Experiment set74S136 for Escherichia coli BW25113

Compare to:

Mpec13

200 most important genes:

  gene name fitness t score description  
b2528 iscA -5.6 -3.0 iron-sulfur cluster assembly protein (NCBI) compare
b3341 rpsG -4.7 -2.5 30S ribosomal protein S7 (NCBI) compare
b0782 moaB -4.2 -3.2 molybdopterin biosynthesis protein B (NCBI) compare
b1863 ruvC -3.6 -2.5 Holliday junction resolvase (NCBI) compare
b1292 sapC -3.6 -3.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4402 yjjY -3.6 -1.6 hypothetical protein (NCBI) compare
b2620 smpB -3.4 -2.1 SsrA-binding protein (NCBI) compare
b0049 apaH -3.3 -4.5 diadenosinetetraphosphatase (NCBI) compare
b1332 ynaJ -3.1 -1.4 predicted inner membrane protein (NCBI) compare
b3390 aroK -2.8 -2.3 shikimate kinase I (NCBI) compare
b4699 fnrS -2.7 -1.2 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b4042 dgkA -2.7 -2.6 diacylglycerol kinase (NCBI) compare
b1860 ruvB -2.6 -1.8 Holliday junction DNA helicase B (NCBI) compare
b0232 yafN -2.6 -1.1 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b0053 surA -2.5 -5.4 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b2285 nuoE -2.2 -3.4 NADH dehydrogenase subunit E (NCBI) compare
b2935 tktA -2.1 -1.5 transketolase 1, thiamin-binding (NCBI) compare
b1600 mdtJ -2.1 -2.4 multidrug efflux system transporter (NCBI) compare
b3916 pfkA -2.1 -2.0 6-phosphofructokinase (NCBI) compare
b4146 yjeK -2.1 -1.4 predicted lysine aminomutase (NCBI) compare
b2699 recA -2.1 -1.4 recombinase A (NCBI) compare
b3636 rpmG -2.1 -1.6 50S ribosomal protein L33 (NCBI) compare
b0739 tolA -2.1 -3.6 cell envelope integrity inner membrane protein TolA (NCBI) compare
b2846 yqeH -2.0 -1.0 orf, hypothetical protein (VIMSS) compare
b2318 truA -2.0 -2.8 tRNA pseudouridine synthase A (NCBI) compare
b4533 ynfO -1.9 -2.6 Qin prophage; predicted protein (NCBI) compare
b0439 lon -1.9 -5.4 DNA-binding ATP-dependent protease La (NCBI) compare
b0630 lipB -1.8 -1.3 protein of lipoate biosynthesis (VIMSS) compare
b4585 sroB -1.8 -1.6 Novel sRNA, function unknown (RefSeq) compare
b2830 nudH -1.7 -1.6 dinucleoside polyphosphate hydrolase (NCBI) compare
b2894 xerD -1.7 -1.1 site-specific tyrosine recombinase XerD (NCBI) compare
b3609 secB -1.6 -4.1 export protein SecB (NCBI) compare
b3620 rfaF -1.6 -4.7 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3426 glpD -1.6 -3.7 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b3816 corA -1.6 -5.3 magnesium/nickel/cobalt transporter (NCBI) compare
b1161 ycgX -1.6 -1.1 hypothetical protein (NCBI) compare
b1553 ydfP -1.5 -2.1 Qin prophage; conserved protein (NCBI) compare
b0222 lpcA -1.5 -2.0 phosphoheptose isomerase (NCBI) compare
b3979 thrT -1.5 -0.5 tRNA-Thr (NCBI) compare
b3977 tyrU -1.5 -0.8 tRNA-Tyr (NCBI) compare
b4458 oxyS -1.5 -1.1 global regulatory RNA (NCBI) compare
b1861 ruvA -1.5 -1.0 Holliday junction DNA helicase motor protein (NCBI) compare
b3811 xerC -1.5 -1.0 site-specific tyrosine recombinase XerC (NCBI) compare
b4594 ymgJ -1.4 -2.2 hypothetical protein (RefSeq) compare
b2278 nuoL -1.4 -5.8 NADH dehydrogenase subunit L (NCBI) compare
b2820 recB -1.4 -1.0 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b1109 ndh -1.4 -2.3 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b3021 ygiT -1.4 -1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b2276 nuoN -1.3 -3.9 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b1536 ydeI -1.3 -0.9 hypothetical protein (NCBI) compare
