Experiment set67S67 for Escherichia coli BW25113

Compare to:

Guanosine 0.35306 mM carbon source

200 most important genes:

  gene name fitness t score description  
b1192 ldcA -7.5 -10.3 L,D-carboxypeptidase A (NCBI) compare
b3839 tatC -2.9 -9.2 TatABCE protein translocation system subunit (NCBI) compare
b2168 fruK -2.7 -2.4 1-phosphofructokinase (NCBI) compare
b1765 ydjA -2.6 -1.4 predicted oxidoreductase (NCBI) compare
b2282 nuoH -2.6 -4.5 NADH dehydrogenase subunit H (NCBI) compare
b0145 dksA -2.5 -3.0 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0990 cspG -2.4 -1.5 DNA-binding transcriptional regulator (NCBI) compare
b1261 trpB -2.4 -2.3 tryptophan synthase subunit beta (NCBI) compare
b2838 lysA -2.4 -9.0 diaminopimelate decarboxylase, PLP-binding (NCBI) compare
b1361 ydaW -2.3 -0.9 orf, hypothetical protein (VIMSS) compare
b0386 proC -2.3 -5.0 pyrroline-5-carboxylate reductase (NCBI) compare
b1291 sapD -2.3 -2.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b4383 deoB -2.3 -7.8 phosphopentomutase (NCBI) compare
b2518 ndk -2.2 -2.4 nucleoside diphosphate kinase (NCBI) compare
b3172 argG -2.2 -8.5 argininosuccinate synthase (NCBI) compare
b1524 yneH -2.1 -1.3 predicted glutaminase (NCBI) compare
b0071 leuD -2.1 -5.6 isopropylmalate isomerase small subunit (NCBI) compare
b3389 aroB -2.1 -8.9 3-dehydroquinate synthase (NCBI) compare
b2752 cysD -2.1 -5.3 sulfate adenylyltransferase subunit 2 (NCBI) compare
b3941 metF -2.0 -6.1 5,10-methylenetetrahydrofolate reductase (NCBI) compare
b1860 ruvB -2.0 -1.4 Holliday junction DNA helicase B (NCBI) compare
b3870 glnA -2.0 -1.9 glutamine synthetase (NCBI) compare
b0033 carB -2.0 -10.5 carbamoyl-phosphate synthase large subunit (NCBI) compare
b0002 thrA -2.0 -10.4 bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) compare
b2329 aroC -1.9 -5.6 chorismate synthase (NCBI) compare
b3958 argC -1.9 -10.6 N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) compare
b2414 cysK -1.9 -8.2 cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) compare
b3281 aroE -1.9 -11.3 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b2021 hisC -1.9 -2.8 histidinol-phosphate aminotransferase (NCBI) compare
b3772 ilvA -1.9 -9.1 threonine dehydratase (NCBI) compare
b4013 metA -1.9 -6.2 homoserine O-succinyltransferase (NCBI) compare
b3957 argE -1.9 -9.5 acetylornithine deacetylase (NCBI) compare
b3771 ilvD -1.9 -10.5 dihydroxy-acid dehydratase (NCBI) compare
b3770 ilvE -1.9 -8.4 branched-chain amino acid aminotransferase (NCBI) compare
b1332 ynaJ -1.9 -1.0 predicted inner membrane protein (NCBI) compare
b4384 deoD -1.9 -7.3 purine nucleoside phosphorylase (NCBI) compare
b3368 cysG -1.8 -11.2 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) compare
b0074 leuA -1.8 -8.1 2-isopropylmalate synthase (NCBI) compare
b0740 tolB -1.8 -5.3 translocation protein TolB precursor (NCBI) compare
b2818 argA -1.8 -6.8 N-acetylglutamate synthase (NCBI) compare
b1259 yciG -1.8 -1.6 orf, hypothetical protein (VIMSS) compare
b4388 serB -1.8 -6.2 3-phosphoserine phosphatase (NCBI) compare
b3960 argH -1.8 -8.8 argininosuccinate lyase (NCBI) compare
b1693 aroD -1.8 -5.7 3-dehydroquinate dehydratase (NCBI) compare
b0907 serC -1.8 -5.0 phosphoserine aminotransferase (NCBI) compare
b0072 leuC -1.8 -8.0 isopropylmalate isomerase large subunit (NCBI) compare
b3774 ilvC -1.8 -10.0 ketol-acid reductoisomerase (NCBI) compare
b2020 hisD -1.8 -7.6 histidinol dehydrogenase (NCBI) compare
b3959 argB -1.8 -7.8 acetylglutamate kinase (RefSeq) compare
