Experiment set8IT093 for Escherichia coli BW25113

Compare to:

LB Aerobic with Tetracycline hydrochloride 0.00000125 mM

200 most important genes:

  gene name fitness t score description  
b0462 acrB -3.5 -13.9 multidrug efflux system protein (NCBI) compare
b0463 acrA -3.4 -9.5 multidrug efflux system (NCBI) compare
b2279 nuoK -3.3 -2.2 NADH dehydrogenase subunit K (NCBI) compare
b4480 hdfR -2.8 -5.0 transcriptional regulator HdfR (NCBI) compare
b3035 tolC -2.8 -6.2 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b3465 yhhF -2.5 -5.5 predicted methyltransferase (NCBI) compare
b2188 yejM -2.4 -7.8 predicted hydrolase, inner membrane (NCBI) compare
b3545 proK -2.4 -2.7 tRNA-Pro (NCBI) compare
b1677 lpp -2.3 -2.6 murein lipoprotein (NCBI) compare
b3764 yifE -2.3 -4.0 hypothetical protein (NCBI) compare
b3341 rpsG -2.3 -1.5 30S ribosomal protein S7 (NCBI) compare
b2814 metZ -2.1 -2.0 tRNA-Met (NCBI) compare
b3163 nlpI -2.0 -2.7 hypothetical protein (NCBI) compare
b4413 sokC -1.9 -2.2 regulatory antisense RNA (NCBI) compare
b1103 ycfF -1.8 -1.7 orf, hypothetical protein (VIMSS) compare
b2282 nuoH -1.8 -2.3 NADH dehydrogenase subunit H (NCBI) compare
b2807 ygdD -1.7 -4.1 conserved inner membrane protein (NCBI) compare
b3021 ygiT -1.7 -1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b0014 dnaK -1.7 -1.2 molecular chaperone DnaK (NCBI) compare
b1882 cheY -1.7 -0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b1607 ydgC -1.7 -2.1 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b4203 rplI -1.6 -3.2 50S ribosomal protein L9 (NCBI) compare
b2553 glnB -1.6 -4.0 regulatory protein P-II for glutamine synthetase (NCBI) compare
b3387 dam -1.6 -7.4 DNA adenine methylase (NCBI) compare
b4608 ryfC -1.5 -2.3 Novel sRNA, function unknown (RefSeq) compare
b1531 marA -1.5 -3.6 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b1863 ruvC -1.5 -1.0 Holliday junction resolvase (NCBI) compare
b0912 ihfB -1.5 -2.8 integration host factor subunit beta (NCBI) compare
b2317 dedA -1.4 -3.8 conserved inner membrane protein (NCBI) compare
b0934 ycbM -1.4 -1.9 putative transport system permease protein (VIMSS) compare
b4201 priB -1.4 -2.2 primosomal replication protein N (NCBI) compare
b3199 yrbK -1.4 -2.2 hypothetical protein (NCBI) compare
b1861 ruvA -1.4 -0.9 Holliday junction DNA helicase motor protein (NCBI) compare
b1346 ydaQ -1.4 -1.4 orf, hypothetical protein (VIMSS) compare
b4603 rseX -1.4 -0.7 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1476 fdnI -1.3 -1.0 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b1667 ydhR -1.3 -2.4 hypothetical protein (NCBI) compare
b0502 ylbG -1.3 -2.7 no description compare
b4410 ecnA -1.3 -1.6 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b3784 rfe -1.3 -8.1 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b3844 fre -1.3 -3.9 NAD(P)H-flavin reductase (NCBI) compare
b0605 ahpC -1.3 -2.7 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b1413 hrpA -1.2 -6.3 ATP-dependent helicase (RefSeq) conserved
b2168 fruK -1.2 -1.3 1-phosphofructokinase (NCBI) compare
b1823 cspC -1.2 -1.7 stress protein, member of the CspA-family (NCBI) compare
b0722 sdhD -1.2 -3.0 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b1595 ynfL -1.2 -1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b1960 vsr -1.2 -2.7 DNA mismatch endonuclease of very short patch repair (NCBI) compare
b1954 dsrA -1.2 -2.1 regulatory antisense RNA (NCBI) compare