b1765 ydjA -1.3 -1.0 predicted oxidoreductase (NCBI) compare
b1837 yebW -1.3 -1.4 orf, hypothetical protein (VIMSS) compare
b0912 ihfB -1.2 -4.0 integration host factor subunit beta (NCBI) compare
b2279 nuoK -1.2 -0.9 NADH dehydrogenase subunit K (NCBI) compare
b3164 pnp -1.2 -2.6 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2567 rnc -1.2 -0.8 ribonuclease III (NCBI) compare
b2281 nuoI -1.2 -2.2 NADH dehydrogenase subunit I (NCBI) compare
b1506 yneL -1.2 -1.0 predicted transcriptional regulator (NCBI) compare
b0737 tolQ -1.2 -1.6 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3741 gidA -1.2 -3.0 glucose-inhibited division protein A (NCBI) compare
b1185 dsbB -1.1 -1.5 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b3621 rfaC -1.1 -3.5 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b1007 b1007 -1.0 -1.4 orf, hypothetical protein (VIMSS) compare
b3778 rep -1.0 -3.7 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1286 rnb -1.0 -1.7 exoribonuclease II (NCBI) compare
b3619 rfaD -1.0 -2.9 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b2282 nuoH -1.0 -1.5 NADH dehydrogenase subunit H (NCBI) compare
b2284 nuoF -1.0 -2.5 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0784 moaD -1.0 -1.9 molybdopterin synthase, small subunit (NCBI) compare
b4695 ykgT -1.0 -1.8 no description compare
b1426 ydcH -1.0 -1.3 orf, hypothetical protein (VIMSS) compare
b1070 flgN -1.0 -1.1 export chaperone for FlgK and FlgL (NCBI) compare
b0933 ssuB -1.0 -2.8 alkanesulfonate transporter subunit (NCBI) compare
b0890 ftsK -1.0 -2.4 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b1992 cobS -1.0 -2.0 cobalamin synthase (NCBI) compare
b4171 miaA -1.0 -1.9 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b1347 ydaC -1.0 -0.5 Rac prophage; predicted protein (NCBI) compare
b3658 selC -0.9 -1.9 tRNA-Sec (NCBI) compare
b1278 pgpB -0.9 -2.0 phosphatidylglycerophosphatase B (NCBI) compare
b0200 gmhB -0.9 -1.1 hypothetical protein (NCBI) compare
b2277 nuoM -0.9 -2.8 NADH dehydrogenase subunit M (NCBI) compare
b3226 yhcK -0.9 -2.5 putative FADA-type transcriptional regulator (VIMSS) compare
b1130 phoP -0.9 -1.6 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b1025 ycdT -0.9 -1.5 predicted diguanylate cyclase (NCBI) compare
b1351 racC -0.9 -0.6 Rac prophage; predicted protein (NCBI) compare
b1855 lpxM -0.9 -2.0 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b0740 tolB -0.9 -2.3 translocation protein TolB precursor (NCBI) compare
b0843 ybjH -0.9 -1.7 hypothetical protein (NCBI) compare
b1165 ymgA -0.9 -0.6 hypothetical protein (NCBI) compare
b0767 ybhE -0.9 -2.4 6-phosphogluconolactonase (NCBI) compare
b2017 yefM -0.9 -1.2 orf, hypothetical protein (VIMSS) compare
b1865 nudB -0.9 -0.8 dATP pyrophosphohydrolase (NCBI) compare
b3889 yiiE -0.9 -2.0 predicted transcriptional regulator (RefSeq) compare
b1279 yciS -0.9 -0.9 conserved inner membrane protein (NCBI) compare
b1628 rsxB -0.9 -1.5 electron transport complex protein RnfB (NCBI) compare
b2684 mprA -0.9 -2.3 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b4608 ryfC -0.9 -2.3 Novel sRNA, function unknown (RefSeq) compare
b0051 ksgA -0.9 -2.2 dimethyladenosine transferase (NCBI) compare
b2814 metZ -0.9 -1.0 tRNA-Met (NCBI) compare
b4541 yehK -0.8 -2.0 hypothetical protein (NCBI) compare
