Experiment set72S532 for Escherichia coli BW25113

Compare to:

Tailocin 256

200 most important genes:

  gene name fitness t score description  
b3035 tolC -7.1 -6.9 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b2531 iscR -6.7 -4.4 DNA-binding transcriptional repressor (NCBI) compare
b0759 galE -6.5 -12.5 UDP-galactose-4-epimerase (VIMSS) compare
b3839 tatC -5.4 -10.9 TatABCE protein translocation system subunit (NCBI) compare
b3628 rfaB -4.9 -3.4 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b3173 yhbX -4.4 -31.3 putative alkaline phosphatase I (VIMSS) conserved
b3198 kdsC -4.1 -6.1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b4171 miaA -4.1 -5.6 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b2620 smpB -3.8 -2.6 SsrA-binding protein (NCBI) compare
b1677 lpp -3.8 -5.6 murein lipoprotein (NCBI) compare
b2188 yejM -3.7 -11.1 predicted hydrolase, inner membrane (NCBI) compare
b0738 tolR -3.1 -5.6 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3261 fis -3.0 -2.9 DNA-binding protein Fis (NCBI) compare
b3979 thrT -3.0 -1.1 tRNA-Thr (NCBI) compare
b2318 truA -2.9 -5.3 tRNA pseudouridine synthase A (NCBI) compare
b2528 iscA -2.7 -3.2 iron-sulfur cluster assembly protein (NCBI) compare
b0741 pal -2.7 -6.5 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b2830 nudH -2.7 -2.6 dinucleoside polyphosphate hydrolase (NCBI) compare
b3183 obgE -2.7 -2.6 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0740 tolB -2.6 -6.5 translocation protein TolB precursor (NCBI) compare
b1861 ruvA -2.3 -2.7 Holliday junction DNA helicase motor protein (NCBI) compare
b3977 tyrU -2.3 -1.7 tRNA-Tyr (NCBI) compare
b0737 tolQ -2.3 -5.0 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3405 ompR -2.2 -6.5 osmolarity response regulator (NCBI) compare
b0739 tolA -2.2 -5.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3863 polA -2.1 -2.0 DNA polymerase I (NCBI) compare
b0890 ftsK -2.1 -6.8 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b2814 metZ -2.1 -2.7 tRNA-Met (NCBI) compare
b4042 dgkA -2.1 -2.8 diacylglycerol kinase (NCBI) compare
b2168 fruK -2.0 -2.0 1-phosphofructokinase (NCBI) compare
b2699 recA -2.0 -1.9 recombinase A (NCBI) compare
b4239 treC -2.0 -2.7 trehalose-6-P hydrolase (NCBI) compare
b1860 ruvB -2.0 -1.8 Holliday junction DNA helicase B (NCBI) compare
b3792 wzxE -1.9 -8.9 O-antigen translocase (NCBI) compare
b3341 rpsG -1.9 -2.5 30S ribosomal protein S7 (NCBI) compare
b4179 vacB -1.9 -7.6 putative enzyme (VIMSS) compare
b3838 tatB -1.8 -5.3 sec-independent translocase (NCBI) compare
b2934 cmtB -1.8 -1.2 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b1863 ruvC -1.8 -3.2 Holliday junction resolvase (NCBI) compare
b0630 lipB -1.8 -2.3 protein of lipoate biosynthesis (VIMSS) compare
b0082 mraW -1.8 -4.7 S-adenosyl-methyltransferase (NCBI) compare
b0406 tgt -1.6 -6.9 queuine tRNA-ribosyltransferase (NCBI) compare
b2894 xerD -1.6 -1.1 site-specific tyrosine recombinase XerD (NCBI) compare
b3613 yibP -1.6 -4.9 putative membrane protein (VIMSS) compare
b3624 rfaZ -1.6 -1.1 lipopolysaccharide core biosynthesis protein (NCBI) compare
b0145 dksA -1.6 -4.1 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b4146 yjeK -1.6 -4.0 predicted lysine aminomutase (NCBI) compare
b0053 surA -1.6 -6.1 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b2029 gnd -1.6 -8.5 6-phosphogluconate dehydrogenase (NCBI) compare
