Experiment set6IT054 for Escherichia coli BW25113

Compare to:

LB with D-Cycloserine 0.1 mg/ml

200 most important genes:

  gene name fitness t score description  
b0683 fur -5.8 -5.4 ferric uptake regulator (NCBI) compare
b0812 dps -5.7 -10.8 DNA protection during starvation conditions (NCBI) compare
b1105 ycfM -5.6 -6.7 predicted outer membrane lipoprotein (NCBI) compare
b0149 mrcB -5.2 -24.4 penicillin-binding protein 1b (NCBI) compare
b3863 polA -5.1 -3.5 DNA polymerase I (NCBI) compare
b2699 recA -4.6 -4.5 recombinase A (NCBI) compare
b2830 nudH -4.5 -5.2 dinucleoside polyphosphate hydrolase (NCBI) compare
b0092 ddlB -4.1 -9.9 D-alanylalanine synthetase (NCBI) compare
b2330 yfcB -3.5 -4.7 putative adenine-specific methylase (VIMSS) compare
b2290 yfbQ -3.3 -16.8 aspartate aminotransferase (NCBI) conserved
b0053 surA -3.2 -12.7 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1190 dadX -2.8 -5.7 alanine racemase (NCBI) compare
b3961 oxyR -2.7 -17.7 DNA-binding transcriptional dual regulator (NCBI) compare
b3463 ftsE -2.7 -9.6 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b2820 recB -2.7 -5.8 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b1103 ycfF -2.7 -3.6 orf, hypothetical protein (VIMSS) compare
b0381 ddlA -2.6 -10.7 D-alanylalanine synthetase (NCBI) compare
b4053 alr -2.5 -12.1 alanine racemase (NCBI) compare
b0920 ycbC -2.5 -6.9 conserved inner membrane protein (NCBI) compare
b1634 tppB -2.4 -10.7 putative tripeptide transporter permease (NCBI) compare
b3405 ompR -2.3 -10.5 osmolarity response regulator (NCBI) compare
b3792 wzxE -2.3 -11.8 O-antigen translocase (NCBI) compare
b0889 lrp -2.2 -7.0 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b3163 nlpI -2.2 -8.0 hypothetical protein (NCBI) compare
b3121 yhaC -2.1 -2.7 hypothetical protein (NCBI) compare
b0439 lon -2.1 -7.7 DNA-binding ATP-dependent protease La (NCBI) compare
b3462 ftsX -2.1 -8.9 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b4375 prfC -2.0 -11.0 peptide chain release factor 3 (NCBI) compare
b1830 prc -2.0 -10.9 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b0741 pal -2.0 -6.7 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0740 tolB -2.0 -8.8 translocation protein TolB precursor (NCBI) compare
b0500 ybbD -2.0 -3.4 hypothetical protein (RefSeq) compare
b1499 ydeO -2.0 -3.7 predicted DNA-binding transcriptional acfivator (NCBI) compare
b3725 pstB -2.0 -5.1 phosphate transporter subunit (NCBI) compare
b2822 recC -2.0 -6.3 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b0739 tolA -1.9 -8.0 cell envelope integrity inner membrane protein TolA (NCBI) compare
b0200 gmhB -1.9 -3.2 hypothetical protein (NCBI) compare
b1863 ruvC -1.9 -5.3 Holliday junction resolvase (NCBI) compare
b3483 yhhH -1.8 -3.1 orf, hypothetical protein (VIMSS) compare
b3613 yibP -1.7 -10.0 putative membrane protein (VIMSS) compare
b3728 pstS -1.7 -7.0 phosphate transporter subunit (NCBI) compare
b2894 xerD -1.7 -3.5 site-specific tyrosine recombinase XerD (NCBI) compare
b0737 tolQ -1.6 -5.0 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3162 deaD -1.6 -6.6 inducible ATP-independent RNA helicase (VIMSS) compare
b2392 mntH -1.6 -8.9 manganese transport protein MntH (NCBI) compare
b0603 ybdO -1.5 -3.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1505 ydeT -1.5 -5.9 hypothetical protein (RefSeq) compare
b1545 pinQ -1.5 -2.6 Qin prophage; predicted site-specific recombinase (NCBI) compare
