Experiment set64S281 for Escherichia coli BW25113

Compare to:

Control_TnG

200 most important genes:

  gene name fitness t score description  
b3613 yibP -2.8 -6.4 putative membrane protein (VIMSS) compare
b3500 gor -2.7 -1.8 glutathione reductase (NCBI) compare
b4699 fnrS -2.7 -1.9 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b3021 ygiT -2.5 -4.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b0739 tolA -2.2 -5.0 cell envelope integrity inner membrane protein TolA (NCBI) compare
b2830 nudH -2.2 -1.5 dinucleoside polyphosphate hydrolase (NCBI) compare
b1476 fdnI -2.1 -1.8 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b0740 tolB -2.1 -6.8 translocation protein TolB precursor (NCBI) compare
b0990 cspG -2.0 -2.1 DNA-binding transcriptional regulator (NCBI) compare
b4042 dgkA -1.9 -2.2 diacylglycerol kinase (NCBI) compare
b1861 ruvA -1.9 -2.1 Holliday junction DNA helicase motor protein (NCBI) compare
b0053 surA -1.8 -6.7 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3816 corA -1.8 -10.4 magnesium/nickel/cobalt transporter (NCBI) compare
b0890 ftsK -1.8 -5.3 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b4202 rpsR -1.7 -1.6 30S ribosomal protein S18 (NCBI) compare
b0200 gmhB -1.7 -1.6 hypothetical protein (NCBI) compare
b0738 tolR -1.7 -3.6 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1863 ruvC -1.7 -2.7 Holliday junction resolvase (NCBI) compare
b3390 aroK -1.7 -2.8 shikimate kinase I (NCBI) compare
b2894 xerD -1.6 -1.0 site-specific tyrosine recombinase XerD (NCBI) compare
b3977 tyrU -1.6 -1.3 tRNA-Tyr (NCBI) compare
b3162 deaD -1.6 -5.0 inducible ATP-independent RNA helicase (VIMSS) compare
b3107 yhaL -1.6 -2.1 orf, hypothetical protein (VIMSS) compare
b0737 tolQ -1.5 -3.8 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1936 intG -1.4 -0.9 predicted defective phage integrase (pseudogene) (RefSeq) compare
b1860 ruvB -1.4 -1.2 Holliday junction DNA helicase B (NCBI) compare
b2699 recA -1.4 -1.5 recombinase A (NCBI) compare
b2853 ygeI -1.4 -0.8 hypothetical protein (NCBI) compare
b1730 ydjO -1.2 -1.4 predicted protein (RefSeq) compare
b1493 gadB -1.2 -1.4 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b3463 ftsE -1.2 -0.8 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b3863 polA -1.2 -1.1 DNA polymerase I (NCBI) compare
b0630 lipB -1.2 -1.1 protein of lipoate biosynthesis (VIMSS) compare
b2168 fruK -1.2 -1.0 1-phosphofructokinase (NCBI) compare
b4201 priB -1.2 -2.8 primosomal replication protein N (NCBI) compare
b0051 ksgA -1.2 -4.2 dimethyladenosine transferase (NCBI) compare
b1293 sapB -1.2 -1.7 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1231 tyrT -1.2 -1.2 tRNA-Tyr (NCBI) compare
b1848 yebG -1.1 -2.0 conserved protein regulated by LexA (NCBI) compare
b3839 tatC -1.1 -4.9 TatABCE protein translocation system subunit (NCBI) compare
b0741 pal -1.1 -3.2 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3811 xerC -1.1 -1.8 site-specific tyrosine recombinase XerC (NCBI) compare
b4647 mokA -1.1 -0.7 no description compare
b3979 thrT -1.1 -0.5 tRNA-Thr (NCBI) compare
b4246 pyrL -1.1 -2.6 pyrBI operon leader peptide (NCBI) compare
b1642 slyA -1.1 -2.3 transcriptional regulator for cryptic hemolysin (VIMSS) compare
b3405 ompR -1.1 -4.4 osmolarity response regulator (NCBI) compare
b0161 degP -1.1 -6.0 serine endoprotease (protease Do), membrane-associated (NCBI) compare
b1558 cspF -1.0 -2.4 Qin prophage; cold shock protein (NCBI) compare
