Experiment set65S22 for Escherichia coli BW25113

Compare to:

Ste41

200 most detrimental genes:

  gene name fitness t score description  
b1334 fnr +7.0 18.4 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b1256 ompW +7.0 50.6 outer membrane protein W (NCBI) compare
b3632 rfaQ +6.0 52.5 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3625 rfaY +5.8 28.4 lipopolysaccharide core biosynthesis protein (NCBI) compare
b1236 galU +5.7 28.9 glucose-1-phosphate uridylyltransferase (NCBI) compare
b0688 pgm +5.6 18.9 phosphoglucomutase (NCBI) compare
b0222 lpcA +5.6 14.7 phosphoheptose isomerase (NCBI) compare
b3842 rfaH +5.6 30.5 transcriptional activator RfaH (NCBI) compare
b3620 rfaF +5.4 27.3 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b3619 rfaD +5.3 20.2 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3052 rfaE +5.1 26.0 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3630 rfaP +5.0 39.7 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b3621 rfaC +5.0 27.8 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b3631 rfaG +4.9 43.3 glucosyltransferase I (NCBI) compare
b1222 narX +4.9 9.3 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b0200 gmhB +4.9 6.6 hypothetical protein (NCBI) compare
b3627 rfaI +4.7 32.0 UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase (NCBI) compare
b4239 treC +4.6 12.3 trehalose-6-P hydrolase (NCBI) compare
b3628 rfaB +4.0 27.9 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase (RefSeq) compare
b2512 yfgL +3.8 14.9 protein assembly complex, lipoprotein component (NCBI) compare
b4177 purA +3.5 6.0 adenylosuccinate synthetase (NCBI) compare
b4313 fimE +3.4 20.2 tyrosine recombinase/inversion of on/off regulator of fimA (NCBI) compare
b3867 hemN +3.1 22.6 O2-independent coproporphyrinogen III oxidase (VIMSS) compare
b3398 yrfF +3.0 10.9 predicted inner membrane protein (NCBI) compare
b4451 ryhB +3.0 2.4 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b0437 clpP +2.9 12.6 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1855 lpxM +2.8 8.9 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b4178 yjeB +2.8 12.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b2531 iscR +2.6 2.7 DNA-binding transcriptional repressor (NCBI) compare
b3609 secB +2.5 5.5 export protein SecB (NCBI) compare
b2215 ompC +2.5 10.1 outer membrane porin protein C (NCBI) compare
b2808 gcvA +2.5 7.6 DNA-binding transcriptional dual regulator (NCBI) compare
b3860 dsbA +2.4 14.9 periplasmic protein disulfide isomerase I (NCBI) compare
b0438 clpX +2.4 12.6 ATP-dependent protease ATP-binding subunit (NCBI) compare
b2684 mprA +2.2 5.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b1659 ydhB +2.2 3.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b1235 rssB +2.2 11.5 response regulator of RpoS (NCBI) compare
b1643 ydhI +2.2 4.4 predicted inner membrane protein (NCBI) compare
b4675 yoaJ +2.1 4.2 expressed protein (RefSeq) compare
b1084 rne +2.1 6.1 fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) compare
b3778 rep +2.1 14.1 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b0782 moaB +2.0 3.4 molybdopterin biosynthesis protein B (NCBI) compare
b1185 dsbB +2.0 4.7 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b1556 b1556 +2.0 4.1 orf, hypothetical protein (VIMSS) compare
b0683 fur +1.9 1.8 ferric uptake regulator (NCBI) compare
