Experiment set9IT033 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Doxycycline hyclate 0.00000078125 mM

200 most important genes:

  gene name fitness t score description  
b3021 ygiT -3.7 -2.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b0462 acrB -3.5 -17.1 multidrug efflux system protein (NCBI) compare
b1334 fnr -3.5 -3.3 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b0463 acrA -3.3 -11.6 multidrug efflux system (NCBI) compare
b1677 lpp -3.2 -3.1 murein lipoprotein (NCBI) compare
b0737 tolQ -2.9 -2.0 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3035 tolC -2.9 -8.0 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b2188 yejM -2.9 -10.4 predicted hydrolase, inner membrane (NCBI) compare
b0677 nagA -2.8 -5.8 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b2346 vacJ -2.7 -8.5 predicted lipoprotein (NCBI) compare
b1855 lpxM -2.7 -6.3 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b3784 rfe -2.7 -13.8 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b4025 pgi -2.6 -8.5 glucose-6-phosphate isomerase (NCBI) compare
b3632 rfaQ -2.6 -14.7 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0053 surA -2.6 -3.5 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0741 pal -2.5 -3.0 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3192 yrbC -2.5 -10.6 predicted ABC-type organic solvent transporter (NCBI) compare
b3194 yrbE -2.5 -11.3 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3193 yrbD -2.4 -9.0 predicted ABC-type organic solvent transporter (NCBI) compare
b2168 fruK -2.4 -1.5 1-phosphofructokinase (NCBI) compare
b3465 yhhF -2.2 -6.3 predicted methyltransferase (NCBI) compare
b1150 ymfR -2.2 -1.7 e14 prophage; predicted protein (NCBI) compare
b3163 nlpI -2.2 -4.8 hypothetical protein (NCBI) compare
b2620 smpB -2.2 -1.4 SsrA-binding protein (NCBI) compare
b0740 tolB -2.1 -3.5 translocation protein TolB precursor (NCBI) compare
b4505 insX -2.1 -2.0 predicted IS protein (RefSeq) compare
b3195 yrbF -2.1 -10.5 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b0739 tolA -2.1 -1.4 cell envelope integrity inner membrane protein TolA (NCBI) compare
b0014 dnaK -2.1 -2.3 molecular chaperone DnaK (NCBI) compare
b2512 yfgL -2.1 -6.0 protein assembly complex, lipoprotein component (NCBI) compare
b3052 rfaE -2.0 -5.0 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3842 rfaH -2.0 -4.8 transcriptional activator RfaH (NCBI) compare
b3199 yrbK -2.0 -2.6 hypothetical protein (NCBI) compare
b3619 rfaD -2.0 -1.9 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3649 rpoZ -1.9 -3.1 DNA-directed RNA polymerase subunit omega (NCBI) compare
b0437 clpP -1.9 -5.4 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1830 prc -1.9 -4.6 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b3631 rfaG -1.9 -9.3 glucosyltransferase I (NCBI) compare
b1429 tehA -1.9 -1.9 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b3191 yrbB -1.8 -8.2 orf, hypothetical protein (VIMSS) compare
b3787 rffD -1.8 -10.3 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b1346 ydaQ -1.8 -2.0 orf, hypothetical protein (VIMSS) compare
b3630 rfaP -1.8 -5.5 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b0438 clpX -1.8 -5.7 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3082 ygjM -1.8 -1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b3229 sspA -1.8 -2.3 stringent starvation protein A (NCBI) compare
b2571 rseB -1.8 -6.7 periplasmic negative regulator of sigmaE (NCBI) compare
b4695 ykgT -1.7 -2.5 no description compare
