Experiment set73S509 for Escherichia coli BW25113

Compare to:

Calbicans

200 most important genes:

  gene name fitness t score description  
b1855 lpxM -3.2 -5.6 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b0949 uup -3.0 -9.5 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b3790 rffC -3.0 -6.9 TDP-fucosamine acetyltransferase (RefSeq) compare
b4603 rseX -2.9 -1.1 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1429 tehA -2.9 -1.9 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b3791 rffA -2.9 -9.9 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b0143 pcnB -2.7 -7.3 poly(A) polymerase I (VIMSS) compare
b2528 iscA -2.7 -2.5 iron-sulfur cluster assembly protein (NCBI) compare
b1175 minD -2.6 -4.7 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b4481 rffT -2.6 -8.4 4-alpha-L-fucosyltransferase (NCBI) compare
b3183 obgE -2.5 -1.7 GTPase involved in cell partioning and DNA repair (NCBI) compare
b3842 rfaH -2.5 -6.8 transcriptional activator RfaH (NCBI) compare
b0439 lon -2.3 -4.1 DNA-binding ATP-dependent protease La (NCBI) compare
b3786 rffE -2.3 -13.9 UDP-N-acetyl glucosamine-2-epimerase (NCBI) compare
b3787 rffD -2.3 -10.5 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase (NCBI) compare
b3794 rffM -2.2 -7.8 putative UDP-N-acetyl-D-mannosaminuronic acid transferase (NCBI) compare
b3443 yrhA -2.2 -2.5 orf, hypothetical protein (VIMSS) compare
b3911 cpxA -2.2 -9.6 two-component sensor protein (NCBI) compare
b0688 pgm -2.2 -2.9 phosphoglucomutase (NCBI) compare
b0049 apaH -2.1 -2.0 diadenosinetetraphosphatase (NCBI) compare
b1765 ydjA -2.1 -1.1 predicted oxidoreductase (NCBI) compare
b3784 rfe -2.1 -11.6 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b1332 ynaJ -2.0 -1.1 predicted inner membrane protein (NCBI) compare
b4171 miaA -1.9 -3.1 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b1573 ydfC -1.9 -1.3 Qin prophage; predicted protein (RefSeq) compare
b1090 plsX -1.9 -3.5 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b3839 tatC -1.9 -3.4 TatABCE protein translocation system subunit (NCBI) compare
b3500 gor -1.9 -1.8 glutathione reductase (NCBI) compare
b3405 ompR -1.8 -3.2 osmolarity response regulator (NCBI) compare
b4702 mgtL -1.8 -2.0 regulatory leader peptide for mgtA (NCBI) compare
b3631 rfaG -1.7 -11.6 glucosyltransferase I (NCBI) compare
b1865 nudB -1.7 -1.6 dATP pyrophosphohydrolase (NCBI) compare
b3778 rep -1.6 -6.2 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b3792 wzxE -1.6 -5.2 O-antigen translocase (NCBI) compare
b4647 mokA -1.6 -1.0 no description compare
b1185 dsbB -1.5 -2.5 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b2318 truA -1.5 -2.8 tRNA pseudouridine synthase A (NCBI) compare
b2846 yqeH -1.5 -1.0 orf, hypothetical protein (VIMSS) compare
b0357 yaiN -1.5 -1.3 putative alpha helix chain (VIMSS) compare
b3162 deaD -1.5 -4.0 inducible ATP-independent RNA helicase (VIMSS) compare
b1108 ycfP -1.5 -2.0 orf, hypothetical protein (VIMSS) compare
b0232 yafN -1.5 -1.1 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1192 ldcA -1.5 -1.4 L,D-carboxypeptidase A (NCBI) compare
b1164 ycgZ -1.4 -1.6 hypothetical protein (NCBI) compare
b3414 gntY -1.4 -4.6 predicted gluconate transport associated protein (NCBI) compare
b0200 gmhB -1.4 -1.3 hypothetical protein (NCBI) compare
b1563 relE -1.4 -1.5 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b0400 phoR -1.4 -6.0 sensory histidine kinase in two-component regulatory system with PhoB (NCBI) compare
