| | gene | name | fitness | t score | description | |
|---|
| b1261 | trpB | -9.9 | -4.2 | tryptophan synthase subunit beta (NCBI) | compare |
| b4388 | serB | -8.3 | -9.9 | 3-phosphoserine phosphatase (NCBI) | compare |
| b0523 | purE | -8.0 | -6.1 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b1192 | ldcA | -8.0 | -7.6 | L,D-carboxypeptidase A (NCBI) | compare |
| b2329 | aroC | -6.9 | -6.8 | chorismate synthase (NCBI) | compare |
| b3389 | aroB | -6.8 | -17.6 | 3-dehydroquinate synthase (NCBI) | compare |
| b3281 | aroE | -6.5 | -22.6 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b2913 | serA | -6.2 | -11.8 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b0908 | aroA | -6.2 | -14.4 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b0907 | serC | -6.0 | -6.7 | phosphoserine aminotransferase (NCBI) | compare |
| b3941 | metF | -5.9 | -10.0 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b3771 | ilvD | -5.8 | -15.6 | dihydroxy-acid dehydratase (NCBI) | compare |
| b0072 | leuC | -5.7 | -13.2 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b0071 | leuD | -5.5 | -8.6 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b2025 | hisF | -5.4 | -5.3 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b3774 | ilvC | -5.4 | -15.6 | ketol-acid reductoisomerase (NCBI) | compare |
| b2557 | purL | -5.4 | -12.9 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b4006 | purH | -5.3 | -14.0 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b2838 | lysA | -5.2 | -9.9 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b1693 | aroD | -5.2 | -10.6 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b4005 | purD | -5.1 | -12.2 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b1290 | sapF | -5.0 | -2.9 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b1281 | pyrF | -5.0 | -5.1 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b0004 | thrC | -4.9 | -8.9 | threonine synthase (NCBI) | compare |
| b1260 | trpA | -4.7 | -3.8 | tryptophan synthase subunit alpha (NCBI) | compare |
| b0145 | dksA | -4.6 | -3.2 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b2023 | hisH | -4.6 | -6.1 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b2499 | purM | -4.5 | -6.4 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b0074 | leuA | -4.4 | -7.6 | 2-isopropylmalate synthase (NCBI) | compare |
| b2312 | purF | -4.4 | -7.1 | amidophosphoribosyltransferase (NCBI) | compare |
| b0073 | leuB | -4.4 | -7.8 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b0242 | proB | -4.2 | -5.8 | gamma-glutamyl kinase (NCBI) | compare |
| b2600 | tyrA | -4.1 | -7.5 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b3829 | metE | -4.1 | -16.3 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b0740 | tolB | -4.0 | -7.3 | translocation protein TolB precursor (NCBI) | compare |
| b0738 | tolR | -3.9 | -5.9 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b0739 | tolA | -3.8 | -6.3 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b3405 | ompR | -3.8 | -7.1 | osmolarity response regulator (NCBI) | compare |
| b2476 | purC | -3.8 | -4.0 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b3770 | ilvE | -3.8 | -14.6 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b0243 | proA | -3.8 | -10.7 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b2021 | hisC | -3.7 | -4.8 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b3390 | aroK | -3.6 | -2.8 | shikimate kinase I (NCBI) | compare |
| b2020 | hisD | -3.6 | -8.4 | histidinol dehydrogenase (NCBI) | compare |
| b2599 | pheA | -3.5 | -6.6 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b2830 | nudH | -3.5 | -2.1 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b4214 | cysQ | -3.5 | -11.3 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b3828 | metR | -3.4 | -10.4 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b0142 | folK | -3.4 | -0.8 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b0726 | sucA | -3.4 | -5.1 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b3870 | glnA | -3.4 | -6.1 | glutamine synthetase (NCBI) | compare |
