Experiment set81S205 for Escherichia coli BW25113

Compare to:

CA_0.05

200 most important genes:

  gene name fitness t score description  
b2288 nuoA -2.7 -3.2 NADH dehydrogenase I chain A (VIMSS) compare
b0726 sucA -2.5 -5.8 alpha-ketoglutarate decarboxylase (NCBI) compare
b2287 nuoB -2.4 -3.6 NADH dehydrogenase subunit B (NCBI) compare
b2281 nuoI -2.4 -3.9 NADH dehydrogenase subunit I (NCBI) compare
b2280 nuoJ -2.4 -4.9 NADH dehydrogenase subunit J (NCBI) compare
b2276 nuoN -2.3 -6.1 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b3500 gor -2.3 -1.5 glutathione reductase (NCBI) compare
b3052 rfaE -2.0 -3.8 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b1480 sra -2.0 -2.1 30S ribosomal subunit protein S22 (NCBI) compare
b2286 nuoC -2.0 -6.0 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b2283 nuoG -2.0 -6.8 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b2278 nuoL -2.0 -8.1 NADH dehydrogenase subunit L (NCBI) compare
b1613 manA -1.9 -2.2 mannose-6-phosphate isomerase (VIMSS) compare
b2284 nuoF -1.9 -5.1 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0630 lipB -1.9 -1.3 protein of lipoate biosynthesis (VIMSS) compare
b4603 rseX -1.9 -1.6 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b2285 nuoE -1.8 -2.6 NADH dehydrogenase subunit E (NCBI) compare
b4171 miaA -1.8 -3.1 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b0080 fruR -1.8 -5.5 DNA-binding transcriptional dual regulator (NCBI) compare
b1346 ydaQ -1.7 -1.8 orf, hypothetical protein (VIMSS) compare
b3842 rfaH -1.7 -5.4 transcriptional activator RfaH (NCBI) compare
b4676 yoaK -1.7 -0.9 expressed protein (RefSeq) compare
b4593 ymgI -1.7 -1.1 hypothetical protein (RefSeq) compare
b0721 sdhC -1.7 -3.2 succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) compare
b3443 yrhA -1.6 -2.1 orf, hypothetical protein (VIMSS) compare
b2277 nuoM -1.6 -4.7 NADH dehydrogenase subunit M (NCBI) compare
b0437 clpP -1.6 -4.9 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b2498 upp -1.6 -2.8 uracil phosphoribosyltransferase (VIMSS) compare
b3620 rfaF -1.6 -3.5 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b0018 mokC -1.5 -1.5 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b0617 citD -1.5 -2.1 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b1724 ydiZ -1.5 -2.9 hypothetical protein (NCBI) compare
b4414 tff -1.5 -3.4 unknown RNA (NCBI) compare
b2906 visC -1.5 -4.9 hypothetical protein (NCBI) compare
b0439 lon -1.4 -3.4 DNA-binding ATP-dependent protease La (NCBI) compare
b0738 tolR -1.4 -1.3 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3631 rfaG -1.4 -8.9 glucosyltransferase I (NCBI) compare
b0623 cspE -1.4 -2.3 cold shock protein E (NCBI) compare
b1161 ycgX -1.4 -0.9 hypothetical protein (NCBI) compare
b1084 rne -1.4 -4.3 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b4701 sokX -1.4 -1.0 sok-related sRNA, function unknown (RefSeq) compare
b4493 gapC -1.3 -3.9 no description compare
b1332 ynaJ -1.3 -1.0 predicted inner membrane protein (NCBI) compare
b3236 mdh -1.3 -6.5 malate dehydrogenase (NCBI) compare
b3621 rfaC -1.3 -3.3 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1236 galU -1.3 -2.2 glucose-1-phosphate uridylyltransferase (NCBI) compare
b0724 sdhB -1.3 -4.9 succinate dehydrogenase, FeS subunit (NCBI) compare
b4232 fbp -1.3 -7.5 fructose-1,6-bisphosphatase (NCBI) compare
b4005 purD -1.3 -6.1 phosphoribosylamine--glycine ligase (NCBI) compare
