Experiment set8IT078 for Escherichia coli BW25113

Compare to:

LB Aerobic with Novobiocin sodium salt 0.0000625 mM

200 most important genes:

  gene name fitness t score description  
b0463 acrA -5.1 -4.9 multidrug efflux system (NCBI) compare
b0462 acrB -4.9 -6.7 multidrug efflux system protein (NCBI) compare
b1085 b1085 -4.1 -2.8 orf, hypothetical protein (VIMSS) compare
b3035 tolC -3.8 -3.7 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b1677 lpp -3.8 -2.5 murein lipoprotein (NCBI) compare
b2512 yfgL -3.7 -2.6 protein assembly complex, lipoprotein component (NCBI) compare
b2494 yfgC -3.2 -7.7 predicted peptidase (NCBI) compare
b0178 hlpA -3.2 -4.3 periplasmic chaperone (NCBI) compare
b4451 ryhB -3.0 -2.0 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b1855 lpxM -3.0 -4.4 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b1830 prc -2.8 -2.7 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b4201 priB -2.8 -2.6 primosomal replication protein N (NCBI) compare
b3842 rfaH -2.8 -3.3 transcriptional activator RfaH (NCBI) compare
b1176 minC -2.7 -2.6 septum formation inhibitor (NCBI) compare
b2168 fruK -2.7 -1.8 1-phosphofructokinase (NCBI) compare
b0605 ahpC -2.7 -3.6 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3632 rfaQ -2.7 -10.9 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3609 secB -2.6 -3.5 export protein SecB (NCBI) compare
b0015 dnaJ -2.6 -7.5 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b2299 yfcD -2.6 -4.7 predicted NUDIX hydrolase (NCBI) compare
b3052 rfaE -2.5 -2.9 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b1853 yebK -2.4 -3.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b3404 envZ -2.4 -9.4 osmolarity sensor protein (NCBI) compare
b3791 rffA -2.4 -7.2 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b2413 cysZ -2.4 -6.4 putative sulfate transport protein CysZ (NCBI) compare
b2215 ompC -2.3 -6.7 outer membrane porin protein C (NCBI) compare
b3163 nlpI -2.3 -3.1 hypothetical protein (NCBI) compare
b0222 lpcA -2.3 -1.6 phosphoheptose isomerase (NCBI) compare
b3199 yrbK -2.3 -2.7 hypothetical protein (NCBI) compare
b3794 rffM -2.3 -7.0 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b3387 dam -2.3 -8.9 DNA adenine methylase (NCBI) compare
b0677 nagA -2.3 -4.5 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b3405 ompR -2.3 -6.2 osmolarity response regulator (NCBI) compare
b3631 rfaG -2.2 -7.3 glucosyltransferase I (NCBI) compare
b4159 yjeP -2.2 -15.1 predicted mechanosensitive channel (NCBI) compare
b3621 rfaC -2.1 -2.1 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b4481 rffT -2.1 -5.7 4-alpha-L-fucosyltransferase (NCBI) compare
b3630 rfaP -2.1 -4.0 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b0014 dnaK -2.1 -1.4 molecular chaperone DnaK (NCBI) compare
b4000 hupA -2.1 -4.9 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b0053 surA -2.1 -1.4 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3032 cpdA -2.1 -6.6 cyclic 3',5'-adenosine monophosphate phosphodiesterase (NCBI) compare
b2314 dedD -2.1 -3.5 putative lipoprotein (VIMSS) compare
b1175 minD -2.1 -3.8 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b0683 fur -2.0 -1.3 ferric uptake regulator (NCBI) compare
b0738 tolR -2.0 -1.4 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1954 dsrA -2.0 -2.5 regulatory antisense RNA (NCBI) compare
b3784 rfe -2.0 -10.8 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b1882 cheY -1.9 -1.0 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b3620 rfaF -1.9 -2.3 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b2317 dedA -1.9 -4.3 conserved inner membrane protein (NCBI) compare