b0688 pgm -1.7 -3.0 phosphoglucomutase (NCBI) compare
b0222 lpcA -1.7 -2.9 phosphoheptose isomerase (NCBI) compare
b4237 nrdG -1.7 -7.8 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b3443 yrhA -1.7 -1.1 orf, hypothetical protein (VIMSS) compare
b1936 intG -1.7 -1.1 predicted defective phage integrase (pseudogene) (RefSeq) compare
b2017 yefM -1.7 -1.0 orf, hypothetical protein (VIMSS) compare
b3627 rfaI -1.7 -5.8 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b0178 hlpA -1.7 -4.3 periplasmic chaperone (NCBI) compare
b0471 ybaB -1.7 -3.6 hypothetical protein (NCBI) compare
b4503 yafF -1.6 -1.1 no description compare
b3786 rffE -1.6 -10.6 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b1758 b1758 -1.6 -1.7 putative cytochrome oxidase (VIMSS) compare
b1882 cheY -1.6 -0.8 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b2317 dedA -1.6 -3.6 conserved inner membrane protein (NCBI) compare
b1103 ycfF -1.6 -1.7 orf, hypothetical protein (VIMSS) compare
b2174 b2174 -1.6 -7.1 orf, hypothetical protein (VIMSS) compare
b4509 ylcG -1.5 -2.4 DLP12 prophage; predicted protein (NCBI) compare
b0605 ahpC -1.5 -3.8 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b4238 nrdD -1.5 -10.7 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b3839 tatC -1.5 -5.4 TatABCE protein translocation system subunit (NCBI) compare
b0730 mngR -1.5 -1.0 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b3621 rfaC -1.5 -3.5 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1438 ydcQ -1.5 -3.7 predicted DNA-binding transcriptional regulator (RefSeq) compare
b3628 rfaB -1.4 -5.8 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b3026 qseC -1.4 -1.4 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1236 galU -1.4 -3.0 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3794 rffM -1.4 -6.4 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b0957 ompA -1.4 -2.7 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b0683 fur -1.4 -1.4 ferric uptake regulator (NCBI) compare
b3930 menA -1.4 -10.0 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b3600 mtlD -1.4 -7.5 mannitol-1-phosphate 5-dehydrogenase (NCBI) compare
b3609 secB -1.3 -3.8 export protein SecB (NCBI) compare
b0877 ybjX -1.3 -6.1 hypothetical protein (NCBI) compare
b0819 ybiS -1.3 -6.6 hypothetical protein (NCBI) compare
b0145 dksA -1.3 -2.4 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b4529 ydbJ -1.3 -1.3 hypothetical protein (NCBI) compare
b3620 rfaF -1.3 -3.6 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b4458 oxyS -1.3 -1.2 global regulatory RNA (NCBI) compare
b2572 rseA -1.3 -5.1 anti-sigma factor (NCBI) compare
b1506 yneL -1.3 -1.2 predicted transcriptional regulator (NCBI) compare
b4402 yjjY -1.3 -1.1 hypothetical protein (NCBI) compare
b2064 asmA -1.2 -4.0 predicted assembly protein (NCBI) compare
b0080 fruR -1.2 -4.9 DNA-binding transcriptional dual regulator (NCBI) compare
b1192 ldcA -1.2 -4.1 L,D-carboxypeptidase A (NCBI) compare
b4480 hdfR -1.2 -4.2 transcriptional regulator HdfR (NCBI) compare
b4608 ryfC -1.2 -3.2 Novel sRNA, function unknown (RefSeq) compare
b1413 hrpA -1.2 -6.7 ATP-dependent helicase (RefSeq) conserved
b1823 cspC -1.2 -1.7 stress protein, member of the CspA-family (NCBI) compare
b4383 deoB -1.2 -6.2 phosphopentomutase (NCBI) compare
b2859 ygeO -1.2 -1.5 hypothetical protein (RefSeq) compare
b1765 ydjA -1.2 -1.2 predicted oxidoreductase (NCBI) compare
b1104 ycfL -1.2 -2.0 hypothetical protein (NCBI) compare
b3838 tatB -1.2 -5.7 sec-independent translocase (NCBI) compare
