Experiment set9IT061 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Zinc Pyrithione 0.0000025 mM

200 most important genes:

  gene name fitness t score description  
b0902 pflA -5.3 -7.2 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b0903 pflB -5.1 -9.1 pyruvate formate lyase I (NCBI) compare
b1334 fnr -3.8 -3.6 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b4237 nrdG -3.7 -10.6 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b4238 nrdD -3.5 -20.2 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b0049 apaH -3.2 -2.2 diadenosinetetraphosphatase (NCBI) compare
b2784 relA -3.1 -10.6 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b0053 surA -2.9 -3.9 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3292 zntR -2.8 -3.2 zinc-responsive transcriptional regulator (NCBI) compare
b4025 pgi -2.6 -9.9 glucose-6-phosphate isomerase (NCBI) compare
b3052 rfaE -2.6 -5.5 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3792 wzxE -2.6 -6.3 O-antigen translocase (NCBI) compare
b1429 tehA -2.5 -2.3 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b0737 tolQ -2.4 -2.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1865 nudB -2.4 -2.2 dATP pyrophosphohydrolase (NCBI) compare
b3390 aroK -2.4 -2.2 shikimate kinase I (NCBI) compare
b3469 zntA -2.4 -3.9 zinc, cobalt and lead efflux system (NCBI) compare
b2528 iscA -2.4 -2.6 iron-sulfur cluster assembly protein (NCBI) compare
b0740 tolB -2.4 -3.8 translocation protein TolB precursor (NCBI) compare
b0484 copA -2.3 -13.8 copper transporter (NCBI) compare
b3839 tatC -2.3 -7.2 TatABCE protein translocation system subunit (NCBI) compare
b4402 yjjY -2.3 -1.5 hypothetical protein (NCBI) compare
b3229 sspA -2.3 -3.0 stringent starvation protein A (NCBI) compare
b2506 yfgI -2.2 -3.5 hypothetical protein (NCBI) compare
b1984 asnW -2.2 -1.4 tRNA-Asn (NCBI) compare
b3790 rffC -2.2 -7.2 TDP-fucosamine acetyltransferase (RefSeq) compare
b0212 gloB -2.2 -4.2 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b4535 yniD -2.2 -1.4 predicted protein (RefSeq) compare
b0406 tgt -2.1 -7.4 queuine tRNA-ribosyltransferase (NCBI) compare
b3409 feoB -2.1 -16.5 ferrous iron transport protein B (NCBI) compare
b0683 fur -2.1 -1.9 ferric uptake regulator (NCBI) compare
b3787 rffD -2.1 -11.7 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b3784 rfe -2.0 -13.7 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b0741 pal -2.0 -3.9 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3408 feoA -2.0 -11.6 ferrous iron transport protein A (NCBI) compare
b2576 srmB -2.0 -3.4 ATP-dependent RNA helicase (NCBI) compare
b2553 glnB -2.0 -5.0 regulatory protein P-II for glutamine synthetase (NCBI) compare
b0677 nagA -2.0 -6.2 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b3930 menA -1.9 -14.2 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b3341 rpsG -1.9 -1.7 30S ribosomal protein S7 (NCBI) compare
b4481 rffT -1.9 -7.4 4-alpha-L-fucosyltransferase (NCBI) compare
b3794 rffM -1.9 -8.2 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b3786 rffE -1.8 -12.7 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b0438 clpX -1.8 -6.6 ATP-dependent protease ATP-binding subunit (NCBI) compare
b0222 lpcA -1.8 -3.1 phosphoheptose isomerase (NCBI) compare
b3791 rffA -1.8 -8.3 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b0739 tolA -1.8 -2.3 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1503 ydeR -1.8 -2.8 predicted fimbrial-like adhesin protein (NCBI) compare
b2479 gcvR -1.8 -5.4 transcriptional regulation of gcv operon (VIMSS) compare