b1861 ruvA -1.4 -0.9 Holliday junction DNA helicase motor protein (NCBI) compare
b1293 sapB -1.4 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4201 priB -1.3 -1.9 primosomal replication protein N (NCBI) compare
b3630 rfaP -1.3 -6.5 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2910 zapA -1.3 -5.1 protein that localizes to the cytokinetic ring (NCBI) compare
b1286 rnb -1.3 -1.9 exoribonuclease II (NCBI) compare
b3935 priA -1.3 -3.3 primosome assembly protein PriA (NCBI) compare
b1648 b1648 -1.3 -1.4 orf, hypothetical protein (VIMSS) compare
b1850 eda -1.3 -1.1 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b1739 osmE -1.3 -2.4 DNA-binding transcriptional activator (NCBI) compare
b4522 yciX_1 -1.3 -3.0 hypothetical protein (NCBI) compare
b2531 iscR -1.3 -1.3 DNA-binding transcriptional repressor (NCBI) compare
b3164 pnp -1.2 -2.3 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b3706 trmE -1.2 -2.2 tRNA modification GTPase (NCBI) compare
b2114 metG -1.2 -1.7 methionyl-tRNA synthetase (NCBI) compare
b3341 rpsG -1.2 -1.3 30S ribosomal protein S7 (NCBI) compare
b4410 ecnA -1.2 -1.2 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b0739 tolA -1.2 -1.4 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1104 ycfL -1.2 -1.1 hypothetical protein (NCBI) compare
b0737 tolQ -1.2 -1.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1607 ydgC -1.2 -1.0 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b1485 ddpC -1.2 -3.2 D-ala-D-ala transporter subunit (NCBI) compare
b3026 qseC -1.2 -2.2 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1758 b1758 -1.2 -1.0 putative cytochrome oxidase (VIMSS) compare
b1362 rzpR -1.2 -2.3 putative Rac prophage endopeptidase (VIMSS) compare
b0685 ybfE -1.1 -1.5 orf, hypothetical protein (VIMSS) compare
b4179 vacB -1.1 -4.3 putative enzyme (VIMSS) compare
b2222 atoA -1.1 -3.8 acetyl-CoA:acetoacetyl-CoA transferase, beta subunit (NCBI) compare
b1882 cheY -1.1 -0.4 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b3916 pfkA -1.1 -1.0 6-phosphofructokinase (NCBI) compare
b3387 dam -1.1 -6.5 DNA adenine methylase (NCBI) compare
b1999 yeeP -1.1 -2.9 putative histone (VIMSS) compare
b2082 ogrK -1.1 -2.1 DNA-binding transcriptional regulator prophage P2 remnant (NCBI) compare
b2642 yfjW -1.1 -1.3 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b1591 b1591 -1.0 -1.8 putative oxidoreductase component (VIMSS) compare
b4325 yjiC -1.0 -2.6 orf, hypothetical protein (VIMSS) compare
b1921 fliZ -1.0 -2.4 orf, hypothetical protein (VIMSS) compare
b0630 lipB -1.0 -0.9 protein of lipoate biosynthesis (VIMSS) compare
b1412 azoR -1.0 -1.5 acyl carrier protein phosphodiesterase (NCBI) compare
b1730 ydjO -1.0 -0.7 predicted protein (RefSeq) compare
b2237 inaA -1.0 -1.9 hypothetical protein (NCBI) compare
b3626 rfaJ -1.0 -3.4 UDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase (NCBI) compare
b3180 yhbY -1.0 -3.7 predicted RNA-binding protein (NCBI) compare
b0841 ybjG -1.0 -3.4 undecaprenyl pyrophosphate phosphatase (NCBI) compare
b4407 thiS -1.0 -1.4 sulfur carrier protein ThiS (NCBI) compare
b4436 ryeC -0.9 -1.1 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b4520 ymgF -0.9 -1.2 hypothetical protein (NCBI) compare
b1595 ynfL -0.9 -1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b0740 tolB -0.9 -1.6 translocation protein TolB precursor (NCBI) compare
