Experiment set8IT061 for Escherichia coli BW25113

Compare to:

LB Aerobic with Zinc Pyrithione 0.0000025 mM

200 most important genes:

  gene name fitness t score description  
b0484 copA -4.6 -10.7 copper transporter (NCBI) compare
b1677 lpp -3.9 -2.6 murein lipoprotein (NCBI) compare
b3786 rffE -3.8 -11.8 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b3035 tolC -3.8 -5.1 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b3787 rffD -3.7 -10.5 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b3784 rfe -3.7 -12.1 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b0605 ahpC -3.6 -3.5 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3794 rffM -3.6 -7.5 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b0080 fruR -3.5 -5.3 DNA-binding transcriptional dual regulator (NCBI) compare
b4481 rffT -3.4 -5.2 4-alpha-L-fucosyltransferase (NCBI) compare
b0677 nagA -3.4 -2.3 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b3791 rffA -3.3 -5.0 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b3764 yifE -3.2 -4.9 hypothetical protein (NCBI) compare
b1830 prc -3.0 -2.1 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b4046 yjbK -3.0 -6.9 putative regulator (VIMSS) compare
b0463 acrA -3.0 -11.4 multidrug efflux system (NCBI) compare
b2688 gshA -3.0 -6.2 glutamate--cysteine ligase (NCBI) compare
b2553 glnB -2.9 -5.4 regulatory protein P-II for glutamine synthetase (NCBI) compare
b3790 rffC -2.9 -4.8 TDP-fucosamine acetyltransferase (RefSeq) compare
b3468 yhhN -2.8 -11.4 conserved inner membrane protein (NCBI) compare
b3163 nlpI -2.8 -2.7 hypothetical protein (NCBI) compare
b2168 fruK -2.7 -1.8 1-phosphofructokinase (NCBI) compare
b3341 rpsG -2.7 -1.8 30S ribosomal protein S7 (NCBI) compare
b1831 proQ -2.6 -4.2 putative solute/DNA competence effector (NCBI) compare
b1185 dsbB -2.6 -3.7 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b2707 srlR -2.5 -6.9 DNA-bindng transcriptional repressor (NCBI) compare
b1684 sufA -2.5 -3.2 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b3644 yicC -2.5 -6.1 hypothetical protein (NCBI) compare
b0724 sdhB -2.5 -7.3 succinate dehydrogenase, FeS subunit (NCBI) compare
b2531 iscR -2.4 -1.6 DNA-binding transcriptional repressor (NCBI) compare
b3631 rfaG -2.4 -7.8 glucosyltransferase I (NCBI) compare
b1324 tpx -2.4 -4.4 thiol peroxidase (NCBI) compare
b0722 sdhD -2.4 -5.2 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b3860 dsbA -2.4 -7.5 periplasmic protein disulfide isomerase I (NCBI) compare
b3237 argR -2.4 -3.2 arginine repressor (NCBI) compare
b2512 yfgL -2.4 -5.5 protein assembly complex, lipoprotein component (NCBI) compare
b1907 tyrP -2.4 -5.2 tyrosine transporter (NCBI) compare
b3181 greA -2.3 -4.8 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b3842 rfaH -2.3 -4.6 transcriptional activator RfaH (NCBI) compare
b2947 gshB -2.3 -3.4 glutathione synthetase (NCBI) compare
b3803 hemX -2.3 -10.2 predicted uroporphyrinogen III methylase (NCBI) compare
b3199 yrbK -2.2 -3.0 hypothetical protein (NCBI) compare
b3908 sodA -2.2 -6.6 superoxide dismutase, manganese (VIMSS) compare
b3632 rfaQ -2.2 -13.3 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0462 acrB -2.2 -7.9 multidrug efflux system protein (NCBI) compare
b0222 lpcA -2.2 -2.0 phosphoheptose isomerase (NCBI) compare
b0059 hepA -2.1 -13.4 ATP-dependent helicase HepA (NCBI) compare
b3630 rfaP -2.1 -2.5 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2808 gcvA -2.1 -2.5 DNA-binding transcriptional dual regulator (NCBI) compare
