipoprotein (NCBI) compare
b4237 nrdG -3.0 -11.4 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b0957 ompA -3.0 -4.4 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b2617 smpA -2.9 -3.8 small membrane protein A (VIMSS) compare
b1830 prc -2.8 -4.2 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0053 surA -2.7 -3.2 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3842 rfaH -2.6 -4.8 transcriptional activator RfaH (NCBI) compare
b4509 ylcG -2.5 -3.3 DLP12 prophage; predicted protein (NCBI) compare
b4025 pgi -2.5 -8.8 glucose-6-phosphate isomerase (NCBI) compare
b0049 apaH -2.5 -2.9 diadenosinetetraphosphatase (NCBI) compare
b1429 tehA -2.5 -2.3 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b2188 yejM -2.5 -10.4 predicted hydrolase, inner membrane (NCBI) compare
b0145 dksA -2.5 -2.4 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3632 rfaQ -2.3 -15.1 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3620 rfaF -2.2 -3.9 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3630 rfaP -2.1 -4.5 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1185 dsbB -2.1 -3.8 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b1855 lpxM -2.1 -5.7 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b4592 yccB -2.1 -2.5 hypothetical protein (RefSeq) compare
b3619 rfaD -2.0 -2.3 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b2419 yfeK -2.0 -3.1 hypothetical protein (NCBI) compare
b0683 fur -1.9 -1.7 ferric uptake regulator (NCBI) compare
b3631 rfaG -1.9 -10.1 glucosyltransferase I (NCBI) compare
b3621 rfaC -1.9 -3.3 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b0014 dnaK -1.8 -2.3 molecular chaperone DnaK (NCBI) compare
b0902 pflA -1.7 -6.8 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b3195 yrbF -1.7 -9.3 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b2494 yfgC -1.7 -6.9 predicted peptidase (NCBI) compare
b2572 rseA -1.6 -4.1 anti-sigma factor (NCBI) compare
b2859 ygeO -1.6 -1.5 hypothetical protein (RefSeq) compare
b0623 cspE -1.6 -2.2 cold shock protein E (NCBI) compare
b0740 tolB -1.6 -3.5 translocation protein TolB precursor (NCBI) compare
b2064 asmA -1.5 -5.1 predicted assembly protein (NCBI) compare
b0739 tolA -1.5 -2.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1249 cls -1.5 -5.7 cardiolipin synthetase (NCBI) compare
b3002 yqhA -1.5 -2.7 hypothetical protein (NCBI) compare
b3609 secB -1.5 -3.1 export protein SecB (NCBI) compare
b3839 tatC -1.5 -5.8 TatABCE protein translocation system subunit (NCBI) compare
b1506 yneL -1.5 -1.3 predicted transcriptional regulator (NCBI) compare
b0688 pgm -1.5 -2.8 phosphoglucomutase (NCBI) compare
b4535 yniD -1.5 -1.6 predicted protein (RefSeq) compare
b1334 fnr -1.5 -2.5 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b2346 vacJ -1.4 -6.5 predicted lipoprotein (NCBI) compare
b4402 yjjY -1.4 -1.2 hypothetical protein (NCBI) compare
b0741 pal -1.4 -3.1 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b4702 mgtL -1.4 -1.7 regulatory leader peptide for mgtA (NCBI) compare
b3194 yrbE -1.4 -7.8 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1348 lar -1.4 -1.6 Rac prophage; restriction alleviation protein (NCBI) compare
b3935 priA -1.3 -2.6 primosome assembly protein PriA (NCBI) compare
b0738 tolR -1.3 -1.7 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3026 qseC -1.3 -1.9 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b3192 yrbC -1.3 -6.7 predicted ABC-type organic solvent transporter (NCBI) compare
b0903 pflB -1.3 -8.0 pyruvate formate lyase I (NCBI) compare
b0737 tolQ -1.3 -2.2 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1438 ydcQ -1.3 -2.5 predicted DNA-binding transcriptional regulator (RefSeq) compare
b1161 ycgX -1.2 -0.8 hypothetical protein (NCBI) compare
b1361 ydaW -1.2 -0.6 orf, hypothetical protein (VIMSS) compare
b0547 ybcN -1.2 -2.9 DLP12 prophage; predicted protein (NCBI) compare
b1236 galU -1.2 -2.5 glucose-1-phosphate uridylyltransferase (NCBI) compare
b1279 yciS -1.2 -1.2 conserved inner membrane protein (NCBI) compare
b3021 ygiT -1.2 -2.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b0550 rusA -1.2 -2.5 DLP12 prophage; endonuclease RUS (NCBI) compare
b2174 b2174 -1.2 -6.0 orf, hypothetical protein (VIMSS) compare