b0073 leuB -1.8 -7.1 3-isopropylmalate dehydrogenase (VIMSS) compare
b2764 cysJ -1.8 -7.3 sulfite reductase, alpha subunit, flavoprotein (NCBI) compare
b0934 ycbM -1.8 -3.8 putative transport system permease protein (VIMSS) compare
b2025 hisF -1.7 -4.5 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b0738 tolR -1.7 -3.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2019 hisG -1.7 -3.5 ATP phosphoribosyltransferase (NCBI) compare
b2600 tyrA -1.7 -5.4 fused chorismate mutase T/prephenate dehydrogenase (NCBI) compare
b2288 nuoA -1.7 -3.2 NADH dehydrogenase I chain A (VIMSS) compare
b2762 cysH -1.7 -5.1 phosphoadenosine phosphosulfate reductase (NCBI) compare
b2913 serA -1.7 -6.2 D-3-phosphoglycerate dehydrogenase (NCBI) compare
b0722 sdhD -1.7 -4.2 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b0032 carA -1.6 -5.7 carbamoyl-phosphate synthase small subunit (NCBI) compare
b2423 cysW -1.6 -4.4 sulfate/thiosulfate transporter subunit (NCBI) compare
b0243 proA -1.6 -5.7 gamma-glutamyl phosphate reductase (NCBI) compare
b0726 sucA -1.6 -4.2 alpha-ketoglutarate decarboxylase (NCBI) compare
b0438 clpX -1.6 -4.9 ATP-dependent protease ATP-binding subunit (NCBI) compare
b2022 hisB -1.6 -4.9 imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) compare
b0004 thrC -1.6 -5.4 threonine synthase (NCBI) compare
b4631 ykgQ -1.5 -1.4 no description compare
b1062 pyrC -1.5 -5.4 dihydroorotase (NCBI) compare
b3956 ppc -1.5 -9.1 phosphoenolpyruvate carboxylase (NCBI) compare
b0003 thrB -1.5 -4.2 homoserine kinase (NCBI) compare
b2839 lysR -1.5 -3.9 DNA-binding transcriptional dual regulator (NCBI) compare
b0953 rmf -1.5 -2.9 ribosome modulation factor (NCBI) compare
b0908 aroA -1.5 -6.7 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b0889 lrp -1.5 -3.5 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b4163 glyV -1.4 -1.6 tRNA-Gly (NCBI) compare
b2599 pheA -1.4 -3.9 fused chorismate mutase P/prephenate dehydratase (NCBI) compare
b4695 ykgT -1.4 -2.7 no description compare
b1260 trpA -1.4 -2.6 tryptophan synthase subunit alpha (NCBI) compare
b1660 ydhC -1.4 -4.1 predicted transporter (NCBI) compare
b2751 cysN -1.4 -4.7 sulfate adenylyltransferase subunit 1 (NCBI) compare
b1841 yobA -1.4 -2.0 hypothetical protein (NCBI) compare
b1235 rssB -1.4 -5.2 response regulator of RpoS (NCBI) compare
b3939 metB -1.4 -6.6 cystathionine gamma-synthase (NCBI) compare
b3790 rffC -1.4 -3.5 TDP-fucosamine acetyltransferase (RefSeq) compare
b2763 cysI -1.4 -6.3 sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) compare
b0242 proB -1.4 -4.2 gamma-glutamyl kinase (NCBI) compare
b1837 yebW -1.4 -2.1 orf, hypothetical protein (VIMSS) compare
b0720 gltA -1.3 -3.5 citrate synthase (NCBI) compare
b2424 cysU -1.3 -2.1 sulfate/thiosulfate transporter subunit (NCBI) compare
b2846 yqeH -1.3 -0.8 orf, hypothetical protein (VIMSS) compare
b2784 relA -1.3 -6.5 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b2750 cysC -1.3 -3.7 adenylylsulfate kinase (NCBI) compare
b2377 yfdY -1.3 -3.4 predicted inner membrane protein (NCBI) compare
b2579 yfiD -1.3 -2.0 pyruvate formate lyase subunit (NCBI) compare
b4535 yniD -1.3 -1.2 predicted protein (RefSeq) compare
b4603 rseX -1.3 -0.8 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b3672 ivbL -1.3 -2.9 ilvB operon leader peptide (NCBI) compare
b2276 nuoN -1.3 -3.8 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b1281 pyrF -1.3 -2.2 orotidine 5'-phosphate decarboxylase (NCBI) compare
