Experiment set9IT032 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Ciprofloxacin Hydrochloride 0.00000001953125 mM

200 most important genes:

  gene name fitness t score description  
b0462 acrB -4.6 -16.2 multidrug efflux system protein (NCBI) compare
b0463 acrA -4.5 -10.9 multidrug efflux system (NCBI) compare
b1429 tehA -3.7 -2.5 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b2509 xseA -3.6 -9.1 exodeoxyribonuclease VII large subunit (NCBI) compare
b4201 priB -3.5 -3.3 primosomal replication protein N (NCBI) compare
b3035 tolC -3.1 -8.9 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0049 apaH -2.4 -3.2 diadenosinetetraphosphatase (NCBI) compare
b3163 nlpI -2.4 -5.4 hypothetical protein (NCBI) compare
b3792 wzxE -2.3 -6.2 O-antigen translocase (NCBI) compare
b4238 nrdD -2.1 -14.5 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b2215 ompC -2.1 -9.0 outer membrane porin protein C (NCBI) compare
b0145 dksA -2.1 -3.3 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b1454 yncG -2.0 -2.6 predicted enzyme (NCBI) compare
b1334 fnr -2.0 -2.8 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b4237 nrdG -1.9 -9.1 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b1259 yciG -1.7 -1.6 orf, hypothetical protein (VIMSS) compare
b4503 yafF -1.7 -1.1 no description compare
b0053 surA -1.7 -5.0 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1882 cheY -1.6 -0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b2616 recN -1.6 -8.4 recombination and repair protein (NCBI) compare
b1865 nudB -1.6 -1.7 dATP pyrophosphohydrolase (NCBI) compare
b0912 ihfB -1.5 -2.5 integration host factor subunit beta (NCBI) compare
b0728 sucC -1.5 -5.8 succinyl-CoA synthetase subunit beta (NCBI) compare
b0799 dinG -1.5 -7.3 ATP-dependent DNA helicase (NCBI) compare
b0765 modC -1.4 -4.9 molybdate transporter subunit (NCBI) compare
b1823 cspC -1.4 -2.0 stress protein, member of the CspA-family (NCBI) compare
b3935 priA -1.3 -2.8 primosome assembly protein PriA (NCBI) compare
b0949 uup -1.3 -5.3 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b3761 trpT -1.3 -2.1 tRNA-Trp (NCBI) compare
b3930 menA -1.3 -10.1 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b2498 upp -1.3 -2.8 uracil phosphoribosyltransferase (VIMSS) compare
b0239 frsA -1.3 -6.9 fermentation/respiration switch protein (NCBI) compare
b0902 pflA -1.2 -5.3 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b0014 dnaK -1.2 -1.7 molecular chaperone DnaK (NCBI) compare
b3652 recG -1.2 -6.5 ATP-dependent DNA helicase (NCBI) compare
b0440 hupB -1.2 -4.0 HU, DNA-binding transcriptional regulator, beta subunit (NCBI) compare
b3096 yqjB -1.1 -3.5 hypothetical protein (NCBI) compare
b0729 sucD -1.1 -2.8 succinyl-CoA synthetase subunit alpha (NCBI) compare
b3341 rpsG -1.1 -1.4 30S ribosomal protein S7 (NCBI) compare
b0783 moaC -1.1 -4.1 molybdenum cofactor biosynthesis protein C (NCBI) compare
b2479 gcvR -1.1 -3.8 transcriptional regulation of gcv operon (VIMSS) compare
b3813 uvrD -1.1 -8.3 DNA-dependent ATPase I and helicase II (NCBI) compare
b4701 sokX -1.1 -0.7 sok-related sRNA, function unknown (RefSeq) compare
b0605 ahpC -1.1 -3.0 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b2807 ygdD -1.1 -3.5 conserved inner membrane protein (NCBI) compare
b0688 pgm -1.0 -2.4 phosphoglucomutase (NCBI) compare
b3838 tatB -1.0 -5.6 sec-independent translocase (NCBI) compare
b0881 clpS -1.0 -1.7 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b0785 moaE -1.0 -3.8 molybdopterin synthase, large subunit (NCBI) compare
