Experiment set9IT038 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Trimethoprim 0.0000003125 mM

200 most important genes:

  gene name fitness t score description  
b1105 ycfM -3.8 -5.1 predicted outer membrane lipoprotein (NCBI) compare
b1192 ldcA -3.8 -6.2 L,D-carboxypeptidase A (NCBI) compare
b0149 mrcB -3.6 -13.6 penicillin-binding protein 1b (NCBI) compare
b1865 nudB -3.6 -2.4 dATP pyrophosphohydrolase (NCBI) compare
b4592 yccB -3.2 -3.3 hypothetical protein (RefSeq) compare
b0920 ycbC -2.6 -5.2 conserved inner membrane protein (NCBI) compare
b0728 sucC -2.6 -8.2 succinyl-CoA synthetase subunit beta (NCBI) compare
b0053 surA -2.5 -5.1 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0729 sucD -2.2 -4.4 succinyl-CoA synthetase subunit alpha (NCBI) compare
b0737 tolQ -2.2 -2.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4237 nrdG -2.0 -9.4 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b1429 tehA -2.0 -2.2 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b0740 tolB -2.0 -4.2 translocation protein TolB precursor (NCBI) compare
b4238 nrdD -1.9 -13.7 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b1765 ydjA -1.9 -1.7 predicted oxidoreductase (NCBI) compare
b2506 yfgI -1.8 -3.1 hypothetical protein (NCBI) compare
b1882 cheY -1.7 -0.8 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b0741 pal -1.7 -3.5 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b4535 yniD -1.6 -1.6 predicted protein (RefSeq) compare
b3839 tatC -1.6 -6.2 TatABCE protein translocation system subunit (NCBI) compare
b1847 yebF -1.5 -1.9 predicted protein (RefSeq) compare
b0641 rlpB -1.5 -3.1 minor lipoprotein (NCBI) compare
b3609 secB -1.5 -3.5 export protein SecB (NCBI) compare
b1830 prc -1.4 -4.3 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b1334 fnr -1.4 -2.6 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b3443 yrhA -1.4 -1.3 orf, hypothetical protein (VIMSS) compare
b4025 pgi -1.4 -7.0 glucose-6-phosphate isomerase (NCBI) compare
b2393 nupC -1.4 -6.0 nucleoside (except guanosine) transporter (NCBI) compare
b3163 nlpI -1.4 -3.9 hypothetical protein (NCBI) compare
b0957 ompA -1.3 -3.6 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b2501 ppk -1.3 -6.9 polyphosphate kinase (NCBI) compare
b4201 priB -1.3 -2.0 primosomal replication protein N (NCBI) compare
b1217 chaB -1.3 -1.6 cation transport regulator (NCBI) compare
b1252 tonB -1.3 -2.6 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b0765 modC -1.3 -5.1 molybdate transporter subunit (NCBI) compare
b4407 thiS -1.3 -2.4 sulfur carrier protein ThiS (NCBI) compare
b3237 argR -1.2 -3.7 arginine repressor (NCBI) compare
b3792 wzxE -1.2 -5.3 O-antigen translocase (NCBI) compare
b1361 ydaW -1.2 -0.6 orf, hypothetical protein (VIMSS) compare
b0462 acrB -1.2 -9.6 multidrug efflux system protein (NCBI) compare
b2175 spr -1.2 -3.3 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b0049 apaH -1.2 -2.6 diadenosinetetraphosphatase (NCBI) compare
b1493 gadB -1.2 -0.8 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b1434 ydcN -1.2 -2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b2343 b2343 -1.2 -1.9 orf, hypothetical protein (VIMSS) compare
b1739 osmE -1.2 -2.4 DNA-binding transcriptional activator (NCBI) compare
b0239 frsA -1.1 -6.4 fermentation/respiration switch protein (NCBI) compare
b3341 rpsG -1.1 -1.4 30S ribosomal protein S7 (NCBI) compare
