Experiment set8IT016 for Escherichia coli BW25113

Compare to:

LB Aerobic with 8-hydroxy-nitroquinoline 0.00000125 mM

200 most important genes:

  gene name fitness t score description  
b1346 ydaQ -2.7 -2.4 orf, hypothetical protein (VIMSS) compare
b3035 tolC -2.2 -8.5 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0014 dnaK -2.2 -2.0 molecular chaperone DnaK (NCBI) compare
b1291 sapD -2.1 -1.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0142 folK -2.1 -1.2 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b1860 ruvB -2.0 -1.3 Holliday junction DNA helicase B (NCBI) compare
b4701 sokX -1.9 -1.2 sok-related sRNA, function unknown (RefSeq) compare
b3500 gor -1.7 -1.6 glutathione reductase (NCBI) compare
b0730 mngR -1.7 -1.1 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b0737 tolQ -1.7 -1.9 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1506 yneL -1.7 -1.8 predicted transcriptional regulator (NCBI) compare
b1863 ruvC -1.7 -2.1 Holliday junction resolvase (NCBI) compare
b0053 surA -1.7 -3.8 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0740 tolB -1.5 -3.1 translocation protein TolB precursor (NCBI) compare
b0222 lpcA -1.5 -2.8 phosphoheptose isomerase (NCBI) compare
b0726 sucA -1.5 -3.5 alpha-ketoglutarate decarboxylase (NCBI) compare
b4520 ymgF -1.5 -1.3 hypothetical protein (NCBI) compare
b4503 yafF -1.4 -0.9 no description compare
b0989 cspH -1.4 -1.8 stress protein, member of the CspA-family (NCBI) compare
b3620 rfaF -1.4 -4.3 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b1429 tehA -1.4 -1.3 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b2498 upp -1.4 -2.1 uracil phosphoribosyltransferase (VIMSS) compare
b1607 ydgC -1.3 -2.2 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b3183 obgE -1.3 -1.2 GTPase involved in cell partioning and DNA repair (NCBI) compare
b1290 sapF -1.3 -1.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3052 rfaE -1.3 -4.0 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b2168 fruK -1.3 -1.5 1-phosphofructokinase (NCBI) compare
b1358 ydaT -1.3 -1.1 Rac prophage; predicted protein (NCBI) compare
b2279 nuoK -1.3 -2.1 NADH dehydrogenase subunit K (NCBI) compare
b3405 ompR -1.2 -5.5 osmolarity response regulator (NCBI) compare
b2531 iscR -1.2 -1.4 DNA-binding transcriptional repressor (NCBI) compare
b3621 rfaC -1.2 -3.7 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b2085 b2085 -1.2 -2.3 orf, hypothetical protein (VIMSS) compare
b3082 ygjM -1.1 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b3619 rfaD -1.1 -2.5 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3204 ptsN -1.1 -3.6 sugar-specific enzyme IIA component of PTS (NCBI) compare
b4201 priB -1.1 -2.1 primosomal replication protein N (NCBI) compare
b0724 sdhB -1.1 -5.1 succinate dehydrogenase, FeS subunit (NCBI) compare
b1877 yecT -1.1 -1.0 orf, hypothetical protein (VIMSS) compare
b3977 tyrU -1.1 -1.0 tRNA-Tyr (NCBI) compare
b1920 fliY -1.1 -2.1 cystine transporter subunit (NCBI) compare
b3629 rfaS -1.1 -1.6 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1505 ydeT -1.1 -0.7 hypothetical protein (RefSeq) compare
b1531 marA -1.1 -3.4 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b4630 ykgP -1.1 -2.2 no description compare
b4202 rpsR -1.1 -1.1 30S ribosomal protein S18 (NCBI) compare
b2830 nudH -1.1 -0.9 dinucleoside polyphosphate hydrolase (NCBI) compare
b1454 yncG -1.0 -1.8 predicted enzyme (NCBI) compare
