Experiment set8IT058 for Escherichia coli BW25113

Compare to:

LB Aerobic with 2-Mercaptopyridine N-oxide sodium salt 0.0000078125 mM

200 most important genes:

  gene name fitness t score description  
b0484 copA -4.1 -9.5 copper transporter (NCBI) compare
b3764 yifE -3.4 -3.3 hypothetical protein (NCBI) compare
b3961 oxyR -3.3 -9.9 DNA-binding transcriptional dual regulator (NCBI) compare
b0605 ahpC -3.2 -3.0 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3784 rfe -3.1 -10.8 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b3794 rffM -3.1 -6.5 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b4046 yjbK -3.0 -5.3 putative regulator (VIMSS) compare
b0677 nagA -2.9 -2.0 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b3786 rffE -2.9 -10.8 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b3787 rffD -2.8 -9.8 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b3035 tolC -2.8 -5.9 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b3790 rffC -2.8 -3.8 TDP-fucosamine acetyltransferase (RefSeq) compare
b3791 rffA -2.8 -4.2 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b2553 glnB -2.8 -4.5 regulatory protein P-II for glutamine synthetase (NCBI) compare
b1677 lpp -2.6 -2.5 murein lipoprotein (NCBI) compare
b4480 hdfR -2.6 -4.7 transcriptional regulator HdfR (NCBI) compare
b2707 srlR -2.6 -6.0 DNA-bindng transcriptional repressor (NCBI) compare
b3803 hemX -2.5 -9.0 predicted uroporphyrinogen III methylase (NCBI) compare
b2688 gshA -2.5 -5.1 glutamate--cysteine ligase (NCBI) compare
b0247 ykfG -2.3 -1.7 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b2279 nuoK -2.3 -2.2 NADH dehydrogenase subunit K (NCBI) compare
b0125 hpt -2.3 -4.6 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b4481 rffT -2.3 -5.2 4-alpha-L-fucosyltransferase (NCBI) compare
b3468 yhhN -2.3 -7.5 conserved inner membrane protein (NCBI) compare
b0080 fruR -2.3 -5.3 DNA-binding transcriptional dual regulator (NCBI) compare
b1830 prc -2.3 -2.2 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0463 acrA -2.2 -9.4 multidrug efflux system (NCBI) compare
b3341 rpsG -2.2 -1.4 30S ribosomal protein S7 (NCBI) compare
b1607 ydgC -2.1 -2.3 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b1831 proQ -2.1 -3.3 putative solute/DNA competence effector (NCBI) compare
b2947 gshB -2.1 -2.8 glutathione synthetase (NCBI) compare
b3349 slyD -2.1 -5.6 FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) (NCBI) compare
b2531 iscR -2.0 -1.3 DNA-binding transcriptional repressor (NCBI) compare
b0082 mraW -2.0 -2.3 S-adenosyl-methyltransferase (NCBI) compare
b3163 nlpI -1.9 -2.6 hypothetical protein (NCBI) compare
b3908 sodA -1.9 -5.3 superoxide dismutase, manganese (VIMSS) compare
b3075 ebgR -1.9 -4.6 DNA-binding transcriptional repressor (NCBI) compare
b0912 ihfB -1.9 -3.2 integration host factor subunit beta (NCBI) compare
b0059 hepA -1.9 -10.5 ATP-dependent helicase HepA (NCBI) compare
b3860 dsbA -1.8 -5.5 periplasmic protein disulfide isomerase I (NCBI) compare
b0263 afuB -1.8 -2.3 CP4-6 prophage; predicted ferric trasnporter subunit (RefSeq) compare
b3842 rfaH -1.8 -3.6 transcriptional activator RfaH (NCBI) compare
b3052 rfaE -1.8 -2.9 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3131 agaR -1.8 -3.6 DNA-binding transcriptional dual regulator (NCBI) compare
b3199 yrbK -1.8 -2.3 hypothetical protein (NCBI) compare
b1550 b1550 -1.7 -1.0 orf, hypothetical protein (VIMSS) compare
b2808 gcvA -1.7 -1.7 DNA-binding transcriptional dual regulator (NCBI) compare
b0462 acrB -1.7 -11.0 multidrug efflux system protein (NCBI) compare
b0722 sdhD -1.7 -3.9 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b1882 cheY -1.7 -0.8 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b0724 sdhB -1.7 -5.4 succinate dehydrogenase, FeS subunit (NCBI) compare
b1739 osmE -1.7 -2.4 DNA-binding transcriptional activator (NCBI) compare
b2258 b2258 -1.7 -1.4 putative transport/receptor protein (VIMSS) compare
b4178 yjeB -1.6 -4.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b0014 dnaK -1.6 -1.1 molecular chaperone DnaK (NCBI) compare
b0222 lpcA -1.6 -1.5 phosphoheptose isomerase (NCBI) compare
b2512 yfgL -1.6 -4.0 protein assembly complex, lipoprotein component (NCBI) compare
b3631 rfaG -1.6 -6.5 glucosyltransferase I (NCBI) compare
b3621 rfaC -1.6 -1.5 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1594 dgsA -1.6 -2.8 DNA-binding transcriptional repressor (NCBI) compare
b0142 folK -1.6 -0.8 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b2392 mntH -1.5 -6.2 manganese transport protein MntH (NCBI) compare
b0407 yajC -1.5 -2.2 preprotein translocase subunit YajC (NCBI) compare
b3292 zntR -1.5 -1.0 zinc-responsive transcriptional regulator (NCBI) compare
b1531 marA -1.5 -3.5 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b0683 fur -1.5 -1.0 ferric uptake regulator (NCBI) compare
b0738 tolR -1.5 -1.0 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3414 gntY -1.5 -3.5 predicted gluconate transport associated protein (NCBI) compare
b2436 hemF -1.4 -3.8 coproporphyrinogen III oxidase (NCBI) compare
b1231 tyrT -1.4 -1.0 tRNA-Tyr (NCBI) compare
b0720 gltA -1.4 -4.6 citrate synthase (NCBI) compare
b3226 yhcK -1.4 -3.3 putative FADA-type transcriptional regulator (VIMSS) compare
b2285 nuoE -1.4 -1.8 NADH dehydrogenase subunit E (NCBI) compare
b3469 zntA -1.4 -1.6 zinc, cobalt and lead efflux system (NCBI) compare
b1680 sufS -1.4 -4.9 selenocysteine lyase (NCBI) compare
b2990 hybG -1.3 -2.4 hydrogenase 2 accessory protein (NCBI) compare
b0723 sdhA -1.3 -6.9 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b2951 yggS -1.3 -3.6 predicted enzyme (NCBI) compare
b0015 dnaJ -1.3 -5.7 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b3761 trpT -1.3 -1.4 tRNA-Trp (NCBI) compare
b3545 proK -1.3 -1.8 tRNA-Pro (NCBI) compare
b1482 osmC -1.3 -1.8 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b3260 dusB -1.3 -4.9 tRNA-dihydrouridine synthase B (NCBI) compare
b1682 sufC -1.3 -3.7 cysteine desulfurase ATPase component (NCBI) compare
b3620 rfaF -1.3 -1.9 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b2280 nuoJ -1.3 -3.4 NADH dehydrogenase subunit J (NCBI) compare
b2937 speB -1.3 -4.1 agmatinase (NCBI) compare
b2286 nuoC -1.2 -3.6 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b0406 tgt -1.2 -4.2 queuine tRNA-ribosyltransferase (NCBI) compare
b1074 flgC -1.2 -1.7 flagellar basal-body rod protein C (NCBI) compare
b2518 ndk -1.2 -1.4 nucleoside diphosphate kinase (NCBI) compare
b3237 argR -1.2 -2.6 arginine repressor (NCBI) compare
b3742 mioC -1.2 -3.7 flavodoxin (NCBI) compare
b1863 ruvC -1.2 -1.1 Holliday junction resolvase (NCBI) compare
b2318 truA -1.2 -1.4 tRNA pseudouridine synthase A (NCBI) compare
b1324 tpx -1.2 -2.4 thiol peroxidase (NCBI) compare
b2288 nuoA -1.2 -2.2 NADH dehydrogenase I chain A (VIMSS) compare
b4191 ulaR -1.2 -2.6 DNA-binding transcriptional dual regulator (NCBI) compare