b0082 mraW -1.2 -2.6 S-adenosyl-methyltransferase (NCBI) compare
b3193 yrbD -1.2 -6.3 predicted ABC-type organic solvent transporter (NCBI) compare
b2085 b2085 -1.1 -2.6 orf, hypothetical protein (VIMSS) compare
b2528 iscA -1.1 -1.4 iron-sulfur cluster assembly protein (NCBI) compare
b2215 ompC -1.1 -5.0 outer membrane porin protein C (NCBI) compare
b4701 sokX -1.1 -0.7 sok-related sRNA, function unknown (RefSeq) compare
b1108 ycfP -1.1 -1.5 orf, hypothetical protein (VIMSS) compare
b4699 fnrS -1.1 -0.7 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b1763 topB -1.1 -3.7 DNA topoisomerase III (NCBI) compare
b2571 rseB -1.1 -5.2 periplasmic negative regulator of sigmaE (NCBI) compare
b2814 metZ -1.1 -1.3 tRNA-Met (NCBI) compare
b2939 yqgB -1.1 -1.3 predicted protein (RefSeq) compare
b4589 ylcI -1.1 -2.4 hypothetical protein (RefSeq) compare
b1527 yneK -1.0 -1.3 hypothetical protein (NCBI) compare
b1642 slyA -1.0 -1.7 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b1104 ycfL -1.0 -1.3 hypothetical protein (NCBI) compare
b2165 yeiN -1.0 -3.4 hypothetical protein (NCBI) compare
b4570 lomR -1.0 -1.3 no description compare
b0548 ninE -1.0 -1.5 DLP12 prophage; conserved protein (NCBI) compare
b0990 cspG -1.0 -0.6 DNA-binding transcriptional regulator (NCBI) compare
b4221 ytfN -1.0 -8.0 hypothetical protein (NCBI) compare
b0296 ykgM -1.0 -2.2 50S ribosomal protein L31 (NCBI) compare
b0814 ompX -1.0 -3.0 outer membrane protein X (NCBI) compare
b1125 potB -1.0 -3.1 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b4220 ytfM -1.0 -6.8 predicted outer membrane protein and surface antigen (NCBI) compare
b3860 dsbA -1.0 -5.0 periplasmic protein disulfide isomerase I (NCBI) compare
b0226 dinJ -0.9 -3.3 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b3237 argR -0.9 -2.9 arginine repressor (NCBI) compare
b0239 frsA -0.9 -5.3 fermentation/respiration switch protein (NCBI) compare
b4218 ytfL -0.9 -5.6 predicted inner membrane protein (NCBI) compare
b3790 rffC -0.9 -3.8 TDP-fucosamine acetyltransferase (RefSeq) compare
b1346 ydaQ -0.9 -1.3 orf, hypothetical protein (VIMSS) compare
b2168 fruK -0.9 -0.8 1-phosphofructokinase (NCBI) compare
b1620 malI -0.9 -1.8 DNA-binding transcriptional repressor (NCBI) compare
b1085 b1085 -0.9 -1.5 orf, hypothetical protein (VIMSS) compare
b1563 relE -0.9 -1.3 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b2531 iscR -0.9 -0.9 DNA-binding transcriptional repressor (NCBI) compare
b2783 chpR -0.9 -1.8 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b0386 proC -0.9 -2.9 pyrroline-5-carboxylate reductase (NCBI) compare
b1969 yedW -0.9 -1.5 putative 2-component transcriptional regulator (VIMSS) compare
b0767 ybhE -0.8 -2.4 6-phosphogluconolactonase (NCBI) compare
b2221 atoD -0.8 -1.8 acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (NCBI) compare
b2784 relA -0.8 -4.9 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b2369 evgA -0.8 -1.2 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b0232 yafN -0.8 -0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3082 ygjM -0.8 -1.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1730 ydjO -0.8 -0.5 predicted protein (RefSeq) compare
b3600 mtlD -0.8 -5.5 mannitol-1-phosphate 5-dehydrogenase (NCBI) compare
b0436 tig -0.8 -4.4 trigger factor (NCBI) compare
b3784 rfe -0.8 -5.9 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b1503 ydeR -0.8 -1.7 predicted fimbrial-like adhesin protein (NCBI) compare
b4046 yjbK -0.8 -2.9 putative regulator (VIMSS) compare
b3162 deaD -0.8 -2.1 inducible ATP-independent RNA helicase (VIMSS) compare
b4233 mpl -0.8 -5.2 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase (NCBI) compare
b1252 tonB -0.8 -1.8 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b4096 phnL -0.8 -2.5 carbon-phosphorus lyase complex subunit (NCBI) compare
b1150 ymfR -0.8 -0.8 e14 prophage; predicted protein (NCBI) compare
b2620 smpB -0.8 -0.8 SsrA-binding protein (NCBI) compare
b3930 menA -0.8 -5.9 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b3741 gidA -0.8 -2.1 glucose-inhibited division protein A (NCBI) compare
b0881 clpS -0.8 -1.2 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b1692 ydiB -0.8 -1.5 quinate/shikimate 5-dehydrogenase, NAD(P)-binding (NCBI) compare
