Experiment set71S174 for Escherichia coli BW25113

Compare to:

Sodium-DL-Lactate

200 most detrimental genes:

  gene name fitness t score description  
b1332 ynaJ +2.1 1.5 predicted inner membrane protein (NCBI) compare
b3979 thrT +1.9 1.3 tRNA-Thr (NCBI) compare
b2741 rpoS +1.7 7.2 RNA polymerase sigma factor (NCBI) compare
b1429 tehA +1.4 1.5 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b2939 yqgB +1.3 1.8 predicted protein (RefSeq) compare
b3933 ftsN +1.2 6.2 essential cell division protein (NCBI) compare
b1607 ydgC +1.1 1.1 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b4373 rimI +1.1 2.3 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b0746 valZ +1.1 2.8 tRNA-Val (NCBI) compare
b3199 yrbK +1.1 4.3 hypothetical protein (NCBI) compare
b3021 ygiT +1.0 1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b1205 ychH +1.0 2.6 predicted inner membrane protein (NCBI) compare
b0407 yajC +1.0 1.7 preprotein translocase subunit YajC (NCBI) compare
b1293 sapB +1.0 1.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1147 ymfL +1.0 3.5 e14 prophage; predicted DNA-binding transcriptional regulator (RefSeq) compare
b0247 ykfG +1.0 1.6 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b1358 ydaT +1.0 1.5 Rac prophage; predicted protein (NCBI) compare
b0784 moaD +1.0 2.8 molybdopterin synthase, small subunit (NCBI) compare
b2642 yfjW +0.9 1.0 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b4595 yciY +0.9 2.7 hypothetical protein (RefSeq) compare
b2646 ypjF +0.9 2.7 CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system (NCBI) compare
b2904 gcvH +0.9 2.9 glycine cleavage system protein H (NCBI) compare
b1830 prc +0.9 4.1 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b4676 yoaK +0.9 0.5 expressed protein (RefSeq) compare
b1278 pgpB +0.9 0.9 phosphatidylglycerophosphatase B (NCBI) compare
b1038 csgF +0.8 2.8 predicted transport protein (NCBI) compare
b4655 ythA +0.8 1.4 expressed protein (RefSeq) compare
b4594 ymgJ +0.8 2.9 hypothetical protein (RefSeq) compare
b1819 manZ +0.8 4.8 mannose-specific enzyme IID component of PTS (NCBI) compare
b4402 yjjY +0.8 0.8 hypothetical protein (NCBI) compare
b3753 rbsR +0.8 5.7 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b3027 ygiZ +0.8 0.6 conserved inner membrane protein (NCBI) compare
b1085 b1085 +0.8 1.6 orf, hypothetical protein (VIMSS) compare
b1095 fabF +0.8 4.7 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b4174 hflK +0.8 4.9 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b0989 cspH +0.8 2.3 stress protein, member of the CspA-family (NCBI) compare
b1725 yniA +0.8 3.2 predicted phosphotransferase/kinase (NCBI) compare
b4370 leuQ +0.8 1.5 tRNA-Leu (NCBI) compare
b0706 ybfD +0.8 1.4 hypothetical protein (NCBI) compare
b3484 yhhI +0.7 2.5 predicted transposase (NCBI) compare
b2569 lepA +0.7 2.6 GTP-binding protein LepA (NCBI) compare
b2199 ccmC +0.7 2.8 heme exporter subunit (NCBI) compare
b1231 tyrT +0.7 0.8 tRNA-Tyr (NCBI) compare
b1550 b1550 +0.7 1.1 orf, hypothetical protein (VIMSS) compare
b4458 oxyS +0.7 1.1 global regulatory RNA (NCBI) compare
b3929 rraA +0.7 3.8 ribonuclease activity regulator protein RraA (NCBI) compare
b0998 torD +0.7 1.0 chaperone protein TorD (NCBI) compare
b3229 sspA +0.7 2.3 stringent starvation protein A (NCBI) compare
b3916 pfkA +0.7 1.7 6-phosphofructokinase (NCBI) compare
b2005 yeeV +0.7 3.1 CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system (NCBI) compare
