| | gene | name | fitness | t score | description | |
|---|
| b1281 | pyrF | -8.1 | -5.6 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b0523 | purE | -8.0 | -5.5 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b0907 | serC | -7.9 | -7.7 | phosphoserine aminotransferase (NCBI) | compare |
| b2025 | hisF | -7.6 | -7.4 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b0243 | proA | -7.5 | -11.6 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b4388 | serB | -7.5 | -7.3 | 3-phosphoserine phosphatase (NCBI) | compare |
| b2020 | hisD | -7.5 | -11.5 | histidinol dehydrogenase (NCBI) | compare |
| b0242 | proB | -7.4 | -8.9 | gamma-glutamyl kinase (NCBI) | compare |
| b0073 | leuB | -7.2 | -12.1 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0074 | leuA | -7.2 | -12.9 | 2-isopropylmalate synthase (NCBI) | compare |
| b0004 | thrC | -7.2 | -11.0 | threonine synthase (NCBI) | compare |
| b0071 | leuD | -7.1 | -10.9 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b0002 | thrA | -6.9 | -21.3 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b1693 | aroD | -6.9 | -9.4 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b3941 | metF | -6.8 | -15.0 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3774 | ilvC | -6.8 | -21.0 | ketol-acid reductoisomerase (NCBI) | compare |
| b3960 | argH | -6.8 | -16.5 | argininosuccinate lyase (NCBI) | compare |
| b3771 | ilvD | -6.8 | -18.1 | dihydroxy-acid dehydratase (NCBI) | compare |
| b3642 | pyrE | -6.7 | -6.5 | orotate phosphoribosyltransferase (NCBI) | compare |
| b0072 | leuC | -6.6 | -17.0 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b2838 | lysA | -6.5 | -15.8 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b4005 | purD | -6.5 | -13.2 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b0386 | proC | -6.4 | -9.9 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b3772 | ilvA | -6.4 | -19.0 | threonine dehydratase (NCBI) | compare |
| b0945 | pyrD | -6.4 | -18.4 | dihydroorotate dehydrogenase (NCBI) | compare |
| b3956 | ppc | -6.4 | -24.5 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b3957 | argE | -6.4 | -20.4 | acetylornithine deacetylase (NCBI) | compare |
| b2023 | hisH | -6.4 | -9.7 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b3828 | metR | -6.4 | -15.4 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b3389 | aroB | -6.4 | -18.8 | 3-dehydroquinate synthase (NCBI) | compare |
| b2022 | hisB | -6.4 | -12.0 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b0033 | carB | -6.3 | -22.5 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b4006 | purH | -6.3 | -17.1 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b1062 | pyrC | -6.2 | -13.9 | dihydroorotase (NCBI) | compare |
| b3770 | ilvE | -6.2 | -17.1 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2329 | aroC | -6.2 | -7.4 | chorismate synthase (NCBI) | compare |
| b3829 | metE | -6.2 | -21.2 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b2784 | relA | -6.2 | -14.4 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b2913 | serA | -6.2 | -12.6 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0522 | purK | -6.2 | -13.2 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b3281 | aroE | -6.2 | -23.9 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b1260 | trpA | -6.1 | -5.9 | tryptophan synthase subunit alpha (NCBI) | compare |
| b3959 | argB | -6.1 | -16.7 | acetylglutamate kinase (RefSeq) | compare |
| b2557 | purL | -6.1 | -16.2 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b3172 | argG | -6.1 | -17.5 | argininosuccinate synthase (NCBI) | compare |
| b0908 | aroA | -6.0 | -14.6 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b2312 | purF | -6.0 | -10.3 | amidophosphoribosyltransferase (NCBI) | compare |