b0688 pgm -1.8 -3.4 phosphoglucomutase (NCBI) compare
b0437 clpP -1.8 -5.7 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b3163 nlpI -1.7 -5.1 hypothetical protein (NCBI) compare
b3621 rfaC -1.7 -4.0 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b4589 ylcI -1.7 -3.5 hypothetical protein (RefSeq) compare
b3619 rfaD -1.7 -3.0 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b1936 intG -1.7 -1.1 predicted defective phage integrase (pseudogene) (RefSeq) compare
b3631 rfaG -1.7 -11.0 glucosyltransferase I (NCBI) compare
b2512 yfgL -1.7 -5.6 protein assembly complex, lipoprotein component (NCBI) compare
b3620 rfaF -1.7 -4.8 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0080 fruR -1.7 -6.6 DNA-binding transcriptional dual regulator (NCBI) compare
b4042 dgkA -1.7 -2.2 diacylglycerol kinase (NCBI) compare
b0082 mraW -1.7 -3.5 S-adenosyl-methyltransferase (NCBI) compare
b3630 rfaP -1.7 -7.5 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b3842 rfaH -1.6 -5.3 transcriptional activator RfaH (NCBI) compare
b1882 cheY -1.6 -0.7 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b0730 mngR -1.6 -1.1 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b1183 umuD -1.6 -2.4 DNA polymerase V, subunit D (NCBI) compare
b3838 tatB -1.6 -7.8 sec-independent translocase (NCBI) compare
b1677 lpp -1.6 -2.7 murein lipoprotein (NCBI) compare
b0738 tolR -1.6 -1.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0178 hlpA -1.5 -4.1 periplasmic chaperone (NCBI) compare
b3035 tolC -1.5 -7.3 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b1506 yneL -1.5 -1.3 predicted transcriptional regulator (NCBI) compare
b0357 yaiN -1.5 -2.3 putative alpha helix chain (VIMSS) compare
b1949 fliQ -1.5 -1.9 flagellar biosynthesis protein Q (NCBI) compare
b1049 mdoH -1.5 -7.6 glucosyltransferase MdoH (NCBI) compare
b3649 rpoZ -1.5 -3.1 DNA-directed RNA polymerase subunit omega (NCBI) compare
b3916 pfkA -1.5 -1.4 6-phosphofructokinase (NCBI) compare
b2175 spr -1.5 -3.4 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b3726 pstA -1.5 -4.1 phosphate transporter subunit (NCBI) compare
b2424 cysU -1.5 -2.9 sulfate/thiosulfate transporter subunit (NCBI) compare
b3755 yieP -1.4 -7.3 predicted transcriptional regulator (NCBI) compare
b4178 yjeB -1.4 -4.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b2897 ygfY -1.4 -4.0 hypothetical protein (NCBI) compare
b0237 pepD -1.4 -6.9 aminoacyl-histidine dipeptidase (peptidase D) (NCBI) compare
b0226 dinJ -1.4 -3.0 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b0439 lon -1.4 -3.4 DNA-binding ATP-dependent protease La (NCBI) compare
b0722 sdhD -1.4 -4.6 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b4519 icdC -1.4 -4.0 no description compare
b4702 mgtL -1.4 -1.9 regulatory leader peptide for mgtA (NCBI) compare
b3742 mioC -1.4 -3.9 flavodoxin (NCBI) compare
b0014 dnaK -1.4 -1.9 molecular chaperone DnaK (NCBI) compare
b1482 osmC -1.4 -2.0 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b3204 ptsN -1.4 -4.7 sugar-specific enzyme IIA component of PTS (NCBI) compare
b2286 nuoC -1.4 -4.8 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b2288 nuoA -1.3 -3.2 NADH dehydrogenase I chain A (VIMSS) compare
b3349 slyD -1.3 -6.2 FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) (NCBI) compare
b0471 ybaB -1.3 -3.1 hypothetical protein (NCBI) compare
b2168 fruK -1.3 -1.1 1-phosphofructokinase (NCBI) compare
b2276 nuoN -1.3 -4.9 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b3493 pitA -1.3 -5.3 phosphate transporter, low-affinity (NCBI) compare