b1642 slyA -1.1 -1.3 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b0763 modA -1.1 -4.0 molybdate transporter subunit (NCBI) compare
b0827 moeA -1.1 -3.4 molybdopterin biosynthesis protein (NCBI) compare
b4453 ldrD -1.0 -1.2 toxic polypeptide, small (NCBI) compare
b4503 yafF -1.0 -0.9 no description compare
b3857 mobA -1.0 -4.1 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b3838 tatB -1.0 -5.6 sec-independent translocase (NCBI) compare
b3836 b3836 -1.0 -2.9 orf, hypothetical protein (VIMSS) compare
b1108 ycfP -1.0 -2.5 orf, hypothetical protein (VIMSS) compare
b0781 moaA -1.0 -4.9 molybdenum cofactor biosynthesis protein A (NCBI) compare
b0463 acrA -1.0 -6.2 multidrug efflux system (NCBI) compare
b0903 pflB -1.0 -6.7 pyruvate formate lyase I (NCBI) compare
b3930 menA -1.0 -7.7 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b4596 yciZ -1.0 -1.7 hypothetical protein (RefSeq) compare
b3863 polA -1.0 -0.6 DNA polymerase I (NCBI) compare
b2859 ygeO -1.0 -1.4 hypothetical protein (RefSeq) compare
b0902 pflA -1.0 -4.2 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b1818 manY -0.9 -1.5 mannose-specific enzyme IIC component of PTS (NCBI) compare
b2446 yffO -0.9 -1.9 CPZ-55 prophage; predicted protein (NCBI) compare
b4508 peaD -0.9 -3.2 putative sensory transduction regulator (VIMSS) compare
b4529 ydbJ -0.9 -1.1 hypothetical protein (NCBI) compare
b1524 yneH -0.9 -0.9 predicted glutaminase (NCBI) compare
b0142 folK -0.9 -0.4 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b0232 yafN -0.9 -0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1084 rne -0.9 -2.9 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b1936 intG -0.9 -0.7 predicted defective phage integrase (pseudogene) (RefSeq) compare
b3794 rffM -0.9 -4.0 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b4181 yjfI -0.9 -1.8 hypothetical protein (NCBI) compare
b1730 ydjO -0.8 -0.5 predicted protein (RefSeq) compare
b1238 tdk -0.8 -2.3 thymidine kinase (NCBI) compare
b3469 zntA -0.8 -3.7 zinc, cobalt and lead efflux system (NCBI) compare
b2804 fucU -0.8 -1.8 L-fucose mutarotase (NCBI) compare
b2512 yfgL -0.8 -3.5 protein assembly complex, lipoprotein component (NCBI) compare
b1125 potB -0.8 -2.8 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b2263 yfbB -0.8 -1.6 predicted peptidase (NCBI) compare
b1346 ydaQ -0.8 -1.2 orf, hypothetical protein (VIMSS) compare
b0738 tolR -0.8 -1.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2369 evgA -0.8 -1.3 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b1575 dicB -0.8 -0.8 Qin prophage; cell division inhibition protein (NCBI) compare
b1506 yneL -0.8 -0.9 predicted transcriptional regulator (NCBI) compare
b3035 tolC -0.8 -4.4 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0683 fur -0.8 -0.9 ferric uptake regulator (NCBI) compare
b1355 b1355 -0.8 -1.8 orf, hypothetical protein (VIMSS) compare
b3387 dam -0.8 -5.2 DNA adenine methylase (NCBI) compare
b0226 dinJ -0.8 -3.2 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b2258 b2258 -0.8 -1.1 putative transport/receptor protein (VIMSS) compare
b1984 asnW -0.8 -0.8 tRNA-Asn (NCBI) compare
b3292 zntR -0.8 -2.0 zinc-responsive transcriptional regulator (NCBI) compare
b4519 icdC -0.8 -2.6 no description compare
b2744 surE -0.8 -4.2 acid phosphatase (NCBI) compare
b2450 yffS -0.8 -1.5 CPZ-55 prophage; predicted protein (RefSeq) compare
b1600 mdtJ -0.8 -0.9 multidrug efflux system transporter (NCBI) compare
b1344 ydaO -0.8 -2.6 predicted C32 tRNA thiolase (NCBI) compare