| b0386 | proC | -3.4 | -5.2 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b0049 | apaH | -3.3 | -5.5 | diadenosinetetraphosphatase (NCBI) | compare |
| b3979 | thrT | -3.3 | -0.8 | tRNA-Thr (NCBI) | compare |
| b0564 | appY | -3.3 | -1.0 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b4593 | ymgI | -3.1 | -1.7 | hypothetical protein (RefSeq) | compare |
| b3772 | ilvA | -3.1 | -13.5 | threonine dehydratase (NCBI) | compare |
| b0737 | tolQ | -3.1 | -3.4 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b0003 | thrB | -3.1 | -6.9 | homoserine kinase (NCBI) | compare |
| b0033 | carB | -3.1 | -13.7 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b2022 | hisB | -3.1 | -6.3 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b4245 | pyrB | -3.1 | -13.8 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b1062 | pyrC | -3.0 | -10.8 | dihydroorotase (NCBI) | compare |
| b0945 | pyrD | -3.0 | -12.3 | dihydroorotate dehydrogenase (NCBI) | compare |
| b3959 | argB | -2.9 | -12.3 | acetylglutamate kinase (RefSeq) | compare |
| b2026 | hisI | -2.9 | -7.8 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b2750 | cysC | -2.9 | -5.7 | adenylylsulfate kinase (NCBI) | compare |
| b3956 | ppc | -2.9 | -16.0 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b3613 | yibP | -2.9 | -7.4 | putative membrane protein (VIMSS) | compare |
| b1730 | ydjO | -2.9 | -1.3 | predicted protein (RefSeq) | compare |
| b0720 | gltA | -2.8 | -7.5 | citrate synthase (NCBI) | compare |
| b4013 | metA | -2.8 | -6.4 | homoserine O-succinyltransferase (NCBI) | compare |
| b0002 | thrA | -2.8 | -12.2 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b3939 | metB | -2.7 | -8.8 | cystathionine gamma-synthase (NCBI) | compare |
| b1263 | trpD | -2.7 | -2.1 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b2894 | xerD | -2.7 | -1.4 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b3172 | argG | -2.7 | -12.4 | argininosuccinate synthase (NCBI) | compare |
| b2818 | argA | -2.6 | -8.5 | N-acetylglutamate synthase (NCBI) | compare |
| b2564 | pdxJ | -2.6 | -6.9 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b2414 | cysK | -2.6 | -9.9 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b2934 | cmtB | -2.6 | -1.2 | predicted mannitol-specific enzyme IIA component of PTS (NCBI) | compare |
| b2024 | hisA | -2.6 | -2.8 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b1262 | trpC | -2.6 | -4.1 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b0032 | carA | -2.6 | -5.8 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b0522 | purK | -2.6 | -8.5 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b2567 | rnc | -2.6 | -1.4 | ribonuclease III (NCBI) | compare |
| b3958 | argC | -2.6 | -12.1 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b3642 | pyrE | -2.5 | -6.2 | orotate phosphoribosyltransferase (NCBI) | compare |
| b2763 | cysI | -2.5 | -8.8 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b0741 | pal | -2.5 | -4.0 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b3960 | argH | -2.5 | -11.0 | argininosuccinate lyase (NCBI) | compare |
| b2019 | hisG | -2.5 | -4.2 | ATP phosphoribosyltransferase (NCBI) | compare |
| b2762 | cysH | -2.5 | -9.8 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b3839 | tatC | -2.4 | -5.8 | TatABCE protein translocation system subunit (NCBI) | compare |
| b3916 | pfkA | -2.4 | -3.7 | 6-phosphofructokinase (NCBI) | compare |
| b4042 | dgkA | -2.4 | -3.2 | diacylglycerol kinase (NCBI) | compare |
| b3706 | trmE | -2.4 | -8.3 | tRNA modification GTPase (NCBI) | compare |
| b0439 | lon | -2.4 | -6.2 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3957 | argE | -2.4 | -11.6 | acetylornithine deacetylase (NCBI) | compare |
| b1860 | ruvB | -2.3 | -1.7 | Holliday junction DNA helicase B (NCBI) | compare |