| b2564 | pdxJ | -6.0 | -7.1 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b4214 | cysQ | -5.9 | -19.8 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b2026 | hisI | -5.9 | -9.7 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b2021 | hisC | -5.9 | -9.8 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b0052 | pdxA | -5.9 | -14.7 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b2476 | purC | -5.9 | -4.1 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b2024 | hisA | -5.8 | -4.9 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b3958 | argC | -5.8 | -20.4 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b2499 | purM | -5.7 | -10.1 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b2762 | cysH | -5.7 | -12.1 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0032 | carA | -5.5 | -10.1 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b2818 | argA | -5.5 | -13.4 | N-acetylglutamate synthase (NCBI) | compare |
| b2479 | gcvR | -5.5 | -7.5 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0726 | sucA | -5.5 | -3.8 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b1192 | ldcA | -5.4 | -8.8 | L,D-carboxypeptidase A (NCBI) | compare |
| b1263 | trpD | -5.3 | -5.3 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b4013 | metA | -5.2 | -7.7 | homoserine O-succinyltransferase (NCBI) | compare |
| b0145 | dksA | -5.2 | -6.1 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b2764 | cysJ | -5.1 | -17.3 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b2340 | sixA | -5.1 | -9.0 | phosphohistidine phosphatase (NCBI) | compare |
| b2600 | tyrA | -5.1 | -8.3 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b2320 | pdxB | -5.1 | -9.9 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b0049 | apaH | -5.0 | -10.5 | diadenosinetetraphosphatase (NCBI) | compare |
| b0142 | folK | -5.0 | -2.1 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b2414 | cysK | -4.9 | -12.5 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b0200 | gmhB | -4.8 | -3.3 | hypothetical protein (NCBI) | compare |
| b1261 | trpB | -4.8 | -3.7 | tryptophan synthase subunit beta (NCBI) | compare |
| b0003 | thrB | -4.7 | -7.5 | homoserine kinase (NCBI) | compare |
| b3939 | metB | -4.7 | -15.9 | cystathionine gamma-synthase (NCBI) | compare |
| b4702 | mgtL | -4.7 | -5.5 | regulatory leader peptide for mgtA (NCBI) | compare |
| b3008 | metC | -4.6 | -13.6 | cystathionine beta-lyase (NCBI) | compare |
| b2019 | hisG | -4.5 | -5.8 | ATP phosphoribosyltransferase (NCBI) | compare |
| b3204 | ptsN | -4.5 | -11.1 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b2763 | cysI | -4.4 | -13.9 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b2751 | cysN | -4.3 | -9.5 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b0889 | lrp | -4.3 | -6.4 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b3870 | glnA | -4.3 | -5.8 | glutamine synthetase (NCBI) | compare |
| b2830 | nudH | -4.3 | -4.1 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b2750 | cysC | -4.2 | -8.1 | adenylylsulfate kinase (NCBI) | compare |
| b1129 | phoQ | -4.1 | -11.1 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b0720 | gltA | -4.0 | -10.5 | citrate synthase (NCBI) | compare |
| b4177 | purA | -4.0 | -2.8 | adenylosuccinate synthetase (NCBI) | compare |
| b3368 | cysG | -4.0 | -20.4 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b4245 | pyrB | -4.0 | -15.1 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b3781 | trxA | -4.0 | -7.9 | thioredoxin 1 (VIMSS) | compare |
| b2752 | cysD | -4.0 | -7.4 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b3916 | pfkA | -4.0 | -8.4 | 6-phosphofructokinase (NCBI) | compare |
| b0630 | lipB | -3.6 | -4.9 | protein of lipoate biosynthesis (VIMSS) | compare |
| b2839 | lysR | -3.6 | -7.2 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b1130 | phoP | -3.5 | -11.0 | DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) | compare |
| b2501 | ppk | -3.5 | -15.1 | polyphosphate kinase (NCBI) | compare |
| b3386 | rpe | -3.5 | -2.4 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b3390 | aroK | -3.4 | -5.2 | shikimate kinase I (NCBI) | compare |
| b4242 | mgtA | -3.2 | -18.5 | magnesium transporter (NCBI) | compare |