b1900 araG -0.9 -2.9 fused L-arabinose transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b1671 ydhX -0.9 -1.4 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b1588 ynfF -0.9 -2.9 oxidoreductase subunit (RefSeq) compare
b3181 greA -0.9 -1.5 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b4649 ysaD -0.9 -2.3 no description compare
b1346 ydaQ -0.9 -1.1 orf, hypothetical protein (VIMSS) compare
b1123 potD -0.9 -3.4 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b1618 uidR -0.9 -2.4 DNA-binding transcriptional repressor (NCBI) compare
b2617 smpA -0.9 -2.4 small membrane protein A (VIMSS) compare
b3390 aroK -0.9 -1.2 shikimate kinase I (NCBI) compare
b3644 yicC -0.9 -3.3 hypothetical protein (NCBI) compare
b3199 yrbK -0.9 -2.2 hypothetical protein (NCBI) compare
b1290 sapF -0.8 -0.7 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4415 hokE -0.8 -2.5 toxic polypeptide, small (NCBI) compare
b0145 dksA -0.8 -2.2 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b1857 yebL -0.8 -2.1 putative adhesin (VIMSS) compare
b1144 ymfJ -0.8 -1.5 orf, hypothetical protein (VIMSS) compare
b0741 pal -0.8 -1.8 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1493 gadB -0.8 -0.5 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b3237 argR -0.8 -2.3 arginine repressor (NCBI) compare
b3950 frwB -0.8 -2.2 predicted enzyme IIB component of PTS (NCBI) compare
b4178 yjeB -0.8 -2.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b1712 ihfA -0.8 -0.7 integration host factor subunit alpha (NCBI) compare
b2017 yefM -0.8 -1.1 orf, hypothetical protein (VIMSS) compare
b1603 pntA -0.8 -1.5 NAD(P) transhydrogenase subunit alpha (NCBI) compare
b0683 fur -0.8 -0.5 ferric uptake regulator (NCBI) compare
b3860 dsbA -0.8 -4.2 periplasmic protein disulfide isomerase I (NCBI) compare
b0802 ybiJ -0.8 -1.7 hypothetical protein (NCBI) compare
b2198 ccmD -0.8 -1.1 cytochrome c biogenesis protein (NCBI) compare
b3021 ygiT -0.8 -1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b4369 leuP -0.8 -1.3 tRNA-Leu (NCBI) compare
b0976 hyaE -0.8 -2.2 protein involved in processing of HyaA and HyaB proteins (NCBI) compare
b0908 aroA -0.8 -3.7 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b1186 nhaB -0.8 -3.0 NhaB sodium/proton transporter (Katherine Huang) compare
b0888 trxB -0.8 -1.4 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b3838 tatB -0.8 -3.3 sec-independent translocase (NCBI) compare
b0406 tgt -0.8 -3.1 queuine tRNA-ribosyltransferase (NCBI) compare
b3260 dusB -0.8 -2.6 tRNA-dihydrouridine synthase B (NCBI) compare
b4503 yafF -0.8 -0.4 no description compare
b2620 smpB -0.7 -0.6 SsrA-binding protein (NCBI) compare
b3961 oxyR -0.7 -4.6 DNA-binding transcriptional dual regulator (NCBI) compare
b2044 wcaL -0.7 -1.7 predicted glycosyl transferase (NCBI) compare
b2498 upp -0.7 -1.5 uracil phosphoribosyltransferase (VIMSS) compare
b4414 tff -0.7 -1.7 unknown RNA (NCBI) compare
b2136 yohD -0.7 -1.2 orf, hypothetical protein (VIMSS) compare
b2510 b2510 -0.7 -1.8 orf, hypothetical protein (VIMSS) compare
b2934 cmtB -0.7 -0.6 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b0471 ybaB -0.7 -1.9 hypothetical protein (NCBI) compare
b3009 yghB -0.7 -3.6 conserved inner membrane protein (NCBI) compare
b4416 rybA -0.7 -0.9 unknown RNA (NCBI) compare
b1444 ydcW -0.7 -2.5 medium chain aldehyde dehydrogenase (NCBI) compare
b2446 yffO -0.7 -1.6 CPZ-55 prophage; predicted protein (NCBI) compare