b1551 b1551 -1.0 -0.6 orf, hypothetical protein (VIMSS) compare
b3426 glpD -1.0 -2.2 sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding (NCBI) compare
b0617 citD -1.0 -2.3 citrate lyase, acyl carrier (gamma) subunit (NCBI) compare
b1842 holE -1.0 -1.6 DNA polymerase III, theta subunit (NCBI) compare
b3778 rep -1.0 -6.0 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b1185 dsbB -1.0 -2.9 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b0088 murD -1.0 -1.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b1850 eda -1.0 -1.7 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b4414 tff -1.0 -2.0 unknown RNA (NCBI) compare
b0149 mrcB -1.0 -8.0 penicillin-binding protein 1b (NCBI) compare
b3261 fis -1.0 -1.6 DNA-binding protein Fis (NCBI) compare
b0767 ybhE -1.0 -3.7 6-phosphogluconolactonase (NCBI) compare
b1292 sapC -1.0 -1.7 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1368 ynaA -0.9 -2.4 Rac prophage; predicted tail protein (RefSeq) compare
b3082 ygjM -0.9 -1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b0437 clpP -0.9 -4.3 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1506 yneL -0.9 -1.5 predicted transcriptional regulator (NCBI) compare
b1109 ndh -0.9 -3.2 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b2528 iscA -0.9 -1.0 iron-sulfur cluster assembly protein (NCBI) compare
b0439 lon -0.9 -3.8 DNA-binding ATP-dependent protease La (NCBI) compare
b0912 ihfB -0.9 -3.6 integration host factor subunit beta (NCBI) compare
b1192 ldcA -0.9 -4.7 L,D-carboxypeptidase A (NCBI) compare
b4546 ypeB -0.9 -1.1 hypothetical protein (NCBI) compare
b3636 rpmG -0.9 -1.6 50S ribosomal protein L33 (NCBI) compare
b1865 nudB -0.9 -1.3 dATP pyrophosphohydrolase (NCBI) compare
b4172 hfq -0.9 -0.5 RNA-binding protein Hfq (NCBI) compare
b4048 yjbM -0.8 -1.2 hypothetical protein (NCBI) compare
b2935 tktA -0.8 -1.6 transketolase 1, thiamin-binding (NCBI) compare
b3916 pfkA -0.8 -2.1 6-phosphofructokinase (NCBI) compare
b1286 rnb -0.8 -1.9 exoribonuclease II (NCBI) compare
b1882 cheY -0.8 -0.6 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b3169 nusA -0.8 -2.0 transcription elongation factor NusA (NCBI) compare
b2276 nuoN -0.8 -3.5 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b0364 yaiS -0.8 -2.6 orf, hypothetical protein (VIMSS) compare
b2450 yffS -0.8 -2.0 CPZ-55 prophage; predicted protein (RefSeq) compare
b2498 upp -0.8 -2.0 uracil phosphoribosyltransferase (VIMSS) compare
b1482 osmC -0.8 -1.6 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b3493 pitA -0.7 -3.8 phosphate transporter, low-affinity (NCBI) compare
b2288 nuoA -0.7 -2.0 NADH dehydrogenase I chain A (VIMSS) compare
b3741 gidA -0.7 -2.7 glucose-inhibited division protein A (NCBI) compare
b0726 sucA -0.7 -2.5 alpha-ketoglutarate decarboxylase (NCBI) compare
b1291 sapD -0.7 -1.2 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3414 gntY -0.7 -3.4 predicted gluconate transport associated protein (NCBI) compare
b0049 apaH -0.7 -1.6 diadenosinetetraphosphatase (NCBI) compare
b0819 ybiS -0.7 -5.2 hypothetical protein (NCBI) compare
b1382 ynbE -0.7 -1.3 predicted lipoprotein (NCBI) compare
b1298 ycjL -0.7 -2.3 probable amidotransferase subunit (VIMSS) compare
b0438 clpX -0.7 -3.6 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3728 pstS -0.7 -1.8 phosphate transporter subunit (NCBI) compare
b3229 sspA -0.7 -1.8 stringent starvation protein A (NCBI) compare
b1346 ydaQ -0.7 -0.9 orf, hypothetical protein (VIMSS) compare
b1667 ydhR -0.7 -2.1 hypothetical protein (NCBI) compare