b3792 wzxE -1.3 -5.1 O-antigen translocase (NCBI) compare
b0437 clpP -1.3 -4.8 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b0739 tolA -1.2 -3.4 cell envelope integrity inner membrane protein TolA (NCBI) compare
b2567 rnc -1.2 -0.8 ribonuclease III (NCBI) compare
b3642 pyrE -1.2 -2.9 orotate phosphoribosyltransferase (NCBI) compare
b3008 metC -1.2 -6.5 cystathionine beta-lyase (NCBI) compare
b3761 trpT -1.2 -1.7 tRNA-Trp (NCBI) compare
b0200 gmhB -1.2 -1.8 hypothetical protein (NCBI) compare
b2597 yfiA -1.2 -1.7 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b2964 nupG -1.2 -6.6 transport of nucleosides, permease protein (VIMSS) compare
b2281 nuoI -1.2 -2.1 NADH dehydrogenase subunit I (NCBI) compare
b0232 yafN -1.2 -0.6 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b1298 ycjL -1.2 -2.7 probable amidotransferase subunit (VIMSS) compare
b2278 nuoL -1.2 -5.5 NADH dehydrogenase subunit L (NCBI) compare
b3671 ilvB -1.2 -7.2 acetolactate synthase large subunit (NCBI) compare
b2422 cysA -1.2 -4.2 sulfate/thiosulfate transporter subunit (NCBI) compare
b1290 sapF -1.2 -1.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3791 rffA -1.2 -4.3 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b0888 trxB -1.2 -3.0 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b2283 nuoG -1.2 -4.6 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b3838 tatB -1.1 -3.4 sec-independent translocase (NCBI) compare
b3613 yibP -1.1 -3.6 putative membrane protein (VIMSS) compare
b2318 truA -1.1 -3.1 tRNA pseudouridine synthase A (NCBI) compare
b2188 yejM -1.1 -6.3 predicted hydrolase, inner membrane (NCBI) compare
b2279 nuoK -1.1 -1.4 NADH dehydrogenase subunit K (NCBI) compare
b2280 nuoJ -1.1 -3.9 NADH dehydrogenase subunit J (NCBI) compare
b2479 gcvR -1.1 -3.7 transcriptional regulation of gcv operon (VIMSS) compare
b4018 iclR -1.1 -5.6 repressor of aceBA operon (VIMSS) compare
b2023 hisH -1.1 -3.0 imidazole glycerol phosphate synthase subunit HisH (NCBI) compare
b1217 chaB -1.0 -1.0 cation transport regulator (NCBI) compare
b1232 purU -1.0 -3.6 formyltetrahydrofolate deformylase (NCBI) compare
b1503 ydeR -1.0 -2.2 predicted fimbrial-like adhesin protein (NCBI) compare
b0075 leuL -1.0 -3.7 leu operon leader peptide (NCBI) compare
b1659 ydhB -1.0 -2.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1399 paaX -1.0 -3.6 DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive (NCBI) compare
b2258 b2258 -1.0 -1.0 putative transport/receptor protein (VIMSS) compare
b4481 rffT -1.0 -4.2 4-alpha-L-fucosyltransferase (NCBI) compare
b3500 gor -1.0 -1.3 glutathione reductase (NCBI) compare
b4410 ecnA -1.0 -1.1 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b4191 ulaR -1.0 -3.1 DNA-binding transcriptional dual regulator (NCBI) compare
b2286 nuoC -1.0 -3.1 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b3773 ilvY -1.0 -4.6 DNA-binding transcriptional dual regulator (NCBI) compare
b4416 rybA -1.0 -1.2 unknown RNA (NCBI) compare
b1582 ynfA -1.0 -1.1 hypothetical protein (NCBI) compare
b0945 pyrD -1.0 -4.7 dihydroorotate dehydrogenase (NCBI) compare
b1709 btuD -1.0 -0.5 vitamin B12-transporter ATPase (NCBI) compare
b3650 spoT -0.9 -3.2 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) compare
b3935 priA -0.9 -2.0 primosome assembly protein PriA (NCBI) compare
b3237 argR -0.9 -2.8 arginine repressor (NCBI) compare
b1262 trpC -0.9 -3.6 N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) compare
