Experiment set8IT052 for Escherichia coli BW25113

Compare to:

LB Aerobic with Nitrofurantoin 0.00003125 mM

200 most important genes:

  gene name fitness t score description  
b1913 uvrC -5.3 -3.6 excinuclease ABC, subunit C; repair of UV damage to DNA (VIMSS) conserved
b4058 uvrA -5.3 -12.7 excinuclease ABC subunit A (NCBI) conserved
b0779 uvrB -5.0 -4.9 excinuclease ABC subunit B (NCBI) conserved
b3961 oxyR -5.0 -8.3 DNA-binding transcriptional dual regulator (NCBI) compare
b0472 recR -4.9 -6.7 recombination protein RecR (NCBI) conserved
b3908 sodA -4.8 -5.6 superoxide dismutase, manganese (VIMSS) compare
b2565 recO -4.5 -6.0 DNA repair protein RecO (NCBI) conserved
b3247 cafA -4.1 -10.8 bundles of cytoplasmic filaments (VIMSS) compare
b3700 recF -4.0 -10.4 recombination protein F (NCBI) conserved
b2784 relA -4.0 -6.7 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b4585 sroB -3.9 -1.5 Novel sRNA, function unknown (RefSeq) compare
b3035 tolC -3.9 -5.9 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b2688 gshA -3.6 -4.3 glutamate--cysteine ligase (NCBI) compare
b3813 uvrD -3.5 -14.1 DNA-dependent ATPase I and helicase II (NCBI) compare
b2501 ppk -3.5 -7.8 polyphosphate kinase (NCBI) compare
b0881 clpS -3.4 -1.9 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b2259 pmrD -3.4 -1.3 polymyxin resistance protein B (VIMSS) compare
b2947 gshB -3.3 -2.3 glutathione synthetase (NCBI) compare
b1677 lpp -3.2 -3.0 murein lipoprotein (NCBI) compare
b4451 ryhB -3.1 -2.0 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b4201 priB -3.1 -3.0 primosomal replication protein N (NCBI) compare
b4410 ecnA -3.1 -1.7 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b2168 fruK -3.0 -1.9 1-phosphofructokinase (NCBI) compare
b2892 recJ -2.9 -10.3 ssDNA exonuclease, 5' --> 3'-specific (NCBI) compare
b3871 bipA -2.9 -8.8 GTP-binding protein (NCBI) compare
b0579 ybdF -2.9 -3.0 hypothetical protein (NCBI) compare
b2553 glnB -2.8 -5.2 regulatory protein P-II for glutamine synthetase (NCBI) compare
b1830 prc -2.7 -4.0 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b2531 iscR -2.6 -1.7 DNA-binding transcriptional repressor (NCBI) compare
b0462 acrB -2.6 -15.3 multidrug efflux system protein (NCBI) compare
b0957 ompA -2.6 -3.7 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b0212 gloB -2.6 -3.0 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b0088 murD -2.6 -2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b1252 tonB -2.5 -3.3 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b0149 mrcB -2.5 -12.9 penicillin-binding protein 1b (NCBI) compare
b3652 recG -2.5 -5.5 ATP-dependent DNA helicase (NCBI) compare
b3414 gntY -2.5 -5.3 predicted gluconate transport associated protein (NCBI) compare
b3387 dam -2.5 -10.0 DNA adenine methylase (NCBI) compare
b2948 yqgE -2.4 -3.2 orf, hypothetical protein (VIMSS) compare
b1493 gadB -2.4 -0.9 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b2175 spr -2.4 -4.3 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b1175 minD -2.4 -4.6 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b0849 grxA -2.4 -1.8 glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a) (NCBI) compare
b0439 lon -2.4 -2.3 DNA-binding ATP-dependent protease La (NCBI) compare
b3163 nlpI -2.3 -3.7 hypothetical protein (NCBI) compare
b2684 mprA -2.2 -2.5 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b1176 minC -2.2 -3.2 septum formation inhibitor (NCBI) compare
b0015 dnaJ -2.2 -7.2 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b0143 pcnB -2.2 -6.4 poly(A) polymerase I (VIMSS) compare