b0764 modB -0.8 -3.2 molybdate ABC transporter permease protein (NCBI) compare
b3545 proK -0.7 -1.2 tRNA-Pro (NCBI) compare
b2991 hybF -0.7 -3.0 protein involved with the maturation of hydrogenases 1 and 2 (NCBI) compare
b2037 rfbX -0.7 -3.6 predicted polisoprenol-linked O-antigen transporter (NCBI) compare
b1951 rcsA -0.7 -0.5 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b3082 ygjM -0.7 -1.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b3563 yiaB -0.7 -1.9 orf, hypothetical protein (VIMSS) compare
b3479 nikD -0.7 -4.1 nickel transporter subunit (NCBI) compare
b3388 damX -0.7 -5.5 hypothetical protein (NCBI) compare
b1677 lpp -0.7 -1.5 murein lipoprotein (NCBI) compare
b1658 purR -0.7 -2.4 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b1025 ycdT -0.7 -0.8 predicted diguanylate cyclase (NCBI) compare
b0088 murD -0.7 -1.4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b4655 ythA -0.7 -0.9 expressed protein (RefSeq) compare
b1861 ruvA -0.7 -0.4 Holliday junction DNA helicase motor protein (NCBI) compare
b2727 hypB -0.7 -2.9 GTP hydrolase involved in nickel liganding into hydrogenases (NCBI) compare
b1955 yedP -0.7 -2.1 hypothetical protein (NCBI) compare
b3742 mioC -0.7 -2.7 flavodoxin (NCBI) compare
b3806 cyaA -0.7 -2.7 adenylate cyclase (NCBI) compare
b2398 yfeC -0.7 -2.6 orf, hypothetical protein (VIMSS) compare
b3446 yrhB -0.7 -2.5 hypothetical protein (NCBI) compare
b0009 mog -0.7 -3.8 molybdenum cofactor biosynthesis protein (NCBI) compare
b1221 narL -0.7 -2.6 DNA-binding response regulator in two-component regulatory system with NarX (or NarQ) (NCBI) compare
b0970 yccA -0.7 -2.3 inner membrane protein (NCBI) compare
b1527 yneK -0.7 -1.1 hypothetical protein (NCBI) compare
b0739 tolA -0.7 -1.3 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3094 exuR -0.7 -2.9 negative regulator of exu regulon, exuT, uxaAC, and uxuB (VIMSS) compare
b0222 lpcA -0.7 -1.5 phosphoheptose isomerase (NCBI) compare
b4390 nadR -0.6 -3.7 probable nadAB transcriptional regulator (VIMSS) compare
b2877 ygfJ -0.6 -3.6 hypothetical protein (NCBI) compare
b0556 rzpD -0.6 -2.4 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b0535 fimZ -0.6 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b0783 moaC -0.6 -2.7 molybdenum cofactor biosynthesis protein C (NCBI) compare
b3619 rfaD -0.6 -1.9 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3791 rffA -0.6 -3.2 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b1382 ynbE -0.6 -1.1 predicted lipoprotein (NCBI) compare
b2165 yeiN -0.6 -2.3 hypothetical protein (NCBI) compare
b0406 tgt -0.6 -2.6 queuine tRNA-ribosyltransferase (NCBI) compare
b0890 ftsK -0.6 -1.2 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b1503 ydeR -0.6 -1.5 predicted fimbrial-like adhesin protein (NCBI) compare
b1968 yedV -0.6 -1.0 predicted sensory kinase in two-component regulatory system with YedW (NCBI) compare
b2314 dedD -0.6 -1.8 putative lipoprotein (VIMSS) compare
b0436 tig -0.6 -3.5 trigger factor (NCBI) compare
b3973 birA -0.6 -1.3 biotin--protein ligase (NCBI) compare
b4509 ylcG -0.6 -1.4 DLP12 prophage; predicted protein (NCBI) compare
b2490 b2490 -0.6 -1.7 putative protein processing element (VIMSS) compare
b4579 yaiX -0.6 -2.3 no description compare
b0785 moaE -0.6 -2.6 molybdopterin synthase, large subunit (NCBI) compare