b3636 rpmG -1.6 -2.9 50S ribosomal protein L33 (NCBI) compare
b2569 lepA -1.5 -5.1 GTP-binding protein LepA (NCBI) compare
b3500 gor -1.5 -1.8 glutathione reductase (NCBI) compare
b2820 recB -1.5 -1.4 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b3811 xerC -1.5 -2.3 site-specific tyrosine recombinase XerC (NCBI) compare
b2708 gutQ -1.4 -4.7 orf, hypothetical protein (VIMSS) compare
b3082 ygjM -1.4 -2.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b2297 pta -1.4 -1.0 phosphate acetyltransferase (NCBI) compare
b2947 gshB -1.4 -4.9 glutathione synthetase (NCBI) compare
b2688 gshA -1.3 -6.4 glutamate--cysteine ligase (NCBI) compare
b0386 proC -1.3 -4.6 pyrroline-5-carboxylate reductase (NCBI) compare
b1278 pgpB -1.3 -2.4 phosphatidylglycerophosphatase B (NCBI) compare
b3229 sspA -1.3 -3.5 stringent starvation protein A (NCBI) compare
b0167 glnD -1.3 -5.6 PII uridylyl-transferase (NCBI) compare
b3190 yrbA -1.3 -6.0 orf, hypothetical protein (VIMSS) compare
b3414 gntY -1.3 -5.1 predicted gluconate transport associated protein (NCBI) compare
b3871 bipA -1.3 -8.7 GTP-binding protein (NCBI) compare
b0114 aceE -1.3 -1.2 pyruvate dehydrogenase subunit E1 (NCBI) compare
b0439 lon -1.2 -5.7 DNA-binding ATP-dependent protease La (NCBI) compare
b3784 rfe -1.2 -8.8 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b1709 btuD -1.2 -1.4 vitamin B12-transporter ATPase (NCBI) compare
b3806 cyaA -1.2 -5.5 adenylate cyclase (NCBI) compare
b0232 yafN -1.2 -0.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1865 nudB -1.2 -2.0 dATP pyrophosphohydrolase (NCBI) compare
b2037 rfbX -1.2 -7.0 predicted polisoprenol-linked O-antigen transporter (NCBI) compare
b2567 rnc -1.2 -1.5 ribonuclease III (NCBI) compare
b3706 trmE -1.2 -4.1 tRNA modification GTPase (NCBI) compare
b4472 yhdP -1.1 -9.8 conserved membrane protein, predicted transporter (NCBI) compare
b2501 ppk -1.1 -6.1 polyphosphate kinase (NCBI) compare
b3426 glpD -1.1 -3.9 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b1175 minD -1.1 -3.8 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b0462 acrB -1.1 -9.2 multidrug efflux system protein (NCBI) compare
b2935 tktA -1.1 -2.6 transketolase 1, thiamin-binding (NCBI) compare
b2284 nuoF -1.1 -4.5 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b3741 gidA -1.1 -4.7 glucose-inhibited division protein A (NCBI) compare
b4503 yafF -1.1 -1.1 no description compare
b1607 ydgC -1.1 -1.8 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b4414 tff -1.0 -1.9 unknown RNA (NCBI) compare
b3387 dam -1.0 -8.0 DNA adenine methylase (NCBI) compare
b2576 srmB -1.0 -3.4 ATP-dependent RNA helicase (NCBI) compare
b3629 rfaS -1.0 -3.5 lipopolysaccharide core biosynthesis protein (NCBI) compare
b2350 yfdG -1.0 -4.1 CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) (NCBI) compare
b4155 yjeA -1.0 -0.7 putative lysyl-tRNA synthetase (VIMSS) compare
b2652 ileY -1.0 -1.1 tRNA-Ile (NCBI) compare
b0033 carB -1.0 -6.9 carbamoyl-phosphate synthase large subunit (NCBI) compare
b1257 yciE -0.9 -0.6 hypothetical protein (NCBI) compare
b1648 b1648 -0.9 -0.6 orf, hypothetical protein (VIMSS) compare
b4647 mokA -0.9 -0.8 no description compare
b3778 rep -0.9 -5.5 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b2288 nuoA -0.9 -1.9 NADH dehydrogenase I chain A (VIMSS) compare