b1346 ydaQ -1.0 -1.4 orf, hypothetical protein (VIMSS) compare
b2279 nuoK -1.0 -1.6 NADH dehydrogenase subunit K (NCBI) compare
b2085 b2085 -1.0 -2.4 orf, hypothetical protein (VIMSS) compare
b1563 relE -1.0 -1.5 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b0798 ybiA -1.0 -1.8 hypothetical protein (NCBI) compare
b4642 yoeD -1.0 -2.5 no description compare
b0782 moaB -1.0 -1.7 molybdopterin biosynthesis protein B (NCBI) compare
b2553 glnB -1.0 -2.6 regulatory protein P-II for glutamine synthetase (NCBI) compare
b4025 pgi -1.0 -5.1 glucose-6-phosphate isomerase (NCBI) compare
b0437 clpP -0.9 -3.5 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1506 yneL -0.9 -0.9 predicted transcriptional regulator (NCBI) compare
b0764 modB -0.9 -3.3 molybdate ABC transporter permease protein (NCBI) compare
b3868 glnG -0.9 -3.3 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b4533 ynfO -0.9 -1.3 Qin prophage; predicted protein (NCBI) compare
b1847 yebF -0.9 -1.3 predicted protein (RefSeq) compare
b2954 yggV -0.9 -3.1 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b1575 dicB -0.9 -0.9 Qin prophage; cell division inhibition protein (NCBI) compare
b1693 aroD -0.9 -3.8 3-dehydroquinate dehydratase (NCBI) compare
b0763 modA -0.9 -3.4 molybdate transporter subunit (NCBI) compare
b1588 ynfF -0.9 -2.7 oxidoreductase subunit (RefSeq) compare
b4535 yniD -0.9 -1.2 predicted protein (RefSeq) compare
b1222 narX -0.9 -2.9 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b3778 rep -0.9 -4.0 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1600 mdtJ -0.9 -0.8 multidrug efflux system transporter (NCBI) compare
b1108 ycfP -0.9 -2.0 orf, hypothetical protein (VIMSS) compare
b3764 yifE -0.9 -3.3 hypothetical protein (NCBI) compare
b0953 rmf -0.9 -1.8 ribosome modulation factor (NCBI) compare
b4389 radA -0.9 -5.5 predicted repair protein (NCBI) conserved
b2892 recJ -0.9 -5.2 ssDNA exonuclease, 5' --> 3'-specific (NCBI) compare
b2281 nuoI -0.9 -1.9 NADH dehydrogenase subunit I (NCBI) compare
b0471 ybaB -0.8 -1.8 hypothetical protein (NCBI) compare
b0623 cspE -0.8 -1.1 cold shock protein E (NCBI) compare
b1936 intG -0.8 -0.7 predicted defective phage integrase (pseudogene) (RefSeq) compare
b0548 ninE -0.8 -2.4 DLP12 prophage; conserved protein (NCBI) compare
b2565 recO -0.8 -3.0 DNA repair protein RecO (NCBI) compare
b0088 murD -0.8 -1.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b1007 b1007 -0.8 -1.4 orf, hypothetical protein (VIMSS) compare
b3839 tatC -0.8 -4.0 TatABCE protein translocation system subunit (NCBI) compare
b2579 yfiD -0.8 -1.4 pyruvate formate lyase subunit (NCBI) compare
b4480 hdfR -0.8 -3.4 transcriptional regulator HdfR (NCBI) compare
b3129 sohA -0.8 -2.6 predicted regulator (NCBI) compare
b0617 citD -0.8 -1.7 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b1614 ydgA -0.8 -2.6 hypothetical protein (NCBI) compare
b1183 umuD -0.8 -1.4 DNA polymerase V, subunit D (NCBI) compare
b2939 yqgB -0.8 -1.0 predicted protein (RefSeq) compare
b1461 ydcE -0.8 -1.3 4-oxalocrotonate tautomerase (NCBI) compare
b4458 oxyS -0.8 -0.6 global regulatory RNA (NCBI) compare
b1863 ruvC -0.8 -0.7 Holliday junction resolvase (NCBI) compare
b1368 ynaA -0.8 -1.1 Rac prophage; predicted tail protein (RefSeq) compare
b2282 nuoH -0.8 -1.9 NADH dehydrogenase subunit H (NCBI) compare
b0957 ompA -0.8 -2.2 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b1248 b1248 -0.8 -1.7 orf, hypothetical protein (VIMSS) compare
