Experiment set9IT014 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Zinc Pyrithione 0.00000125 mM

200 most important genes:

  gene name fitness t score description  
b1334 fnr -4.3 -2.9 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b0902 pflA -3.9 -7.4 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b1150 ymfR -3.7 -2.1 e14 prophage; predicted protein (NCBI) compare
b0903 pflB -3.3 -13.7 pyruvate formate lyase I (NCBI) compare
b1217 chaB -2.8 -2.5 cation transport regulator (NCBI) compare
b2528 iscA -2.8 -2.6 iron-sulfur cluster assembly protein (NCBI) compare
b1765 ydjA -2.5 -1.9 predicted oxidoreductase (NCBI) compare
b3977 tyrU -2.3 -1.3 tRNA-Tyr (NCBI) compare
b1346 ydaQ -2.3 -2.1 orf, hypothetical protein (VIMSS) compare
b3292 zntR -2.3 -2.7 zinc-responsive transcriptional regulator (NCBI) compare
b4535 yniD -2.2 -1.4 predicted protein (RefSeq) compare
b0741 pal -2.1 -4.0 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3469 zntA -2.0 -5.2 zinc, cobalt and lead efflux system (NCBI) compare
b0053 surA -2.0 -5.1 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b4503 yafF -1.8 -1.2 no description compare
b3792 wzxE -1.7 -6.0 O-antigen translocase (NCBI) compare
b1429 tehA -1.7 -1.8 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b0738 tolR -1.7 -1.6 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1882 cheY -1.7 -0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b3500 gor -1.7 -1.6 glutathione reductase (NCBI) compare
b1727 yniC -1.7 -3.1 predicted hydrolase (NCBI) compare
b0998 torD -1.7 -1.7 chaperone protein TorD (NCBI) compare
b0239 frsA -1.6 -8.3 fermentation/respiration switch protein (NCBI) compare
b4025 pgi -1.6 -7.7 glucose-6-phosphate isomerase (NCBI) compare
b0730 mngR -1.6 -1.0 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b2620 smpB -1.6 -1.5 SsrA-binding protein (NCBI) compare
b2279 nuoK -1.6 -2.1 NADH dehydrogenase subunit K (NCBI) compare
b4596 yciZ -1.5 -2.3 hypothetical protein (RefSeq) compare
b3930 menA -1.5 -11.3 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b0737 tolQ -1.5 -2.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4237 nrdG -1.5 -7.7 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b1642 slyA -1.5 -2.1 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b4402 yjjY -1.5 -1.3 hypothetical protein (NCBI) compare
b1259 yciG -1.5 -1.8 orf, hypothetical protein (VIMSS) compare
b1677 lpp -1.5 -2.5 murein lipoprotein (NCBI) compare
b0740 tolB -1.4 -3.5 translocation protein TolB precursor (NCBI) compare
b3390 aroK -1.4 -1.8 shikimate kinase I (NCBI) compare
b1290 sapF -1.4 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0784 moaD -1.4 -2.9 molybdopterin synthase, small subunit (NCBI) compare
b3839 tatC -1.4 -5.6 TatABCE protein translocation system subunit (NCBI) compare
b1279 yciS -1.4 -1.4 conserved inner membrane protein (NCBI) compare
b1291 sapD -1.4 -1.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2569 lepA -1.3 -3.2 GTP-binding protein LepA (NCBI) compare
b1273 yciN -1.3 -1.7 hypothetical protein (NCBI) compare
b0683 fur -1.2 -1.3 ferric uptake regulator (NCBI) compare
b0688 pgm -1.2 -2.8 phosphoglucomutase (NCBI) compare
b4238 nrdD -1.2 -9.9 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b1361 ydaW -1.2 -0.6 orf, hypothetical protein (VIMSS) compare
b2859 ygeO -1.2 -1.7 hypothetical protein (RefSeq) compare
b0439 lon -1.2 -3.2 DNA-binding ATP-dependent protease La (NCBI) compare