b2822 recC -0.9 -3.9 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b1293 sapB -0.9 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1627 rsxA -0.9 -3.0 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b2040 rfbD -0.9 -6.4 dTDP-4-dehydrorhamnose reductase subunit, NAD(P)-binding, of dTDP-L-rhamnose synthase (NCBI) compare
b4045 yjbJ -0.9 -1.5 predicted stress response protein (NCBI) compare
b0463 acrA -0.9 -4.4 multidrug efflux system (NCBI) compare
b0303 ykgI -0.9 -0.6 orf, hypothetical protein (VIMSS) compare
b3728 pstS -0.9 -3.1 phosphate transporter subunit (NCBI) compare
b2278 nuoL -0.8 -5.2 NADH dehydrogenase subunit L (NCBI) compare
b1192 ldcA -0.8 -3.9 L,D-carboxypeptidase A (NCBI) compare
b4557 yidD -0.8 -3.2 hypothetical protein (NCBI) compare
b1334 fnr -0.8 -2.7 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b2363 yfdT -0.8 -2.9 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b0683 fur -0.8 -1.1 ferric uptake regulator (NCBI) compare
b4538 yoeF -0.8 -1.9 hypothetical protein (RefSeq) compare
b1842 holE -0.8 -2.3 DNA polymerase III, theta subunit (NCBI) compare
b0032 carA -0.8 -3.6 carbamoyl-phosphate synthase small subunit (NCBI) compare
b4201 priB -0.8 -2.9 primosomal replication protein N (NCBI) compare
b3257 yhdT -0.8 -2.9 conserved inner membrane protein (NCBI) compare
b0405 queA -0.8 -3.7 S-adenosylmethionine:tRNA ribosyltransferase-isomerase (NCBI) compare
b2506 yfgI -0.8 -1.0 hypothetical protein (NCBI) compare
b1536 ydeI -0.8 -1.0 hypothetical protein (NCBI) compare
b2944 sprT -0.8 -3.3 hypothetical protein (NCBI) compare
b4702 mgtL -0.8 -1.2 regulatory leader peptide for mgtA (NCBI) compare
b1269 rluB -0.8 -2.0 23S rRNA pseudouridylate synthase (NCBI) compare
b4653 yicT -0.8 -1.6 no description compare
b0677 nagA -0.8 -4.0 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b1049 mdoH -0.8 -5.2 glucosyltransferase MdoH (NCBI) compare
b2684 mprA -0.7 -2.7 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b0730 mngR -0.7 -1.2 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b1084 rne -0.7 -3.1 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b1907 tyrP -0.7 -3.7 tyrosine transporter (NCBI) compare
b0149 mrcB -0.7 -5.7 penicillin-binding protein 1b (NCBI) compare
b2277 nuoM -0.7 -3.9 NADH dehydrogenase subunit M (NCBI) compare
b0142 folK -0.7 -0.5 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b1105 ycfM -0.7 -3.0 predicted outer membrane lipoprotein (NCBI) compare
b1850 eda -0.7 -2.5 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b3916 pfkA -0.7 -2.0 6-phosphofructokinase (NCBI) compare
b4413 sokC -0.7 -1.3 regulatory antisense RNA (NCBI) compare
b4325 yjiC -0.7 -2.9 orf, hypothetical protein (VIMSS) compare
b2516 yfgA -0.7 -2.9 hypothetical protein (NCBI) compare
b0726 sucA -0.7 -2.8 alpha-ketoglutarate decarboxylase (NCBI) compare
b0767 ybhE -0.7 -2.1 6-phosphogluconolactonase (NCBI) compare
b2906 visC -0.7 -4.1 hypothetical protein (NCBI) compare
b2329 aroC -0.7 -3.8 chorismate synthase (NCBI) compare
b4509 ylcG -0.7 -1.6 DLP12 prophage; predicted protein (NCBI) compare
b0014 dnaK -0.7 -1.8 molecular chaperone DnaK (NCBI) compare
b3181 greA -0.7 -3.7 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b3260 dusB -0.7 -2.9 tRNA-dihydrouridine synthase B (NCBI) compare
b3616 tdh -0.7 -3.2 L-threonine 3-dehydrogenase (NCBI) compare
b1248 b1248 -0.7 -2.0 orf, hypothetical protein (VIMSS) compare