b1739 osmE -0.8 -1.7 DNA-binding transcriptional activator (NCBI) compare
b1282 yciH -0.8 -1.6 orf, hypothetical protein (VIMSS) compare
b2896 ygfX -0.8 -3.6 hypothetical protein (NCBI) compare
b2276 nuoN -0.8 -3.2 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b1109 ndh -0.8 -2.2 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b2104 thiM -0.8 -2.3 hydroxyethylthiazole kinase (NCBI) compare
b0827 moeA -0.8 -2.7 molybdopterin biosynthesis protein (NCBI) compare
b2597 yfiA -0.8 -1.4 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b0481 ybaK -0.7 -2.1 hypothetical protein (NCBI) compare
b0018 mokC -0.7 -1.0 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b2286 nuoC -0.7 -3.0 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b4191 ulaR -0.7 -2.1 DNA-binding transcriptional dual regulator (NCBI) compare
b0806 ybiM -0.7 -1.9 orf, hypothetical protein (VIMSS) compare
b2456 cchB -0.7 -2.3 predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) compare
b1252 tonB -0.7 -1.6 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b4045 yjbJ -0.7 -1.4 predicted stress response protein (NCBI) compare
b4594 ymgJ -0.7 -1.1 hypothetical protein (RefSeq) compare
b2814 metZ -0.7 -1.1 tRNA-Met (NCBI) compare
b0903 pflB -0.7 -4.8 pyruvate formate lyase I (NCBI) compare
b1125 potB -0.7 -2.4 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b0888 trxB -0.7 -1.7 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b0740 tolB -0.7 -2.0 translocation protein TolB precursor (NCBI) compare
b3857 mobA -0.7 -3.7 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b2189 proL -0.7 -1.0 tRNA-Pro (NCBI) compare
b1758 b1758 -0.7 -1.0 putative cytochrome oxidase (VIMSS) compare
b3784 rfe -0.7 -5.4 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b4179 vacB -0.7 -2.8 putative enzyme (VIMSS) compare
b1729 ydjN -0.7 -1.8 predicted transporter (NCBI) compare
b4571 wbbL -0.7 -1.8 no description compare
b2948 yqgE -0.7 -2.0 orf, hypothetical protein (VIMSS) compare
b2362 yfdS -0.7 -2.4 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b4570 lomR -0.7 -1.1 no description compare
b1861 ruvA -0.7 -0.4 Holliday junction DNA helicase motor protein (NCBI) compare
b4360 yjjA -0.7 -2.0 putative glycoprotein/receptor (VIMSS) compare
b1520 b1520 -0.7 -2.0 orf, hypothetical protein (VIMSS) compare
b0781 moaA -0.7 -3.6 molybdenum cofactor biosynthesis protein A (NCBI) compare
b1270 btuR -0.7 -1.4 cob(I)yrinic acid a,c-diamide adenosyltransferase (NCBI) compare
b1830 prc -0.7 -2.3 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b3890 yiiF -0.7 -1.8 orf, hypothetical protein (VIMSS) compare
b0009 mog -0.6 -3.7 molybdenum cofactor biosynthesis protein (NCBI) compare
b4520 ymgF -0.6 -0.4 hypothetical protein (NCBI) compare
b1120 cobB -0.6 -2.1 deacetylase of acs and cheY, regulates chemotaxis (NCBI) compare
b1536 ydeI -0.6 -0.4 hypothetical protein (NCBI) compare
b1503 ydeR -0.6 -1.5 predicted fimbrial-like adhesin protein (NCBI) compare
b4042 dgkA -0.6 -1.3 diacylglycerol kinase (NCBI) compare
b2184 yejH -0.6 -3.8 DNA damage response helicase (yejH or radD) (from data) compare
b1848 yebG -0.6 -1.0 conserved protein regulated by LexA (NCBI) compare
b2022 hisB -0.6 -3.3 imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) compare
b1123 potD -0.6 -2.3 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b2271 yfbL -0.6 -2.4 putative aminopeptidase (VIMSS) compare