b1192 ldcA -1.3 -4.6 L,D-carboxypeptidase A (NCBI) compare
b1236 galU -1.3 -3.0 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3290 trkA -1.2 -0.8 potassium transporter peripheral membrane component (NCBI) compare
b1693 aroD -1.2 -5.0 3-dehydroquinate dehydratase (NCBI) compare
b0101 yacG -1.2 -3.1 zinc-binding protein (NCBI) compare
b4383 deoB -1.2 -7.0 phosphopentomutase (NCBI) compare
b1291 sapD -1.2 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0450 glnK -1.2 -2.7 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b1235 rssB -1.2 -5.5 response regulator of RpoS (NCBI) compare
b4570 lomR -1.2 -1.5 no description compare
b1948 fliP -1.2 -4.2 flagellar biosynthesis protein P (NCBI) compare
b3500 gor -1.2 -1.3 glutathione reductase (NCBI) compare
b1881 cheZ -1.2 -3.5 chemotaxis regulator, protein phosphatase for CheY (NCBI) compare
b1438 ydcQ -1.2 -3.5 predicted DNA-binding transcriptional regulator (RefSeq) compare
b0827 moeA -1.2 -3.8 molybdopterin biosynthesis protein (NCBI) compare
b1940 fliH -1.2 -4.2 flagellar biosynthesis; export of flagellar proteins? (VIMSS) compare
b1048 mdoG -1.2 -4.3 glucan biosynthesis protein, periplasmic (NCBI) compare
b3727 pstC -1.2 -5.0 phosphate transporter subunit (NCBI) compare
b3867 hemN -1.2 -8.6 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b3205 yhbJ -1.2 -3.2 hypothetical protein (NCBI) compare
b1892 flhD -1.2 -4.3 DNA-binding transcriptional dual regulator with FlhC (RefSeq) compare
b2398 yfeC -1.2 -3.4 orf, hypothetical protein (VIMSS) compare
b2948 yqgE -1.2 -2.4 orf, hypothetical protein (VIMSS) compare
b2895 fldB -1.1 -2.6 flavodoxin 2 (NCBI) compare
b1830 prc -1.1 -3.6 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b3183 obgE -1.1 -1.0 GTPase involved in cell partioning and DNA repair (NCBI) compare
b1942 fliJ -1.1 -1.2 flagellar biosynthesis chaperone (NCBI) compare
b1922 fliA -1.1 -4.4 flagellar biosynthesis; alternative sigma factor 28; regulation of flagellar operons (VIMSS) compare
b3387 dam -1.1 -7.3 DNA adenine methylase (NCBI) compare
b2990 hybG -1.1 -1.8 hydrogenase 2 accessory protein (NCBI) compare
b2363 yfdT -1.1 -1.6 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b2830 nudH -1.1 -1.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b1298 ycjL -1.1 -2.2 probable amidotransferase subunit (VIMSS) compare
b3237 argR -1.1 -3.5 arginine repressor (NCBI) compare
b0051 ksgA -1.1 -3.1 dimethyladenosine transferase (NCBI) compare
b4416 rybA -1.1 -1.1 unknown RNA (NCBI) compare
b4503 yafF -1.1 -0.9 no description compare
b0149 mrcB -1.1 -7.9 penicillin-binding protein 1b (NCBI) compare
b1938 fliF -1.1 -5.4 flagellar M-ring protein (NCBI) compare
b0239 frsA -1.1 -5.6 fermentation/respiration switch protein (NCBI) compare
b4181 yjfI -1.1 -2.3 hypothetical protein (NCBI) compare
b2498 upp -1.1 -2.5 uracil phosphoribosyltransferase (VIMSS) compare
b0548 ninE -1.1 -2.5 DLP12 prophage; conserved protein (NCBI) compare
b3728 pstS -1.1 -1.8 phosphate transporter subunit (NCBI) compare
b1286 rnb -1.1 -1.8 exoribonuclease II (NCBI) compare
b0764 modB -1.1 -3.7 molybdate ABC transporter permease protein (NCBI) compare
b2330 yfcB -1.1 -0.9 putative adenine-specific methylase (VIMSS) compare
b0386 proC -1.1 -3.8 pyrroline-5-carboxylate reductase (NCBI) compare
b1923 fliC -1.1 -5.4 flagellin (NCBI) compare
b3094 exuR -1.1 -4.4 negative regulator of exu regulon, exuT, uxaAC, and uxuB (VIMSS) compare
b1083 flgL -1.1 -3.8 flagellar hook-associated protein L (NCBI) compare