b4529 ydbJ -1.2 -1.1 hypothetical protein (NCBI) compare
b1686 ydiI -1.2 -1.9 hypothetical protein (NCBI) compare
b0683 fur -1.2 -1.1 ferric uptake regulator (NCBI) compare
b2906 visC -1.2 -3.8 hypothetical protein (NCBI) compare
b0430 cyoC -1.2 -2.9 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b4431 rprA -1.2 -1.6 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b0053 surA -1.1 -1.7 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1074 flgC -1.1 -2.1 flagellar basal-body rod protein C (NCBI) compare
b3002 yqhA -1.1 -1.9 hypothetical protein (NCBI) compare
b1830 prc -1.1 -2.8 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b1847 yebF -1.1 -1.2 predicted protein (RefSeq) compare
b2017 yefM -1.1 -1.5 orf, hypothetical protein (VIMSS) compare
b2278 nuoL -1.1 -5.1 NADH dehydrogenase subunit L (NCBI) compare
b0724 sdhB -1.1 -4.2 succinate dehydrogenase, FeS subunit (NCBI) compare
b0145 dksA -1.1 -0.8 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3931 hslU -1.1 -6.4 ATP-dependent protease ATP-binding subunit (NCBI) compare
b0429 cyoD -1.1 -3.3 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b2114 metG -1.1 -1.9 methionyl-tRNA synthetase (NCBI) compare
b1575 dicB -1.1 -1.3 Qin prophage; cell division inhibition protein (NCBI) compare
b4533 ynfO -1.1 -1.6 Qin prophage; predicted protein (NCBI) compare
b4550 yhdL -1.1 -3.0 hypothetical protein (NCBI) compare
b4676 yoaK -1.1 -0.7 expressed protein (RefSeq) compare
b1693 aroD -1.0 -3.6 3-dehydroquinate dehydratase (NCBI) compare
b1524 yneH -1.0 -0.9 predicted glutaminase (NCBI) compare
b3650 spoT -1.0 -4.0 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) compare
b2829 ptsP -1.0 -6.8 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b2363 yfdT -1.0 -1.1 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b3096 yqjB -1.0 -3.3 hypothetical protein (NCBI) compare
b2006 yeeW -1.0 -2.7 CP4-44 prophage; predicted protein (RefSeq) compare
b2286 nuoC -1.0 -3.2 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b0819 ybiS -1.0 -4.9 hypothetical protein (NCBI) compare
b1860 ruvB -1.0 -0.6 Holliday junction DNA helicase B (NCBI) compare
b2174 b2174 -1.0 -4.6 orf, hypothetical protein (VIMSS) compare
b2215 ompC -1.0 -4.7 outer membrane porin protein C (NCBI) compare
b4370 leuQ -1.0 -1.4 tRNA-Leu (NCBI) compare
b2356 yfdM -1.0 -1.6 orf, hypothetical protein (VIMSS) compare
b1192 ldcA -1.0 -3.0 L,D-carboxypeptidase A (NCBI) compare
b3017 sufI -1.0 -6.3 repressor protein for FtsI (NCBI) compare
b0432 cyoA -1.0 -5.7 cytochrome o ubiquinol oxidase subunit II (NCBI) compare
b1648 b1648 -1.0 -1.4 orf, hypothetical protein (VIMSS) compare
b1357 ydaS -0.9 -1.4 Rac prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b1109 ndh -0.9 -2.3 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b1739 osmE -0.9 -1.8 DNA-binding transcriptional activator (NCBI) compare
b3082 ygjM -0.9 -0.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b2635 ypjK -0.9 -1.3 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b0741 pal -0.9 -1.7 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0738 tolR -0.9 -1.4 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4000 hupA -0.9 -2.9 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b3239 yhcO -0.9 -2.1 predicted barnase inhibitor (NCBI) compare
b1620 malI -0.9 -1.6 DNA-binding transcriptional repressor (NCBI) compare
b2288 nuoA -0.9 -1.9 NADH dehydrogenase I chain A (VIMSS) compare