b4426 isrA -0.7 -1.4 unknown RNA (NCBI) compare
b1164 ycgZ -0.6 -1.1 hypothetical protein (NCBI) compare
b1156 tfaE -0.6 -2.9 e14 prophage; predicted tail fiber assembly protein (NCBI) compare
b1161 ycgX -0.6 -0.8 hypothetical protein (NCBI) compare
b3781 trxA -0.6 -2.3 thioredoxin 1 (VIMSS) compare
b0685 ybfE -0.6 -2.2 orf, hypothetical protein (VIMSS) compare
b3388 damX -0.6 -5.2 hypothetical protein (NCBI) compare
b1198 dhaM -0.6 -2.7 fused predicted dihydroxyacetone-specific PTS enzymes: HPr component/EI component (RefSeq) compare
b0080 fruR -0.6 -3.2 DNA-binding transcriptional dual regulator (NCBI) compare
b0705 ybfL -0.6 -0.4 putative receptor protein (VIMSS) compare
b1855 lpxM -0.6 -2.2 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b0015 dnaJ -0.6 -4.4 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b2284 nuoF -0.6 -2.4 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b3387 dam -0.6 -4.6 DNA adenine methylase (NCBI) compare
b0888 trxB -0.6 -2.2 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b4179 vacB -0.6 -2.7 putative enzyme (VIMSS) compare
b1613 manA -0.6 -1.3 mannose-6-phosphate isomerase (VIMSS) compare
b1400 paaY -0.6 -1.7 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b4180 rlmB -0.6 -3.8 23S rRNA (Gm2251)-methyltransferase (NCBI) compare
b4655 ythA -0.6 -0.8 expressed protein (RefSeq) compare
b3973 birA -0.6 -2.1 biotin--protein ligase (NCBI) compare
b2808 gcvA -0.6 -1.8 DNA-binding transcriptional dual regulator (NCBI) compare
b3630 rfaP -0.6 -3.9 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b2569 lepA -0.6 -2.3 GTP-binding protein LepA (NCBI) compare
b3026 qseC -0.6 -2.2 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b0167 glnD -0.6 -2.2 PII uridylyl-transferase (NCBI) compare
b2444 yffM -0.6 -1.5 CPZ-55 prophage; predicted protein (NCBI) compare
b4319 fimG -0.6 -3.2 minor component of type 1 fimbriae (NCBI) compare
b1242 ychE -0.6 -2.1 predicted inner membrane protein (NCBI) compare
b1973 yodA -0.6 -2.2 conserved metal-binding protein (NCBI) compare
b4178 yjeB -0.6 -2.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b3649 rpoZ -0.6 -1.6 DNA-directed RNA polymerase subunit omega (NCBI) compare
b3792 wzxE -0.6 -3.0 O-antigen translocase (NCBI) compare
b1058 yceO -0.5 -0.3 hypothetical protein (NCBI) compare
b2356 yfdM -0.5 -1.5 orf, hypothetical protein (VIMSS) compare
b2435 amiA -0.5 -3.4 N-acetylmuramoyl-l-alanine amidase I (NCBI) compare
b1563 relE -0.5 -0.8 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b1591 b1591 -0.5 -1.4 putative oxidoreductase component (VIMSS) compare
b4402 yjjY -0.5 -0.4 hypothetical protein (NCBI) compare
b2330 yfcB -0.5 -1.0 putative adenine-specific methylase (VIMSS) compare
b3935 priA -0.5 -1.4 primosome assembly protein PriA (NCBI) compare
b3237 argR -0.5 -2.3 arginine repressor (NCBI) compare
b0142 folK -0.5 -0.4 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b2449 yffR -0.5 -2.7 CPZ-55 prophage; predicted protein (NCBI) compare
b0678 nagB -0.5 -2.3 glucosamine-6-phosphate deaminase (NCBI) compare
b2579 yfiD -0.5 -1.1 pyruvate formate lyase subunit (NCBI) compare
b1526 yneJ -0.5 -2.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b2782 chpA -0.5 -2.3 toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease (NCBI) compare
b2597 yfiA -0.5 -1.1 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b4685 yrbN -0.5 -1.3 expressed protein (RefSeq) compare
b2443 yffL -0.5 -2.0 CPZ-55 prophage; predicted protein (NCBI) compare