| b3773 | ilvY | -2.3 | -8.7 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2320 | pdxB | -2.3 | -8.1 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b0683 | fur | -2.3 | -1.1 | ferric uptake regulator (NCBI) | compare |
| b2764 | cysJ | -2.2 | -7.9 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b2188 | yejM | -2.2 | -9.6 | predicted hydrolase, inner membrane (NCBI) | compare |
| b3368 | cysG | -2.2 | -13.1 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b2784 | relA | -2.2 | -8.5 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b4202 | rpsR | -2.2 | -2.1 | 30S ribosomal protein S18 (NCBI) | compare |
| b0014 | dnaK | -2.2 | -2.1 | molecular chaperone DnaK (NCBI) | compare |
| b0889 | lrp | -2.1 | -3.9 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b1258 | yciF | -2.1 | -1.8 | hypothetical protein (NCBI) | compare |
| b2752 | cysD | -2.1 | -8.2 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b0888 | trxB | -2.1 | -4.3 | thioredoxin reductase, FAD/NAD(P)-binding (NCBI) | compare |
| b3811 | xerC | -2.1 | -1.4 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b0052 | pdxA | -2.1 | -8.2 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b1129 | phoQ | -2.1 | -2.5 | sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) | compare |
| b2479 | gcvR | -2.1 | -4.8 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b3008 | metC | -2.1 | -9.4 | cystathionine beta-lyase (NCBI) | compare |
| b3671 | ilvB | -2.1 | -12.1 | acetolactate synthase large subunit (NCBI) | compare |
| b4177 | purA | -2.1 | -1.4 | adenylosuccinate synthetase (NCBI) | compare |
| b2751 | cysN | -2.0 | -7.9 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b1264 | trpE | -2.0 | -3.1 | anthranilate synthase component I (NCBI) | compare |
| b0053 | surA | -2.0 | -5.6 | peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) | compare |
| b1677 | lpp | -1.9 | -4.5 | murein lipoprotein (NCBI) | compare |
| b0585 | fes | -1.8 | -5.5 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b3650 | spoT | -1.8 | -5.8 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b1863 | ruvC | -1.8 | -2.0 | Holliday junction resolvase (NCBI) | compare |
| b0437 | clpP | -1.8 | -5.0 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b1951 | rcsA | -1.8 | -2.4 | DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) | compare |
| b0113 | pdhR | -1.8 | -4.2 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b2340 | sixA | -1.8 | -4.6 | phosphohistidine phosphatase (NCBI) | compare |
| b1765 | ydjA | -1.7 | -1.3 | predicted oxidoreductase (NCBI) | compare |
| b2424 | cysU | -1.7 | -2.8 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2501 | ppk | -1.7 | -7.0 | polyphosphate kinase (NCBI) | compare |
| b0075 | leuL | -1.7 | -3.8 | leu operon leader peptide (NCBI) | compare |
| b2318 | truA | -1.7 | -2.0 | tRNA pseudouridine synthase A (NCBI) | compare |
| b2500 | purN | -1.7 | -6.8 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b3026 | qseC | -1.7 | -3.4 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b0200 | gmhB | -1.7 | -1.7 | hypothetical protein (NCBI) | compare |
| b2839 | lysR | -1.6 | -4.1 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2330 | yfcB | -1.6 | -2.1 | putative adenine-specific methylase (VIMSS) | compare |
| b4171 | miaA | -1.6 | -3.4 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b0890 | ftsK | -1.6 | -6.1 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b0592 | fepB | -1.6 | -6.9 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3619 | rfaD | -1.5 | -3.6 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b1292 | sapC | -1.5 | -1.7 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0161 | degP | -1.5 | -5.1 | serine endoprotease (protease Do), membrane-associated (NCBI) | compare |
| b1058 | yceO | -1.5 | -0.5 | hypothetical protein (NCBI) | compare |
| b3621 | rfaC | -1.5 | -5.0 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b4503 | yafF | -1.5 | -0.9 | no description | compare |
| b1332 | ynaJ | -1.4 | -0.7 | predicted inner membrane protein (NCBI) | compare |