b4505 insX +0.7 1.3 predicted IS protein (RefSeq) compare
b1336 ydaH +0.7 3.0 putative pump protein (transport) (VIMSS) compare
b4048 yjbM +0.7 1.7 hypothetical protein (NCBI) compare
b1593 b1593 +0.7 2.7 orf, hypothetical protein (VIMSS) compare
b1493 gadB +0.7 0.6 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b1542 ydfI +0.7 1.9 predicted mannonate dehydrogenase (NCBI) compare
b1806 yeaY +0.7 3.9 predicted lipoprotein (NCBI) compare
b1013 ycdC +0.7 2.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b3163 nlpI +0.7 3.1 hypothetical protein (NCBI) compare
b4279 yjhB +0.7 0.5 putative transport protein (VIMSS) compare
b2726 hypA +0.7 2.7 protein involved in nickel insertion into hydrogenases 3 (NCBI) compare
b0641 rlpB +0.6 2.0 minor lipoprotein (NCBI) compare
b1572 ydfB +0.6 1.1 orf, hypothetical protein (VIMSS) compare
b4406 yaeP +0.6 1.1 hypothetical protein (NCBI) compare
b1581 rspA +0.6 1.5 predicted dehydratase (NCBI) compare
b1362 rzpR +0.6 1.3 putative Rac prophage endopeptidase (VIMSS) compare
b1758 b1758 +0.6 0.8 putative cytochrome oxidase (VIMSS) compare
b1615 uidC +0.6 2.3 membrane-associated protein (VIMSS) compare
b1553 ydfP +0.6 0.9 Qin prophage; conserved protein (NCBI) compare
b3138 agaB +0.6 2.3 N-acetylgalactosamine-specific enzyme IIB component of PTS (NCBI) compare
b2195 ccmG +0.6 2.6 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b1438 ydcQ +0.6 3.3 predicted DNA-binding transcriptional regulator (RefSeq) compare
b4513 kdpF +0.6 1.9 potassium ion accessory transporter subunit (NCBI) compare
b0966 hspQ +0.6 3.2 DNA-binding protein, hemimethylated (RefSeq) compare
b1946 fliN +0.6 2.0 flagellar motor switch protein (NCBI) compare
b0809 glnQ +0.6 2.9 glutamine ABC transporter ATP-binding protein (NCBI) compare
b1667 ydhR +0.6 0.8 hypothetical protein (NCBI) compare
b1813 yeaB +0.6 3.3 predicted NUDIX hydrolase (NCBI) compare
b0865 ybjP +0.6 2.3 predicted lipoprotein (NCBI) compare
b2426 ucpA +0.6 0.9 putative oxidoreductase (VIMSS) compare
b1685 ydiH +0.6 0.9 predicted protein (RefSeq) compare
b2419 yfeK +0.6 1.7 hypothetical protein (NCBI) compare
b1992 cobS +0.6 1.4 cobalamin synthase (NCBI) compare
b4408 csrB +0.6 2.4 CsrA-binding sRNA, antagonizing CsrA regulation (NCBI) compare
b3778 rep +0.6 3.3 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1505 ydeT +0.6 1.3 hypothetical protein (RefSeq) compare
b3029 ygiN +0.6 2.2 quinol monooxygenase (NCBI) compare
b4631 ykgQ +0.6 1.1 no description compare
b1427 rimL +0.6 1.8 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b2248 yfaX +0.6 1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b3012 yqhE +0.6 3.8 orf, hypothetical protein (VIMSS) compare
b1519 tam +0.5 2.8 trans-aconitate 2-methyltransferase (NCBI) compare
b4163 glyV +0.5 0.9 tRNA-Gly (NCBI) compare
b1882 cheY +0.5 0.3 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b4477 dgoA +0.5 1.9 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (NCBI) compare
b1001 yccE +0.5 0.4 hypothetical protein (NCBI) compare
b2183 rsuA +0.5 2.3 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b2317 dedA +0.5 2.5 conserved inner membrane protein (NCBI) compare
b1302 puuE +0.5 2.0 GABA aminotransferase, PLP-dependent (NCBI) compare
b4653 yicT +0.5 1.3 no description compare
b1567 intK +0.5 1.1 Qin prophage; predicted protein (RefSeq) compare
b1847 yebF +0.5 1.0 predicted protein (RefSeq) compare