b0523 purE -1.3 -2.7 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b3204 ptsN -1.2 -2.9 sugar-specific enzyme IIA component of PTS (NCBI) compare
b3844 fre -1.2 -4.6 NAD(P)H-flavin reductase (NCBI) compare
b2476 purC -1.2 -2.9 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b2947 gshB -1.2 -3.0 glutathione synthetase (NCBI) compare
b1109 ndh -1.2 -3.0 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b2846 yqeH -1.2 -0.7 orf, hypothetical protein (VIMSS) compare
b1217 chaB -1.2 -1.7 cation transport regulator (NCBI) compare
b1231 tyrT -1.2 -1.1 tRNA-Tyr (NCBI) compare
b4191 ulaR -1.2 -3.0 DNA-binding transcriptional dual regulator (NCBI) compare
b0723 sdhA -1.2 -6.7 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b0928 aspC -1.2 -4.2 aspartate aminotransferase, PLP-dependent (NCBI) compare
b1291 sapD -1.1 -1.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1183 umuD -1.1 -2.3 DNA polymerase V, subunit D (NCBI) compare
b3860 dsbA -1.1 -4.9 periplasmic protein disulfide isomerase I (NCBI) compare
b2499 purM -1.1 -3.0 phosphoribosylaminoimidazole synthetase (NCBI) compare
b2279 nuoK -1.1 -1.4 NADH dehydrogenase subunit K (NCBI) compare
b2830 nudH -1.1 -0.7 dinucleoside polyphosphate hydrolase (NCBI) compare
b3183 obgE -1.1 -1.0 GTPase involved in cell partioning and DNA repair (NCBI) compare
b2897 ygfY -1.1 -2.0 hypothetical protein (NCBI) compare
b1949 fliQ -1.1 -1.7 flagellar biosynthesis protein Q (NCBI) compare
b2318 truA -1.1 -2.2 tRNA pseudouridine synthase A (NCBI) compare
b1334 fnr -1.1 -2.2 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b3627 rfaI -1.1 -5.9 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b4406 yaeP -1.1 -2.5 hypothetical protein (NCBI) compare
b1175 minD -1.1 -3.4 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b0722 sdhD -1.1 -4.2 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b4178 yjeB -1.0 -2.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b2312 purF -1.0 -4.6 amidophosphoribosyltransferase (NCBI) compare
b4139 aspA -1.0 -6.0 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b3169 nusA -1.0 -1.5 transcription elongation factor NusA (NCBI) compare
b3728 pstS -1.0 -1.4 phosphate transporter subunit (NCBI) compare
b2569 lepA -1.0 -2.2 GTP-binding protein LepA (NCBI) compare
b1777 b1777 -1.0 -1.0 orf, hypothetical protein (VIMSS) compare
b3962 udhA -1.0 -4.3 putative oxidoreductase (VIMSS) compare
b1733 chbG -1.0 -2.7 hypothetical protein (NCBI) compare
b0720 gltA -1.0 -3.9 citrate synthase (NCBI) compare
b1709 btuD -1.0 -1.0 vitamin B12-transporter ATPase (NCBI) compare
b2557 purL -1.0 -5.9 phosphoribosylformylglycinamidine synthase (NCBI) compare
b0564 appY -1.0 -0.6 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b4006 purH -1.0 -5.6 bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) compare
b1185 dsbB -0.9 -1.9 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b1551 b1551 -0.9 -0.6 orf, hypothetical protein (VIMSS) compare
b1855 lpxM -0.9 -1.8 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b1505 ydeT -0.9 -0.9 hypothetical protein (RefSeq) compare
b0881 clpS -0.9 -1.6 ATP-dependent Clp protease adaptor protein ClpS (NCBI) compare
b2699 recA -0.9 -0.6 recombinase A (NCBI) compare
b4613 dinQ -0.9 -1.6 Damage inducible, function unknown (RefSeq) compare
b1129 phoQ -0.9 -0.6 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b2831 mutH -0.9 -3.1 DNA mismatch repair protein (NCBI) compare