b3164 pnp +1.9 4.6 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b2498 upp +1.9 3.9 uracil phosphoribosyltransferase (VIMSS) compare
b0143 pcnB +1.8 6.3 poly(A) polymerase I (VIMSS) compare
b3725 pstB +1.8 1.7 phosphate transporter subunit (NCBI) compare
b4529 ydbJ +1.8 1.0 hypothetical protein (NCBI) compare
b0739 tolA +1.8 5.0 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3387 dam +1.8 13.4 DNA adenine methylase (NCBI) compare
b4415 hokE +1.7 4.4 toxic polypeptide, small (NCBI) compare
b0279 yagM +1.7 1.9 CP4-6 prophage; predicted protein (NCBI) compare
b1346 ydaQ +1.7 2.0 orf, hypothetical protein (VIMSS) compare
b1902 yecI +1.7 5.3 predicted ferritin-like protein (NCBI) compare
b0740 tolB +1.7 5.7 translocation protein TolB precursor (NCBI) compare
b1758 b1758 +1.6 1.0 putative cytochrome oxidase (VIMSS) compare
b4426 isrA +1.6 2.6 unknown RNA (NCBI) compare
b1293 sapB +1.6 1.6 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1130 phoP +1.6 2.7 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b1040 csgD +1.6 3.1 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b0145 dksA +1.6 3.4 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0460 hha +1.6 5.5 modulator of gene expression, with H-NS (NCBI) compare
b3806 cyaA +1.6 5.4 adenylate cyclase (NCBI) compare
b1263 trpD +1.6 2.3 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b1754 b1754 +1.6 1.8 orf, hypothetical protein (VIMSS) compare
b4490 efeU +1.5 5.2 no description compare
b0998 torD +1.5 0.9 chaperone protein TorD (NCBI) compare
b3290 trkA +1.5 3.3 potassium transporter peripheral membrane component (NCBI) compare
b4215 ytfI +1.5 2.6 hypothetical protein (NCBI) compare
b1001 yccE +1.5 0.6 hypothetical protein (NCBI) compare
b1182 hlyE +1.5 0.7 hemolysin E (VIMSS) compare
b1257 yciE +1.5 0.5 hypothetical protein (NCBI) compare
b1167 ymgC +1.5 0.5 hypothetical protein (NCBI) compare
b1961 dcm +1.5 1.3 DNA cytosine methylase (NCBI) compare
b4408 csrB +1.5 2.6 CsrA-binding sRNA, antagonizing CsrA regulation (NCBI) compare
b1347 ydaC +1.5 0.4 Rac prophage; predicted protein (NCBI) compare
b4570 lomR +1.5 1.3 no description compare
b2567 rnc +1.5 1.0 ribonuclease III (NCBI) compare
b1767 ansA +1.5 3.0 cytoplasmic asparaginase I (NCBI) compare
b1462 b1462 +1.4 1.9 orf, hypothetical protein (VIMSS) compare
b2055 wcaE +1.4 0.6 predicted glycosyl transferase (NCBI) compare
b2284 nuoF +1.4 4.6 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b0178 hlpA +1.4 3.7 periplasmic chaperone (NCBI) compare
b0843 ybjH +1.4 1.3 hypothetical protein (NCBI) compare
b3545 proK +1.4 1.3 tRNA-Pro (NCBI) compare
b4552 yrhC +1.4 0.7 no description compare
b4505 insX +1.4 1.0 predicted IS protein (RefSeq) compare
b2297 pta +1.4 1.0 phosphate acetyltransferase (NCBI) compare
b1567 intK +1.4 2.1 Qin prophage; predicted protein (RefSeq) compare
b4630 ykgP +1.4 1.8 no description compare
b3761 trpT +1.4 1.5 tRNA-Trp (NCBI) compare
b0737 tolQ +1.4 4.1 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4155 yjeA +1.4 1.1 putative lysyl-tRNA synthetase (VIMSS) compare
b2905 gcvT +1.4 4.9 glycine cleavage system aminomethyltransferase T (NCBI) compare
b0741 pal +1.4 4.6 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b1611 fumC +1.4 4.2 fumarate hydratase (NCBI) compare
b1877 yecT +1.4 3.1 orf, hypothetical protein (VIMSS) compare
b3405 ompR +1.4 4.3 osmolarity response regulator (NCBI) compare
b4535 yniD +1.4 1.0 predicted protein (RefSeq) compare