b3726 pstA -0.8 -2.4 phosphate transporter subunit (NCBI) compare
b1482 osmC -0.7 -1.1 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b1951 rcsA -0.7 -0.5 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b1241 adhE -0.7 -4.5 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b3836 b3836 -0.7 -2.2 orf, hypothetical protein (VIMSS) compare
b1769 ydjE -0.7 -2.8 predicted transporter (NCBI) compare
b4608 ryfC -0.7 -1.7 Novel sRNA, function unknown (RefSeq) compare
b3068 ygjF -0.7 -2.0 G/U mismatch-specific DNA glycosylase (NCBI) compare
b4203 rplI -0.7 -2.3 50S ribosomal protein L9 (NCBI) compare
b1575 dicB -0.7 -0.8 Qin prophage; cell division inhibition protein (NCBI) compare
b2576 srmB -0.7 -1.6 ATP-dependent RNA helicase (NCBI) compare
b1689 b1689 -0.7 -1.6 orf, hypothetical protein (VIMSS) compare
b3803 hemX -0.7 -4.8 predicted uroporphyrinogen III methylase (NCBI) compare
b1556 b1556 -0.7 -1.2 orf, hypothetical protein (VIMSS) compare
b3792 wzxE -0.7 -3.2 O-antigen translocase (NCBI) compare
b3616 tdh -0.7 -2.9 L-threonine 3-dehydrogenase (NCBI) compare
b1789 yeaL -0.7 -2.3 conserved inner membrane protein (NCBI) compare
b3863 polA -0.7 -0.6 DNA polymerase I (NCBI) compare
b3563 yiaB -0.7 -1.8 orf, hypothetical protein (VIMSS) compare
b1818 manY -0.7 -1.4 mannose-specific enzyme IIC component of PTS (NCBI) compare
b4558 yifL -0.7 -3.2 predicted lipoprotein (NCBI) compare
b3761 trpT -0.7 -1.2 tRNA-Trp (NCBI) compare
b4341 yjiS -0.7 -2.4 hypothetical protein (NCBI) compare
b1600 mdtJ -0.7 -0.8 multidrug efflux system transporter (NCBI) compare
b0679 nagE -0.7 -4.7 fused N-acetyl glucosamine specific PTS enzyme: IIC, IIB , and IIA components (NCBI) compare
b2937 speB -0.7 -3.3 agmatinase (NCBI) compare
b2808 gcvA -0.7 -1.7 DNA-binding transcriptional dual regulator (NCBI) compare
b1595 ynfL -0.7 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b4441 glmY -0.7 -1.1 sRNA activator of glmS mRNA (RefSeq) compare
b1290 sapF -0.7 -1.1 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1344 ydaO -0.7 -1.4 predicted C32 tRNA thiolase (NCBI) compare
b3706 trmE -0.7 -1.8 tRNA modification GTPase (NCBI) compare
b3786 rffE -0.7 -4.9 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b3129 sohA -0.7 -1.7 predicted regulator (NCBI) compare
b4594 ymgJ -0.7 -1.0 hypothetical protein (RefSeq) compare
b1579 intQ -0.6 -1.0 Qin prophage; predicted defective integrase (RefSeq) compare
b1480 sra -0.6 -0.5 30S ribosomal subunit protein S22 (NCBI) compare
b0009 mog -0.6 -3.6 molybdenum cofactor biosynthesis protein (NCBI) compare
b2144 sanA -0.6 -4.2 hypothetical protein (NCBI) compare
b0890 ftsK -0.6 -1.1 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b4416 rybA -0.6 -0.8 unknown RNA (NCBI) compare
b1693 aroD -0.6 -2.9 3-dehydroquinate dehydratase (NCBI) compare
b3838 tatB -0.6 -3.1 sec-independent translocase (NCBI) compare
b1407 ydbD -0.6 -2.0 orf, hypothetical protein (VIMSS) compare
b2354 yfdK -0.6 -2.2 CPS-53 (KpLE1) prophage; conserved protein (NCBI) compare
b0317 yahC -0.6 -3.1 predicted inner membrane protein (NCBI) compare
b4431 rprA -0.6 -1.1 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b4451 ryhB -0.6 -0.9 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b3963 fabR -0.6 -4.0 DNA-binding transcriptional repressor (RefSeq) compare
b1258 yciF -0.6 -0.4 hypothetical protein (NCBI) compare
b4520 ymgF -0.6 -0.5 hypothetical protein (NCBI) compare
b0904 focA -0.6 -3.1 formate transporter (NCBI) compare
b1192 ldcA -0.6 -2.2 L,D-carboxypeptidase A (NCBI) compare
b3405 ompR -0.6 -2.3 osmolarity response regulator (NCBI) compare
b3387 dam -0.6 -4.1 DNA adenine methylase (NCBI) compare
b3147 yraM -0.6 -4.6 hypothetical protein (NCBI) compare
b1536 ydeI -0.6 -0.4 hypothetical protein (NCBI) compare
b1961 dcm -0.6 -1.0 DNA cytosine methylase (NCBI) compare
b2792 yqcC -0.6 -1.9 hypothetical protein (NCBI) compare
b1727 yniC -0.6 -0.8 predicted hydrolase (NCBI) compare
b4045 yjbJ -0.6 -1.5 predicted stress response protein (NCBI) compare


Specific Phenotypes

For 2 genes in this experiment

For stress Novobiocin sodium salt in Escherichia coli BW25113

For stress Novobiocin sodium salt across organisms