Experiment set9IT034 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Doxycycline hyclate 0.000000390625 mM

200 most important genes:

  gene name fitness t score description  
b1334 fnr -4.3 -3.0 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b1765 ydjA -3.7 -2.1 predicted oxidoreductase (NCBI) compare
b0463 acrA -3.7 -12.4 multidrug efflux system (NCBI) compare
b0462 acrB -3.5 -18.8 multidrug efflux system protein (NCBI) compare
b3035 tolC -3.1 -9.1 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0683 fur -3.0 -2.0 ferric uptake regulator (NCBI) compare
b0677 nagA -3.0 -5.6 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b0741 pal -2.9 -3.8 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0053 surA -2.7 -4.1 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0737 tolQ -2.6 -2.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4025 pgi -2.5 -9.1 glucose-6-phosphate isomerase (NCBI) compare
b3199 yrbK -2.5 -3.4 hypothetical protein (NCBI) compare
b2188 yejM -2.5 -10.9 predicted hydrolase, inner membrane (NCBI) compare
b1855 lpxM -2.5 -6.7 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b3632 rfaQ -2.5 -16.1 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3052 rfaE -2.3 -5.4 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3977 tyrU -2.3 -1.3 tRNA-Tyr (NCBI) compare
b4509 ylcG -2.3 -3.6 DLP12 prophage; predicted protein (NCBI) compare
b3163 nlpI -2.2 -5.4 hypothetical protein (NCBI) compare
b4535 yniD -2.2 -1.5 predicted protein (RefSeq) compare
b0437 clpP -2.1 -6.0 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b0178 hlpA -2.1 -5.2 periplasmic chaperone (NCBI) compare
b0438 clpX -2.1 -7.0 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3842 rfaH -2.1 -5.5 transcriptional activator RfaH (NCBI) compare
b1429 tehA -2.0 -2.2 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b0222 lpcA -2.0 -3.4 phosphoheptose isomerase (NCBI) compare
b3194 yrbE -2.0 -10.3 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2346 vacJ -2.0 -8.2 predicted lipoprotein (NCBI) compare
b3082 ygjM -2.0 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b2512 yfgL -1.9 -6.4 protein assembly complex, lipoprotein component (NCBI) compare
b3229 sspA -1.9 -3.0 stringent starvation protein A (NCBI) compare
b3621 rfaC -1.9 -3.6 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b3631 rfaG -1.9 -10.5 glucosyltransferase I (NCBI) compare
b1176 minC -1.8 -3.0 septum formation inhibitor (NCBI) compare
b0014 dnaK -1.8 -2.5 molecular chaperone DnaK (NCBI) compare
b3192 yrbC -1.8 -9.6 predicted ABC-type organic solvent transporter (NCBI) compare
b0688 pgm -1.8 -3.4 phosphoglucomutase (NCBI) compare
b4237 nrdG -1.8 -7.7 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b4238 nrdD -1.8 -13.5 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b3195 yrbF -1.8 -10.3 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b0049 apaH -1.8 -2.8 diadenosinetetraphosphatase (NCBI) compare
b0740 tolB -1.7 -3.5 translocation protein TolB precursor (NCBI) compare
b1236 galU -1.7 -3.3 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3620 rfaF -1.7 -4.4 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b1882 cheY -1.7 -0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b3784 rfe -1.7 -11.4 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b0739 tolA -1.6 -2.6 cell envelope integrity inner membrane protein TolA (NCBI) compare