b1523 yneG -1.0 -2.2 hypothetical protein (NCBI) compare
b1231 tyrT -1.0 -1.0 tRNA-Tyr (NCBI) compare
b4676 yoaK -1.0 -0.8 expressed protein (RefSeq) compare
b3026 qseC -1.0 -2.3 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1536 ydeI -1.0 -0.6 hypothetical protein (NCBI) compare
b4640 yoeG -1.0 -1.3 no description compare
b1600 mdtJ -1.0 -1.0 multidrug efflux system transporter (NCBI) compare
b0439 lon -0.9 -3.0 DNA-binding ATP-dependent protease La (NCBI) compare
b2318 truA -0.9 -2.1 tRNA pseudouridine synthase A (NCBI) compare
b3250 mreC -0.9 -1.8 cell wall structural complex MreBCD transmembrane component MreC (NCBI) compare
b0888 trxB -0.9 -2.0 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b1936 intG -0.9 -0.7 predicted defective phage integrase (pseudogene) (RefSeq) compare
b2518 ndk -0.9 -1.6 nucleoside diphosphate kinase (NCBI) compare
b3613 yibP -0.9 -1.8 putative membrane protein (VIMSS) compare
b3962 udhA -0.9 -3.8 putative oxidoreductase (VIMSS) compare
b1482 osmC -0.9 -1.6 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b1684 sufA -0.9 -2.3 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b2363 yfdT -0.9 -1.5 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b1493 gadB -0.9 -0.7 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b0018 mokC -0.9 -1.3 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b1025 ycdT -0.9 -0.8 predicted diguanylate cyclase (NCBI) compare
b1861 ruvA -0.9 -1.0 Holliday junction DNA helicase motor protein (NCBI) compare
b2814 metZ -0.9 -1.4 tRNA-Met (NCBI) compare
b2614 grpE -0.9 -1.6 heat shock protein (NCBI) compare
b0814 ompX -0.9 -2.6 outer membrane protein X (NCBI) compare
b3414 gntY -0.9 -3.3 predicted gluconate transport associated protein (NCBI) compare
b1192 ldcA -0.9 -3.1 L,D-carboxypeptidase A (NCBI) compare
b1690 ydiM -0.9 -0.8 predicted transporter (NCBI) compare
b1575 dicB -0.9 -1.3 Qin prophage; cell division inhibition protein (NCBI) compare
b1292 sapC -0.8 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0200 gmhB -0.8 -0.6 hypothetical protein (NCBI) compare
b3181 greA -0.8 -3.0 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b0082 mraW -0.8 -2.0 S-adenosyl-methyltransferase (NCBI) compare
b1576 ydfD -0.8 -0.5 Qin prophage; predicted protein (NCBI) compare
b0688 pgm -0.8 -1.8 phosphoglucomutase (NCBI) compare
b1258 yciF -0.8 -0.5 hypothetical protein (NCBI) compare
b1579 intQ -0.8 -1.5 Qin prophage; predicted defective integrase (RefSeq) compare
b1248 b1248 -0.8 -1.8 orf, hypothetical protein (VIMSS) compare
b0738 tolR -0.8 -1.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4413 sokC -0.8 -1.5 regulatory antisense RNA (NCBI) compare
b3443 yrhA -0.8 -0.7 orf, hypothetical protein (VIMSS) compare
b1270 btuR -0.8 -2.7 cob(I)yrinic acid a,c-diamide adenosyltransferase (NCBI) compare
b4570 lomR -0.8 -1.4 no description compare
b3390 aroK -0.8 -1.2 shikimate kinase I (NCBI) compare
b1612 fumA -0.8 -2.3 fumarate hydratase (fumarase A), aerobic Class I (NCBI) compare
b4551 yheV -0.8 -1.6 hypothetical protein (NCBI) compare
b0097 yacA -0.8 -1.5 orf, hypothetical protein (VIMSS) compare
b1558 cspF -0.8 -1.1 Qin prophage; cold shock protein (NCBI) compare
b2071 yegJ -0.8 -0.8 hypothetical protein (NCBI) compare
b4163 glyV -0.8 -0.9 tRNA-Gly (NCBI) compare
b1765 ydjA -0.8 -0.9 predicted oxidoreductase (NCBI) compare
b1685 ydiH -0.8 -1.1 predicted protein (RefSeq) compare