b3778 rep -0.9 -4.1 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b2343 b2343 -0.9 -0.8 orf, hypothetical protein (VIMSS) compare
b0806 ybiM -0.9 -1.4 orf, hypothetical protein (VIMSS) compare
b3237 argR -0.9 -2.4 arginine repressor (NCBI) compare
b1536 ydeI -0.9 -0.5 hypothetical protein (NCBI) compare
b3082 ygjM -0.8 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b4045 yjbJ -0.8 -2.0 predicted stress response protein (NCBI) compare
b1550 b1550 -0.8 -0.8 orf, hypothetical protein (VIMSS) compare
b0222 lpcA -0.8 -1.0 phosphoheptose isomerase (NCBI) compare
b4179 vacB -0.8 -3.1 putative enzyme (VIMSS) compare
b3636 rpmG -0.8 -0.9 50S ribosomal protein L33 (NCBI) compare
b1497 b1497 -0.8 -0.5 putative enzyme (VIMSS) compare
b1823 cspC -0.8 -1.2 stress protein, member of the CspA-family (NCBI) compare
b4594 ymgJ -0.8 -1.8 hypothetical protein (RefSeq) compare
b2061 wzb -0.8 -1.5 protein-tyrosine phosphatase (NCBI) compare
b2477 nlpB -0.8 -2.3 lipoprotein-34 (VIMSS) compare
b3834 yigP -0.8 -3.6 hypothetical protein (NCBI) compare
b1861 ruvA -0.8 -0.5 Holliday junction DNA helicase motor protein (NCBI) compare
b0504 ybbS -0.8 -2.6 DNA-binding transcriptional activator of the allD operon (NCBI) compare
b3601 mtlR -0.8 -3.3 DNA-binding repressor (NCBI) compare
b3281 aroE -0.8 -5.4 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b3649 rpoZ -0.8 -1.6 DNA-directed RNA polymerase subunit omega (NCBI) compare
b0049 apaH -0.8 -1.1 diadenosinetetraphosphatase (NCBI) compare
b0368 tauD -0.8 -2.0 taurine dioxygenase (NCBI) compare
b1412 azoR -0.8 -1.8 acyl carrier protein phosphodiesterase (NCBI) compare
b1130 phoP -0.8 -0.8 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b1796 yoaG -0.8 -2.1 hypothetical protein (NCBI) compare
b2009 sbmC -0.7 -2.4 DNA gyrase inhibitor (NCBI) compare
b0225 yafQ -0.7 -2.5 predicted toxin of the YafQ-DinJ toxin-antitoxin system (NCBI) compare
b1563 relE -0.7 -1.3 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b3849 trkH -0.7 -4.4 potassium transporter (NCBI) compare
b0145 dksA -0.7 -1.4 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b4515 ybgT -0.7 -1.1 hypothetical protein (NCBI) compare
b4378 yjjV -0.7 -3.9 predicted DNase (NCBI) compare
b2895 fldB -0.7 -1.2 flavodoxin 2 (NCBI) compare
b2951 yggS -0.7 -3.2 predicted enzyme (NCBI) compare
b0866 ybjQ -0.7 -1.0 hypothetical protein (NCBI) compare
b0791 ybhQ -0.7 -2.8 predicted inner membrane protein (NCBI) compare
b4416 rybA -0.7 -1.1 unknown RNA (NCBI) compare
b1348 lar -0.7 -1.3 Rac prophage; restriction alleviation protein (NCBI) compare
b1677 lpp -0.7 -1.0 murein lipoprotein (NCBI) compare
b1762 b1762 -0.7 -1.6 orf, hypothetical protein (VIMSS) compare
b4201 priB -0.7 -1.5 primosomal replication protein N (NCBI) compare
b3616 tdh -0.7 -3.0 L-threonine 3-dehydrogenase (NCBI) compare
b0729 sucD -0.7 -1.5 succinyl-CoA synthetase subunit alpha (NCBI) compare
b3806 cyaA -0.7 -2.6 adenylate cyclase (NCBI) compare
b0303 ykgI -0.7 -0.4 orf, hypothetical protein (VIMSS) compare
b3839 tatC -0.7 -2.2 TatABCE protein translocation system subunit (NCBI) compare
b2939 yqgB -0.7 -0.9 predicted protein (RefSeq) compare
b1658 purR -0.7 -2.3 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b1591 b1591 -0.7 -1.1 putative oxidoreductase component (VIMSS) compare
b4532 yncN -0.7 -1.9 orf, hypothetical protein (VIMSS) compare
b1865 nudB -0.7 -1.2 dATP pyrophosphohydrolase (NCBI) compare