| b0222 | lpcA | -1.4 | -2.3 | phosphoheptose isomerase (NCBI) | compare |
| b3398 | yrfF | -1.4 | -3.5 | predicted inner membrane protein (NCBI) | compare |
| b3204 | ptsN | -1.4 | -4.1 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b2820 | recB | -1.4 | -1.6 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b3261 | fis | -1.4 | -2.4 | DNA-binding protein Fis (NCBI) | compare |
| b0590 | fepD | -1.4 | -5.0 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2822 | recC | -1.4 | -5.9 | exonuclease V (RecBCD complex), gamma chain (NCBI) | compare |
| b0077 | ilvI | -1.4 | -8.5 | acetolactate synthase III large subunit (NCBI) | compare |
| b3781 | trxA | -1.3 | -4.1 | thioredoxin 1 (VIMSS) | compare |
| b0589 | fepG | -1.3 | -5.6 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2313 | cvpA | -1.3 | -3.1 | membrane protein required for colicin V production (NCBI) | compare |
| b4535 | yniD | -1.3 | -1.3 | predicted protein (RefSeq) | compare |
| b1709 | btuD | -1.3 | -0.9 | vitamin B12-transporter ATPase (NCBI) | compare |
| b1101 | ptsG | -1.3 | -7.2 | fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) | compare |
| b2422 | cysA | -1.3 | -5.7 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b1476 | fdnI | -1.3 | -0.9 | formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) | compare |
| b3741 | gidA | -1.2 | -4.9 | glucose-inhibited division protein A (NCBI) | compare |
| b1861 | ruvA | -1.2 | -1.3 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b3237 | argR | -1.2 | -3.1 | arginine repressor (NCBI) | compare |
| b1524 | yneH | -1.2 | -1.0 | predicted glutaminase (NCBI) | compare |
| b1949 | fliQ | -1.2 | -2.9 | flagellar biosynthesis protein Q (NCBI) | compare |
| b1103 | ycfF | -1.2 | -1.5 | orf, hypothetical protein (VIMSS) | compare |
| b4025 | pgi | -1.2 | -5.0 | glucose-6-phosphate isomerase (NCBI) | compare |
| b4520 | ymgF | -1.2 | -2.0 | hypothetical protein (NCBI) | compare |
| b2699 | recA | -1.2 | -1.4 | recombinase A (NCBI) | compare |
| b1182 | hlyE | -1.1 | -0.7 | hemolysin E (VIMSS) | compare |
| b1347 | ydaC | -1.1 | -0.4 | Rac prophage; predicted protein (NCBI) | compare |
| b2506 | yfgI | -1.1 | -1.8 | hypothetical protein (NCBI) | compare |
| b4246 | pyrL | -1.0 | -1.5 | pyrBI operon leader peptide (NCBI) | compare |
| b0149 | mrcB | -1.0 | -7.2 | penicillin-binding protein 1b (NCBI) | compare |
| b2215 | ompC | -1.0 | -4.5 | outer membrane porin protein C (NCBI) | compare |
| b1001 | yccE | -1.0 | -0.5 | hypothetical protein (NCBI) | compare |
| b0303 | ykgI | -1.0 | -0.6 | orf, hypothetical protein (VIMSS) | compare |
| b0588 | fepC | -1.0 | -3.8 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0755 | gpmA | -1.0 | -3.5 | phosphoglyceromutase (NCBI) | compare |
| b3636 | rpmG | -1.0 | -1.8 | 50S ribosomal protein L33 (NCBI) | compare |
| b3082 | ygjM | -1.0 | -1.8 | predicted DNA-binding transcriptional regulator (NCBI) | compare |
| b0928 | aspC | -1.0 | -4.4 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0078 | ilvH | -1.0 | -4.5 | acetolactate synthase small subunit (NCBI) | compare |
| b1502 | ydeQ | -1.0 | -2.7 | predicted fimbrial-like adhesin protein (NCBI) | compare |
| b2051 | wcaH | -1.0 | -1.0 | GDP-mannose mannosyl hydrolase (VIMSS) | compare |
| b0133 | panC | -1.0 | -5.3 | pantoate--beta-alanine ligase (NCBI) | conserved |
| b0088 | murD | -1.0 | -1.3 | UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) | compare |
| b4545 | ypdJ | -1.0 | -0.7 | no description | compare |
| b2285 | nuoE | -1.0 | -1.3 | NADH dehydrogenase subunit E (NCBI) | compare |
| b3213 | gltD | -1.0 | -5.6 | glutamate synthase, 4Fe-4S protein, small subunit (NCBI) | compare |
| b2683 | ygaH | -0.9 | -4.3 | predicted inner membrane protein (NCBI) | compare |
| b1138 | ymfE | -0.9 | -1.3 | e14 prophage; predicted inner membrane protein (NCBI) | compare |
| b0438 | clpX | -0.9 | -3.6 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |