Experiment set9IT026 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Mecillinam 0.0000078125 mM

200 most important genes:

  gene name fitness t score description  
b1105 ycfM -5.9 -4.1 predicted outer membrane lipoprotein (NCBI) compare
b1192 ldcA -4.9 -4.8 L,D-carboxypeptidase A (NCBI) compare
b0149 mrcB -4.5 -5.4 penicillin-binding protein 1b (NCBI) compare
b2175 spr -4.0 -3.9 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b1865 nudB -3.7 -2.4 dATP pyrophosphohydrolase (NCBI) compare
b1334 fnr -3.5 -4.0 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b0741 pal -3.5 -2.4 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b4025 pgi -3.2 -8.8 glucose-6-phosphate isomerase (NCBI) compare
b0737 tolQ -3.1 -2.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0740 tolB -3.0 -2.1 translocation protein TolB precursor (NCBI) compare
b3205 yhbJ -2.8 -4.1 hypothetical protein (NCBI) compare
b4237 nrdG -2.7 -11.4 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b3792 wzxE -2.6 -4.9 O-antigen translocase (NCBI) compare
b1103 ycfF -2.4 -2.2 orf, hypothetical protein (VIMSS) compare
b0053 surA -2.4 -4.7 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b4238 nrdD -2.3 -15.6 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b4053 alr -2.3 -9.1 alanine racemase (NCBI) compare
b3839 tatC -2.3 -6.7 TatABCE protein translocation system subunit (NCBI) compare
b1429 tehA -2.2 -2.4 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b4402 yjjY -2.1 -1.4 hypothetical protein (NCBI) compare
b0386 proC -2.1 -5.3 pyrroline-5-carboxylate reductase (NCBI) compare
b0739 tolA -2.0 -2.3 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1150 ymfR -1.8 -1.7 e14 prophage; predicted protein (NCBI) compare
b1293 sapB -1.8 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1882 cheY -1.8 -0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b1346 ydaQ -1.8 -2.2 orf, hypothetical protein (VIMSS) compare
b0920 ycbC -1.8 -4.7 conserved inner membrane protein (NCBI) compare
b0222 lpcA -1.8 -3.2 phosphoheptose isomerase (NCBI) compare
b0738 tolR -1.6 -1.9 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1176 minC -1.6 -2.8 septum formation inhibitor (NCBI) compare
b4655 ythA -1.6 -1.7 expressed protein (RefSeq) compare
b1175 minD -1.6 -4.2 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b1765 ydjA -1.5 -1.6 predicted oxidoreductase (NCBI) compare
b3930 menA -1.4 -11.1 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b1292 sapC -1.4 -2.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0381 ddlA -1.4 -5.5 D-alanylalanine synthetase (NCBI) compare
b3388 damX -1.4 -10.1 hypothetical protein (NCBI) compare
b2912 ygfA -1.3 -2.4 putative ligase (VIMSS) compare
b0782 moaB -1.3 -2.3 molybdopterin biosynthesis protein B (NCBI) compare
b2830 nudH -1.3 -1.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b1850 eda -1.3 -2.3 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b1874 cutC -1.3 -2.3 copper homeostasis protein (NCBI) compare
b2498 upp -1.3 -2.6 uracil phosphoribosyltransferase (VIMSS) compare
b4535 yniD -1.3 -1.6 predicted protein (RefSeq) compare
b3836 b3836 -1.2 -4.3 orf, hypothetical protein (VIMSS) compare
b2951 yggS -1.2 -4.4 predicted enzyme (NCBI) compare
b3838 tatB -1.2 -6.2 sec-independent translocase (NCBI) compare
b1104 ycfL -1.2 -1.2 hypothetical protein (NCBI) compare
b0049 apaH -1.2 -2.6 diadenosinetetraphosphatase (NCBI) compare
b1600 mdtJ -1.1 -0.8 multidrug efflux system transporter (NCBI) compare
b2215 ompC -1.1 -6.4 outer membrane porin protein C (NCBI) compare
b4701 sokX -1.1 -0.7 sok-related sRNA, function unknown (RefSeq) compare
b1598 ydgD -1.1 -5.1 predicted peptidase (NCBI) compare
b0877 ybjX -1.1 -4.9 hypothetical protein (NCBI) compare
b0998 torD -1.1 -1.3 chaperone protein TorD (NCBI) compare
b3398 yrfF -1.1 -2.8 predicted inner membrane protein (NCBI) compare
b0439 lon -1.0 -3.2 DNA-binding ATP-dependent protease La (NCBI) compare
b4413 sokC -1.0 -1.6 regulatory antisense RNA (NCBI) compare
b4571 wbbL -1.0 -2.6 no description compare
b3387 dam -1.0 -6.5 DNA adenine methylase (NCBI) compare
b3163 nlpI -1.0 -3.6 hypothetical protein (NCBI) compare
b2528 iscA -1.0 -1.2 iron-sulfur cluster assembly protein (NCBI) compare
b3361 fic -1.0 -3.8 stationary-phase protein, cell division (NCBI) compare
b3778 rep -1.0 -4.3 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4435 isrC -1.0 -2.0 unknown RNA (NCBI) compare
b3621 rfaC -1.0 -3.1 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b2579 yfiD -0.9 -1.7 pyruvate formate lyase subunit (NCBI) compare
b1575 dicB -0.9 -1.0 Qin prophage; cell division inhibition protein (NCBI) compare
b1185 dsbB -0.9 -2.4 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b4000 hupA -0.9 -3.1 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b4522 yciX_1 -0.9 -1.7 hypothetical protein (NCBI) compare
b1830 prc -0.9 -3.3 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0438 clpX -0.9 -4.2 ATP-dependent protease ATP-binding subunit (NCBI) compare
b0232 yafN -0.9 -0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1591 b1591 -0.9 -1.4 putative oxidoreductase component (VIMSS) compare
b0949 uup -0.9 -4.6 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1726 yniB -0.9 -1.5 predicted inner membrane protein (NCBI) compare
b0145 dksA -0.8 -2.0 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3727 pstC -0.8 -3.9 phosphate transporter subunit (NCBI) compare
b4041 plsB -0.8 -1.7 glycerol-3-phosphate acyltransferase (VIMSS) compare
b0765 modC -0.8 -3.8 molybdate transporter subunit (NCBI) compare
b2998 yghW -0.8 -3.1 hypothetical protein (NCBI) compare
b4702 mgtL -0.8 -1.4 regulatory leader peptide for mgtA (NCBI) compare
b3794 rffM -0.8 -4.7 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b4294 insA-7 -0.8 -2.0 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b1951 rcsA -0.8 -0.5 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b0827 moeA -0.8 -3.0 molybdopterin biosynthesis protein (NCBI) compare
b0764 modB -0.8 -3.3 molybdate ABC transporter permease protein (NCBI) compare
b4529 ydbJ -0.8 -1.0 hypothetical protein (NCBI) compare
b3619 rfaD -0.8 -2.3 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0110 ampD -0.8 -3.8 N-acetyl-anhydromuranmyl-L-alanine amidase (NCBI) compare
b0460 hha -0.8 -2.6 modulator of gene expression, with H-NS (NCBI) compare
b3791 rffA -0.8 -4.4 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b3052 rfaE -0.8 -3.0 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b1861 ruvA -0.8 -0.5 Holliday junction DNA helicase motor protein (NCBI) compare
b4406 yaeP -0.8 -1.6 hypothetical protein (NCBI) compare
b3341 rpsG -0.8 -1.0 30S ribosomal protein S7 (NCBI) compare
b4481 rffT -0.8 -4.0 4-alpha-L-fucosyltransferase (NCBI) compare
b3787 rffD -0.8 -5.5 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b2446 yffO -0.8 -1.6 CPZ-55 prophage; predicted protein (NCBI) compare
b2510 b2510 -0.8 -3.1 orf, hypothetical protein (VIMSS) compare
b3404 envZ -0.8 -4.9 osmolarity sensor protein (NCBI) compare
b0535 fimZ -0.8 -1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b4592 yccB -0.8 -1.4 hypothetical protein (RefSeq) compare
b2910 zapA -0.7 -3.2 protein that localizes to the cytokinetic ring (NCBI) compare
b4042 dgkA -0.7 -1.5 diacylglycerol kinase (NCBI) compare
b4541 yehK -0.7 -2.3 hypothetical protein (NCBI) compare
b1589 ynfG -0.7 -1.8 oxidoreductase, Fe-S subunit (NCBI) compare
b1693 aroD -0.7 -3.4 3-dehydroquinate dehydratase (NCBI) compare
b1727 yniC -0.7 -1.8 predicted hydrolase (NCBI) compare
b2962 yggX -0.7 -2.3 hypothetical protein (NCBI) compare
b3803 hemX -0.7 -4.9 predicted uroporphyrinogen III methylase (NCBI) compare
b3786 rffE -0.7 -5.6 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b1025 ycdT -0.7 -0.7 predicted diguanylate cyclase (NCBI) compare
b0218 yafU -0.7 -1.5 predicted inner membrane protein (RefSeq) compare
b0785 moaE -0.7 -2.6 molybdopterin synthase, large subunit (NCBI) compare
b4640 yoeG -0.7 -1.1 no description compare
b4504 ykfH -0.7 -2.5 hypothetical protein (NCBI) compare
b1258 yciF -0.7 -0.4 hypothetical protein (NCBI) compare
b4596 yciZ -0.7 -1.3 hypothetical protein (RefSeq) compare
b1144 ymfJ -0.7 -1.6 orf, hypothetical protein (VIMSS) compare
b1109 ndh -0.7 -2.2 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b3755 yieP -0.7 -3.7 predicted transcriptional regulator (NCBI) compare
b1503 ydeR -0.7 -1.7 predicted fimbrial-like adhesin protein (NCBI) compare
b1084 rne -0.7 -2.6 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b0161 degP -0.7 -3.6 serine endoprotease (protease Do), membrane-associated (NCBI) compare
b0783 moaC -0.7 -3.0 molybdenum cofactor biosynthesis protein C (NCBI) compare
b3890 yiiF -0.7 -1.8 orf, hypothetical protein (VIMSS) compare
b4418 sraB -0.7 -1.4 unknown RNA (NCBI) compare
b0970 yccA -0.7 -2.4 inner membrane protein (NCBI) compare
b0143 pcnB -0.6 -3.0 poly(A) polymerase I (VIMSS) compare
b3784 rfe -0.6 -4.8 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b1860 ruvB -0.6 -0.4 Holliday junction DNA helicase B (NCBI) compare
b1095 fabF -0.6 -3.6 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2939 yqgB -0.6 -0.7 predicted protein (RefSeq) compare
b4536 yobH -0.6 -2.3 hypothetical protein (NCBI) compare
b0239 frsA -0.6 -3.4 fermentation/respiration switch protein (NCBI) compare
b1527 yneK -0.6 -1.1 hypothetical protein (NCBI) compare
b0926 ycbK -0.6 -3.1 hypothetical protein (NCBI) compare
b0009 mog -0.6 -3.6 molybdenum cofactor biosynthesis protein (NCBI) compare
b2369 evgA -0.6 -1.3 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b1279 yciS -0.6 -0.8 conserved inner membrane protein (NCBI) compare
b2456 cchB -0.6 -2.8 predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) compare
b1363 trkG -0.6 -0.4 Rac prophage; potassium transporter subunit (NCBI) compare
b0841 ybjG -0.6 -2.3 undecaprenyl pyrophosphate phosphatase (NCBI) compare
b3150 yraP -0.6 -2.5 hypothetical protein (NCBI) compare
b2318 truA -0.6 -1.6 tRNA pseudouridine synthase A (NCBI) compare
b3281 aroE -0.6 -5.0 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b0862 artQ -0.6 -1.7 arginine transporter subunit (NCBI) compare
b3356 yhfA -0.6 -2.1 hypothetical protein (NCBI) compare