b1749 xthA -1.5 -5.0 exonuclease III (NCBI) conserved
b4704 arrS -1.5 -3.1 Antisense sRNA ArrS, function unknown (NCBI) compare
b2853 ygeI -1.4 -3.5 hypothetical protein (NCBI) compare
b3390 aroK -1.4 -3.9 shikimate kinase I (NCBI) compare
b0237 pepD -1.4 -9.3 aminoacyl-histidine dipeptidase (peptidase D) (NCBI) compare
b1861 ruvA -1.4 -4.4 Holliday junction DNA helicase motor protein (NCBI) compare
b1257 yciE -1.4 -4.3 hypothetical protein (NCBI) compare
b3442 yhhZ -1.3 -2.4 hypothetical protein (NCBI) compare
b2379 yfdZ -1.3 -7.8 hypothetical protein (NCBI) conserved
b1176 minC -1.3 -6.6 septum formation inhibitor (NCBI) compare
b2297 pta -1.3 -2.9 phosphate acetyltransferase (NCBI) compare
b4128 yjdK -1.3 -5.5 hypothetical protein (NCBI) compare
b4497 yeeL -1.3 -4.6 no description compare
b1693 aroD -1.2 -7.3 3-dehydroquinate dehydratase (NCBI) compare
b2847 yqeI -1.2 -6.2 predicted transcriptional regulator (NCBI) compare
b1347 ydaC -1.2 -1.8 Rac prophage; predicted protein (NCBI) compare
b0738 tolR -1.2 -4.6 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1175 minD -1.2 -4.9 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b0630 lipB -1.2 -3.1 protein of lipoate biosynthesis (VIMSS) compare
b3839 tatC -1.2 -8.6 TatABCE protein translocation system subunit (NCBI) compare
b3813 uvrD -1.2 -9.3 DNA-dependent ATPase I and helicase II (NCBI) compare
b4171 miaA -1.2 -7.0 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b3652 recG -1.2 -8.7 ATP-dependent DNA helicase (NCBI) compare
b4253 yjgL -1.1 -5.0 orf, hypothetical protein (VIMSS) compare
b1497 b1497 -1.1 -3.6 putative enzyme (VIMSS) compare
b0310 ykgH -1.1 -4.6 predicted inner membrane protein (NCBI) compare
b4202 rpsR -1.1 -2.7 30S ribosomal protein S18 (NCBI) compare
b3512 GadE -1.1 -3.0 acid-responsive regulator of gadA and gadBC (Katherine Huang) compare
b3281 aroE -1.1 -9.6 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b0145 dksA -1.1 -4.5 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b1409 ynbB -1.1 -4.0 predicted CDP-diglyceride synthase (NCBI) compare
b3341 rpsG -1.1 -1.9 30S ribosomal protein S7 (NCBI) compare
b1095 fabF -1.1 -6.4 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2110 yehC -1.1 -4.7 predicted periplasmic pilin chaperone (NCBI) compare
b0232 yafN -1.1 -1.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3404 envZ -1.1 -6.8 osmolarity sensor protein (NCBI) compare
b4651 yibW -1.1 -1.6 no description compare
b0114 aceE -1.1 -4.3 pyruvate dehydrogenase subunit E1 (NCBI) compare
b3205 yhbJ -1.1 -4.7 hypothetical protein (NCBI) compare
b1323 tyrR -1.1 -6.3 DNA-binding transcriptional dual regulator, tyrosine-binding (NCBI) compare
b4279 yjhB -1.0 -2.8 putative transport protein (VIMSS) compare
b3935 priA -1.0 -1.3 primosome assembly protein PriA (NCBI) compare
b2111 yehD -1.0 -2.3 predicted fimbrial-like adhesin protein (NCBI) compare
b0472 recR -1.0 -7.9 recombination protein RecR (NCBI) compare
b1001 yccE -1.0 -2.7 hypothetical protein (NCBI) compare
b0726 sucA -1.0 -4.1 alpha-ketoglutarate decarboxylase (NCBI) compare
b0890 ftsK -1.0 -6.8 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b0279 yagM -1.0 -4.4 CP4-6 prophage; predicted protein (NCBI) compare
b0118 acnB -1.0 -3.7 aconitate hydratase (NCBI) compare
b1097 yceG -1.0 -6.0 predicted aminodeoxychorismate lyase (NCBI) compare
b1167 ymgC -1.0 -1.6 hypothetical protein (NCBI) compare