b3493 pitA -0.8 -3.5 phosphate transporter, low-affinity (NCBI) compare
b3414 gntY -0.8 -2.3 predicted gluconate transport associated protein (NCBI) compare
b3443 yrhA -0.8 -0.8 orf, hypothetical protein (VIMSS) compare
b1088 yceD -0.8 -2.3 hypothetical protein (NCBI) compare
b1850 eda -0.8 -1.1 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b1595 ynfL -0.8 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b3706 trmE -0.8 -2.6 tRNA modification GTPase (NCBI) compare
b1572 ydfB -0.8 -1.1 orf, hypothetical protein (VIMSS) compare
b1235 rssB -0.8 -3.1 response regulator of RpoS (NCBI) compare
b3858 yihD -0.8 -1.5 hypothetical protein (NCBI) compare
b1346 ydaQ -0.8 -0.9 orf, hypothetical protein (VIMSS) compare
b0726 sucA -0.8 -1.5 alpha-ketoglutarate decarboxylase (NCBI) compare
b2280 nuoJ -0.8 -2.5 NADH dehydrogenase subunit J (NCBI) compare
b2286 nuoC -0.8 -2.0 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b1434 ydcN -0.8 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b1942 fliJ -0.8 -1.0 flagellar biosynthesis chaperone (NCBI) compare
b1527 yneK -0.8 -1.8 hypothetical protein (NCBI) compare
b3842 rfaH -0.8 -2.7 transcriptional activator RfaH (NCBI) compare
b4101 phnG -0.7 -1.4 carbon-phosphorus lyase complex subunit (NCBI) compare
b4676 yoaK -0.7 -0.4 expressed protein (RefSeq) compare
b1696 ydiP -0.7 -1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b3649 rpoZ -0.7 -1.8 DNA-directed RNA polymerase subunit omega (NCBI) compare
b2104 thiM -0.7 -1.6 hydroxyethylthiazole kinase (NCBI) compare
b0685 ybfE -0.7 -1.1 orf, hypothetical protein (VIMSS) compare
b0746 valZ -0.7 -1.1 tRNA-Val (NCBI) compare
b0438 clpX -0.7 -2.9 ATP-dependent protease ATP-binding subunit (NCBI) compare
b0688 pgm -0.7 -1.4 phosphoglucomutase (NCBI) compare
b3398 yrfF -0.7 -1.8 predicted inner membrane protein (NCBI) compare
b0471 ybaB -0.7 -1.4 hypothetical protein (NCBI) compare
b2198 ccmD -0.7 -0.9 cytochrome c biogenesis protein (NCBI) compare
b3071 yqjI -0.7 -2.2 predicted transcriptional regulator (NCBI) compare
b1917 yecC -0.7 -1.5 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b4435 isrC -0.7 -1.1 unknown RNA (NCBI) compare
b1891 flhC -0.7 -1.8 DNA-binding transcriptional dual regulator with FlhD (NCBI) compare
b3871 bipA -0.7 -3.4 GTP-binding protein (NCBI) compare
b2325 yfcL -0.7 -1.8 hypothetical protein (NCBI) compare
b1438 ydcQ -0.7 -1.8 predicted DNA-binding transcriptional regulator (RefSeq) compare
b1182 hlyE -0.7 -0.4 hemolysin E (VIMSS) compare
b4603 rseX -0.7 -0.4 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1236 galU -0.7 -2.1 glucose-1-phosphate uridylyltransferase (NCBI) compare
b4701 sokX -0.7 -0.6 sok-related sRNA, function unknown (RefSeq) compare
b1612 fumA -0.7 -1.6 fumarate hydratase (fumarase A), aerobic Class I (NCBI) compare
b1427 rimL -0.7 -1.8 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b0418 pgpA -0.7 -2.2 phosphatidylglycerophosphatase A (NCBI) compare
b0122 yacC -0.7 -2.2 orf, hypothetical protein (VIMSS) conserved
b3210 arcB -0.7 -3.2 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b2707 srlR -0.7 -2.0 DNA-bindng transcriptional repressor (NCBI) compare
b0326 yahL -0.7 -1.0 hypothetical protein (NCBI) compare
b3807 cyaY -0.6 -2.4 frataxin-like protein (NCBI) compare
b3098 yqjD -0.6 -1.8 hypothetical protein (NCBI) compare