b1951 rcsA -0.6 -0.5 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b2051 wcaH -0.6 -1.1 GDP-mannose mannosyl hydrolase (VIMSS) compare
b2476 purC -0.6 -1.6 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b1579 intQ -0.6 -1.0 Qin prophage; predicted defective integrase (RefSeq) compare
b3237 argR -0.6 -2.0 arginine repressor (NCBI) compare
b2366 dsdA -0.6 -2.2 D-serine dehydratase (NCBI) compare
b1590 ynfH -0.6 -2.1 oxidoreductase, membrane subunit (NCBI) compare
b3392 yrfA -0.6 -3.4 orf, hypothetical protein (VIMSS) compare
b1205 ychH -0.6 -1.1 predicted inner membrane protein (NCBI) compare
b0896 dmsC -0.6 -3.4 dimethyl sulfoxide reductase, anaerobic, subunit C (NCBI) compare
b1531 marA -0.6 -1.2 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b3644 yicC -0.6 -2.8 hypothetical protein (NCBI) compare
b4000 hupA -0.6 -1.8 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b1291 sapD -0.6 -0.7 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1918 yecS -0.6 -1.9 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1634 tppB -0.6 -2.3 putative tripeptide transporter permease (NCBI) compare
b2792 yqcC -0.6 -1.9 hypothetical protein (NCBI) compare
b2288 nuoA -0.6 -1.7 NADH dehydrogenase I chain A (VIMSS) compare
b0707 ybgA -0.6 -1.7 hypothetical protein (NCBI) compare
b1785 yeaI -0.6 -0.9 predicted diguanylate cyclase (NCBI) compare
b0585 fes -0.6 -2.4 enterobactin/ferric enterobactin esterase (NCBI) compare
b4589 ylcI -0.6 -1.5 hypothetical protein (RefSeq) compare
b3871 bipA -0.6 -4.0 GTP-binding protein (NCBI) compare
b3480 nikE -0.6 -3.5 nickel transporter subunit (NCBI) compare
b1126 potA -0.6 -2.7 putrescine/spermidine ABC transporter ATPase protein (NCBI) compare
b1824 yobF -0.6 -1.5 hypothetical protein (NCBI) compare
b1874 cutC -0.6 -0.9 copper homeostasis protein (NCBI) compare
b1161 ycgX -0.6 -0.5 hypothetical protein (NCBI) compare
b3238 yhcN -0.6 -1.1 orf, hypothetical protein (VIMSS) compare
b0685 ybfE -0.6 -1.5 orf, hypothetical protein (VIMSS) compare
b1968 yedV -0.6 -1.0 predicted sensory kinase in two-component regulatory system with YedW (NCBI) compare
b0761 modE -0.6 -2.8 DNA-binding transcriptional dual regulator (NCBI) compare
b0560 nohB -0.6 -1.3 DLP12 prophage; DNA packaging protein (NCBI) compare
b2277 nuoM -0.6 -2.4 NADH dehydrogenase subunit M (NCBI) compare
b3863 polA -0.6 -0.5 DNA polymerase I (NCBI) compare
b4653 yicT -0.6 -1.3 no description compare
b1434 ydcN -0.6 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b1493 gadB -0.6 -0.5 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b2822 recC -0.6 -1.4 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b1969 yedW -0.6 -1.3 putative 2-component transcriptional regulator (VIMSS) compare
b4242 mgtA -0.6 -3.4 magnesium transporter (NCBI) compare
b3870 glnA -0.5 -1.0 glutamine synthetase (NCBI) compare
b4606 ypfM -0.5 -1.8 hypothetical protein (RefSeq) compare
b1235 rssB -0.5 -2.6 response regulator of RpoS (NCBI) compare
b2266 elaB -0.5 -1.4 hypothetical protein (NCBI) compare
b1620 malI -0.5 -1.2 DNA-binding transcriptional repressor (NCBI) compare
b1363 trkG -0.5 -0.3 Rac prophage; potassium transporter subunit (NCBI) compare
b2283 nuoG -0.5 -2.8 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b0737 tolQ -0.5 -1.2 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare


Specific Phenotypes

For 5 genes in this experiment

For stress Ciprofloxacin Hydrochloride in Escherichia coli BW25113

For stress Ciprofloxacin Hydrochloride across organisms