b4480 hdfR -2.1 -3.5 transcriptional regulator HdfR (NCBI) compare
b2278 nuoL -2.1 -7.4 NADH dehydrogenase subunit L (NCBI) compare
b2258 b2258 -2.1 -1.7 putative transport/receptor protein (VIMSS) compare
b3621 rfaC -2.1 -2.0 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1882 cheY -2.0 -0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b3292 zntR -2.0 -1.4 zinc-responsive transcriptional regulator (NCBI) compare
b2282 nuoH -2.0 -2.9 NADH dehydrogenase subunit H (NCBI) compare
b4178 yjeB -2.0 -5.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b3349 slyD -2.0 -6.4 FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) (NCBI) compare
b2617 smpA -1.9 -2.9 small membrane protein A (VIMSS) compare
b2937 speB -1.9 -6.0 agmatinase (NCBI) compare
b0082 mraW -1.9 -2.8 S-adenosyl-methyltransferase (NCBI) compare
b2280 nuoJ -1.9 -4.9 NADH dehydrogenase subunit J (NCBI) compare
b2276 nuoN -1.9 -4.6 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b1658 purR -1.9 -5.6 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b1506 yneL -1.9 -1.2 predicted transcriptional regulator (NCBI) compare
b2392 mntH -1.9 -7.5 manganese transport protein MntH (NCBI) compare
b0957 ompA -1.9 -2.9 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b4101 phnG -1.9 -3.8 carbon-phosphorus lyase complex subunit (NCBI) compare
b1861 ruvA -1.8 -1.2 Holliday junction DNA helicase motor protein (NCBI) compare
b3469 zntA -1.8 -2.2 zinc, cobalt and lead efflux system (NCBI) compare
b0738 tolR -1.8 -2.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4191 ulaR -1.8 -3.6 DNA-binding transcriptional dual regulator (NCBI) compare
b3620 rfaF -1.8 -2.4 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b2318 truA -1.8 -2.5 tRNA pseudouridine synthase A (NCBI) compare
b0741 pal -1.8 -2.0 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1382 ynbE -1.8 -2.0 predicted lipoprotein (NCBI) compare
b0015 dnaJ -1.7 -7.4 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b0014 dnaK -1.7 -1.6 molecular chaperone DnaK (NCBI) compare
b0723 sdhA -1.7 -9.2 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b2436 hemF -1.7 -4.9 coproporphyrinogen III oxidase (NCBI) compare
b3414 gntY -1.7 -4.6 predicted gluconate transport associated protein (NCBI) compare
b2285 nuoE -1.7 -2.4 NADH dehydrogenase subunit E (NCBI) compare
b0053 surA -1.7 -2.0 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1236 galU -1.7 -2.2 glucose-1-phosphate uridylyltransferase (NCBI) compare
b2288 nuoA -1.7 -3.1 NADH dehydrogenase I chain A (VIMSS) compare
b3229 sspA -1.7 -1.1 stringent starvation protein A (NCBI) compare
b2183 rsuA -1.6 -3.3 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b3601 mtlR -1.6 -5.6 DNA-binding repressor (NCBI) compare
b0429 cyoD -1.6 -4.8 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b2029 gnd -1.6 -5.9 6-phosphogluconate dehydrogenase (NCBI) compare
b3390 aroK -1.6 -1.1 shikimate kinase I (NCBI) compare
b0122 yacC -1.6 -4.3 orf, hypothetical protein (VIMSS) compare
b3619 rfaD -1.6 -1.1 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b4701 sokX -1.6 -1.0 sok-related sRNA, function unknown (RefSeq) compare
b3250 mreC -1.6 -2.2 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b0683 fur -1.6 -1.4 ferric uptake regulator (NCBI) compare
b0688 pgm -1.6 -1.8 phosphoglucomutase (NCBI) compare
b2287 nuoB -1.5 -3.0 NADH dehydrogenase subunit B (NCBI) compare
b0406 tgt -1.5 -5.6 queuine tRNA-ribosyltransferase (NCBI) compare