| b0912 | ihfB | -3.2 | -7.6 | integration host factor subunit beta (NCBI) | compare |
| b4171 | miaA | -3.2 | -10.2 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b3671 | ilvB | -3.2 | -17.5 | acetolactate synthase large subunit (NCBI) | compare |
| b2599 | pheA | -3.2 | -5.9 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b1262 | trpC | -3.2 | -4.6 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b3706 | trmE | -3.1 | -8.8 | tRNA modification GTPase (NCBI) | compare |
| b0114 | aceE | -3.1 | -5.9 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b0739 | tolA | -3.1 | -9.4 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b0683 | fur | -3.1 | -4.4 | ferric uptake regulator (NCBI) | compare |
| b0928 | aspC | -3.0 | -11.4 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b2500 | purN | -2.9 | -6.9 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b0118 | acnB | -2.9 | -6.9 | aconitate hydratase (NCBI) | compare |
| b3236 | mdh | -2.8 | -9.6 | malate dehydrogenase (NCBI) | compare |
| b0750 | nadA | -2.7 | -5.6 | quinolinate synthetase (NCBI) | compare |
| b3650 | spoT | -2.7 | -7.9 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b0113 | pdhR | -2.6 | -4.5 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b3741 | gidA | -2.6 | -11.9 | glucose-inhibited division protein A (NCBI) | compare |
| b2318 | truA | -2.5 | -7.7 | tRNA pseudouridine synthase A (NCBI) | compare |
| b0888 | trxB | -2.5 | -5.8 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b4025 | pgi | -2.3 | -11.7 | glucose-6-phosphate isomerase (NCBI) | compare |
| b2424 | cysU | -2.3 | -6.1 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b1264 | trpE | -2.3 | -4.2 | anthranilate synthase component I (NCBI) | compare |
| b1860 | ruvB | -2.3 | -4.1 | Holliday junction DNA helicase B (NCBI) | compare |
| b0738 | tolR | -2.2 | -7.1 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3811 | xerC | -2.1 | -5.6 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b1712 | ihfA | -2.1 | -6.7 | integration host factor subunit alpha (NCBI) | compare |
| b3773 | ilvY | -2.1 | -10.1 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3237 | argR | -2.0 | -6.9 | arginine repressor (NCBI) | compare |
| b2820 | recB | -2.0 | -4.6 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b0109 | nadC | -1.9 | -9.0 | nicotinate-nucleotide pyrophosphorylase (NCBI) | compare |
| b1861 | ruvA | -1.9 | -3.6 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b0767 | ybhE | -1.9 | -6.2 | 6-phosphogluconolactonase (NCBI) | compare |
| b0740 | tolB | -1.9 | -6.8 | translocation protein TolB precursor (NCBI) | compare |
| b0737 | tolQ | -1.9 | -5.7 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b2822 | recC | -1.8 | -7.0 | exonuclease V (RecBCD complex), gamma chain (NCBI) | compare |
| b0890 | ftsK | -1.8 | -10.0 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b3398 | yrfF | -1.8 | -5.4 | predicted inner membrane protein (NCBI) | compare |
| b3169 | nusA | -1.7 | -3.5 | transcription elongation factor NusA (NCBI) | compare |
| b2313 | cvpA | -1.7 | -3.4 | membrane protein required for colicin V production (NCBI) | compare |
| b2574 | nadB | -1.7 | -10.1 | L-aspartate oxidase (NCBI) | compare |
| b2422 | cysA | -1.7 | -8.3 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b0741 | pal | -1.7 | -5.8 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b0688 | pgm | -1.6 | -6.3 | phosphoglucomutase (NCBI) | compare |
| b1865 | nudB | -1.6 | -3.0 | dATP pyrophosphohydrolase (NCBI) | compare |
| b1863 | ruvC | -1.6 | -4.1 | Holliday junction resolvase (NCBI) | compare |
| b4246 | pyrL | -1.5 | -4.7 | pyrBI operon leader peptide (NCBI) | compare |
| b3250 | mreC | -1.5 | -1.6 | cell wall structural complex MreBCD transmembrane component MreC (NCBI) | compare |
| b0088 | murD | -1.5 | -2.2 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) | compare |
| b3026 | qseC | -1.5 | -6.3 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b2518 | ndk | -1.5 | -4.3 | nucleoside diphosphate kinase (NCBI) | compare |