b2618 b2618 -2.2 -3.8 orf, hypothetical protein (VIMSS) compare
b0113 pdhR -2.1 -4.6 transcriptional regulator of pyruvate dehydrogenase complex (NCBI) compare
b1882 cheY -2.1 -0.8 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b3621 rfaC -2.1 -3.2 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1863 ruvC -2.1 -1.4 Holliday junction resolvase (NCBI) compare
b1954 dsrA -2.1 -2.0 regulatory antisense RNA (NCBI) compare
b0463 acrA -2.1 -9.4 multidrug efflux system (NCBI) compare
b4505 insX -2.0 -1.1 predicted IS protein (RefSeq) compare
b0222 lpcA -2.0 -2.3 phosphoheptose isomerase (NCBI) compare
b1861 ruvA -2.0 -1.3 Holliday junction DNA helicase motor protein (NCBI) compare
b0142 folK -2.0 -0.7 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b2189 proL -1.9 -1.6 tRNA-Pro (NCBI) compare
b3822 recQ -1.9 -11.0 ATP-dependent DNA helicase (NCBI) compare
b3052 rfaE -1.9 -4.0 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b2616 recN -1.9 -8.6 recombination and repair protein (NCBI) conserved
b1109 ndh -1.9 -3.8 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b4595 yciY -1.9 -1.9 hypothetical protein (RefSeq) compare
b3229 sspA -1.9 -1.3 stringent starvation protein A (NCBI) compare
b3726 pstA -1.9 -3.8 phosphate transporter subunit (NCBI) compare
b1064 grxB -1.9 -3.7 glutaredoxin 2 (Grx2) (NCBI) compare
b3842 rfaH -1.9 -5.1 transcriptional activator RfaH (NCBI) compare
b2895 fldB -1.9 -3.1 flavodoxin 2 (NCBI) compare
b3390 aroK -1.8 -1.2 shikimate kinase I (NCBI) compare
b3781 trxA -1.8 -4.4 thioredoxin 1 (VIMSS) compare
b0688 pgm -1.8 -1.7 phosphoglucomutase (NCBI) compare
b3500 gor -1.8 -1.2 glutathione reductase (NCBI) compare
b3839 tatC -1.8 -6.2 TatABCE protein translocation system subunit (NCBI) compare
b1290 sapF -1.8 -1.6 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0053 surA -1.8 -2.1 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3237 argR -1.8 -3.6 arginine repressor (NCBI) compare
b0799 dinG -1.7 -7.3 ATP-dependent DNA helicase (NCBI) compare
b3619 rfaD -1.7 -1.7 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b4701 sokX -1.7 -0.9 sok-related sRNA, function unknown (RefSeq) compare
b1070 flgN -1.7 -1.2 export chaperone for FlgK and FlgL (NCBI) compare
b0683 fur -1.7 -1.5 ferric uptake regulator (NCBI) compare
b1150 ymfR -1.7 -0.8 e14 prophage; predicted protein (NCBI) compare
b1860 ruvB -1.7 -1.1 Holliday junction DNA helicase B (NCBI) compare
b2329 aroC -1.7 -4.7 chorismate synthase (NCBI) compare
b3673 emrD -1.7 -8.4 2-module integral membrane pump; multidrug resistance (VIMSS) compare
b4407 thiS -1.7 -1.7 sulfur carrier protein ThiS (NCBI) compare
b1049 mdoH -1.7 -7.3 glucosyltransferase MdoH (NCBI) compare
b3616 tdh -1.7 -4.2 L-threonine 3-dehydrogenase (NCBI) compare
b1476 fdnI -1.6 -0.8 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b2258 b2258 -1.6 -1.2 putative transport/receptor protein (VIMSS) compare
b1514 lsrC -1.6 -2.1 AI2 transporter (NCBI) compare
b2576 srmB -1.6 -1.5 ATP-dependent RNA helicase (NCBI) compare
b1837 yebW -1.6 -2.5 orf, hypothetical protein (VIMSS) compare
b0145 dksA -1.6 -1.5 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b1103 ycfF -1.6 -1.3 orf, hypothetical protein (VIMSS) compare
b1607 ydgC -1.6 -1.7 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b1814 sdaA -1.6 -3.4 L-serine deaminase I (NCBI) compare
b0738 tolR -1.6 -2.4 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1575 dicB -1.5 -1.9 Qin prophage; cell division inhibition protein (NCBI) compare