b0724 sdhB -1.8 -5.7 succinate dehydrogenase, FeS subunit (NCBI) compare
b1429 tehA -1.8 -1.1 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b0149 mrcB -1.8 -9.8 penicillin-binding protein 1b (NCBI) compare
b3787 rffD -1.8 -8.9 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b1103 ycfF -1.8 -1.6 orf, hypothetical protein (VIMSS) compare
b2174 b2174 -1.8 -6.7 orf, hypothetical protein (VIMSS) compare
b2532 yfhQ -1.8 -3.1 predicted methyltransferase (NCBI) compare
b3790 rffC -1.8 -4.0 TDP-fucosamine acetyltransferase (RefSeq) compare
b2501 ppk -1.8 -6.6 polyphosphate kinase (NCBI) compare
b4220 ytfM -1.8 -9.5 predicted outer membrane protein and surface antigen (NCBI) compare
b0726 sucA -1.8 -3.0 alpha-ketoglutarate decarboxylase (NCBI) compare
b3619 rfaD -1.7 -1.2 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b1192 ldcA -1.7 -4.2 L,D-carboxypeptidase A (NCBI) compare
b1531 marA -1.7 -3.7 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b1831 proQ -1.7 -3.4 putative solute/DNA competence effector (NCBI) compare
b3935 priA -1.7 -1.4 primosome assembly protein PriA (NCBI) compare
b2617 smpA -1.7 -2.6 small membrane protein A (VIMSS) compare
b4221 ytfN -1.6 -12.0 hypothetical protein (NCBI) compare
b0688 pgm -1.6 -1.5 phosphoglucomutase (NCBI) compare
b4538 yoeF -1.6 -1.5 hypothetical protein (RefSeq) compare
b3017 sufI -1.6 -9.0 repressor protein for FtsI (NCBI) compare
b3194 yrbE -1.6 -8.1 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b3778 rep -1.6 -3.5 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1860 ruvB -1.6 -1.0 Holliday junction DNA helicase B (NCBI) compare
b4603 rseX -1.6 -0.8 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1575 dicB -1.6 -1.7 Qin prophage; cell division inhibition protein (NCBI) compare
b4701 sokX -1.6 -1.0 sok-related sRNA, function unknown (RefSeq) compare
b3786 rffE -1.5 -9.2 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b3192 yrbC -1.5 -7.1 predicted ABC-type organic solvent transporter (NCBI) compare
b1594 dgsA -1.5 -2.9 DNA-binding transcriptional repressor (NCBI) compare
b1984 asnW -1.5 -1.4 tRNA-Asn (NCBI) compare
b3195 yrbF -1.5 -7.9 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b1236 galU -1.5 -2.4 glucose-1-phosphate uridylyltransferase (NCBI) compare
b1863 ruvC -1.5 -1.6 Holliday junction resolvase (NCBI) compare
b3193 yrbD -1.5 -6.8 predicted ABC-type organic solvent transporter (NCBI) compare
b4171 miaA -1.5 -1.7 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0436 tig -1.5 -5.6 trigger factor (NCBI) compare
b1348 lar -1.5 -1.6 Rac prophage; restriction alleviation protein (NCBI) compare
b0957 ompA -1.5 -2.7 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b2188 yejM -1.4 -6.6 predicted hydrolase, inner membrane (NCBI) compare
b3803 hemX -1.4 -7.5 predicted uroporphyrinogen III methylase (NCBI) compare
b1907 tyrP -1.4 -3.8 tyrosine transporter (NCBI) compare
b2642 yfjW -1.4 -0.9 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b0723 sdhA -1.4 -7.1 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b3236 mdh -1.4 -5.9 malate dehydrogenase (NCBI) compare
b3226 yhcK -1.4 -3.6 putative FADA-type transcriptional regulator (VIMSS) compare
b3740 gidB -1.4 -7.8 glucose-inhibited division protein B (NCBI) compare
b0739 tolA -1.4 -1.3 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3792 wzxE -1.4 -3.9 O-antigen translocase (NCBI) compare