| b2911 | ssrS | -1.5 | -2.7 | 6S regulatory RNA (NCBI) | compare |
| b1677 | lpp | -1.5 | -3.0 | murein lipoprotein (NCBI) | compare |
| b3672 | ivbL | -1.5 | -3.0 | ilvB operon leader peptide (NCBI) | compare |
| b3839 | tatC | -1.5 | -8.4 | TatABCE protein translocation system subunit (NCBI) | compare |
| b0075 | leuL | -1.4 | -2.9 | leu operon leader peptide (NCBI) | compare |
| b0078 | ilvH | -1.4 | -10.2 | acetolactate synthase small subunit (NCBI) | compare |
| b3863 | polA | -1.4 | -1.8 | DNA polymerase I (NCBI) | compare |
| b0722 | sdhD | -1.4 | -5.5 | succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) | compare |
| b2423 | cysW | -1.4 | -5.9 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b1101 | ptsG | -1.3 | -10.2 | fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) | compare |
| b0077 | ilvI | -1.3 | -8.1 | acetolactate synthase III large subunit (NCBI) | compare |
| b0437 | clpP | -1.3 | -7.4 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b4480 | hdfR | -1.3 | -5.2 | transcriptional regulator HdfR (NCBI) | compare |
| b1857 | yebL | -1.2 | -7.2 | putative adhesin (VIMSS) | compare |
| b2894 | xerD | -1.2 | -2.4 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b0721 | sdhC | -1.2 | -4.2 | succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI) | compare |
| b3082 | ygjM | -1.2 | -1.7 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b3764 | yifE | -1.1 | -4.2 | hypothetical protein (NCBI) | compare |
| b2425 | cysP | -1.1 | -3.8 | thiosulfate transporter subunit (NCBI) | compare |
| b3619 | rfaD | -1.1 | -5.7 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b0439 | lon | -1.1 | -5.1 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b1185 | dsbB | -1.1 | -4.4 | reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) | compare |
| b2029 | gnd | -1.1 | -7.3 | 6-phosphogluconate dehydrogenase (NCBI) | compare |
| b3213 | gltD | -1.0 | -7.4 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b3728 | pstS | -1.0 | -4.6 | phosphate transporter subunit (NCBI) | compare |
| b2282 | nuoH | -1.0 | -3.6 | NADH dehydrogenase subunit H (NCBI) | compare |
| b1859 | znuB | -1.0 | -4.7 | high-affinity zinc transporter membrane component (NCBI) | compare |
| b2689 | yqaA | -1.0 | -2.4 | conserved inner membrane protein (NCBI) | compare |
| b0548 | ninE | -1.0 | -2.3 | DLP12 prophage; conserved protein (NCBI) | compare |
| b2188 | yejM | -1.0 | -6.1 | predicted hydrolase, inner membrane (NCBI) | compare |
| b0957 | ompA | -1.0 | -3.8 | outer membrane protein A (3a;II*;G;d) (NCBI) | compare |
| b1850 | eda | -1.0 | -1.5 | keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) | compare |
| b1858 | znuC | -1.0 | -5.0 | high-affinity zinc transporter ATPase (NCBI) | compare |
| b0001 | thrL | -1.0 | -0.8 | thr operon leader peptide (NCBI) | compare |
| b3290 | trkA | -1.0 | -3.3 | potassium transporter peripheral membrane component (NCBI) | compare |
| b3052 | rfaE | -1.0 | -5.8 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b2699 | recA | -1.0 | -2.5 | recombinase A (NCBI) | compare |
| b3935 | priA | -0.9 | -1.2 | primosome assembly protein PriA (NCBI) | compare |
| b1084 | rne | -0.9 | -4.0 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b1232 | purU | -0.9 | -5.1 | formyltetrahydrofolate deformylase (NCBI) | compare |
| b1984 | asnW | -0.9 | -1.3 | tRNA-Asn (NCBI) | compare |
| b2281 | nuoI | -0.9 | -3.0 | NADH dehydrogenase subunit I (NCBI) | compare |
| b0723 | sdhA | -0.9 | -6.4 | succinate dehydrogenase flavoprotein subunit (NCBI) | compare |
| b2286 | nuoC | -0.9 | -4.5 | NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) | compare |
| b0724 | sdhB | -0.9 | -4.5 | succinate dehydrogenase, FeS subunit (NCBI) | compare |
| b4488 | ilvG | -0.9 | -4.5 | no description | compare |
| b0189 | yaeO | -0.9 | -3.9 | orf, hypothetical protein (VIMSS) | compare |
| b2277 | nuoM | -0.9 | -4.4 | NADH dehydrogenase subunit M (NCBI) | compare |
| b0014 | dnaK | -0.9 | -1.9 | molecular chaperone DnaK (NCBI) | compare |