b0741 pal -1.2 -1.5 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0430 cyoC -1.2 -3.0 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b2317 dedA -1.2 -3.1 conserved inner membrane protein (NCBI) compare
b0931 pncB -1.2 -3.2 nicotinate phosphoribosyltransferase (NCBI) compare
b3229 sspA -1.2 -0.8 stringent starvation protein A (NCBI) compare
b2741 rpoS -1.2 -3.3 RNA polymerase sigma factor (NCBI) compare
b4515 ybgT -1.2 -1.4 hypothetical protein (NCBI) compare
b3094 exuR -1.1 -3.3 negative regulator of exu regulon, exuT, uxaAC, and uxuB (VIMSS) compare
b2282 nuoH -1.1 -1.9 NADH dehydrogenase subunit H (NCBI) compare
b0888 trxB -1.1 -1.6 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b0092 ddlB -1.1 -3.5 D-alanylalanine synthetase (NCBI) compare
b1765 ydjA -1.1 -0.9 predicted oxidoreductase (NCBI) compare
b3390 aroK -1.1 -0.8 shikimate kinase I (NCBI) compare
b2283 nuoG -1.1 -4.0 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b1683 ynhE -1.1 -4.3 orf, hypothetical protein (VIMSS) compare
b1729 ydjN -1.1 -2.9 predicted transporter (NCBI) compare
b2284 nuoF -1.1 -2.7 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0053 surA -1.1 -1.5 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b2897 ygfY -1.1 -2.1 hypothetical protein (NCBI) compare
b1185 dsbB -1.1 -2.2 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b3977 tyrU -1.1 -0.7 tRNA-Tyr (NCBI) compare
b3071 yqjI -1.1 -2.5 predicted transcriptional regulator (NCBI) compare
b3630 rfaP -1.1 -3.4 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b3806 cyaA -1.1 -2.1 adenylate cyclase (NCBI) compare
b0617 citD -1.1 -1.7 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b2962 yggX -1.0 -2.1 hypothetical protein (NCBI) compare
b4370 leuQ -1.0 -1.5 tRNA-Leu (NCBI) compare
b2277 nuoM -1.0 -2.8 NADH dehydrogenase subunit M (NCBI) compare
b1523 yneG -1.0 -1.9 hypothetical protein (NCBI) compare
b3726 pstA -1.0 -2.0 phosphate transporter subunit (NCBI) compare
b2614 grpE -1.0 -1.4 heat shock protein (NCBI) compare
b0721 sdhC -1.0 -2.9 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b0688 pgm -1.0 -1.2 phosphoglucomutase (NCBI) compare
b2113 mrp -1.0 -3.3 putative ATPase (VIMSS) compare
b4676 yoaK -1.0 -0.6 expressed protein (RefSeq) compare
b3500 gor -1.0 -0.7 glutathione reductase (NCBI) compare
b0798 ybiA -1.0 -1.4 hypothetical protein (NCBI) compare
b2156 lysP -1.0 -5.4 lysine transporter (NCBI) compare
b1823 cspC -1.0 -1.4 stress protein, member of the CspA-family (NCBI) compare
b1681 sufD -1.0 -3.6 component of SufBCD complex (NCBI) compare
b4260 pepA -1.0 -5.5 leucyl aminopeptidase (NCBI) compare
b2276 nuoN -1.0 -2.8 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b1333 uspE -1.0 -2.2 stress-induced protein (NCBI) compare
b0428 cyoE -1.0 -4.0 protoheme IX farnesyltransferase (NCBI) compare
b0920 ycbC -1.0 -2.7 conserved inner membrane protein (NCBI) compare
b0122 yacC -1.0 -2.3 orf, hypothetical protein (VIMSS) compare
b2906 visC -1.0 -3.2 hypothetical protein (NCBI) compare
b0729 sucD -1.0 -2.1 succinyl-CoA synthetase subunit alpha (NCBI) compare
b1860 ruvB -1.0 -0.6 Holliday junction DNA helicase B (NCBI) compare
b0676 nagC -1.0 -4.1 DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine (NCBI) compare
b4598 yncL -0.9 -1.7 hypothetical protein (RefSeq) compare
b1236 galU -0.9 -1.7 glucose-1-phosphate uridylyltransferase (NCBI) compare
b3410 yhgG -0.9 -3.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b1103 ycfF -0.9 -1.1 orf, hypothetical protein (VIMSS) compare
b4589 ylcI -0.9 -1.4 hypothetical protein (RefSeq) compare