b0240 crl +0.5 2.4 DNA-binding transcriptional regulator (NCBI) compare
b1862 yebB +0.5 2.3 orf, hypothetical protein (VIMSS) compare
b3164 pnp +0.5 1.1 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b4543 ypaA +0.5 2.0 predicted protein (NCBI) compare
b2272 yfbM +0.5 1.9 hypothetical protein (NCBI) compare
b2794 yqcD +0.5 2.7 hypothetical protein (NCBI) compare
b3999 yjaG +0.5 2.4 hypothetical protein (NCBI) compare
b1762 b1762 +0.5 1.8 orf, hypothetical protein (VIMSS) compare
b0263 afuB +0.5 1.7 CP4-6 prophage; predicted ferric trasnporter subunit (RefSeq) compare
b3718 yieK +0.5 2.4 hypothetical protein (NCBI) compare
b1683 ynhE +0.5 3.7 orf, hypothetical protein (VIMSS) compare
b2314 dedD +0.5 2.0 putative lipoprotein (VIMSS) compare
b1380 ldhA +0.5 1.6 D-lactate dehydrogenase (NCBI) compare
b3658 selC +0.5 1.7 tRNA-Sec (NCBI) compare
b1194 ycgR +0.5 1.8 protein involved in flagellar function (NCBI) compare
b0610 rnk +0.5 1.7 nucleoside diphosphate kinase regulator (NCBI) compare
b1880 flhB +0.5 2.5 flagellar biosynthesis protein B (NCBI) compare
b1650 nemA +0.5 2.5 N-ethylmaleimide reductase, FMN-linked (NCBI) compare
b4391 yjjK +0.5 3.4 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b2572 rseA +0.5 1.6 anti-sigma factor (NCBI) compare
b0548 ninE +0.5 1.5 DLP12 prophage; conserved protein (NCBI) compare
b3977 tyrU +0.5 0.4 tRNA-Tyr (NCBI) compare
b0454 ybaZ +0.5 2.9 predicted methyltransferase (NCBI) compare
b0059 hepA +0.5 3.6 ATP-dependent helicase HepA (NCBI) compare
b4316 fimC +0.5 2.7 periplasmic chaperone, required for type 1 fimbriae (VIMSS) compare
b2717 hycI +0.5 3.1 protease involved in processing C-terminal end of HycE (NCBI) compare
b0461 ybaJ +0.5 2.7 hypothetical protein (NCBI) compare
b0736 ybgC +0.5 1.3 predicted acyl-CoA thioesterase (NCBI) compare
b1822 rrmA +0.5 1.3 23S rRNA m1G745 methyltransferase (NCBI) compare
b2058 wcaB +0.5 0.7 predicted acyl transferase (NCBI) compare
b3443 yrhA +0.5 0.8 orf, hypothetical protein (VIMSS) compare
b2905 gcvT +0.5 2.6 glycine cleavage system aminomethyltransferase T (NCBI) compare
b1757 b1757 +0.5 2.1 putative thiosulfate sulfur transferase (VIMSS) compare
b4097 phnK +0.5 1.5 carbon-phosphorus lyase complex subunit (NCBI) compare
b1524 yneH +0.5 0.5 predicted glutaminase (NCBI) compare
b0212 gloB +0.5 1.0 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b3292 zntR +0.5 2.0 zinc-responsive transcriptional regulator (NCBI) compare
b1315 ycjS +0.5 1.8 predicted oxidoreductase, NADH-binding (NCBI) compare
b1824 yobF +0.5 1.3 hypothetical protein (NCBI) compare
b3068 ygjF +0.5 1.9 G/U mismatch-specific DNA glycosylase (NCBI) compare
b1360 ydaV +0.5 1.3 Rac prophage; predicted DNA replication protein (NCBI) compare
b0765 modC +0.5 1.6 molybdate transporter subunit (NCBI) compare
b2903 gcvP +0.5 3.3 glycine dehydrogenase (NCBI) compare
b0550 rusA +0.5 1.4 DLP12 prophage; endonuclease RUS (NCBI) compare
b2004 yeeU +0.5 1.1 CP4-44 prophage; antitoxin of the YeeV-YeeU toxin-antitoxin system (NCBI) compare
b0711 ybgJ +0.4 2.5 predicted enzyme subunit (NCBI) compare
b3861 yihF +0.4 3.1 putative GTP-binding protein (VIMSS) compare
b4172 hfq +0.4 0.4 RNA-binding protein Hfq (NCBI) compare
b1613 manA +0.4 0.8 mannose-6-phosphate isomerase (VIMSS) compare
b1512 lsrR +0.4 2.6 lsr operon transcriptional repressor (NCBI) compare