b0125 hpt -1.5 -4.1 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b0740 tolB -1.5 -2.0 translocation protein TolB precursor (NCBI) compare
b1088 yceD -1.5 -3.2 hypothetical protein (NCBI) compare
b2286 nuoC -1.5 -4.5 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b3726 pstA -1.5 -3.1 phosphate transporter subunit (NCBI) compare
b3075 ebgR -1.5 -4.7 DNA-binding transcriptional repressor (NCBI) compare
b1104 ycfL -1.5 -2.0 hypothetical protein (NCBI) compare
b1860 ruvB -1.5 -0.9 Holliday junction DNA helicase B (NCBI) compare
b3627 rfaI -1.5 -5.2 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b4139 aspA -1.5 -6.8 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b3742 mioC -1.5 -4.8 flavodoxin (NCBI) compare
b1863 ruvC -1.4 -1.8 Holliday junction resolvase (NCBI) compare
b0407 yajC -1.4 -2.6 preprotein translocase subunit YajC (NCBI) compare
b3465 yhhF -1.4 -5.1 predicted methyltransferase (NCBI) compare
b1908 yecA -1.4 -5.4 conserved metal-binding protein (NCBI) compare
b2284 nuoF -1.4 -3.2 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0737 tolQ -1.4 -1.3 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4546 ypeB -1.4 -1.1 hypothetical protein (NCBI) compare
b2283 nuoG -1.4 -4.9 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b2277 nuoM -1.4 -4.1 NADH dehydrogenase subunit M (NCBI) compare
b2279 nuoK -1.3 -2.0 NADH dehydrogenase subunit K (NCBI) compare
b1192 ldcA -1.3 -4.2 L,D-carboxypeptidase A (NCBI) compare
b3131 agaR -1.3 -3.5 DNA-binding transcriptional dual regulator (NCBI) compare
b3409 feoB -1.3 -10.7 ferrous iron transport protein B (NCBI) compare
b3236 mdh -1.3 -6.4 malate dehydrogenase (NCBI) compare
b4676 yoaK -1.3 -0.8 expressed protein (RefSeq) compare
b1176 minC -1.3 -2.7 septum formation inhibitor (NCBI) compare
b1575 dicB -1.3 -1.6 Qin prophage; cell division inhibition protein (NCBI) compare
b1573 ydfC -1.3 -1.5 Qin prophage; predicted protein (RefSeq) compare
b2951 yggS -1.3 -4.0 predicted enzyme (NCBI) compare
b2156 lysP -1.3 -7.1 lysine transporter (NCBI) compare
b2704 srlB -1.2 -2.2 glucitol/sorbitol-specific enzyme IIA component of PTS (NCBI) compare
b3408 feoA -1.2 -7.9 ferrous iron transport protein A (NCBI) compare
b0678 nagB -1.2 -3.8 glucosamine-6-phosphate deaminase (NCBI) compare
b0912 ihfB -1.2 -2.1 integration host factor subunit beta (NCBI) compare
b4384 deoD -1.2 -6.6 purine nucleoside phosphorylase (NCBI) compare
b4232 fbp -1.2 -7.4 fructose-1,6-bisphosphatase (NCBI) compare
b3545 proK -1.2 -1.9 tRNA-Pro (NCBI) compare
b4383 deoB -1.2 -5.7 phosphopentomutase (NCBI) compare
b3961 oxyR -1.2 -1.9 DNA-binding transcriptional dual regulator (NCBI) compare
b3500 gor -1.2 -1.1 glutathione reductase (NCBI) compare
b0730 mngR -1.2 -0.8 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b1563 relE -1.2 -1.3 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b4595 yciY -1.2 -1.8 hypothetical protein (RefSeq) compare
b0836 yliH -1.2 -2.6 hypothetical protein (NCBI) compare
b3472 b3472 -1.2 -4.9 orf, hypothetical protein (VIMSS) compare
b3195 yrbF -1.2 -7.3 predicted toluene transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b0721 sdhC -1.2 -3.6 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b1253 yciA -1.2 -3.0 predicted hydrolase (NCBI) compare
b0888 trxB -1.2 -2.2 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b4522 yciX_1 -1.2 -2.1 hypothetical protein (NCBI) compare
b1989 asnV -1.2 -2.1 tRNA-Asn (NCBI) compare
b2346 vacJ -1.2 -5.5 predicted lipoprotein (NCBI) compare