b1551 b1551 +1.3 0.5 orf, hypothetical protein (VIMSS) compare
b1497 b1497 +1.3 0.7 putative enzyme (VIMSS) compare
b1499 ydeO +1.3 0.6 predicted DNA-binding transcriptional acfivator (NCBI) compare
b2755 ygbT +1.3 5.6 hypothetical protein (NCBI) compare
b0439 lon +1.3 5.2 DNA-binding ATP-dependent protease La (NCBI) compare
b1258 yciF +1.3 1.3 hypothetical protein (NCBI) compare
b1690 ydiM +1.3 2.6 predicted transporter (NCBI) compare
b2572 rseA +1.3 2.4 anti-sigma factor (NCBI) compare
b1165 ymgA +1.3 0.7 hypothetical protein (NCBI) compare
b1363 trkG +1.3 0.8 Rac prophage; potassium transporter subunit (NCBI) compare
b1576 ydfD +1.3 0.6 Qin prophage; predicted protein (NCBI) compare
b1563 relE +1.3 1.7 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b0759 galE +1.3 5.2 UDP-galactose-4-epimerase (VIMSS) compare
b2272 yfbM +1.3 2.5 hypothetical protein (NCBI) compare
b1624 b1624 +1.3 3.4 orf, hypothetical protein (VIMSS) compare
b2579 yfiD +1.3 1.5 pyruvate formate lyase subunit (NCBI) compare
b4589 ylcI +1.3 0.8 hypothetical protein (RefSeq) compare
b1351 racC +1.3 0.7 Rac prophage; predicted protein (NCBI) compare
b1904 yecR +1.3 2.3 hypothetical protein (NCBI) compare
b0080 fruR +1.3 4.5 DNA-binding transcriptional dual regulator (NCBI) compare
b1264 trpE +1.3 3.9 anthranilate synthase component I (NCBI) compare
b1158 pin +1.3 3.4 e14 prophage; site-specific DNA recombinase (NCBI) compare
b1954 dsrA +1.3 1.8 regulatory antisense RNA (NCBI) compare
b0190 yaeQ +1.3 3.9 hypothetical protein (NCBI) compare
b3121 yhaC +1.3 0.6 hypothetical protein (NCBI) compare
b2409 yfeR +1.3 2.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1143 ymfI +1.3 0.8 orf, hypothetical protein (VIMSS) compare
b1409 ynbB +1.3 0.8 predicted CDP-diglyceride synthase (NCBI) compare
b0603 ybdO +1.3 0.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b4588 ylcH +1.2 2.6 hypothetical protein, DLP12 prophage (RefSeq) compare
b4013 metA +1.2 3.6 homoserine O-succinyltransferase (NCBI) compare
b4293 fecI +1.2 2.7 KpLE2 phage-like element; RNA polymerase, sigma 19 factor (NCBI) compare
b2847 yqeI +1.2 0.9 predicted transcriptional regulator (NCBI) compare
b1121 ycfZ +1.2 2.2 predicted inner membrane protein (NCBI) compare
b3844 fre +1.2 5.5 NAD(P)H-flavin reductase (NCBI) compare
b2625 yfjI +1.2 1.7 CP4-57 prophage; predicted protein (NCBI) compare
b4443 gcvB +1.2 0.4 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b4289 fecC +1.2 5.8 KpLE2 phage-like element; iron-dicitrate transporter subunit (NCBI) compare
b3780 rhlB +1.2 6.0 ATP-dependent RNA helicase (NCBI) compare
b2421 cysM +1.2 3.4 cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI) compare
b4410 ecnA +1.2 1.0 entericidin A membrane lipoprotein, antidote entericidin B (NCBI) compare
b3930 menA +1.2 7.2 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b2289 lrhA +1.2 5.5 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes (NCBI) compare
b3082 ygjM +1.2 1.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b2104 thiM +1.2 2.6 hydroxyethylthiazole kinase (NCBI) compare
b2814 metZ +1.2 1.0 tRNA-Met (NCBI) compare
b3094 exuR +1.2 2.9 negative regulator of exu regulon, exuT, uxaAC, and uxuB (VIMSS) compare
b4190 yjfP +1.2 3.9 predicted hydrolase (NCBI) compare
b2876 b2876 +1.2 3.5 orf, hypothetical protein (VIMSS) compare
b2051 wcaH +1.2 0.6 GDP-mannose mannosyl hydrolase (VIMSS) compare