b1476 fdnI -0.7 -0.8 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b0888 trxB -0.7 -2.4 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b2276 nuoN -0.7 -2.9 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b0705 ybfL -0.7 -0.4 putative receptor protein (VIMSS) compare
b4202 rpsR -0.7 -1.0 30S ribosomal protein S18 (NCBI) compare
b1040 csgD -0.6 -1.3 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b4506 ykgO -0.6 -3.0 rpmJ (L36) paralog (NCBI) compare
b4180 rlmB -0.6 -3.7 23S rRNA (Gm2251)-methyltransferase (NCBI) compare
b1196 ycgY -0.6 -2.2 hypothetical protein (NCBI) compare
b4695 ykgT -0.6 -1.8 no description compare
b2317 dedA -0.6 -2.7 conserved inner membrane protein (NCBI) compare
b3404 envZ -0.6 -4.5 osmolarity sensor protein (NCBI) compare
b1048 mdoG -0.6 -3.0 glucan biosynthesis protein, periplasmic (NCBI) compare
b1347 ydaC -0.6 -0.3 Rac prophage; predicted protein (NCBI) compare
b3021 ygiT -0.6 -0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b3727 pstC -0.6 -3.1 phosphate transporter subunit (NCBI) compare
b1038 csgF -0.6 -2.0 predicted transport protein (NCBI) compare
b1951 rcsA -0.6 -1.1 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b1551 b1551 -0.6 -0.3 orf, hypothetical protein (VIMSS) compare
b0503 ybbB -0.6 -2.6 tRNA 2-selenouridine synthase, selenophosphate-dependent (NCBI) compare
b3836 b3836 -0.6 -2.3 orf, hypothetical protein (VIMSS) compare
b4481 rffT -0.6 -3.7 4-alpha-L-fucosyltransferase (NCBI) compare
b1671 ydhX -0.6 -1.9 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b2285 nuoE -0.6 -1.5 NADH dehydrogenase subunit E (NCBI) compare
b2955 yggW -0.6 -3.6 coproporphyrinogen III oxidase (NCBI) compare
b0798 ybiA -0.6 -1.6 hypothetical protein (NCBI) compare
b2637 yfjT -0.6 -1.9 CP4-57 prophage; predicted protein (NCBI) compare
b1804 rnd -0.6 -2.9 ribonuclease D (NCBI) compare
b1165 ymgA -0.6 -0.4 hypothetical protein (NCBI) compare
b0819 ybiS -0.6 -4.2 hypothetical protein (NCBI) compare
b1231 tyrT -0.6 -0.7 tRNA-Tyr (NCBI) compare
b3095 yqjA -0.6 -4.2 conserved inner membrane protein (NCBI) compare
b4384 deoD -0.6 -3.8 purine nucleoside phosphorylase (NCBI) compare
b2064 asmA -0.6 -3.0 predicted assembly protein (NCBI) compare
b4596 yciZ -0.6 -1.2 hypothetical protein (RefSeq) compare
b4521 ycgI -0.6 -2.1 hypothetical protein (NCBI) compare
b4025 pgi -0.5 -3.6 glucose-6-phosphate isomerase (NCBI) compare
b3742 mioC -0.5 -2.0 flavodoxin (NCBI) compare
b3617 kbl -0.5 -3.6 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b4049 dusA -0.5 -3.6 tRNA-dihydrouridine synthase A (RefSeq) compare
b0585 fes -0.5 -3.4 enterobactin/ferric enterobactin esterase (NCBI) compare
b0945 pyrD -0.5 -3.4 dihydroorotate dehydrogenase (NCBI) compare
b2286 nuoC -0.5 -2.8 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b4535 yniD -0.5 -0.6 predicted protein (RefSeq) compare
b2319 usg -0.5 -1.9 hypothetical protein (NCBI) compare
b2156 lysP -0.5 -3.5 lysine transporter (NCBI) compare
b0436 tig -0.5 -3.2 trigger factor (NCBI) compare
b1553 ydfP -0.5 -1.4 Qin prophage; conserved protein (NCBI) compare
b2504 yfgG -0.5 -0.9 Negative regulator of nickel and cobalt uptake (YfgG) (from data) compare
b3622 rfaL -0.5 -1.6 O-antigen ligase (NCBI) compare


Specific Phenotypes

For 3 genes in this experiment

For stress Tailocin 256 in Escherichia coli BW25113

For stress Tailocin 256 across organisms