b3786 rffE -0.6 -4.6 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b0888 trxB -0.6 -1.5 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b1083 flgL -0.6 -2.2 flagellar hook-associated protein L (NCBI) compare
b4494 arpB -0.6 -0.5 no description compare
b1097 yceG -0.6 -2.7 predicted aminodeoxychorismate lyase (NCBI) conserved
b2571 rseB -0.6 -3.0 periplasmic negative regulator of sigmaE (NCBI) compare
b2215 ompC -0.6 -3.6 outer membrane porin protein C (NCBI) compare
b3129 sohA -0.6 -1.4 predicted regulator (NCBI) compare
b1824 yobF -0.6 -1.6 hypothetical protein (NCBI) compare
b3472 b3472 -0.6 -3.0 orf, hypothetical protein (VIMSS) compare
b2959 yggL -0.6 -1.8 orf, hypothetical protein (VIMSS) compare
b1674 ydhY -0.6 -2.9 predicted 4Fe-4S ferridoxin-type protein (NCBI) compare
b0437 clpP -0.6 -2.5 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1863 ruvC -0.6 -0.7 Holliday junction resolvase (NCBI) compare
b2471 yffB -0.6 -1.6 hypothetical protein (NCBI) compare
b1579 intQ -0.6 -1.0 Qin prophage; predicted defective integrase (RefSeq) compare
b0990 cspG -0.6 -0.5 DNA-binding transcriptional regulator (NCBI) compare
b2518 ndk -0.6 -1.2 nucleoside diphosphate kinase (NCBI) compare
b0438 clpX -0.6 -2.8 ATP-dependent protease ATP-binding subunit (NCBI) compare
b1860 ruvB -0.6 -0.3 Holliday junction DNA helicase B (NCBI) compare
b0092 ddlB -0.6 -2.4 D-alanylalanine synthetase (NCBI) compare
b0384 psiF -0.6 -1.8 induced by phosphate starvation (VIMSS) compare
b1773 ydjI -0.6 -0.6 predicted aldolase (NCBI) compare
b0826 moeB -0.6 -2.4 molybdopterin biosynthesis protein MoeB (NCBI) compare
b2248 yfaX -0.6 -1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b0767 ybhE -0.5 -1.5 6-phosphogluconolactonase (NCBI) compare
b2271 yfbL -0.5 -2.2 putative aminopeptidase (VIMSS) compare
b0386 proC -0.5 -2.1 pyrroline-5-carboxylate reductase (NCBI) compare
b4538 yoeF -0.5 -0.7 hypothetical protein (RefSeq) compare
b1363 trkG -0.5 -0.3 Rac prophage; potassium transporter subunit (NCBI) compare
b0908 aroA -0.5 -3.1 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b1103 ycfF -0.5 -0.5 orf, hypothetical protein (VIMSS) compare
b1877 yecT -0.5 -0.7 orf, hypothetical protein (VIMSS) compare
b1290 sapF -0.5 -0.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3628 rfaB -0.5 -3.1 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b2279 nuoK -0.5 -1.0 NADH dehydrogenase subunit K (NCBI) compare
b1242 ychE -0.5 -1.7 predicted inner membrane protein (NCBI) compare
b1778 yeaA -0.5 -1.0 methionine sulfoxide reductase B (NCBI) compare
b2997 hybO -0.5 -3.0 hydrogenase 2, small subunit (NCBI) compare
b3354 yheU -0.5 -2.8 hypothetical protein (NCBI) compare
b3652 recG -0.5 -3.1 ATP-dependent DNA helicase (NCBI) compare
b1295 ymjA -0.5 -1.3 hypothetical protein (NCBI) compare
b4577 sgrS -0.5 -1.1 small antisense RNA (NCBI) compare
b3784 rfe -0.5 -3.9 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b1408 b1408 -0.5 -1.5 probable enzyme (VIMSS) compare
b1253 yciA -0.5 -1.5 predicted hydrolase (NCBI) compare
b4594 ymgJ -0.5 -0.9 hypothetical protein (RefSeq) compare
b2424 cysU -0.5 -0.9 sulfate/thiosulfate transporter subunit (NCBI) compare
b0530 sfmA -0.5 -0.9 putative fimbrial-like protein (VIMSS) compare
b1648 b1648 -0.5 -0.8 orf, hypothetical protein (VIMSS) compare
b1121 ycfZ -0.5 -0.3 predicted inner membrane protein (NCBI) compare


Specific Phenotypes

For 2 genes in this experiment

For stress Trimethoprim in Escherichia coli BW25113

For stress Trimethoprim across organisms