b1183 umuD +1.2 1.2 DNA polymerase V, subunit D (NCBI) compare
b0903 pflB +1.2 6.7 pyruvate formate lyase I (NCBI) compare
b1850 eda +1.2 1.6 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b4025 pgi +1.2 5.6 glucose-6-phosphate isomerase (NCBI) compare
b0118 acnB +1.1 0.7 aconitate hydratase (NCBI) compare
b4697 yrdF +1.1 1.9 no description compare
b3043 ygiL +1.1 3.9 predicted fimbrial-like adhesin protein (NCBI) compare
b1465 narV +1.1 1.3 nitrate reductase 2 (NRZ), gamma subunit (NCBI) compare
b4325 yjiC +1.1 3.1 orf, hypothetical protein (VIMSS) compare
b4509 ylcG +1.1 1.6 DLP12 prophage; predicted protein (NCBI) compare
b0593 entC +1.1 3.7 isochorismate synthase (NCBI) compare
b1443 ydcV +1.1 2.1 predicted spermidine/putrescine transporter subunit (NCBI) compare
b2279 nuoK +1.1 1.4 NADH dehydrogenase subunit K (NCBI) compare
b3337 bfd +1.1 2.1 bacterioferritin-associated ferredoxin (NCBI) compare
b4582 yoeA +1.1 1.6 no description compare
b0806 ybiM +1.1 1.0 orf, hypothetical protein (VIMSS) compare
b1151 ymfO +1.1 1.9 e14 prophage; conserved protein (RefSeq) compare
b1699 ydiS +1.1 2.0 predicted oxidoreductase with FAD/NAD(P)-binding domain (NCBI) compare
b0580 ybdJ +1.1 1.2 predicted inner membrane protein (NCBI) compare
b3101 yqjF +1.1 2.3 orf, hypothetical protein (VIMSS) compare
b1604 ydgH +1.1 2.6 hypothetical protein (NCBI) compare
b2189 proL +1.1 1.0 tRNA-Pro (NCBI) compare
b1129 phoQ +1.1 0.7 sensory histidine kinase in two-compoent regulatory system with PhoP (NCBI) compare
b3562 yiaA +1.1 6.2 orf, hypothetical protein (VIMSS) compare
b3442 yhhZ +1.1 0.4 hypothetical protein (NCBI) compare
b2277 nuoM +1.1 4.3 NADH dehydrogenase subunit M (NCBI) compare
b2257 arnT +1.1 3.7 4-amino-4-deoxy-L-arabinose transferase (NCBI) compare
b0303 ykgI +1.1 0.7 orf, hypothetical protein (VIMSS) compare
b0503 ybbB +1.1 1.8 tRNA 2-selenouridine synthase, selenophosphate-dependent (NCBI) compare
b0523 purE +1.1 1.7 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b2024 hisA +1.1 1.3 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) compare
b1190 dadX +1.1 2.7 alanine racemase (NCBI) compare
b1970 yedX +1.1 2.5 hypothetical protein (NCBI) compare
b0729 sucD +1.1 2.3 succinyl-CoA synthetase subunit alpha (NCBI) compare
b0630 lipB +1.1 1.1 protein of lipoate biosynthesis (VIMSS) compare
b4660 yhiL +1.1 0.5 no description compare
b4128 yjdK +1.1 0.6 hypothetical protein (NCBI) compare
b2742 nlpD +1.1 3.7 predicted outer membrane lipoprotein (NCBI) compare
b4092 phnP +1.1 4.1 carbon-phosphorus lyase complex accessory protein (NCBI) compare
b0500 ybbD +1.1 0.4 hypothetical protein (RefSeq) compare
b3504 yhiS +1.1 0.5 hypothetical protein (RefSeq) compare
b1833 yebS +1.1 2.2 conserved inner membrane protein (NCBI) compare
b1395 paaH +1.1 3.4 3-hydroxybutyryl-CoA dehydrogenase (NCBI) compare
b1502 ydeQ +1.1 1.8 predicted fimbrial-like adhesin protein (NCBI) compare
b4508 peaD +1.1 2.3 putative sensory transduction regulator (VIMSS) compare
b1407 ydbD +1.1 4.5 orf, hypothetical protein (VIMSS) compare
b3673 emrD +1.1 4.6 2-module integral membrane pump; multidrug resistance (VIMSS) compare
b3606 yibK +1.1 2.6 predicted rRNA methylase (NCBI) compare
b2792 yqcC +1.0 2.0 hypothetical protein (NCBI) compare


Specific Phenotypes

For 18 genes in this experiment

For phage MOI 10 in Escherichia coli BW25113

For phage MOI 10 across organisms