b4418 sraB -0.7 -1.4 unknown RNA (NCBI) compare
b0428 cyoE -0.7 -3.5 protoheme IX farnesyltransferase (NCBI) compare
b1693 aroD -0.7 -2.9 3-dehydroquinate dehydratase (NCBI) compare
b1518 lsrG -0.7 -1.0 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b0888 trxB -0.7 -2.0 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b2528 iscA -0.7 -1.1 iron-sulfur cluster assembly protein (NCBI) compare
b1351 racC -0.7 -0.4 Rac prophage; predicted protein (NCBI) compare
b1007 b1007 -0.6 -0.9 orf, hypothetical protein (VIMSS) compare
b1533 ydeD -0.6 -1.1 orf, hypothetical protein (VIMSS) compare
b0826 moeB -0.6 -2.0 molybdopterin biosynthesis protein MoeB (NCBI) compare
b3870 glnA -0.6 -1.7 glutamine synthetase (NCBI) compare
b0438 clpX -0.6 -2.4 ATP-dependent protease ATP-binding subunit (NCBI) compare
b1506 yneL -0.6 -0.8 predicted transcriptional regulator (NCBI) compare
b1286 rnb -0.6 -1.2 exoribonuclease II (NCBI) compare
b4415 hokE -0.6 -3.2 toxic polypeptide, small (NCBI) compare
b0088 murD -0.6 -0.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b1090 plsX -0.6 -2.1 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b2754 ygbF -0.6 -1.1 orf, hypothetical protein (VIMSS) compare
b1772 b1772 -0.6 -2.4 putative kinase (VIMSS) compare
b0053 surA -0.6 -0.7 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0890 ftsK -0.6 -1.1 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b3180 yhbY -0.6 -2.5 predicted RNA-binding protein (NCBI) compare
b1804 rnd -0.6 -2.5 ribonuclease D (NCBI) compare
b1124 potC -0.6 -2.8 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b1739 osmE -0.6 -1.4 DNA-binding transcriptional activator (NCBI) compare
b2017 yefM -0.6 -0.9 orf, hypothetical protein (VIMSS) compare
b1942 fliJ -0.6 -0.8 flagellar biosynthesis chaperone (NCBI) compare
b2564 pdxJ -0.6 -2.7 pyridoxal phosphate biosynthetic protein (NCBI) compare
b1290 sapF -0.6 -0.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3619 rfaD -0.6 -1.4 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0143 pcnB -0.6 -2.3 poly(A) polymerase I (VIMSS) compare
b4402 yjjY -0.6 -0.5 hypothetical protein (NCBI) compare
b0346 mhpR -0.6 -1.5 DNA-binding transcriptional activator, 3HPP-binding (RefSeq) compare
b2433 b2433 -0.6 -1.3 orf, hypothetical protein (VIMSS) compare
b1726 yniB -0.6 -1.4 predicted inner membrane protein (NCBI) compare
b3164 pnp -0.6 -0.9 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b1235 rssB -0.6 -2.5 response regulator of RpoS (NCBI) compare
b1657 ydhP -0.6 -2.6 predicted transporter (NCBI) compare
b1989 asnV -0.6 -1.4 tRNA-Asn (NCBI) compare
b1258 yciF -0.6 -0.6 hypothetical protein (NCBI) compare
b4144 yjeI -0.6 -2.3 orf, hypothetical protein (VIMSS) compare
b1499 ydeO -0.6 -0.3 predicted DNA-binding transcriptional acfivator (NCBI) compare
b3389 aroB -0.6 -3.0 3-dehydroquinate synthase (NCBI) compare
b0212 gloB -0.6 -1.0 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b4194 ulaB -0.6 -1.8 L-ascorbate-specific enzyme IIB component of PTS (NCBI) compare
b3916 pfkA -0.6 -0.4 6-phosphofructokinase (NCBI) compare
b4454 rdlD -0.6 -1.8 sRNA antisense regulator affects LdrD translation; proposed addiction module in LDR-D repeat, with toxic peptide LdrD (RefSeq) compare
b1394 paaG -0.6 -2.3 enoyl-CoA hydratase (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in toxin experiments

For toxin double orbital, continuous, 205cpm across organisms