b3962 udhA -1.4 -4.0 putative oxidoreductase (VIMSS) compare
b0065 yabI -1.3 -4.3 conserved inner membrane protein (NCBI) compare
b0505 allA -1.3 -2.0 ureidoglycolate hydrolase (NCBI) compare
b3860 dsbA -1.3 -5.6 periplasmic protein disulfide isomerase I (NCBI) compare
b1095 fabF -1.3 -5.1 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b0730 mngR -1.3 -0.9 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b1198 dhaM -1.3 -4.0 fused predicted dihydroxyacetone-specific PTS enzymes: HPr component/EI component (RefSeq) compare
b1304 pspA -1.3 -2.2 regulatory protein for phage-shock-protein operon (NCBI) compare
b1346 ydaQ -1.3 -1.4 orf, hypothetical protein (VIMSS) compare
b3933 ftsN -1.3 -7.2 essential cell division protein (NCBI) compare
b0737 tolQ -1.3 -1.4 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4139 aspA -1.3 -5.8 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b4676 yoaK -1.3 -0.8 expressed protein (RefSeq) compare
b1286 rnb -1.3 -1.6 exoribonuclease II (NCBI) compare
b4436 ryeC -1.3 -1.4 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b2741 rpoS -1.3 -3.7 RNA polymerase sigma factor (NCBI) compare
b1185 dsbB -1.3 -2.2 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b1604 ydgH -1.3 -3.1 hypothetical protein (NCBI) compare
b0741 pal -1.2 -2.2 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b2572 rseA -1.2 -3.7 anti-sigma factor (NCBI) compare
b1763 topB -1.2 -2.7 DNA topoisomerase III (NCBI) compare
b0249 ykfF -1.2 -2.1 CP4-6 prophage; predicted protein (NCBI) compare
b4588 ylcH -1.2 -2.9 hypothetical protein, DLP12 prophage (RefSeq) compare
b3191 yrbB -1.2 -5.8 orf, hypothetical protein (VIMSS) compare
b3398 yrfF -1.2 -2.0 predicted inner membrane protein (NCBI) compare
b3627 rfaI -1.1 -4.4 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b3963 fabR -1.1 -6.5 DNA-binding transcriptional repressor (RefSeq) compare
b2665 ygaU -1.1 -3.9 hypothetical protein (NCBI) compare
b2346 vacJ -1.1 -4.7 predicted lipoprotein (NCBI) compare
b4503 yafF -1.1 -0.7 no description compare
b0706 ybfD -1.1 -1.0 hypothetical protein (NCBI) compare
b4453 ldrD -1.1 -1.8 toxic polypeptide, small (NCBI) compare
b1584 speG -1.1 -4.4 spermidine N1-acetyltransferase (NCBI) compare
b2666 yqaE -1.1 -2.3 predicted membrane protein (NCBI) compare
b1105 ycfM -1.1 -2.3 predicted outer membrane lipoprotein (NCBI) compare
b4025 pgi -1.1 -4.6 glucose-6-phosphate isomerase (NCBI) compare
b2893 dsbC -1.1 -3.9 protein disulfide isomerase II (NCBI) compare
b1323 tyrR -1.1 -3.2 DNA-binding transcriptional dual regulator, tyrosine-binding (NCBI) compare
b1620 malI -1.1 -1.9 DNA-binding transcriptional repressor (NCBI) compare
b4568 ytjA -1.1 -1.5 predicted protein (RefSeq) compare
b1684 sufA -1.1 -2.2 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b3031 yqiA -1.1 -4.2 predicted esterase (NCBI) compare
b1765 ydjA -1.1 -0.9 predicted oxidoreductase (NCBI) compare
b2807 ygdD -1.1 -3.1 conserved inner membrane protein (NCBI) compare
b3198 kdsC -1.1 -1.7 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b3094 exuR -1.1 -3.2 negative regulator of exu regulon, exuT, uxaAC, and uxuB (VIMSS) compare
b0740 tolB -1.1 -2.2 translocation protein TolB precursor (NCBI) compare
b3641 ttk -1.1 -4.7 putative transcriptional regulator (VIMSS) compare
b1928 yedD -1.0 -3.3 hypothetical protein (NCBI) compare
b2808 gcvA -1.0 -2.4 DNA-binding transcriptional dual regulator (NCBI) compare