b1814 sdaA -1.0 -4.2 L-serine deaminase I (NCBI) compare
b2366 dsdA -1.0 -4.9 D-serine dehydratase (NCBI) compare
b3206 npr -1.0 -3.3 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b0585 fes -0.9 -5.8 enterobactin/ferric enterobactin esterase (NCBI) compare
b3727 pstC -0.9 -5.0 phosphate transporter subunit (NCBI) compare
b3504 yhiS -0.9 -2.3 hypothetical protein (RefSeq) compare
b0303 ykgI -0.9 -2.4 orf, hypothetical protein (VIMSS) compare
b1058 yceO -0.9 -1.5 hypothetical protein (NCBI) compare
b4000 hupA -0.9 -5.0 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b2625 yfjI -0.9 -4.0 CP4-57 prophage; predicted protein (NCBI) compare
b3636 rpmG -0.9 -1.8 50S ribosomal protein L33 (NCBI) compare
b1363 trkG -0.9 -3.9 Rac prophage; potassium transporter subunit (NCBI) compare
b3764 yifE -0.9 -5.0 hypothetical protein (NCBI) compare
b4480 hdfR -0.9 -4.7 transcriptional regulator HdfR (NCBI) compare
b3120 yhaB -0.9 -2.6 orf, hypothetical protein (VIMSS) compare
b3027 ygiZ -0.9 -2.0 conserved inner membrane protein (NCBI) compare
b2829 ptsP -0.9 -7.2 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b2055 wcaE -0.9 -3.1 predicted glycosyl transferase (NCBI) compare
b1576 ydfD -0.9 -2.1 Qin prophage; predicted protein (NCBI) compare
b1831 proQ -0.9 -2.2 putative solute/DNA competence effector (NCBI) compare
b2565 recO -0.8 -5.8 DNA repair protein RecO (NCBI) compare
b3933 ftsN -0.8 -6.6 essential cell division protein (NCBI) compare
b4685 yrbN -0.8 -2.1 expressed protein (RefSeq) compare
b2859 ygeO -0.8 -2.1 hypothetical protein (RefSeq) compare
b2947 gshB -0.8 -3.4 glutathione synthetase (NCBI) compare
b1104 ycfL -0.8 -1.0 hypothetical protein (NCBI) compare
b3726 pstA -0.8 -4.2 phosphate transporter subunit (NCBI) compare
b1730 ydjO -0.8 -1.7 predicted protein (RefSeq) compare
b2935 tktA -0.8 -3.9 transketolase 1, thiamin-binding (NCBI) compare
b1290 sapF -0.8 -1.6 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2363 yfdT -0.8 -2.4 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b4201 priB -0.8 -3.4 primosomal replication protein N (NCBI) compare
b4017 arpA -0.8 -4.0 regulator of acetyl CoA synthetase (NCBI) compare
b2350 yfdG -0.8 -3.8 CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) (NCBI) compare
b2642 yfjW -0.8 -1.3 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b2951 yggS -0.8 -3.3 predicted enzyme (NCBI) compare
b4172 hfq -0.7 -1.6 RNA-binding protein Hfq (NCBI) compare
b2512 yfgL -0.7 -5.0 protein assembly complex, lipoprotein component (NCBI) compare
b3237 argR -0.7 -4.7 arginine repressor (NCBI) compare
b4558 yifL -0.7 -2.6 predicted lipoprotein (NCBI) compare
b3700 recF -0.7 -5.7 recombination protein F (NCBI) compare
b0143 pcnB -0.7 -4.8 poly(A) polymerase I (VIMSS) compare
b0494 tesA -0.7 -3.4 multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 (NCBI) compare
b2652 ileY -0.7 -2.4 tRNA-Ile (NCBI) compare
b0326 yahL -0.7 -4.2 hypothetical protein (NCBI) compare
b4590 ybfK -0.7 -2.9 hypothetical protein (RefSeq) compare
b1161 ycgX -0.7 -0.8 hypothetical protein (NCBI) compare
b3871 bipA -0.7 -5.9 GTP-binding protein (NCBI) compare
b3609 secB -0.7 -2.3 export protein SecB (NCBI) compare
b4345 mcrC -0.7 -1.9 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC (NCBI) compare
b1860 ruvB -0.7 -1.5 Holliday junction DNA helicase B (NCBI) compare
b3811 xerC -0.7 -3.2 site-specific tyrosine recombinase XerC (NCBI) compare