b1658 purR -0.8 -3.2 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b1951 rcsA -0.8 -0.6 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b0836 yliH -0.8 -1.8 hypothetical protein (NCBI) compare
b1159 mcrA -0.8 -0.5 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b1503 ydeR -0.8 -1.7 predicted fimbrial-like adhesin protein (NCBI) compare
b1762 b1762 -0.8 -1.5 orf, hypothetical protein (VIMSS) compare
b3493 pitA -0.8 -3.2 phosphate transporter, low-affinity (NCBI) compare
b3005 exbD -0.7 -3.3 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b1830 prc -0.7 -2.7 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b2504 yfgG -0.7 -0.5 Negative regulator of nickel and cobalt uptake (YfgG) (from data) compare
b1130 phoP -0.7 -0.5 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b2285 nuoE -0.7 -1.1 NADH dehydrogenase subunit E (NCBI) compare
b3631 rfaG -0.7 -5.5 glucosyltransferase I (NCBI) compare
b2286 nuoC -0.7 -3.0 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b1252 tonB -0.7 -1.7 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b2110 yehC -0.7 -0.6 predicted periplasmic pilin chaperone (NCBI) compare
b3761 trpT -0.7 -1.3 tRNA-Trp (NCBI) compare
b3806 cyaA -0.7 -2.8 adenylate cyclase (NCBI) compare
b2340 sixA -0.7 -2.5 phosphohistidine phosphatase (NCBI) compare
b2479 gcvR -0.7 -2.6 transcriptional regulation of gcv operon (VIMSS) compare
b3742 mioC -0.7 -2.3 flavodoxin (NCBI) compare
b3778 rep -0.7 -3.3 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b4242 mgtA -0.7 -4.3 magnesium transporter (NCBI) compare
b1409 ynbB -0.7 -0.4 predicted CDP-diglyceride synthase (NCBI) compare
b4685 yrbN -0.7 -1.5 expressed protein (RefSeq) compare
b3652 recG -0.7 -4.1 ATP-dependent DNA helicase (NCBI) compare
b1293 sapB -0.7 -0.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4494 arpB -0.7 -0.6 no description compare
b3839 tatC -0.7 -3.5 TatABCE protein translocation system subunit (NCBI) compare
b4497 yeeL -0.7 -0.4 no description compare
b0706 ybfD -0.7 -1.0 hypothetical protein (NCBI) compare
b0080 fruR -0.7 -3.2 DNA-binding transcriptional dual regulator (NCBI) compare
b2369 evgA -0.7 -1.3 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b1182 hlyE -0.7 -0.4 hemolysin E (VIMSS) compare
b1165 ymgA -0.7 -0.4 hypothetical protein (NCBI) compare
b1758 b1758 -0.7 -0.9 putative cytochrome oxidase (VIMSS) compare
b0721 sdhC -0.7 -2.2 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b0678 nagB -0.7 -2.8 glucosamine-6-phosphate deaminase (NCBI) compare
b2274 yfbO -0.7 -2.1 predicted protein (RefSeq) compare
b2895 fldB -0.7 -1.8 flavodoxin 2 (NCBI) compare
b2809 b2809 -0.7 -2.0 orf, hypothetical protein (VIMSS) compare
b1038 csgF -0.7 -1.5 predicted transport protein (NCBI) compare
b1905 ftn -0.7 -4.0 ferritin iron storage protein (cytoplasmic) (NCBI) compare
b2189 proL -0.7 -1.2 tRNA-Pro (NCBI) compare
b1601 ydgG -0.7 -2.8 predicted inner membrane protein (NCBI) compare
b1535 ydeH -0.7 -2.7 hypothetical protein (NCBI) compare
b1551 b1551 -0.7 -0.3 orf, hypothetical protein (VIMSS) compare
b1499 ydeO -0.7 -0.3 predicted DNA-binding transcriptional acfivator (NCBI) compare
b2984 yghR -0.7 -3.8 predicted protein with nucleoside triphosphate hydrolase domain (NCBI) compare
b1497 b1497 -0.7 -0.3 putative enzyme (VIMSS) compare
b4523 yciX -0.7 -1.9 hypothetical protein (RefSeq) compare
b3842 rfaH -0.7 -2.7 transcriptional activator RfaH (NCBI) compare