b1758 b1758 -0.6 -0.7 putative cytochrome oxidase (VIMSS) compare
b2288 nuoA -0.6 -1.1 NADH dehydrogenase I chain A (VIMSS) compare
b4179 vacB -0.6 -2.3 putative enzyme (VIMSS) compare
b3875 ompL -0.6 -1.9 predicted outer membrane porin L (NCBI) compare
b1498 b1498 -0.6 -3.3 putative sulfatase (VIMSS) compare
b2947 gshB -0.6 -1.8 glutathione synthetase (NCBI) compare
b3761 trpT -0.6 -0.9 tRNA-Trp (NCBI) compare
b2929 yggD -0.6 -1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b2012 yeeD -0.6 -1.9 hypothetical protein (NCBI) compare
b3290 trkA -0.6 -1.2 potassium transporter peripheral membrane component (NCBI) compare
b4066 yjcF -0.6 -0.4 hypothetical protein (NCBI) compare
b3026 qseC -0.6 -1.7 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1269 rluB -0.6 -1.8 23S rRNA pseudouridylate synthase (NCBI) compare
b3962 udhA -0.6 -2.5 putative oxidoreductase (VIMSS) compare
b2283 nuoG -0.6 -2.3 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b1862 yebB -0.6 -1.4 orf, hypothetical protein (VIMSS) compare
b0766 ybhA -0.6 -2.8 predicted hydrolase (NCBI) compare
b3727 pstC -0.6 -2.8 phosphate transporter subunit (NCBI) compare
b1669 ydhT -0.6 -1.8 hypothetical protein (NCBI) compare
b0822 ybiV -0.6 -1.7 predicted hydrolase (NCBI) compare
b1462 b1462 -0.6 -1.6 orf, hypothetical protein (VIMSS) compare
b3002 yqhA -0.6 -0.7 hypothetical protein (NCBI) compare
b2287 nuoB -0.6 -1.4 NADH dehydrogenase subunit B (NCBI) compare
b4375 prfC -0.6 -2.4 peptide chain release factor 3 (NCBI) compare
b2456 cchB -0.6 -1.4 predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) compare
b3630 rfaP -0.6 -3.3 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b1811 yoaH -0.6 -2.2 hypothetical protein (NCBI) compare
b4376 osmY -0.6 -2.1 periplasmic protein (NCBI) compare
b4647 mokA -0.6 -0.6 no description compare
b0627 tatE -0.6 -1.0 twin arginine translocase protein E (NCBI) compare
b1104 ycfL -0.6 -1.2 hypothetical protein (NCBI) compare
b0386 proC -0.6 -1.5 pyrroline-5-carboxylate reductase (NCBI) compare
b1476 fdnI -0.6 -0.6 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b2376 ypdI -0.6 -1.2 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b1213 ychQ -0.6 -2.4 predicted transcriptional regulator (NCBI) compare
b2782 chpA -0.6 -1.9 toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease (NCBI) compare
b2110 yehC -0.6 -0.8 predicted periplasmic pilin chaperone (NCBI) compare
b2756 ygcH -0.6 -3.0 hypothetical protein (NCBI) compare
b2962 yggX -0.6 -1.7 hypothetical protein (NCBI) compare
b1939 fliG -0.6 -1.7 flagellar motor switch protein G (NCBI) compare
b0145 dksA -0.6 -1.7 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b1968 yedV -0.6 -1.7 predicted sensory kinase in two-component regulatory system with YedW (NCBI) compare
b1675 ydhZ -0.6 -3.0 hypothetical protein (NCBI) compare
b2618 b2618 -0.6 -1.3 orf, hypothetical protein (VIMSS) compare
b2366 dsdA -0.6 -1.9 D-serine dehydratase (NCBI) compare
b1651 gloA -0.6 -1.0 glyoxalase I, Ni-dependent (NCBI) compare
b0728 sucC -0.6 -2.7 succinyl-CoA synthetase subunit beta (NCBI) compare
b1629 rsxC -0.6 -2.4 electron transport complex protein RnfC (NCBI) compare
b0407 yajC -0.5 -0.9 preprotein translocase subunit YajC (NCBI) compare
b3052 rfaE -0.5 -1.5 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in phage experiments

For phage Phage across organisms