b2576 srmB -1.2 -2.5 ATP-dependent RNA helicase (NCBI) compare
b0763 modA -1.2 -4.6 molybdate transporter subunit (NCBI) compare
b3838 tatB -1.2 -6.2 sec-independent translocase (NCBI) compare
b2479 gcvR -1.2 -4.0 transcriptional regulation of gcv operon (VIMSS) compare
b0549 ybcO -1.2 -2.4 DLP12 prophage; predicted protein (NCBI) compare
b0542 renD -1.2 -2.2 orf, hypothetical protein (VIMSS) compare
b3609 secB -1.2 -3.7 export protein SecB (NCBI) compare
b1506 yneL -1.2 -1.3 predicted transcriptional regulator (NCBI) compare
b0218 yafU -1.1 -2.0 predicted inner membrane protein (RefSeq) compare
b0949 uup -1.1 -5.7 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b0990 cspG -1.1 -0.7 DNA-binding transcriptional regulator (NCBI) compare
b0222 lpcA -1.1 -2.4 phosphoheptose isomerase (NCBI) compare
b3199 yrbK -1.1 -2.4 hypothetical protein (NCBI) compare
b1634 tppB -1.1 -3.7 putative tripeptide transporter permease (NCBI) compare
b3619 rfaD -1.1 -2.6 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b2318 truA -1.1 -2.2 tRNA pseudouridine synthase A (NCBI) compare
b0357 yaiN -1.1 -1.4 putative alpha helix chain (VIMSS) compare
b3836 b3836 -1.1 -4.1 orf, hypothetical protein (VIMSS) compare
b1292 sapC -1.0 -1.7 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2363 yfdT -1.0 -1.6 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b3229 sspA -1.0 -2.0 stringent starvation protein A (NCBI) compare
b1936 intG -1.0 -0.9 predicted defective phage integrase (pseudogene) (RefSeq) compare
b0082 mraW -1.0 -2.5 S-adenosyl-methyltransferase (NCBI) compare
b0049 apaH -1.0 -2.2 diadenosinetetraphosphatase (NCBI) compare
b3857 mobA -1.0 -5.0 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b1025 ycdT -1.0 -0.7 predicted diguanylate cyclase (NCBI) compare
b2424 cysU -1.0 -2.5 sulfate/thiosulfate transporter subunit (NCBI) compare
b3621 rfaC -1.0 -3.2 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b0450 glnK -1.0 -2.1 nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB (NCBI) compare
b0765 modC -1.0 -4.1 molybdate transporter subunit (NCBI) compare
b1070 flgN -0.9 -1.2 export chaperone for FlgK and FlgL (NCBI) compare
b0237 pepD -0.9 -4.9 aminoacyl-histidine dipeptidase (peptidase D) (NCBI) compare
b4519 icdC -0.9 -3.0 no description compare
b0970 yccA -0.9 -3.0 inner membrane protein (NCBI) compare
b0232 yafN -0.9 -0.6 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1161 ycgX -0.9 -0.8 hypothetical protein (NCBI) compare
b0142 folK -0.9 -0.4 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b0437 clpP -0.9 -3.7 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b0781 moaA -0.9 -5.3 molybdenum cofactor biosynthesis protein A (NCBI) compare
b0484 copA -0.9 -6.2 copper transporter (NCBI) compare
b2498 upp -0.9 -2.1 uracil phosphoribosyltransferase (VIMSS) compare
b0785 moaE -0.9 -3.6 molybdopterin synthase, large subunit (NCBI) compare
b1863 ruvC -0.9 -0.8 Holliday junction resolvase (NCBI) compare
b0888 trxB -0.9 -2.1 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b0009 mog -0.9 -4.4 molybdenum cofactor biosynthesis protein (NCBI) compare
b0739 tolA -0.9 -1.7 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1179 ycgL -0.9 -1.7 conserved protein (NCBI) compare
b2646 ypjF -0.8 -2.1 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b2165 yeiN -0.8 -3.1 hypothetical protein (NCBI) compare