b1658 purR -0.9 -3.1 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b1907 tyrP -0.9 -2.8 tyrosine transporter (NCBI) compare
b2683 ygaH -0.9 -2.6 predicted inner membrane protein (NCBI) compare
b4649 ysaD -0.9 -2.1 no description compare
b3950 frwB -0.9 -1.9 predicted enzyme IIB component of PTS (NCBI) compare
b1095 fabF -0.9 -4.0 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b0726 sucA -0.9 -2.1 alpha-ketoglutarate decarboxylase (NCBI) compare
b1399 paaX -0.9 -2.6 DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive (NCBI) compare
b0113 pdhR -0.9 -2.4 transcriptional regulator of pyruvate dehydrogenase complex (NCBI) compare
b0145 dksA -0.9 -1.0 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0728 sucC -0.9 -3.3 succinyl-CoA synthetase subunit beta (NCBI) compare
b3181 greA -0.9 -2.5 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b0737 tolQ -0.9 -0.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2278 nuoL -0.9 -4.1 NADH dehydrogenase subunit L (NCBI) compare
b3465 yhhF -0.9 -3.1 predicted methyltransferase (NCBI) compare
b1679 sufE -0.9 -2.0 cysteine desufuration protein SufE (NCBI) compare
b3739 atpI -0.9 -3.4 membrane-bound ATP synthase, dispensable protein, affects expression of atpB (VIMSS) compare
b1583 ynfB -0.9 -1.5 hypothetical protein (NCBI) compare
b1518 lsrG -0.9 -1.4 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b3601 mtlR -0.9 -3.3 DNA-binding repressor (NCBI) compare
b1648 b1648 -0.9 -1.1 orf, hypothetical protein (VIMSS) compare
b3789 rffH -0.9 -5.4 glucose-1-phosphate thymidylyltransferase (NCBI) compare
b0149 mrcB -0.9 -5.8 penicillin-binding protein 1b (NCBI) compare
b1175 minD -0.9 -2.3 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b3466 yhhL -0.9 -2.3 conserved inner membrane protein (NCBI) compare
b0028 fkpB -0.9 -2.4 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) (NCBI) compare
b3529 yhjK -0.9 -6.5 predicted diguanylate cyclase (RefSeq) compare
b0740 tolB -0.8 -1.4 translocation protein TolB precursor (NCBI) compare
b1253 yciA -0.8 -1.8 predicted hydrolase (NCBI) compare
b1192 ldcA -0.8 -2.6 L,D-carboxypeptidase A (NCBI) compare
b1684 sufA -0.8 -1.8 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b3259 prmA -0.8 -2.5 ribosomal protein L11 methyltransferase (NCBI) compare
b3471 yhhQ -0.8 -3.1 conserved inner membrane protein (NCBI) compare
b1198 dhaM -0.8 -2.6 fused predicted dihydroxyacetone-specific PTS enzymes: HPr component/EI component (RefSeq) compare
b2061 wzb -0.8 -1.4 protein-tyrosine phosphatase (NCBI) compare
b2829 ptsP -0.8 -5.0 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b1514 lsrC -0.8 -1.2 AI2 transporter (NCBI) compare
b4045 yjbJ -0.8 -1.0 predicted stress response protein (NCBI) compare
b4596 yciZ -0.8 -1.2 hypothetical protein (RefSeq) compare
b4557 yidD -0.8 -1.8 hypothetical protein (NCBI) compare
b1286 rnb -0.8 -1.1 exoribonuclease II (NCBI) compare
b3844 fre -0.8 -2.7 NAD(P)H-flavin reductase (NCBI) compare
b3242 yhcR -0.8 -3.0 orf, hypothetical protein (VIMSS) compare
b3409 feoB -0.8 -5.2 ferrous iron transport protein B (NCBI) compare
b1176 minC -0.8 -1.6 septum formation inhibitor (NCBI) compare
b0927 ycbL -0.8 -1.8 predicted metal-binding enzyme (NCBI) compare
b3632 rfaQ -0.8 -6.2 lipopolysaccharide core biosynthesis protein (NCBI) compare


Specific Phenotypes

For 13 genes in this experiment

For stress 2-Mercaptopyridine N-oxide sodium salt in Escherichia coli BW25113

For stress 2-Mercaptopyridine N-oxide sodium salt across organisms