b0730 mngR -1.6 -1.1 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b3465 yhhF -1.6 -5.6 predicted methyltransferase (NCBI) compare
b3193 yrbD -1.6 -7.8 predicted ABC-type organic solvent transporter (NCBI) compare
b0902 pflA -1.6 -7.0 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b1482 osmC -1.6 -2.1 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b3627 rfaI -1.6 -6.7 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b4577 sgrS -1.6 -2.6 small antisense RNA (NCBI) compare
b3630 rfaP -1.6 -6.3 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2939 yqgB -1.5 -1.7 predicted protein (RefSeq) compare
b2620 smpB -1.5 -1.3 SsrA-binding protein (NCBI) compare
b3021 ygiT -1.5 -2.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b3191 yrbB -1.4 -7.5 orf, hypothetical protein (VIMSS) compare
b3600 mtlD -1.4 -8.9 mannitol-1-phosphate 5-dehydrogenase (NCBI) compare
b2258 b2258 -1.4 -1.8 putative transport/receptor protein (VIMSS) compare
b2085 b2085 -1.4 -3.1 orf, hypothetical protein (VIMSS) compare
b3619 rfaD -1.4 -2.6 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b2064 asmA -1.4 -3.3 predicted assembly protein (NCBI) compare
b2498 upp -1.4 -2.8 uracil phosphoribosyltransferase (VIMSS) compare
b1346 ydaQ -1.3 -1.8 orf, hypothetical protein (VIMSS) compare
b3839 tatC -1.3 -5.7 TatABCE protein translocation system subunit (NCBI) compare
b3628 rfaB -1.3 -6.1 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b1830 prc -1.3 -4.1 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0763 modA -1.3 -5.0 molybdate transporter subunit (NCBI) compare
b3930 menA -1.3 -10.1 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b2363 yfdT -1.3 -1.8 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b0783 moaC -1.3 -5.1 molybdenum cofactor biosynthesis protein C (NCBI) compare
b1677 lpp -1.3 -1.7 murein lipoprotein (NCBI) compare
b1382 ynbE -1.3 -1.9 predicted lipoprotein (NCBI) compare
b2174 b2174 -1.3 -6.4 orf, hypothetical protein (VIMSS) compare
b4702 mgtL -1.3 -1.8 regulatory leader peptide for mgtA (NCBI) compare
b4201 priB -1.3 -2.6 primosomal replication protein N (NCBI) compare
b2579 yfiD -1.3 -2.0 pyruvate formate lyase subunit (NCBI) compare
b4653 yicT -1.2 -2.4 no description compare
b0903 pflB -1.2 -8.2 pyruvate formate lyase I (NCBI) compare
b1589 ynfG -1.2 -2.8 oxidoreductase, Fe-S subunit (NCBI) compare
b1831 proQ -1.2 -3.5 putative solute/DNA competence effector (NCBI) compare
b0738 tolR -1.1 -1.7 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3838 tatB -1.1 -5.9 sec-independent translocase (NCBI) compare
b1607 ydgC -1.1 -1.5 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b0218 yafU -1.1 -1.8 predicted inner membrane protein (RefSeq) compare
b0819 ybiS -1.1 -6.4 hypothetical protein (NCBI) compare
b0548 ninE -1.1 -2.3 DLP12 prophage; conserved protein (NCBI) compare
b0080 fruR -1.1 -4.9 DNA-binding transcriptional dual regulator (NCBI) compare
b4594 ymgJ -1.1 -1.7 hypothetical protein (RefSeq) compare
b3609 secB -1.1 -3.5 export protein SecB (NCBI) compare
b0471 ybaB -1.1 -2.9 hypothetical protein (NCBI) compare
b3649 rpoZ -1.1 -2.4 DNA-directed RNA polymerase subunit omega (NCBI) compare
b1217 chaB -1.1 -1.4 cation transport regulator (NCBI) compare
b1613 manA -1.1 -1.6 mannose-6-phosphate isomerase (VIMSS) compare
b1290 sapF -1.0 -1.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2532 yfhQ -1.0 -3.3 predicted methyltransferase (NCBI) compare
b0145 dksA -1.0 -2.2 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b2814 metZ -1.0 -1.4 tRNA-Met (NCBI) compare
b0877 ybjX -1.0 -5.0 hypothetical protein (NCBI) conserved
b1291 sapD -1.0 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4418 sraB -1.0 -1.9 unknown RNA (NCBI) compare
b2808 gcvA -1.0 -2.3 DNA-binding transcriptional dual regulator (NCBI) compare
b2937 speB -1.0 -4.6 agmatinase (NCBI) compare
b3863 polA -1.0 -0.6 DNA polymerase I (NCBI) compare
b1506 yneL -1.0 -0.9 predicted transcriptional regulator (NCBI) compare
b0764 modB -1.0 -4.0 molybdate ABC transporter permease protein (NCBI) compare
b0781 moaA -1.0 -4.8 molybdenum cofactor biosynthesis protein A (NCBI) compare
b1125 potB -0.9 -3.2 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b0785 moaE -0.9 -3.3 molybdopterin synthase, large subunit (NCBI) compare
b4179 vacB -0.9 -3.4 putative enzyme (VIMSS) compare
b2571 rseB -0.9 -4.8 periplasmic negative regulator of sigmaE (NCBI) compare
b1454 yncG -0.9 -1.7 predicted enzyme (NCBI) compare
b3387 dam -0.9 -5.9 DNA adenine methylase (NCBI) compare
b2479 gcvR -0.9 -3.4 transcriptional regulation of gcv operon (VIMSS) compare
b2707 srlR -0.9 -4.2 DNA-bindng transcriptional repressor (NCBI) compare
b0934 ycbM -0.9 -1.8 putative transport system permease protein (VIMSS) compare
b1103 ycfF -0.9 -1.1 orf, hypothetical protein (VIMSS) compare
b0232 yafN -0.9 -0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3197 kdsD -0.9 -5.8 D-arabinose 5-phosphate isomerase (NCBI) compare
b0765 modC -0.9 -3.9 molybdate transporter subunit (NCBI) compare
b0957 ompA -0.9 -2.6 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b0239 frsA -0.9 -5.4 fermentation/respiration switch protein (NCBI) compare
b0247 ykfG -0.9 -1.2 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b4184 yjfL -0.9 -2.3 conserved inner membrane protein (NCBI) compare
b3728 pstS -0.9 -1.4 phosphate transporter subunit (NCBI) compare
b3858 yihD -0.9 -1.6 hypothetical protein (NCBI) compare
b3349 slyD -0.9 -3.9 FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) (NCBI) compare
b1730 ydjO -0.9 -0.5 predicted protein (RefSeq) compare
b0759 galE -0.9 -4.2 UDP-galactose-4-epimerase (VIMSS) compare
b1025 ycdT -0.9 -0.8 predicted diguanylate cyclase (NCBI) compare
b0547 ybcN -0.9 -2.0 DLP12 prophage; predicted protein (NCBI) compare
b3794 rffM -0.9 -4.7 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b1524 yneH -0.9 -0.9 predicted glutaminase (NCBI) compare
b4570 lomR -0.8 -1.5 no description compare
b1413 hrpA -0.8 -5.2 ATP-dependent helicase (RefSeq) conserved
b2528 iscA -0.8 -1.1 iron-sulfur cluster assembly protein (NCBI) compare
b3836 b3836 -0.8 -2.9 orf, hypothetical protein (VIMSS) compare
b2617 smpA -0.8 -2.1 small membrane protein A (VIMSS) compare
b1620 malI -0.8 -1.7 DNA-binding transcriptional repressor (NCBI) compare
b3786 rffE -0.8 -5.9 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b3857 mobA -0.8 -3.4 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b0827 moeA -0.8 -3.3 molybdopterin biosynthesis protein (NCBI) compare
b4383 deoB -0.8 -4.8 phosphopentomutase (NCBI) compare
b1819 manZ -0.8 -2.8 mannose-specific enzyme IID component of PTS (NCBI) compare
b1643 ydhI -0.8 -2.4 predicted inner membrane protein (NCBI) compare
b1503 ydeR -0.8 -1.8 predicted fimbrial-like adhesin protein (NCBI) compare
b0226 dinJ -0.8 -2.9 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b1259 yciG -0.8 -1.3 orf, hypothetical protein (VIMSS) compare
b3479 nikD -0.8 -4.8 nickel transporter subunit (NCBI) compare
b2572 rseA -0.8 -2.2 anti-sigma factor (NCBI) compare
b3405 ompR -0.8 -2.7 osmolarity response regulator (NCBI) compare
b4042 dgkA -0.8 -1.4 diacylglycerol kinase (NCBI) compare
b2993 hybD -0.8 -2.2 predicted maturation element for hydrogenase 2 (NCBI) compare
b3157 yhbT -0.8 -2.5 predicted lipid carrier protein (NCBI) compare
b1951 rcsA -0.8 -0.5 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b0627 tatE -0.8 -1.5 twin arginine translocase protein E (NCBI) compare
b3478 nikC -0.8 -4.6 nickel transporter subunit (NCBI) compare
b1241 adhE -0.8 -4.9 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b0009 mog -0.8 -3.9 molybdenum cofactor biosynthesis protein (NCBI) compare
b0436 tig -0.8 -4.2 trigger factor (NCBI) compare
b0623 cspE -0.7 -1.0 cold shock protein E (NCBI) compare
b4695 ykgT -0.7 -1.4 no description compare
b1150 ymfR -0.7 -0.9 e14 prophage; predicted protein (NCBI) compare
b1591 b1591 -0.7 -1.4 putative oxidoreductase component (VIMSS) compare
b1438 ydcQ -0.7 -1.6 predicted DNA-binding transcriptional regulator (RefSeq) compare
b1231 tyrT -0.7 -0.6 tRNA-Tyr (NCBI) compare
b1579 intQ -0.7 -1.0 Qin prophage; predicted defective integrase (RefSeq) compare
b2807 ygdD -0.7 -2.6 conserved inner membrane protein (NCBI) compare
b3675 yidG -0.7 -3.5 predicted inner membrane protein (NCBI) compare
b0122 yacC -0.7 -2.9 orf, hypothetical protein (VIMSS) compare
b1456 rhsE -0.7 -3.2 rhsE element core protein RshE (RefSeq) compare
b1671 ydhX -0.7 -1.4 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b2215 ompC -0.7 -4.1 outer membrane porin protein C (NCBI) compare
b3644 yicC -0.7 -3.4 hypothetical protein (NCBI) compare
b3414 gntY -0.7 -2.8 predicted gluconate transport associated protein (NCBI) compare
b2997 hybO -0.7 -4.3 hydrogenase 2, small subunit (NCBI) compare
b1686 ydiI -0.7 -1.0 hypothetical protein (NCBI) compare
b3787 rffD -0.7 -5.0 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b4515 ybgT -0.7 -1.2 hypothetical protein (NCBI) compare
b1863 ruvC -0.7 -0.7 Holliday junction resolvase (NCBI) compare
b2996 hybA -0.7 -3.8 hydrogenase 2 4Fe-4S ferredoxin-type component (NCBI) compare
b2274 yfbO -0.7 -2.1 predicted protein (RefSeq) compare
b1707 ydiV -0.7 -1.8 hypothetical protein (NCBI) compare
b0605 ahpC -0.7 -1.7 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b4529 ydbJ -0.7 -0.9 hypothetical protein (NCBI) compare
b1782 mipA -0.7 -2.3 scaffolding protein for murein synthesizing machinery (NCBI) compare
b1520 b1520 -0.7 -2.0 orf, hypothetical protein (VIMSS) compare
b0890 ftsK -0.7 -1.3 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b0506 allR -0.7 -3.0 DNA-binding transcriptional repressor (NCBI) compare
b2248 yfaX -0.7 -1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b1531 marA -0.7 -1.5 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b3068 ygjF -0.7 -2.1 G/U mismatch-specific DNA glycosylase (NCBI) compare
b2317 dedA -0.7 -2.3 conserved inner membrane protein (NCBI) compare
b0556 rzpD -0.7 -2.1 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b4477 dgoA -0.7 -3.0 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (NCBI) compare
b3476 nikA -0.7 -4.4 nickel transporter subunit (NCBI) compare
b2168 fruK -0.6 -0.6 1-phosphofructokinase (NCBI) compare
b2243 glpC -0.6 -3.4 sn-glycerol-3-phosphate dehydrogenase (anaerobic), small subunit (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Doxycycline hyclate across organisms