b0890 ftsK -0.6 -1.2 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b2576 srmB -0.6 -1.6 ATP-dependent RNA helicase (NCBI) compare
b0990 cspG -0.6 -0.5 DNA-binding transcriptional regulator (NCBI) compare
b0491 ybbM -0.6 -3.1 putative metal resistance protein (VIMSS) compare
b1536 ydeI -0.6 -0.5 hypothetical protein (NCBI) compare
b0036 caiD -0.6 -3.2 crotonobetainyl CoA hydratase (RefSeq) compare
b3162 deaD -0.6 -1.7 inducible ATP-independent RNA helicase (VIMSS) compare
b1259 yciG -0.6 -1.0 orf, hypothetical protein (VIMSS) compare
b3742 mioC -0.6 -2.1 flavodoxin (NCBI) compare
b4552 yrhC -0.6 -0.4 no description compare
b1704 aroH -0.6 -2.4 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible (NCBI) compare
b4431 rprA -0.6 -1.1 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b2263 yfbB -0.6 -0.9 predicted peptidase (NCBI) compare
b0688 pgm -0.6 -1.6 phosphoglucomutase (NCBI) compare
b4503 yafF -0.6 -0.6 no description compare
b0989 cspH -0.6 -0.7 stress protein, member of the CspA-family (NCBI) compare
b0357 yaiN -0.6 -1.1 putative alpha helix chain (VIMSS) compare
b1290 sapF -0.6 -1.0 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3933 ftsN -0.6 -3.8 essential cell division protein (NCBI) compare
b2258 b2258 -0.6 -0.9 putative transport/receptor protein (VIMSS) compare
b2288 nuoA -0.6 -1.7 NADH dehydrogenase I chain A (VIMSS) compare
b1430 tehB -0.6 -2.5 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b1777 b1777 -0.6 -1.5 orf, hypothetical protein (VIMSS) compare
b1847 yebF -0.6 -0.9 predicted protein (RefSeq) compare
b1348 lar -0.6 -0.8 Rac prophage; restriction alleviation protein (NCBI) compare
b2163 yeiL -0.6 -2.1 putative transcriptional regulator (VIMSS) compare
b1505 ydeT -0.6 -0.4 hypothetical protein (RefSeq) compare
b0730 mngR -0.6 -0.6 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b1992 cobS -0.6 -1.2 cobalamin synthase (NCBI) compare
b4201 priB -0.6 -1.4 primosomal replication protein N (NCBI) compare
b2492 focB -0.6 -3.5 predicted formate transporter (NCBI) compare
b1545 pinQ -0.6 -0.2 Qin prophage; predicted site-specific recombinase (NCBI) compare
b0729 sucD -0.6 -1.5 succinyl-CoA synthetase subunit alpha (NCBI) compare
b1730 ydjO -0.6 -0.4 predicted protein (RefSeq) compare
b1551 b1551 -0.6 -0.3 orf, hypothetical protein (VIMSS) compare
b1576 ydfD -0.6 -0.3 Qin prophage; predicted protein (NCBI) compare
b0791 ybhQ -0.6 -2.0 predicted inner membrane protein (NCBI) compare
b1690 ydiM -0.6 -0.7 predicted transporter (NCBI) compare
b4593 ymgI -0.6 -0.3 hypothetical protein (RefSeq) compare
b2783 chpR -0.5 -1.1 antitoxin of the ChpA-ChpR toxin-antitoxin system (NCBI) compare
b2744 surE -0.5 -3.3 acid phosphatase (NCBI) compare
b0784 moaD -0.5 -1.3 molybdopterin synthase, small subunit (NCBI) compare
b4520 ymgF -0.5 -0.5 hypothetical protein (NCBI) compare
b0504 ybbS -0.5 -1.5 DNA-binding transcriptional activator of the allD operon (NCBI) compare
b4246 pyrL -0.5 -1.4 pyrBI operon leader peptide (NCBI) compare
b2903 gcvP -0.5 -4.0 glycine dehydrogenase (NCBI) compare
b1497 b1497 -0.5 -0.3 putative enzyme (VIMSS) compare
b1499 ydeO -0.5 -0.3 predicted DNA-binding transcriptional acfivator (NCBI) compare
b0530 sfmA -0.5 -0.9 putative fimbrial-like protein (VIMSS) compare
b3761 trpT -0.5 -1.0 tRNA-Trp (NCBI) compare


Specific Phenotypes

For 2 genes in this experiment

For stress Mecillinam in Escherichia coli BW25113

For stress Mecillinam across organisms