b0721 sdhC -1.1 -3.0 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b2707 srlR -1.1 -3.6 DNA-bindng transcriptional repressor (NCBI) compare
b3162 deaD -1.1 -2.8 inducible ATP-independent RNA helicase (VIMSS) compare
b3803 hemX -1.1 -7.2 predicted uroporphyrinogen III methylase (NCBI) compare
b3741 gidA -1.1 -2.6 glucose-inhibited division protein A (NCBI) compare
b2142 yohK -1.1 -4.7 predicted inner membrane protein (NCBI) compare
b1090 plsX -1.1 -4.3 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b1634 tppB -1.1 -3.7 putative tripeptide transporter permease (NCBI) compare
b3405 ompR -1.1 -3.6 osmolarity response regulator (NCBI) compare
b3226 yhcK -1.1 -3.9 putative FADA-type transcriptional regulator (VIMSS) compare
b2281 nuoI -1.1 -2.4 NADH dehydrogenase subunit I (NCBI) compare
b0888 trxB -1.1 -2.5 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b4179 vacB -1.1 -4.0 putative enzyme (VIMSS) compare
b2283 nuoG -1.0 -5.1 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b4431 rprA -1.0 -1.5 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b3609 secB -1.0 -3.6 export protein SecB (NCBI) compare
b3281 aroE -1.0 -7.9 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b1073 flgB -1.0 -3.8 flagellar basal-body rod protein B (NCBI) compare
b2318 truA -1.0 -2.2 tRNA pseudouridine synthase A (NCBI) compare
b3002 yqhA -1.0 -2.1 hypothetical protein (NCBI) compare
b1850 eda -1.0 -1.7 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b2215 ompC -1.0 -5.9 outer membrane porin protein C (NCBI) compare
b1945 fliM -1.0 -4.7 flagellar motor switch protein M (NCBI) compare
b3389 aroB -1.0 -6.7 3-dehydroquinate synthase (NCBI) compare
b4180 rlmB -1.0 -4.9 23S rRNA (Gm2251)-methyltransferase (NCBI) compare
b1946 fliN -1.0 -3.4 flagellar motor switch protein (NCBI) compare
b4232 fbp -1.0 -6.4 fructose-1,6-bisphosphatase (NCBI) compare
b1150 ymfR -1.0 -0.9 e14 prophage; predicted protein (NCBI) compare
b4184 yjfL -1.0 -2.7 conserved inner membrane protein (NCBI) compare
b0826 moeB -1.0 -5.1 molybdopterin biosynthesis protein MoeB (NCBI) compare
b3026 qseC -1.0 -1.8 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1889 motB -1.0 -3.2 flagellar motor protein MotB (NCBI) compare
b1726 yniB -1.0 -1.6 predicted inner membrane protein (NCBI) compare
b2362 yfdS -1.0 -3.5 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b1095 fabF -1.0 -4.5 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b3870 glnA -1.0 -2.3 glutamine synthetase (NCBI) compare
b1358 ydaT -1.0 -1.0 Rac prophage; predicted protein (NCBI) compare
b2277 nuoM -1.0 -3.9 NADH dehydrogenase subunit M (NCBI) compare
b2951 yggS -1.0 -3.7 predicted enzyme (NCBI) compare
b0908 aroA -1.0 -5.2 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b2620 smpB -1.0 -1.0 SsrA-binding protein (NCBI) compare
b2216 rcsD -0.9 -5.9 phosphotransfer intermediate protein in two-component regulatory system with RcsBC (NCBI) compare
b2284 nuoF -0.9 -3.3 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0142 folK -0.9 -0.4 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b3627 rfaI -0.9 -5.2 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b0928 aspC -0.9 -4.7 aspartate aminotransferase, PLP-dependent (NCBI) compare
b1255 yciC -0.9 -2.5 hypothetical protein (NCBI) compare
b2456 cchB -0.9 -3.0 predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) compare


Specific Phenotypes

For 6 genes in this experiment

For stress Zinc Pyrithione in Escherichia coli BW25113

For stress Zinc Pyrithione across organisms