b3617 kbl -1.5 -6.0 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b1818 manY -1.5 -1.4 mannose-specific enzyme IIC component of PTS (NCBI) compare
b3610 grxC -1.5 -3.9 glutaredoxin 3 (NCBI) compare
b1048 mdoG -1.5 -4.7 glucan biosynthesis protein, periplasmic (NCBI) compare
b1523 yneG -1.5 -1.7 hypothetical protein (NCBI) compare
b1482 osmC -1.5 -2.2 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b0406 tgt -1.5 -5.8 queuine tRNA-ribosyltransferase (NCBI) compare
b2376 ypdI -1.5 -2.3 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b0888 trxB -1.5 -2.6 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b0051 ksgA -1.5 -2.0 dimethyladenosine transferase (NCBI) compare
b1348 lar -1.5 -1.8 Rac prophage; restriction alleviation protein (NCBI) compare
b0685 ybfE -1.5 -2.0 orf, hypothetical protein (VIMSS) compare
b0740 tolB -1.5 -2.6 translocation protein TolB precursor (NCBI) compare
b3169 nusA -1.5 -2.9 transcription elongation factor NusA (NCBI) compare
b2414 cysK -1.5 -7.1 cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) compare
b3609 secB -1.4 -3.6 export protein SecB (NCBI) compare
b3162 deaD -1.4 -1.0 inducible ATP-independent RNA helicase (VIMSS) compare
b2570 rseC -1.4 -4.5 RseC protein involved in reduction of the SoxR iron-sulfur cluster (NCBI) compare
b1594 dgsA -1.4 -3.1 DNA-binding transcriptional repressor (NCBI) compare
b4393 trpR -1.4 -4.6 Trp operon repressor (NCBI) compare
b1556 b1556 -1.4 -1.9 orf, hypothetical protein (VIMSS) compare
b0908 aroA -1.4 -6.4 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b0564 appY -1.4 -0.7 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b3469 zntA -1.4 -5.1 zinc, cobalt and lead efflux system (NCBI) compare
b4180 rlmB -1.4 -5.2 23S rRNA (Gm2251)-methyltransferase (NCBI) compare
b2940 yqgC -1.4 -3.7 hypothetical protein (NCBI) compare
b1503 ydeR -1.4 -2.5 predicted fimbrial-like adhesin protein (NCBI) compare
b4515 ybgT -1.4 -1.4 hypothetical protein (NCBI) compare
b3924 fpr -1.4 -4.3 ferredoxin-NADP reductase (NCBI) compare
b4171 miaA -1.4 -2.0 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b2830 nudH -1.4 -0.9 dinucleoside polyphosphate hydrolase (NCBI) compare
b0092 ddlB -1.4 -3.5 D-alanylalanine synthetase (NCBI) compare
b3816 corA -1.4 -6.4 magnesium/nickel/cobalt transporter (NCBI) compare
b0739 tolA -1.4 -1.9 cell envelope integrity inner membrane protein TolA (NCBI) compare
b0535 fimZ -1.3 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b3620 rfaF -1.3 -3.7 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b4240 treB -1.3 -7.0 fused trehalose(maltose)-specific PTS enzyme: IIB component/IIC component (NCBI) compare
b4596 yciZ -1.3 -1.5 hypothetical protein (RefSeq) compare
b1004 wrbA -1.3 -4.9 TrpR binding protein WrbA (NCBI) compare
b0706 ybfD -1.3 -1.5 hypothetical protein (NCBI) compare
b2421 cysM -1.3 -2.8 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b2617 smpA -1.3 -1.8 small membrane protein A (VIMSS) compare
b3950 frwB -1.3 -2.4 predicted enzyme IIB component of PTS (NCBI) compare
b1198 dhaM -1.3 -3.5 fused predicted dihydroxyacetone-specific PTS enzymes: HPr component/EI component (RefSeq) compare
b0937 ssuE -1.3 -1.8 NAD(P)H-dependent FMN reductase (NCBI) compare
b4685 yrbN -1.3 -2.2 expressed protein (RefSeq) compare
b1506 yneL -1.3 -1.4 predicted transcriptional regulator (NCBI) compare
b3933 ftsN -1.3 -7.2 essential cell division protein (NCBI) compare