b0564 appY -0.7 -1.0 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b3183 obgE -0.7 -1.6 GTPase involved in cell partioning and DNA repair (NCBI) compare
b2617 smpA -0.7 -3.7 small membrane protein A (VIMSS) compare
b2937 speB -0.7 -4.8 agmatinase (NCBI) compare
b3047 yqiH -0.7 -4.1 putative membrane protein (VIMSS) compare
b1548 nohA -0.7 -2.8 Qin prophage; predicted packaging protein (RefSeq) compare
b3386 rpe -0.7 -2.4 ribulose-phosphate 3-epimerase (NCBI) compare
b2288 nuoA -0.7 -2.7 NADH dehydrogenase I chain A (VIMSS) compare
b1160 elbA -0.7 -1.6 hypothetical protein (NCBI) compare
b2650 ypjC -0.7 -1.3 hypothetical protein (RefSeq) compare
b4631 ykgQ -0.7 -1.6 no description compare
b1407 ydbD -0.7 -4.4 orf, hypothetical protein (VIMSS) compare
b0407 yajC -0.7 -1.7 preprotein translocase subunit YajC (NCBI) compare
b2620 smpB -0.7 -2.3 SsrA-binding protein (NCBI) compare
b1121 ycfZ -0.7 -3.4 predicted inner membrane protein (NCBI) compare
b1286 rnb -0.7 -3.0 exoribonuclease II (NCBI) compare
b4494 arpB -0.7 -3.6 no description compare
b2778 ygcG -0.7 -3.4 orf, hypothetical protein (VIMSS) compare
b2501 ppk -0.6 -5.0 polyphosphate kinase (NCBI) compare
b3940 metL -0.6 -4.0 bifunctional aspartate kinase II/homoserine dehydrogenase II (NCBI) compare
b2895 fldB -0.6 -2.5 flavodoxin 2 (NCBI) compare
b3622 rfaL -0.6 -4.7 O-antigen ligase (NCBI) compare
b3649 rpoZ -0.6 -2.2 DNA-directed RNA polymerase subunit omega (NCBI) compare
b2352 yfdI -0.6 -2.3 CPS-53 (KpLE1) prophage; predicted inner membrane protein (NCBI) compare
b2910 zapA -0.6 -3.4 protein that localizes to the cytokinetic ring (NCBI) compare
b2618 b2618 -0.6 -2.8 orf, hypothetical protein (VIMSS) compare
b1368 ynaA -0.6 -2.6 Rac prophage; predicted tail protein (RefSeq) compare
b2291 yfbR -0.6 -1.6 hypothetical protein (NCBI) compare
b0294 ykgK -0.6 -2.6 predicted regulator (NCBI) compare
b2513 yfgM -0.6 -1.6 hypothetical protein (NCBI) compare
b1258 yciF -0.6 -3.0 hypothetical protein (NCBI) compare
b0742 ybgF -0.6 -3.7 hypothetical protein (NCBI) compare
b2576 srmB -0.6 -2.8 ATP-dependent RNA helicase (NCBI) compare
b3021 ygiT -0.6 -1.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b4552 yrhC -0.6 -1.0 no description compare
b4177 purA -0.6 -2.5 adenylosuccinate synthetase (NCBI) compare
b1690 ydiM -0.6 -3.9 predicted transporter (NCBI) compare
b2734 pphB -0.6 -3.3 serine/threonine-specific protein phosphatase 2 (NCBI) compare
b0787 ybhM -0.6 -3.3 conserved inner membrane protein (NCBI) compare
b0300 ykgA -0.6 -3.2 putative ARAC-type regulatory protein (VIMSS) compare
b3026 qseC -0.6 -3.4 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b2892 recJ -0.6 -4.0 ssDNA exonuclease, 5' --> 3'-specific (NCBI) compare
b0028 fkpB -0.6 -1.2 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) (NCBI) compare
b0082 mraW -0.6 -3.0 S-adenosyl-methyltransferase (NCBI) compare
b1951 rcsA -0.6 -2.9 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b2683 ygaH -0.6 -2.9 predicted inner membrane protein (NCBI) compare
b3742 mioC -0.6 -3.4 flavodoxin (NCBI) compare
b1159 mcrA -0.5 -1.6 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b1540 ydfH -0.5 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare


Specific Phenotypes

For 8 genes in this experiment

For stress D-Cycloserine in Escherichia coli BW25113

For stress D-Cycloserine across organisms