b4410 ecnA -1.1 -1.2 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b1831 proQ -1.1 -3.0 putative solute/DNA competence effector (NCBI) compare
b3206 npr -1.1 -3.3 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b3387 dam -1.1 -6.4 DNA adenine methylase (NCBI) compare
b1348 lar -1.1 -1.4 Rac prophage; restriction alleviation protein (NCBI) compare
b0049 apaH -1.1 -2.1 diadenosinetetraphosphatase (NCBI) compare
b2363 yfdT -1.1 -1.4 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b1818 manY -1.0 -2.0 mannose-specific enzyme IIC component of PTS (NCBI) compare
b2494 yfgC -1.0 -4.9 predicted peptidase (NCBI) compare
b0998 torD -1.0 -1.2 chaperone protein TorD (NCBI) compare
b3164 pnp -1.0 -1.9 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b4535 yniD -1.0 -1.2 predicted protein (RefSeq) compare
b2288 nuoA -1.0 -2.5 NADH dehydrogenase I chain A (VIMSS) compare
b1493 gadB -1.0 -0.7 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b4201 priB -1.0 -2.1 primosomal replication protein N (NCBI) compare
b0764 modB -1.0 -3.4 molybdate ABC transporter permease protein (NCBI) compare
b2393 nupC -1.0 -4.5 nucleoside (except guanosine) transporter (NCBI) compare
b0826 moeB -1.0 -4.7 molybdopterin biosynthesis protein MoeB (NCBI) compare
b2659 b2659 -1.0 -0.8 orf, hypothetical protein (VIMSS) compare
b1123 potD -1.0 -3.6 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b0239 frsA -1.0 -5.4 fermentation/respiration switch protein (NCBI) compare
b0763 modA -1.0 -3.8 molybdate transporter subunit (NCBI) compare
b0781 moaA -1.0 -5.2 molybdenum cofactor biosynthesis protein A (NCBI) compare
b0783 moaC -1.0 -3.9 molybdenum cofactor biosynthesis protein C (NCBI) compare
b2318 truA -1.0 -2.2 tRNA pseudouridine synthase A (NCBI) compare
b3034 nudF -1.0 -4.0 ADP-ribose pyrophosphatase (NCBI) compare
b4519 icdC -1.0 -2.8 no description compare
b3237 argR -1.0 -2.6 arginine repressor (NCBI) compare
b1819 manZ -0.9 -3.0 mannose-specific enzyme IID component of PTS (NCBI) compare
b1591 b1591 -0.9 -1.5 putative oxidoreductase component (VIMSS) compare
b0902 pflA -0.9 -4.5 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b0965 b0965 -0.9 -2.2 orf, hypothetical protein (VIMSS) compare
b0950 pqiA -0.9 -4.5 paraquat-inducible membrane protein A (NCBI) compare
b2258 b2258 -0.9 -1.2 putative transport/receptor protein (VIMSS) compare
b0388 aroL -0.9 -3.0 shikimate kinase II (NCBI) compare
b3616 tdh -0.9 -3.6 L-threonine 3-dehydrogenase (NCBI) compare
b1175 minD -0.9 -2.5 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b2830 nudH -0.9 -0.9 dinucleoside polyphosphate hydrolase (NCBI) compare
b4550 yhdL -0.9 -3.7 hypothetical protein (NCBI) compare
b1520 b1520 -0.9 -2.3 orf, hypothetical protein (VIMSS) compare
b3183 obgE -0.9 -0.8 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0009 mog -0.9 -4.5 molybdenum cofactor biosynthesis protein (NCBI) compare
b3790 rffC -0.9 -3.4 TDP-fucosamine acetyltransferase (RefSeq) compare
b2617 smpA -0.9 -2.0 small membrane protein A (VIMSS) compare
b2329 aroC -0.9 -3.0 chorismate synthase (NCBI) compare
b2479 gcvR -0.9 -3.1 transcriptional regulation of gcv operon (VIMSS) compare
b1241 adhE -0.9 -5.3 fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase (NCBI) compare
b3341 rpsG -0.9 -1.1 30S ribosomal protein S7 (NCBI) compare
b0951 pqiB -0.9 -4.6 paraquat-inducible protein B (NCBI) compare
b3228 sspB -0.8 -2.5 ClpXP protease specificity-enhancing factor (NCBI) compare
b0247 ykfG -0.8 -1.1 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b0436 tig -0.8 -4.1 trigger factor (NCBI) compare
b2330 yfcB -0.8 -0.7 putative adenine-specific methylase (VIMSS) compare
b0827 moeA -0.8 -2.5 molybdopterin biosynthesis protein (NCBI) compare
b3349 slyD -0.8 -3.8 FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) (NCBI) compare
b2498 upp -0.8 -1.9 uracil phosphoribosyltransferase (VIMSS) compare
b0226 dinJ -0.8 -2.5 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b0759 galE -0.8 -3.7 UDP-galactose-4-epimerase (VIMSS) compare
b1730 ydjO -0.8 -0.5 predicted protein (RefSeq) compare
b0738 tolR -0.8 -1.0 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3493 pitA -0.8 -3.4 phosphate transporter, low-affinity (NCBI) compare
b0232 yafN -0.8 -0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b0082 mraW -0.8 -2.0 S-adenosyl-methyltransferase (NCBI) compare
b1025 ycdT -0.8 -0.7 predicted diguanylate cyclase (NCBI) compare
b0460 hha -0.8 -2.3 modulator of gene expression, with H-NS (NCBI) compare
b1595 ynfL -0.8 -1.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b1569 dicC -0.8 -2.1 Qin prophage; DNA-binding transcriptional regulator for DicB (NCBI) compare
b2085 b2085 -0.8 -1.8 orf, hypothetical protein (VIMSS) compare
b3479 nikD -0.8 -4.3 nickel transporter subunit (NCBI) compare
b0784 moaD -0.8 -1.5 molybdopterin synthase, small subunit (NCBI) compare
b3644 yicC -0.7 -3.0 hypothetical protein (NCBI) compare
b2198 ccmD -0.7 -1.7 cytochrome c biogenesis protein (NCBI) compare
b2426 ucpA -0.7 -1.5 putative oxidoreductase (VIMSS) compare
b4481 rffT -0.7 -3.5 4-alpha-L-fucosyltransferase (NCBI) compare
b2727 hypB -0.7 -2.8 GTP hydrolase involved in nickel liganding into hydrogenases (NCBI) compare
b2897 ygfY -0.7 -2.2 hypothetical protein (NCBI) compare
b2814 metZ -0.7 -1.0 tRNA-Met (NCBI) compare
b2712 hypF -0.7 -4.7 carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases (NCBI) compare
b3477 nikB -0.7 -4.7 nickel transporter subunit (NCBI) compare
b1960 vsr -0.7 -2.1 DNA mismatch endonuclease of very short patch repair (NCBI) compare
b2783 chpR -0.7 -1.6 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b3785 wzzE -0.7 -5.5 putative transport protein (VIMSS) compare
b0765 modC -0.7 -2.9 molybdate transporter subunit (NCBI) compare
b1160 elbA -0.7 -0.4 hypothetical protein (NCBI) compare
b1951 rcsA -0.7 -0.5 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b1291 sapD -0.7 -0.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0888 trxB -0.7 -1.7 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b0908 aroA -0.7 -3.9 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b2375 yfdX -0.7 -1.4 hypothetical protein (NCBI) compare
b2362 yfdS -0.7 -2.1 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b2698 recX -0.7 -1.6 RecA regulator RecX (NCBI) compare
b3764 yifE -0.7 -2.5 hypothetical protein (NCBI) compare
b0761 modE -0.7 -3.0 DNA-binding transcriptional dual regulator (NCBI) compare
b4702 mgtL -0.7 -1.0 regulatory leader peptide for mgtA (NCBI) compare
b3563 yiaB -0.7 -1.7 orf, hypothetical protein (VIMSS) compare
b3500 gor -0.7 -0.9 glutathione reductase (NCBI) compare
b2274 yfbO -0.7 -2.0 predicted protein (RefSeq) compare
b1088 yceD -0.7 -2.3 hypothetical protein (NCBI) compare
b1762 b1762 -0.7 -0.6 orf, hypothetical protein (VIMSS) compare


Specific Phenotypes

For 3 genes in this experiment

For stress Doxycycline hyclate in Escherichia coli BW25113

For stress Doxycycline hyclate across organisms