b4699 fnrS -1.0 -0.7 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b3472 b3472 -1.0 -4.7 orf, hypothetical protein (VIMSS) compare
b0191 yaeJ -1.0 -2.6 hypothetical protein (NCBI) compare
b0406 tgt -1.0 -3.9 queuine tRNA-ribosyltransferase (NCBI) compare
b2378 ddg -1.0 -3.6 putative heat shock protein (VIMSS) compare
b1111 ycfQ -1.0 -2.3 orf, hypothetical protein (VIMSS) compare
b3644 yicC -1.0 -3.8 hypothetical protein (NCBI) compare
b4407 thiS -1.0 -1.6 sulfur carrier protein ThiS (NCBI) compare
b4585 sroB -1.0 -1.0 Novel sRNA, function unknown (RefSeq) compare
b3026 qseC -1.0 -1.7 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b3931 hslU -1.0 -5.9 ATP-dependent protease ATP-binding subunit (NCBI) compare
b2433 b2433 -1.0 -1.5 orf, hypothetical protein (VIMSS) compare
b4527 b1354 -1.0 -2.7 orf, hypothetical protein (VIMSS) compare
b3813 uvrD -1.0 -6.5 DNA-dependent ATPase I and helicase II (NCBI) compare
b1164 ycgZ -1.0 -0.9 hypothetical protein (NCBI) compare
b0460 hha -1.0 -2.2 modulator of gene expression, with H-NS (NCBI) compare
b0931 pncB -1.0 -2.9 nicotinate phosphoribosyltransferase (NCBI) compare
b0550 rusA -1.0 -1.9 DLP12 prophage; endonuclease RUS (NCBI) compare
b4144 yjeI -1.0 -1.5 orf, hypothetical protein (VIMSS) compare
b3613 yibP -1.0 -0.9 putative membrane protein (VIMSS) compare
b3839 tatC -1.0 -3.8 TatABCE protein translocation system subunit (NCBI) compare
b4410 ecnA -1.0 -1.2 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b2445 yffN -1.0 -2.3 CPZ-55 prophage; predicted protein (RefSeq) compare
b4133 cadC -1.0 -5.6 DNA-binding transcriptional activator (NCBI) compare
b1523 yneG -1.0 -1.7 hypothetical protein (NCBI) compare
b4062 soxS -0.9 -2.6 DNA-binding transcriptional dual regulator (NCBI) compare
b1581 rspA -0.9 -2.0 predicted dehydratase (NCBI) compare
b0339 cynT -0.9 -2.8 carbonic anhydrase (NCBI) compare
b2910 zapA -0.9 -2.4 protein that localizes to the cytokinetic ring (NCBI) compare
b1259 yciG -0.9 -1.0 orf, hypothetical protein (VIMSS) compare
b1861 ruvA -0.9 -0.8 Holliday junction DNA helicase motor protein (NCBI) compare
b1829 htpX -0.9 -2.6 heat shock protein HtpX (NCBI) compare
b3131 agaR -0.9 -2.4 DNA-binding transcriptional dual regulator (NCBI) compare
b2061 wzb -0.9 -1.7 protein-tyrosine phosphatase (NCBI) compare
b4402 yjjY -0.9 -0.6 hypothetical protein (NCBI) compare
b2209 eco -0.9 -1.6 ecotin precursor (NCBI) compare
b1480 sra -0.9 -0.9 30S ribosomal subunit protein S22 (NCBI) compare
b3155 yhbQ -0.9 -2.5 hypothetical protein (NCBI) compare
b0721 sdhC -0.9 -2.5 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b1038 csgF -0.9 -1.6 predicted transport protein (NCBI) compare
b2189 proL -0.9 -1.2 tRNA-Pro (NCBI) compare
b0782 moaB -0.9 -1.2 molybdopterin biosynthesis protein B (NCBI) compare
b1643 ydhI -0.9 -2.9 predicted inner membrane protein (NCBI) compare
b0225 yafQ -0.9 -1.9 predicted toxin of the YafQ-DinJ toxin-antitoxin system (NCBI) compare
b2156 lysP -0.9 -4.9 lysine transporter (NCBI) compare
b0049 apaH -0.9 -1.3 diadenosinetetraphosphatase (NCBI) compare
b4431 rprA -0.9 -1.3 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b1242 ychE -0.9 -2.4 predicted inner membrane protein (NCBI) compare
b1482 osmC -0.9 -1.4 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b2553 glnB -0.9 -2.2 regulatory protein P-II for glutamine synthetase (NCBI) compare


Specific Phenotypes

For 19 genes in this experiment

For stress Novobiocin sodium salt in Escherichia coli BW25113

For stress Novobiocin sodium salt across organisms