b0782 moaB -0.8 -1.6 molybdopterin biosynthesis protein B (NCBI) compare
b0827 moeA -0.8 -3.0 molybdopterin biosynthesis protein (NCBI) compare
b2518 ndk -0.8 -1.6 nucleoside diphosphate kinase (NCBI) compare
b1028 ymdE -0.8 -2.4 orf, hypothetical protein (VIMSS) compare
b1527 yneK -0.8 -1.2 hypothetical protein (NCBI) compare
b3493 pitA -0.8 -3.8 phosphate transporter, low-affinity (NCBI) compare
b4686 yshB -0.8 -2.1 expressed protein (RefSeq) compare
b0210 yafE -0.8 -2.2 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b1196 ycgY -0.8 -1.5 hypothetical protein (NCBI) compare
b3237 argR -0.8 -2.6 arginine repressor (NCBI) compare
b0783 moaC -0.8 -3.6 molybdenum cofactor biosynthesis protein C (NCBI) compare
b0764 modB -0.8 -3.4 molybdate ABC transporter permease protein (NCBI) compare
b0946 ycbW -0.8 -2.5 orf, hypothetical protein (VIMSS) compare
b0826 moeB -0.8 -4.1 molybdopterin biosynthesis protein MoeB (NCBI) compare
b4640 yoeG -0.8 -1.0 no description compare
b0530 sfmA -0.8 -0.8 putative fimbrial-like protein (VIMSS) compare
b4685 yrbN -0.8 -1.5 expressed protein (RefSeq) compare
b4571 wbbL -0.8 -2.0 no description compare
b4179 vacB -0.8 -3.1 putative enzyme (VIMSS) compare
b1454 yncG -0.8 -1.5 predicted enzyme (NCBI) compare
b4570 lomR -0.8 -0.9 no description compare
b1772 b1772 -0.8 -2.2 putative kinase (VIMSS) compare
b4431 rprA -0.8 -1.3 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b0953 rmf -0.8 -1.8 ribosome modulation factor (NCBI) compare
b0535 fimZ -0.8 -1.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1620 malI -0.8 -1.6 DNA-binding transcriptional repressor (NCBI) compare
b1482 osmC -0.8 -1.2 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b3405 ompR -0.8 -2.8 osmolarity response regulator (NCBI) compare
b4579 yaiX -0.8 -2.9 no description compare
b3790 rffC -0.8 -3.2 TDP-fucosamine acetyltransferase (RefSeq) compare
b3183 obgE -0.8 -0.8 GTPase involved in cell partioning and DNA repair (NCBI) compare
b1968 yedV -0.7 -1.0 predicted sensory kinase in two-component regulatory system with YedW (NCBI) compare
b4451 ryhB -0.7 -1.0 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b4042 dgkA -0.7 -1.4 diacylglycerol kinase (NCBI) compare
b0051 ksgA -0.7 -2.1 dimethyladenosine transferase (NCBI) compare
b2085 b2085 -0.7 -1.7 orf, hypothetical protein (VIMSS) compare
b3631 rfaG -0.7 -5.4 glucosyltransferase I (NCBI) compare
b1600 mdtJ -0.7 -0.9 multidrug efflux system transporter (NCBI) compare
b3052 rfaE -0.7 -2.8 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b1861 ruvA -0.7 -0.4 Holliday junction DNA helicase motor protein (NCBI) compare
b1761 gdhA -0.7 -3.5 glutamate dehydrogenase (NCBI) compare
b3204 ptsN -0.7 -2.7 sugar-specific enzyme IIA component of PTS (NCBI) compare
b2369 evgA -0.7 -1.4 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b0212 gloB -0.7 -1.9 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b4435 isrC -0.7 -1.5 unknown RNA (NCBI) compare
b0471 ybaB -0.7 -1.5 hypothetical protein (NCBI) compare
b1877 yecT -0.7 -0.8 orf, hypothetical protein (VIMSS) compare
b4538 yoeF -0.7 -1.0 hypothetical protein (RefSeq) compare
b3778 rep -0.7 -3.4 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3094 exuR -0.7 -3.0 negative regulator of exu regulon, exuT, uxaAC, and uxuB (VIMSS) compare
b0145 dksA -0.7 -1.8 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b1531 marA -0.7 -0.9 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b4181 yjfI -0.7 -1.7 hypothetical protein (NCBI) compare
b1286 rnb -0.7 -1.1 exoribonuclease II (NCBI) compare
b2362 yfdS -0.7 -2.3 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b1123 potD -0.7 -2.8 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b1785 yeaI -0.7 -1.0 predicted diguanylate cyclase (NCBI) compare
b1579 intQ -0.7 -1.0 Qin prophage; predicted defective integrase (RefSeq) compare
b0989 cspH -0.7 -0.8 stress protein, member of the CspA-family (NCBI) compare
b2727 hypB -0.7 -2.7 GTP hydrolase involved in nickel liganding into hydrogenases (NCBI) compare
b4505 insX -0.7 -1.1 predicted IS protein (RefSeq) compare
b1824 yobF -0.7 -1.7 hypothetical protein (NCBI) compare
b3408 feoA -0.7 -5.0 ferrous iron transport protein A (NCBI) compare
b1049 mdoH -0.7 -4.0 glucosyltransferase MdoH (NCBI) compare
b3620 rfaF -0.6 -2.4 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0406 tgt -0.6 -3.2 queuine tRNA-ribosyltransferase (NCBI) compare
b1358 ydaT -0.6 -0.7 Rac prophage; predicted protein (NCBI) compare
b2250 b2250 -0.6 -2.3 orf, hypothetical protein (VIMSS) compare
b0294 ykgK -0.6 -1.2 predicted regulator (NCBI) compare
b1951 rcsA -0.6 -0.6 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b0438 clpX -0.6 -3.1 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3916 pfkA -0.6 -1.2 6-phosphofructokinase (NCBI) compare
b1954 dsrA -0.6 -1.4 regulatory antisense RNA (NCBI) compare
b0508 hyi -0.6 -1.1 hydroxypyruvate isomerase (NCBI) compare
b2728 hypC -0.6 -2.7 protein required for maturation of hydrogenases 1 and 3 (NCBI) compare
b0696 kdpC -0.6 -1.6 potassium-transporting ATPase subunit C (NCBI) compare
b3742 mioC -0.6 -2.7 flavodoxin (NCBI) compare
b3630 rfaP -0.6 -3.7 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b3649 rpoZ -0.6 -1.5 DNA-directed RNA polymerase subunit omega (NCBI) compare
b0388 aroL -0.6 -2.3 shikimate kinase II (NCBI) compare
b4481 rffT -0.6 -3.3 4-alpha-L-fucosyltransferase (NCBI) compare
b3387 dam -0.6 -4.3 DNA adenine methylase (NCBI) compare
b3228 sspB -0.6 -2.2 ClpXP protease specificity-enhancing factor (NCBI) compare
b4608 ryfC -0.6 -1.7 Novel sRNA, function unknown (RefSeq) compare
b0890 ftsK -0.6 -1.4 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b3755 yieP -0.6 -2.9 predicted transcriptional regulator (NCBI) compare
b0617 citD -0.6 -1.4 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b2993 hybD -0.6 -2.3 predicted maturation element for hydrogenase 2 (NCBI) compare
b4536 yobH -0.6 -2.2 hypothetical protein (NCBI) compare
b2398 yfeC -0.6 -2.4 orf, hypothetical protein (VIMSS) compare
b4045 yjbJ -0.6 -1.6 predicted stress response protein (NCBI) compare
b3205 yhbJ -0.6 -1.8 hypothetical protein (NCBI) compare
b3842 rfaH -0.6 -2.5 transcriptional activator RfaH (NCBI) compare
b0560 nohB -0.6 -1.0 DLP12 prophage; DNA packaging protein (NCBI) compare
b1305 pspB -0.6 -1.5 phage shock protein B (NCBI) compare
b1450 b1450 -0.6 -2.1 orf, hypothetical protein (VIMSS) compare
b1607 ydgC -0.6 -0.9 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b0228 yafM -0.6 -2.7 hypothetical protein (NCBI) compare
b1842 holE -0.6 -0.9 DNA polymerase III, theta subunit (NCBI) compare
b0523 purE -0.6 -2.0 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b1735 chbR -0.6 -1.2 DNA-binding transcriptional dual regulator (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Zinc Pyrithione across organisms