b0018 mokC -1.3 -1.0 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b0082 mraW -1.3 -2.4 S-adenosyl-methyltransferase (NCBI) compare
b1183 umuD -1.3 -1.3 DNA polymerase V, subunit D (NCBI) compare
b2181 yejG -1.3 -2.6 hypothetical protein (NCBI) compare
b3868 glnG -1.3 -3.5 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b0580 ybdJ -1.3 -1.8 predicted inner membrane protein (NCBI) compare
b4503 yafF -1.3 -0.6 no description compare
b4202 rpsR -1.3 -0.8 30S ribosomal protein S18 (NCBI) compare
b1823 cspC -1.3 -1.3 stress protein, member of the CspA-family (NCBI) compare
b4445 omrB -1.3 -1.7 sRNA down regulates OM proteins; positively regulated by OmpR/EnvZ; binds Hfq (RefSeq) compare
b0741 pal -1.3 -2.6 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3545 proK -1.2 -1.6 tRNA-Pro (NCBI) compare
b3631 rfaG -1.2 -8.0 glucosyltransferase I (NCBI) compare
b0542 renD -1.2 -1.7 orf, hypothetical protein (VIMSS) compare
b2016 yeeZ -1.2 -4.6 predicted epimerase, with NAD(P)-binding Rossmann-fold domain (NCBI) compare
b1478 adhP -1.2 -2.7 alcohol dehydrogenase (VIMSS) compare
b4579 yaiX -1.2 -3.3 no description compare
b4413 sokC -1.2 -1.2 regulatory antisense RNA (NCBI) compare
b1323 tyrR -1.2 -3.6 DNA-binding transcriptional dual regulator, tyrosine-binding (NCBI) compare
b1192 ldcA -1.2 -3.1 L,D-carboxypeptidase A (NCBI) compare
b0737 tolQ -1.2 -1.7 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0989 cspH -1.2 -1.7 stress protein, member of the CspA-family (NCBI) compare
b0736 ybgC -1.2 -2.6 predicted acyl-CoA thioesterase (NCBI) compare
b1742 b1742 -1.2 -1.7 orf, hypothetical protein (VIMSS) compare
b0949 uup -1.2 -5.6 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1848 yebG -1.2 -0.8 conserved protein regulated by LexA (NCBI) compare
b0840 deoR -1.2 -3.4 DNA-binding transcriptional repressor (NCBI) compare
b3149 yraO -1.2 -3.7 DnaA initiator-associating factor for replication initiation (NCBI) compare
b0296 ykgM -1.2 -2.7 50S ribosomal protein L31 (NCBI) compare
b4480 hdfR -1.2 -3.5 transcriptional regulator HdfR (NCBI) compare
b4589 ylcI -1.2 -1.5 hypothetical protein (RefSeq) compare
b1871 yecP -1.1 -3.1 predicted S-adenosyl-L-methionine-dependent methyltransferase (NCBI) compare
b1627 rsxA -1.1 -2.7 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b2479 gcvR -1.1 -3.4 transcriptional regulation of gcv operon (VIMSS) compare
b1628 rsxB -1.1 -1.8 electron transport complex protein RnfB (NCBI) compare
b1842 holE -1.1 -1.0 DNA polymerase III, theta subunit (NCBI) compare
b2314 dedD -1.1 -2.5 putative lipoprotein (VIMSS) compare
b2229 b2229 -1.1 -2.2 orf, hypothetical protein (VIMSS) compare
b3649 rpoZ -1.1 -2.0 DNA-directed RNA polymerase subunit omega (NCBI) compare
b1874 cutC -1.1 -1.4 copper homeostasis protein (NCBI) compare
b2390 ypeC -1.1 -2.6 hypothetical protein (NCBI) compare
b1305 pspB -1.1 -1.9 phage shock protein B (NCBI) compare
b0191 yaeJ -1.1 -2.2 hypothetical protein (NCBI) compare
b4214 cysQ -1.1 -4.6 PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) compare
b1735 chbR -1.1 -1.8 DNA-binding transcriptional dual regulator (NCBI) compare
b1989 asnV -1.1 -1.5 tRNA-Asn (NCBI) compare
b2614 grpE -1.1 -1.3 heat shock protein (NCBI) compare
b2804 fucU -1.1 -1.4 L-fucose mutarotase (NCBI) compare
b4209 ytfE -1.1 -3.4 predicted regulator of cell morphogenesis and cell wall metabolism (NCBI) compare
b2156 lysP -1.1 -5.3 lysine transporter (NCBI) compare


Specific Phenotypes

For 30 genes in this experiment

For stress Nitrofurantoin in Escherichia coli BW25113

For stress Nitrofurantoin across organisms