b1105 ycfM -0.7 -1.6 predicted outer membrane lipoprotein (NCBI) compare
b1727 yniC -0.7 -1.7 predicted hydrolase (NCBI) compare
b0149 mrcB -0.7 -4.5 penicillin-binding protein 1b (NCBI) compare
b1348 lar -0.7 -1.0 Rac prophage; restriction alleviation protein (NCBI) compare
b2007 yeeX -0.7 -1.1 conserved protein (RefSeq) compare
b1969 yedW -0.7 -2.2 putative 2-component transcriptional regulator (VIMSS) compare
b3493 pitA -0.7 -3.2 phosphate transporter, low-affinity (NCBI) compare
b1989 asnV -0.7 -1.2 tRNA-Asn (NCBI) compare
b0623 cspE -0.7 -1.3 cold shock protein E (NCBI) compare
b1926 fliT -0.7 -1.4 predicted chaperone (NCBI) compare
b3928 yiiU -0.7 -3.3 hypothetical protein (NCBI) compare
b2909 ygfB -0.7 -4.0 orf, hypothetical protein (VIMSS) compare
b3082 ygjM -0.7 -0.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b0849 grxA -0.7 -1.0 glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a) (NCBI) compare
b0564 appY -0.7 -0.7 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b1567 intK -0.7 -1.3 Qin prophage; predicted protein (RefSeq) compare
b1533 ydeD -0.7 -1.6 orf, hypothetical protein (VIMSS) compare
b3761 trpT -0.7 -1.0 tRNA-Trp (NCBI) compare
b2424 cysU -0.7 -1.1 sulfate/thiosulfate transporter subunit (NCBI) compare
b4426 isrA -0.6 -1.3 unknown RNA (NCBI) compare
b1383 ydbL -0.6 -1.6 orf, hypothetical protein (VIMSS) compare
b4578 insP -0.6 -1.5 no description compare
b2009 sbmC -0.6 -1.6 DNA gyrase inhibitor (NCBI) compare
b2175 spr -0.6 -2.4 predicted peptidase, outer membrane lipoprotein (NCBI) compare
b2582 trxC -0.6 -1.1 thioredoxin 2 (NCBI) compare
b1304 pspA -0.6 -1.9 regulatory protein for phage-shock-protein operon (NCBI) compare
b0632 dacA -0.6 -2.7 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b2744 surE -0.6 -2.9 acid phosphatase (NCBI) compare
b2808 gcvA -0.6 -1.7 DNA-binding transcriptional dual regulator (NCBI) compare
b4585 sroB -0.6 -0.7 Novel sRNA, function unknown (RefSeq) compare
b0407 yajC -0.6 -1.7 preprotein translocase subunit YajC (NCBI) compare
b0948 ycbY -0.6 -2.7 predicted methyltransferase (NCBI) compare
b2698 recX -0.6 -1.7 RecA regulator RecX (NCBI) compare
b1382 ynbE -0.6 -0.7 predicted lipoprotein (NCBI) compare
b1675 ydhZ -0.6 -2.3 hypothetical protein (NCBI) compare
b3198 kdsC -0.6 -1.4 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b1085 b1085 -0.6 -1.2 orf, hypothetical protein (VIMSS) compare
b1853 yebK -0.6 -1.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b1804 rnd -0.6 -2.0 ribonuclease D (NCBI) compare
b3741 gidA -0.6 -0.4 glucose-inhibited division protein A (NCBI) compare
b4697 yrdF -0.6 -1.7 no description compare
b0583 entD -0.6 -1.4 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex (NCBI) compare
b4536 yobH -0.6 -2.1 hypothetical protein (NCBI) compare
b0937 ssuE -0.6 -1.4 NAD(P)H-dependent FMN reductase (NCBI) compare
b2363 yfdT -0.6 -1.0 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b1944 fliL -0.6 -2.2 flagellar basal body-associated protein FliL (NCBI) compare
b0249 ykfF -0.6 -1.5 CP4-6 prophage; predicted protein (NCBI) compare
b2142 yohK -0.6 -2.6 predicted inner membrane protein (NCBI) compare
b1307 pspD -0.6 -1.0 peripheral inner membrane phage-shock protein (NCBI) compare
b2906 visC -0.6 -2.5 hypothetical protein (NCBI) compare
b2051 wcaH -0.6 -1.0 GDP-mannose mannosyl hydrolase (VIMSS) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in yeast experiments

For yeast Yeast across organisms