b3912 cpxR -0.9 -4.1 DNA-binding response regulator in two-component regulatory system with CpxA (NCBI) compare
b2532 yfhQ -0.9 -2.9 predicted methyltransferase (NCBI) compare
b3658 selC -0.9 -2.2 tRNA-Sec (NCBI) compare
b1790 yeaM -0.9 -1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b4179 vacB -0.9 -3.8 putative enzyme (VIMSS) compare
b3484 yhhI -0.9 -1.1 predicted transposase (NCBI) compare
b0390 aroM -0.9 -3.7 hypothetical protein (NCBI) compare
b2287 nuoB -0.9 -1.6 NADH dehydrogenase subunit B (NCBI) compare
b3806 cyaA -0.9 -3.0 adenylate cyclase (NCBI) compare
b2285 nuoE -0.9 -1.4 NADH dehydrogenase subunit E (NCBI) compare
b4676 yoaK -0.9 -0.4 expressed protein (RefSeq) compare
b2475 ypfJ -0.9 -4.1 hypothetical protein (NCBI) compare
b0407 yajC -0.9 -1.7 preprotein translocase subunit YajC (NCBI) compare
b1600 mdtJ -0.8 -1.4 multidrug efflux system transporter (NCBI) compare
b1263 trpD -0.8 -1.9 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b1103 ycfF -0.8 -1.0 orf, hypothetical protein (VIMSS) compare
b1827 kdgR -0.8 -1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b0723 sdhA -0.8 -4.8 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b3203 yhbH -0.8 -1.7 predicted ribosome-associated, sigma 54 modulation protein (NCBI) compare
b3728 pstS -0.8 -1.8 phosphate transporter subunit (NCBI) compare
b0428 cyoE -0.8 -3.6 protoheme IX farnesyltransferase (NCBI) compare
b1346 ydaQ -0.8 -1.2 orf, hypothetical protein (VIMSS) compare
b2343 b2343 -0.8 -1.3 orf, hypothetical protein (VIMSS) compare
b4509 ylcG -0.8 -1.7 DLP12 prophage; predicted protein (NCBI) compare
b2902 ygfF -0.8 -2.7 predicted NAD(P)-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain (NCBI) compare
b1360 ydaV -0.8 -1.3 Rac prophage; predicted DNA replication protein (NCBI) compare
b0964 yccT -0.8 -2.7 hypothetical protein (NCBI) compare
b0440 hupB -0.8 -2.7 HU, DNA-binding transcriptional regulator, beta subunit (NCBI) compare
b1854 pykA -0.7 -3.4 pyruvate kinase (NCBI) compare
b2026 hisI -0.7 -3.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) compare
b4414 tff -0.7 -1.4 unknown RNA (NCBI) compare
b1085 b1085 -0.7 -1.3 orf, hypothetical protein (VIMSS) compare
b1874 cutC -0.7 -1.4 copper homeostasis protein (NCBI) compare
b4048 yjbM -0.7 -0.5 hypothetical protein (NCBI) compare
b0471 ybaB -0.7 -1.7 hypothetical protein (NCBI) compare
b4529 ydbJ -0.7 -0.8 hypothetical protein (NCBI) compare
b1518 lsrG -0.7 -1.3 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b4582 yoeA -0.7 -1.6 no description compare
b1523 yneG -0.7 -1.2 hypothetical protein (NCBI) compare
b2912 ygfA -0.7 -2.1 putative ligase (VIMSS) compare
b1357 ydaS -0.7 -1.2 Rac prophage; predicted DNA-binding transcriptional regulator (NCBI) compare
b3213 gltD -0.7 -3.7 glutamate synthase, 4Fe-4S protein, small subunit (NCBI) compare
b3889 yiiE -0.7 -1.5 predicted transcriptional regulator (RefSeq) compare
b1271 yciK -0.7 -1.0 short chain dehydrogenase (NCBI) compare
b3916 pfkA -0.7 -1.8 6-phosphofructokinase (NCBI) compare
b1548 nohA -0.7 -1.3 Qin prophage; predicted packaging protein (RefSeq) compare
b2792 yqcC -0.7 -1.3 hypothetical protein (NCBI) compare
b0724 sdhB -0.7 -2.4 succinate dehydrogenase, FeS subunit (NCBI) compare
b0435 bolA -0.7 -2.3 possible regulator of murein genes (VIMSS) compare
b1836 yebV -0.7 -2.0 orf, hypothetical protein (VIMSS) compare


Specific Phenotypes

For 22 genes in this experiment

For carbon source Guanosine in Escherichia coli BW25113

For carbon source Guanosine across organisms