b2479 gcvR -0.9 -2.7 transcriptional regulation of gcv operon (VIMSS) compare
b4503 yafF -0.9 -0.6 no description compare
b1370 insH-5 -0.9 -1.5 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b1818 manY -0.9 -1.6 mannose-specific enzyme IIC component of PTS (NCBI) compare
b4441 glmY -0.9 -1.5 sRNA activator of glmS mRNA (RefSeq) compare
b1482 osmC -0.9 -1.4 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b3192 yrbC -0.9 -4.7 predicted ABC-type organic solvent transporter (NCBI) compare
b0723 sdhA -0.9 -5.2 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b2144 sanA -0.9 -4.7 hypothetical protein (NCBI) compare
b2318 truA -0.9 -1.4 tRNA pseudouridine synthase A (NCBI) compare
b2445 yffN -0.9 -2.2 CPZ-55 prophage; predicted protein (RefSeq) compare
b2659 b2659 -0.9 -1.4 orf, hypothetical protein (VIMSS) compare
b2280 nuoJ -0.9 -2.7 NADH dehydrogenase subunit J (NCBI) compare
b2346 vacJ -0.9 -3.5 predicted lipoprotein (NCBI) compare
b1070 flgN -0.9 -1.1 export chaperone for FlgK and FlgL (NCBI) compare
b1429 tehA -0.9 -0.7 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b3194 yrbE -0.9 -5.2 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2189 proL -0.8 -1.2 tRNA-Pro (NCBI) compare
b2276 nuoN -0.8 -2.5 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b3191 yrbB -0.8 -4.1 orf, hypothetical protein (VIMSS) compare
b1523 yneG -0.8 -1.6 hypothetical protein (NCBI) compare
b2435 amiA -0.8 -2.9 N-acetylmuramoyl-l-alanine amidase I (NCBI) compare
b0431 cyoB -0.8 -5.0 cytochrome o ubiquinol oxidase subunit I (NCBI) compare
b1984 asnW -0.8 -0.9 tRNA-Asn (NCBI) compare
b0730 mngR -0.8 -0.5 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b1658 purR -0.8 -2.9 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b4511 ybdZ -0.8 -2.2 hypothetical protein (NCBI) compare
b3726 pstA -0.8 -1.8 phosphate transporter subunit (NCBI) compare
b0428 cyoE -0.8 -3.5 protoheme IX farnesyltransferase (NCBI) compare
b1669 ydhT -0.8 -1.6 hypothetical protein (NCBI) compare
b0437 clpP -0.8 -2.4 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1506 yneL -0.8 -0.8 predicted transcriptional regulator (NCBI) compare
b3652 recG -0.8 -3.6 ATP-dependent DNA helicase (NCBI) compare
b0953 rmf -0.8 -1.7 ribosome modulation factor (NCBI) compare
b0721 sdhC -0.8 -2.4 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b0082 mraW -0.8 -1.4 S-adenosyl-methyltransferase (NCBI) compare
b2156 lysP -0.8 -4.5 lysine transporter (NCBI) compare
b3195 yrbF -0.8 -4.7 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b1183 umuD -0.8 -1.1 DNA polymerase V, subunit D (NCBI) compare
b2357 yfdN -0.8 -1.9 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b0862 artQ -0.8 -1.9 arginine transporter subunit (NCBI) compare
b0740 tolB -0.7 -1.4 translocation protein TolB precursor (NCBI) compare
b0617 citD -0.7 -1.3 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b4045 yjbJ -0.7 -1.3 predicted stress response protein (NCBI) compare
b1580 rspB -0.7 -2.6 predicted oxidoreductase, Zn-dependent and NAD(P)-binding (NCBI) compare
b3193 yrbD -0.7 -3.9 predicted ABC-type organic solvent transporter (NCBI) compare
b3632 rfaQ -0.7 -5.7 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0957 ompA -0.7 -1.7 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b2579 yfiD -0.7 -1.1 pyruvate formate lyase subunit (NCBI) compare
b1763 topB -0.7 -2.4 DNA topoisomerase III (NCBI) compare
b1904 yecR -0.7 -1.7 hypothetical protein (NCBI) compare