b0720 gltA -0.5 -2.7 citrate synthase (NCBI) compare
b4458 oxyS -0.5 -0.9 global regulatory RNA (NCBI) compare
b4571 wbbL -0.5 -1.6 no description compare
b3398 yrfF -0.5 -1.6 predicted inner membrane protein (NCBI) compare
b1658 purR -0.5 -2.3 DNA-binding transcriptional repressor, hypoxanthine-binding (NCBI) compare
b4457 csrC -0.5 -1.8 regulatory RNA (NCBI) compare
b2433 b2433 -0.5 -1.4 orf, hypothetical protein (VIMSS) compare
b1920 fliY -0.5 -1.0 cystine transporter subunit (NCBI) compare
b2017 yefM -0.5 -1.2 orf, hypothetical protein (VIMSS) compare
b1839 yebY -0.5 -1.7 hypothetical protein (NCBI) compare
b3611 yibN -0.5 -2.4 predicted rhodanese-related sulfurtransferase (NCBI) compare
b3950 frwB -0.5 -1.5 predicted enzyme IIB component of PTS (NCBI) compare
b1676 pykF -0.5 -1.8 pyruvate kinase (NCBI) compare
b3652 recG -0.5 -3.5 ATP-dependent DNA helicase (NCBI) compare
b1179 ycgL -0.5 -1.4 conserved protein (NCBI) compare
b2937 speB -0.5 -2.8 agmatinase (NCBI) compare
b3465 yhhF -0.5 -2.8 predicted methyltransferase (NCBI) compare
b2105 yohL -0.5 -2.1 hypothetical protein (NCBI) compare
b3210 arcB -0.5 -2.9 hybrid sensory histidine kinase in two-component regulatory system with ArcA (NCBI) compare
b2822 recC -0.5 -2.0 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b2229 b2229 -0.5 -2.3 orf, hypothetical protein (VIMSS) compare
b4413 sokC -0.5 -0.9 regulatory antisense RNA (NCBI) compare
b3094 exuR -0.5 -2.1 negative regulator of exu regulon, exuT, uxaAC, and uxuB (VIMSS) compare
b2895 fldB -0.5 -1.7 flavodoxin 2 (NCBI) compare
b1366 ydaY -0.5 -2.0 Rac prophage; predicted protein (RefSeq) compare
b0082 mraW -0.5 -1.7 S-adenosyl-methyltransferase (NCBI) compare
b0746 valZ -0.5 -1.2 tRNA-Val (NCBI) compare
b2906 visC -0.5 -2.5 hypothetical protein (NCBI) compare
b1279 yciS -0.5 -0.7 conserved inner membrane protein (NCBI) compare
b1693 aroD -0.5 -2.6 3-dehydroquinate dehydratase (NCBI) compare
b1235 rssB -0.5 -2.6 response regulator of RpoS (NCBI) compare
b2277 nuoM -0.5 -2.2 NADH dehydrogenase subunit M (NCBI) compare
b0928 aspC -0.5 -2.1 aspartate aminotransferase, PLP-dependent (NCBI) compare
b1001 yccE -0.5 -0.3 hypothetical protein (NCBI) compare
b4436 ryeC -0.5 -0.9 Novel sRNA, function unknown; paralogous to the other QUAD sRNA genes unknown (RefSeq) compare
b2318 truA -0.5 -0.9 tRNA pseudouridine synthase A (NCBI) compare
b4451 ryhB -0.5 -0.5 Regulatory sRNA mediating positive Fur regulon response; requires Hfq for function; global iron regulator; degraded by RNase E when bound to target (RefSeq) compare
b3198 kdsC -0.5 -1.4 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b2582 trxC -0.5 -1.7 thioredoxin 2 (NCBI) compare
b4093 phnO -0.4 -2.6 predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI) compare
b0619 citA -0.4 -3.0 sensory histidine kinase in two-component regulatory system with citB (NCBI) compare
b2113 mrp -0.4 -2.6 putative ATPase (VIMSS) compare
b1579 intQ -0.4 -1.2 Qin prophage; predicted defective integrase (RefSeq) compare
b1593 b1593 -0.4 -1.2 orf, hypothetical protein (VIMSS) compare
b3609 secB -0.4 -1.4 export protein SecB (NCBI) compare
b4240 treB -0.4 -3.1 fused trehalose(maltose)-specific PTS enzyme: IIB component/IIC component (NCBI) compare
b4409 blr -0.4 -2.4 beta-lactam resistance membrane protein (NCBI) compare
b3404 envZ -0.4 -3.4 osmolarity sensor protein (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in no phage control experiments