b0149 mrcB -0.7 -5.0 penicillin-binding protein 1b (NCBI) compare
b3649 rpoZ -0.7 -1.6 DNA-directed RNA polymerase subunit omega (NCBI) compare
b3630 rfaP -0.7 -3.8 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1742 b1742 -0.7 -1.3 orf, hypothetical protein (VIMSS) compare
b1950 fliR -0.7 -1.3 flagellar biosynthesis protein R (NCBI) compare
b2897 ygfY -0.7 -1.6 hypothetical protein (NCBI) compare
b4341 yjiS -0.6 -2.3 hypothetical protein (NCBI) compare
b4191 ulaR -0.6 -2.0 DNA-binding transcriptional dual regulator (NCBI) compare
b2330 yfcB -0.6 -0.8 putative adenine-specific methylase (VIMSS) compare
b3764 yifE -0.6 -2.4 hypothetical protein (NCBI) compare
b3021 ygiT -0.6 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b2329 aroC -0.6 -2.6 chorismate synthase (NCBI) compare
b4410 ecnA -0.6 -1.2 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b2319 usg -0.6 -2.5 hypothetical protein (NCBI) compare
b2352 yfdI -0.6 -0.4 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b2252 ais -0.6 -1.7 hypothetical protein (NCBI) compare
b1904 yecR -0.6 -1.8 hypothetical protein (NCBI) compare
b1785 yeaI -0.6 -1.1 predicted diguanylate cyclase (NCBI) compare
b4598 yncL -0.6 -1.6 hypothetical protein (RefSeq) compare
b4590 ybfK -0.6 -0.4 hypothetical protein (RefSeq) compare
b1347 ydaC -0.6 -0.3 Rac prophage; predicted protein (NCBI) compare
b1351 racC -0.6 -0.3 Rac prophage; predicted protein (NCBI) compare
b2283 nuoG -0.6 -3.1 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b3844 fre -0.6 -2.8 NAD(P)H-flavin reductase (NCBI) compare
b0890 ftsK -0.6 -1.3 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b3162 deaD -0.6 -1.8 inducible ATP-independent RNA helicase (VIMSS) compare
b1545 pinQ -0.6 -0.3 Qin prophage; predicted site-specific recombinase (NCBI) compare
b4513 kdpF -0.6 -1.5 potassium ion accessory transporter subunit (NCBI) compare
b2277 nuoM -0.6 -2.6 NADH dehydrogenase subunit M (NCBI) compare
b4480 hdfR -0.6 -2.7 transcriptional regulator HdfR (NCBI) compare
b1084 rne -0.6 -2.6 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b4408 csrB -0.6 -1.4 CsrA-binding sRNA, antagonizing CsrA regulation (NCBI) compare
b2617 smpA -0.6 -1.6 small membrane protein A (VIMSS) compare
b0249 ykfF -0.6 -1.4 CP4-6 prophage; predicted protein (NCBI) compare
b2272 yfbM -0.6 -1.3 hypothetical protein (NCBI) compare
b1176 minC -0.6 -1.4 septum formation inhibitor (NCBI) compare
b0505 allA -0.6 -1.4 ureidoglycolate hydrolase (NCBI) compare
b1496 yddA -0.6 -2.3 fused predicted multidrug transporter subunits of ABC superfamily: membrane component/ATP-binding component (NCBI) compare
b1286 rnb -0.6 -1.1 exoribonuclease II (NCBI) compare
b2278 nuoL -0.6 -3.6 NADH dehydrogenase subunit L (NCBI) compare
b3726 pstA -0.6 -2.1 phosphate transporter subunit (NCBI) compare
b1363 trkG -0.6 -0.3 Rac prophage; potassium transporter subunit (NCBI) compare
b0857 potI -0.6 -2.2 putrescine transporter subunit: membrane component of ABC superfamily (NCBI) compare
b0723 sdhA -0.6 -4.1 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b0499 ylbH -0.6 -1.3 conserved protein, rhs-like (RefSeq) compare
b1502 ydeQ -0.6 -0.9 predicted fimbrial-like adhesin protein (NCBI) compare
b2111 yehD -0.6 -1.3 predicted fimbrial-like adhesin protein (NCBI) compare
b2686 emrB -0.6 -3.8 multidrug efflux system protein (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress 8-hydroxy-nitroquinoline across organisms