b3194 yrbE +0.4 2.9 predicted toluene transporter subunit: membrane component of ABC superfamily (NCBI) compare
b1528 ydeA +0.4 2.9 sugar efflux transporter (NCBI) compare
b0686 ybfF +0.4 2.3 hypothetical protein (NCBI) compare
b2428 yfeU +0.4 1.9 N-acetylmuramic acid-6-phosphate etherase (NCBI) compare
b4071 nrfB +0.4 1.2 formate-dependent nitrite reductase; a penta-haeme cytochrome c (VIMSS) compare
b4330 yjiH +0.4 1.6 orf, hypothetical protein (VIMSS) compare
b1741 ydjQ +0.4 1.6 endonuclease of nucleotide excision repair (NCBI) compare
b3625 rfaY +0.4 1.9 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3866 yihI +0.4 1.7 hypothetical protein (NCBI) compare
b1754 b1754 +0.4 0.9 orf, hypothetical protein (VIMSS) compare
b1334 fnr +0.4 1.0 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b2267 elaA +0.4 1.7 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b0713 ybgL +0.4 2.0 hypothetical protein (NCBI) compare
b0227 yafL +0.4 2.5 predicted lipoprotein and C40 family peptidase (NCBI) compare
b4627 ykfL +0.4 2.0 no description compare
b0469 apt +0.4 2.1 adenine phosphoribosyltransferase (NCBI) compare
b3033 yqiB +0.4 1.7 predicted dehydrogenase (NCBI) compare
b3466 yhhL +0.4 1.7 conserved inner membrane protein (NCBI) compare
b0682 ybfN +0.4 2.2 predicted lipoprotein (NCBI) compare
b2771 ygcS +0.4 2.1 putative transport protein (VIMSS) compare
b2061 wzb +0.4 1.0 protein-tyrosine phosphatase (NCBI) compare
b3034 nudF +0.4 1.5 ADP-ribose pyrophosphatase (NCBI) compare
b4497 yeeL +0.4 1.2 no description compare
b1199 dhaL +0.4 2.6 dihydroxyacetone kinase, C-terminal domain (NCBI) compare
b4369 leuP +0.4 1.2 tRNA-Leu (NCBI) compare
b1123 potD +0.4 1.9 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b1388 paaA +0.4 2.2 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation (NCBI) compare
b0895 dmsB +0.4 2.0 dimethyl sulfoxide reductase, anaerobic, subunit B (NCBI) compare
b4413 sokC +0.4 0.8 regulatory antisense RNA (NCBI) compare
b1844 exoX +0.4 1.3 exodeoxyribonuclease X (NCBI) compare
b1538 dcp +0.4 2.3 dipeptidyl carboxypeptidase II (NCBI) compare
b2128 yehW +0.4 1.9 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b0858 ybjO +0.4 1.1 predicted inner membrane protein (NCBI) compare
b1125 potB +0.4 1.2 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b0191 yaeJ +0.4 1.6 hypothetical protein (NCBI) compare
b0850 ybjC +0.4 1.0 predicted inner membrane protein (NCBI) compare
b1829 htpX +0.4 1.9 heat shock protein HtpX (NCBI) compare
b2263 yfbB +0.4 1.3 predicted peptidase (NCBI) compare
b2829 ptsP +0.4 3.1 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b1321 ycjX +0.4 1.6 conserved protein with nucleoside triphosphate hydrolase domain (NCBI) compare
b0977 hyaF +0.4 2.3 protein involved in nickel incorporation into hydrogenase-1 proteins (NCBI) compare
b1939 fliG +0.4 2.3 flagellar motor switch protein G (NCBI) compare
b1738 chbB +0.4 2.5 N,N'-diacetylchitobiose-specific enzyme IIB component of PTS (NCBI) compare
b4394 yjjX +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b3150 yraP +0.4 1.7 hypothetical protein (NCBI) compare
b1289 ycjD +0.4 2.1 hypothetical protein (NCBI) compare
b2252 ais +0.4 1.8 hypothetical protein (NCBI) compare
b1534 ydeE +0.4 1.5 predicted transporter (NCBI) compare


Specific Phenotypes

For 4 genes in this experiment

For carbon source Sodium-DL-Lactate in Escherichia coli BW25113

For carbon source Sodium-DL-Lactate across organisms