b2113 mrp -1.2 -4.2 putative ATPase (VIMSS) compare
b3026 qseC -1.1 -1.1 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1531 marA -1.1 -3.3 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b4171 miaA -1.1 -1.9 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b2897 ygfY -1.1 -2.6 hypothetical protein (NCBI) compare
b1550 b1550 -1.1 -1.1 orf, hypothetical protein (VIMSS) compare
b2906 visC -1.1 -4.2 hypothetical protein (NCBI) compare
b4097 phnK -1.1 -4.0 carbon-phosphorus lyase complex subunit (NCBI) compare
b1109 ndh -1.1 -2.7 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b3226 yhcK -1.1 -3.5 putative FADA-type transcriptional regulator (VIMSS) compare
b3752 rbsK -1.1 -6.3 ribokinase (NCBI) compare
b1476 fdnI -1.1 -0.8 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b1348 lar -1.1 -1.5 Rac prophage; restriction alleviation protein (NCBI) compare
b3467 yhhM -1.1 -3.7 hypothetical protein (NCBI) compare
b0145 dksA -1.1 -1.7 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3410 yhgG -1.1 -4.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b0428 cyoE -1.1 -4.8 protoheme IX farnesyltransferase (NCBI) compare
b3071 yqjI -1.1 -2.4 predicted transcriptional regulator (NCBI) compare
b4202 rpsR -1.1 -0.7 30S ribosomal protein S18 (NCBI) compare
b3807 cyaY -1.1 -5.0 frataxin-like protein (NCBI) compare
b4102 phnF -1.1 -4.3 predicted DNA-binding transcriptional regulator of phosphonate uptake and biodegradation (NCBI) compare
b2114 metG -1.1 -1.5 methionyl-tRNA synthetase (NCBI) compare
b3871 bipA -1.1 -5.7 GTP-binding protein (NCBI) compare
b1164 ycgZ -1.0 -0.9 hypothetical protein (NCBI) compare
b3739 atpI -1.0 -4.1 membrane-bound ATP synthase, dispensable protein, affects expression of atpB (VIMSS) compare
b4042 dgkA -1.0 -0.7 diacylglycerol kinase (NCBI) compare
b3192 yrbC -1.0 -5.9 predicted ABC-type organic solvent transporter (NCBI) compare
b4104 phnE -1.0 -2.2 phosphonate/organophosphate ester transporter subunit (NCBI) compare
b0092 ddlB -1.0 -3.7 D-alanylalanine synthetase (NCBI) compare
b0765 modC -1.0 -3.7 molybdate transporter subunit (NCBI) compare
b1582 ynfA -1.0 -1.9 hypothetical protein (NCBI) compare
b0430 cyoC -1.0 -2.9 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b1346 ydaQ -1.0 -1.2 orf, hypothetical protein (VIMSS) compare
b3628 rfaB -1.0 -3.5 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b4045 yjbJ -1.0 -1.6 predicted stress response protein (NCBI) compare
b0438 clpX -1.0 -3.8 ATP-dependent protease ATP-binding subunit (NCBI) compare
b1095 fabF -1.0 -4.3 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b1272 sohB -1.0 -4.5 predicted inner membrane peptidase (NCBI) compare
b1252 tonB -1.0 -1.8 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b1090 plsX -1.0 -3.1 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b1295 ymjA -1.0 -1.4 hypothetical protein (NCBI) compare
b3806 cyaA -1.0 -2.9 adenylate cyclase (NCBI) compare
b3529 yhjK -1.0 -7.3 predicted diguanylate cyclase (RefSeq) compare
b1728 ydjM -0.9 -2.1 predicted inner membrane protein regulated by LexA (RefSeq) compare
b0249 ykfF -0.9 -2.0 CP4-6 prophage; predicted protein (NCBI) compare
b3398 yrfF -0.9 -1.8 predicted inner membrane protein (NCBI) compare
b2388 glk -0.9 -4.4 glucokinase (NCBI) compare
b2281 nuoI -0.9 -1.6 NADH dehydrogenase subunit I (NCBI) compare


Specific Phenotypes

For 27 genes in this experiment

For stress Zinc Pyrithione in Escherichia coli BW25113

For stress Zinc Pyrithione across organisms