b1793 yoaF -0.7 -1.4 conserved outer membrane protein (NCBI) compare
b2281 nuoI -0.7 -1.2 NADH dehydrogenase subunit I (NCBI) compare
b4046 yjbK -0.7 -2.9 putative regulator (VIMSS) compare
b1663 mdtK -0.7 -3.0 multidrug efflux protein NorM (NCBI) compare
b4547 ypfN -0.7 -2.4 hypothetical protein (NCBI) compare
b3389 aroB -0.7 -4.2 3-dehydroquinate synthase (NCBI) compare
b3414 gntY -0.7 -2.4 predicted gluconate transport associated protein (NCBI) compare
b0189 yaeO -0.7 -2.2 orf, hypothetical protein (VIMSS) compare
b2283 nuoG -0.7 -3.0 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b3642 pyrE -0.7 -2.2 orotate phosphoribosyltransferase (NCBI) compare
b3617 kbl -0.7 -3.1 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b4527 b1354 -0.7 -1.8 orf, hypothetical protein (VIMSS) compare
b3933 ftsN -0.7 -4.4 essential cell division protein (NCBI) compare
b1323 tyrR -0.7 -2.4 DNA-binding transcriptional dual regulator, tyrosine-binding (NCBI) compare
b3029 ygiN -0.7 -0.9 quinol monooxygenase (NCBI) compare
b2285 nuoE -0.7 -1.1 NADH dehydrogenase subunit E (NCBI) compare
b3236 mdh -0.7 -3.5 malate dehydrogenase (NCBI) compare
b4598 yncL -0.7 -1.5 hypothetical protein (RefSeq) compare
b1689 b1689 -0.7 -1.0 orf, hypothetical protein (VIMSS) compare
b0784 moaD -0.7 -1.2 molybdopterin synthase, small subunit (NCBI) compare
b0720 gltA -0.7 -2.6 citrate synthase (NCBI) compare
b0677 nagA -0.7 -2.6 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b0018 mokC -0.7 -0.9 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b4369 leuP -0.7 -1.5 tRNA-Leu (NCBI) compare
b1187 fadR -0.7 -2.4 fatty acid metabolism regulator (NCBI) compare
b4515 ybgT -0.7 -1.1 hypothetical protein (NCBI) compare
b1286 rnb -0.7 -1.1 exoribonuclease II (NCBI) compare
b2666 yqaE -0.7 -2.2 predicted membrane protein (NCBI) compare
b3600 mtlD -0.7 -4.2 mannitol-1-phosphate 5-dehydrogenase (NCBI) compare
b0247 ykfG -0.7 -0.9 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b4701 sokX -0.7 -0.6 sok-related sRNA, function unknown (RefSeq) compare
b0049 apaH -0.7 -0.9 diadenosinetetraphosphatase (NCBI) compare
b3807 cyaY -0.7 -3.1 frataxin-like protein (NCBI) compare
b3932 hslV -0.7 -4.0 ATP-dependent protease peptidase subunit (NCBI) compare
b1936 intG -0.6 -0.4 predicted defective phage integrase (pseudogene) (RefSeq) compare
b1598 ydgD -0.6 -2.6 predicted peptidase (NCBI) compare
b3868 glnG -0.6 -1.9 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b2839 lysR -0.6 -2.5 DNA-binding transcriptional dual regulator (NCBI) compare
b1573 ydfC -0.6 -0.8 Qin prophage; predicted protein (RefSeq) compare
b0481 ybaK -0.6 -2.0 hypothetical protein (NCBI) compare
b2419 yfeK -0.6 -1.1 hypothetical protein (NCBI) compare
b1514 lsrC -0.6 -1.1 AI2 transporter (NCBI) compare
b1448 yncA -0.6 -1.1 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b0877 ybjX -0.6 -2.7 hypothetical protein (NCBI) compare
b2910 zapA -0.6 -2.1 protein that localizes to the cytokinetic ring (NCBI) compare
b3119 tdcR -0.6 -1.2 threonine dehydratase operon activator protein (VIMSS) compare
b2026 hisI -0.6 -3.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) compare
b0773 ybhB -0.6 -1.9 predicted kinase inhibitor (NCBI) compare
b2399 yfeD -0.6 -2.2 predicted DNA-binding transcriptional regulator (RefSeq) compare


Specific Phenotypes

For 3 genes in this experiment

For stress Tetracycline hydrochloride in Escherichia coli BW25113

For stress Tetracycline hydrochloride across organisms